National University Hospital, Singapore

This early-phase study tests a new RNA-based drug (MTL-CEBPA) combined with two standard immunotherapy drugs (atezolizumab and bevacizumab) in people with advanced liver cancer who have not had prior treatment. The main goals are to find the safest dose and see how the tumors res…

This early-phase study tested whether adding the antibiotic ciprofloxacin to standard chemotherapy could help control metastatic pancreatic cancer. Ten adults with untreated, advanced pancreatic cancer took part. The goal was to see if the combination improved tumor response, but…

This study tests the drug Lonsurf in people with metastatic breast cancer that has spread. It aims to see if the drug can stop or slow cancer growth. About 86 adults will take part, and the main goal is to measure how long the cancer stays under control.

This study tests a drug called pacritinib in people with advanced solid tumors (like breast cancer) that have a specific genetic change called 1q21.3 amplification. The goal is to see if the drug can shrink tumors or slow their growth. About 74 adults whose cancer has not respond…

This study tests the safety of a new drug, PRL3-ZUMAB, in people with advanced solid tumors or blood cancers that have not responded to standard treatments. It is the first time this drug is given to humans, after showing good tolerance in animals. The goal is to find the safest …

This study compares two types of root canal sealers—TotalFill® and AH Plus®—to see which one helps heal infections around the tooth root better. About 170 teeth from adult patients at a dental center will be treated and followed with X-rays and pain checks. The goal is to find ou…

This study tests a combination of two drugs, lenvatinib and letrozole, given before surgery to postmenopausal women with a common type of breast cancer (hormone receptor positive). The goal is to see if the drugs can shrink the tumor enough to improve surgical outcomes. About 40 …

This study looks at whether adding surgery after chemotherapy can help people with stage IV stomach cancer that has spread to the abdomen lining live longer. About 300 adults whose cancer responded well to initial treatment will be randomly assigned to either continue chemotherap…

This study compares two spinal anesthesia drugs, prilocaine and bupivacaine, in 50 Asian patients having total knee replacement. Prilocaine may numb the legs for a shorter time, allowing patients to move sooner and start rehabilitation earlier. The goal is to see if prilocaine le…

This study aims to understand how the brain changes after a stroke and how those changes relate to arm recovery. Researchers will use brain scans and electrical recordings from 41 stroke patients to build a model that predicts recovery. The goal is to eventually tailor brain stim…

This study follows 1247 mothers and their children for at least 20 years to learn how genetics, diet, lifestyle, and environment during pregnancy and early childhood affect future health. Researchers will track both mother and child to understand risks for metabolic and mental he…

This study looks at different methods to encourage women in Singapore to get mammograms for early breast cancer detection. It focuses on two groups: women who have never had a mammogram and those who are due for a repeat screening. The goal is to find which outreach strategies wo…

This study is testing a new AI system that uses a 3D scan of a patient's face to predict if they might have a difficult airway during surgery. About 1,000 adults undergoing general anesthesia will participate. The goal is to help doctors prepare better and avoid emergencies.