Could melatonin help heal your gums?
NCT ID NCT07316582
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a melatonin-loaded gel, made from your own blood, can improve gum health in people with stage II periodontitis. About 60 adults with mild to moderate gum disease will receive the treatment. The main goal is to see if it helps reattach gums to teeth.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- Diagnosed with stage II periodontitis based on AAP/EFP 2018 classification • Minimum of two non-adjacent periodontal pockets \<5 mm in different quadrants • Systemically healthy individuals willing to participate and comply with follow-up visits • Radiographic bone loss (ranged from is 10-20% mostly horizontal Exclusion Criteria: History of systemic diseases affecting periodontium (e.g., diabetes, osteoporosis) • Use of antibiotics, anti-inflammatories, or antioxidant supplements in the past 3 months • Smoking or tobacco use • Pregnancy or lactation • Allergy to melatonin or related compounds \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of Dental Medicine for girls Al-Azhar University
New Cairo, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Gentler mouthwash could tame gum disease with fewer side effects
- Algae gel could boost gum disease treatment
- Ozone-Infused sunflower oil gel shows promise for gum health
- Gum disease protein levels tracked after simple treatment
- Gum disease inflammation link explored in new study