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Could a plant extract beat standard root canal treatments?

NCT ID NCT07534943

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether oleanolic acid, a natural plant compound, works better than standard medicines (calcium hydroxide and Ledermix) when placed inside a root canal. The goal is to reduce bacteria and inflammation in teeth with infection. Thirty-six adults with infected single-root teeth will be treated, and researchers will measure pain, bacterial levels, and inflammatory markers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Mar 2026

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Single rooted teeth with pulp necrosis and apical periodontitis. 2. The age ranges from 20 to 60 years. Exclusion Criteria: 1. Patient receiving antibiotic treatment within the preceding 3 months. 2. Patient reporting systemic disease. 3. Teeth that can not be isolated with rubber dam. 4. Teeth with periodontal pockets deeper than 3 mm.

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Conditions

The condition(s) this trial relates to.

periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodotic microbiota Inflammatory cytokines Intracanal medicaments

Contacts and locations

Locations

  • Mansoura University

    Al Mansurah, Dakahlia Governorate, 35511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.