Ozone water during root canals may reduce inflammation

NCT ID NCT07171762

Ongoing Knowledge-focused Sponsor: KEZBAN MELTEM ÇOLAK Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether using ozone water during root canal treatment can reduce oxidative stress (a sign of inflammation) in the jawbone. Sixty adults with a single-rooted tooth and a silent infection will be randomly assigned to receive either ozone water or salt water as a final rinse. Researchers will measure chemical markers of stress in fluid from the tooth before, right after, and one week after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ozonated water
What this could lead to: If successful, this could show that ozone water is a better disinfectant during root canals, potentially improving healing of the jawbone.
What could go wrong: This is a small, early-stage study measuring chemical markers, not actual patient outcomes. The results may not translate to better dental health or pain relief.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APICAL PERIODONTITIS OXIDATIVE STRESS

Contacts and locations

Locations

ATATURK UNIVERSITY, FACULTY of DENTISTRY, Department of ENDODONTICS

Erzurum, Erzurum, 25240, Turkey (Türkiye)

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