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Your DNA could determine root canal success

NCT ID NCT07542223

Knowledge-focused Sponsor: Ataturk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a person's genetic makeup influences how well a tooth infection heals after root canal treatment. Researchers will collect saliva samples from 96 adults with chronic apical periodontitis and analyze specific genes related to inflammation and bone repair. Participants receive standard root canal therapy and are followed for 12 months with X-rays and CT scans to measure healing. The goal is to understand why some people heal better than others and to pave the way for more personalized dental care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

96 people

The number who actually took part.

Started

Feb 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged between 18 and 65 years who present with non-vital teeth showing negative responses to cold testing and electric pulp testing, negative responses to percussion and palpation tests, and radiographic evidence (via intraoral periapical radiography) of apical radiolucency with a Periapical Index (PAI) score of 3 or 4 in mandibular molar teeth will be included in the study.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 and 65 years * Devital mandibular molar teeth with asymptomatic apical periodontitis * Teeth showing negative response to percussion and palpation tests * Teeth with negative responses to cold test and electric pulp testing * Teeth with a Periapical Index (PAI) score of 3 or 4 * Patients classified as ASA I * Patients without any genetic disorders (e.g., Down syndrome, congenital insensitivity to pain, etc.) Exclusion Criteria: * Teeth with internal or external resorption * Teeth with a history of trauma * Teeth with vertical or horizontal root fractures * Teeth with grade 3 mobility and loss of function * Teeth that cannot be isolated with rubber dam or are not restorable * Pregnant women or patients with suspected pregnancy * Root canal curvature greater than 25° according to Schilder's classification * Patients with generalized periodontitis * Presence of periodontal pocket depth greater than 3 mm in the involved tooth * Patients classified as ASA II or higher * Presence of preoperative swelling, sinus tract, or pain on palpation * Patients with bruxism * Teeth with suspected periodontal-endodontic lesions * Teeth with a PAI index below 2 or above 5

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Conditions

The condition(s) this trial relates to.

chronic apical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic apical periodontitis

Contacts and locations

Locations

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi

    Erzurum, Yakutiye, Turkey (Türkiye)

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