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Ozone water during root canals may reduce inflammation

NCT ID NCT07171762

Knowledge-focused Sponsor: KEZBAN MELTEM ÇOLAK Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether using ozone water during root canal treatment can reduce oxidative stress (a sign of inflammation) in the jawbone. Sixty adults with a single-rooted tooth and a silent infection will be randomly assigned to receive either ozone water or salt water as a final rinse. Researchers will measure chemical markers of stress in fluid from the tooth before, right after, and one week after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozonated water
What this could lead to
If successful, this could show that ozone water is a better disinfectant during root canals, potentially improving healing of the jawbone.
What could go wrong
This is a small, early-stage study measuring chemical markers, not actual patient outcomes. The results may not translate to better dental health or pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Oct 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Patients must be between 18 and 65 years of age 2. Single-rooted, asymptomatic apical periodontitis with necrotic teeth 3. Teeth with periapical lesion size classified as score 3 or 4 according to the Orstavik classification 4. Periapical Assessment Index (PAI) of 2 or higher 5. Patients with ASA I status Exclusion Criteria 1. Teeth with multiple roots 2. Patients with ASA II or higher 3. Pregnant women or those suspected of being pregnant 4. Patients with a history of allergies 5. Teeth with excessive material loss where a rubber dam cannot be applied 6. Teeth with root fractures or an open apex 7. Teeth that have previously undergone root canal treatment 8. Presence of canal curvature greater than Schilder 25°, 9. Patients with generalized periodontitis, 10. Presence of a periodontal pocket greater than 3mm in the relevant tooth

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apical periodontitis Oxidative stress

Contacts and locations

Locations

  • ATATURK UNIVERSITY, FACULTY of DENTISTRY, Department of ENDODONTICS

    Erzurum, Erzurum, 25240, Turkey (Türkiye)

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