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New study: shorter numbing agent may get knee replacement patients moving faster

NCT ID NCT07329582

Symptom relief Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two numbing medicines given as spinal anesthesia for total knee replacement surgery. The goal is to see if prilocaine, which wears off faster than bupivacaine, helps patients regain leg movement sooner and start rehabilitation earlier. About 50 Asian adults having elective knee replacement will take part. The research aims to improve recovery and patient satisfaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

50 people

The number who actually took part.

Started

May 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * undergoing elective unilateral total knee replacement * Able to give informed consent Exclusion Criteria: * Patients of age \< 21 or \> 90 years old * American Society of Anaesthesiologists (ASA) physical status\> III * Extremes of weight: \<40kg or BMI \>40 * Contra-indications to spinal anaesthesia, prilocaine or bupivacaine (including allergy to local anaesthesia agents or patients at high risk for methaemoglobinemia) * Complex TKR as deemed by surgeons * Patient refusal * Failure of spinal anaesthesia resulting in conversion to general anaesthesia, prior to start of operation * Patients with prostate hyperplasia or urogenital pathologies * Planning to conceive / pregnant women / breastfeeding

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee replacement surgery Knee replacement, total

Contacts and locations

Locations

  • National University Hospital Singapore

    Singapore, 119074, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.