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Your own blood could help heal gum disease bone loss

NCT ID NCT07261878

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a concentrate from the patient's own blood (injectable platelet rich fibrin, or I-PRF) to a standard bone graft helps repair bone defects caused by advanced gum disease. Twenty adults with stage III periodontitis and deep gum pockets will receive either the combination treatment or the graft alone during surgery. Researchers will measure bone fill and gum health at 3 and 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet rich fibrin (I-PRF) and xenograft
What this could lead to
If it works, this could offer a better way to repair bone damage from advanced gum disease using the patient's own blood.
What could go wrong
This is a very small early study with only 20 people, so results may not apply widely. The treatment is surgical and carries typical risks like infection or poor healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient should have localized Periodontitis stage III grade B with pocket depth ≥ 6mm; indicated for periodontal surgery 2. Patient's agreement to the surgical procedure and clinical trial. 3. Age ranged between 30-55 years old. 4. Intrabony defects with depth ≥3mm. 5. Free from any systemic conditions and no previous drug affect bone metabolism Exclusion Criteria: 1. Smoking. 2. Pregnant women. 3. Patients in variation in anatomical landmarks. 4. Patients with psychological problems. 5. Patients with abnormal habits.

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Conditions

The condition(s) this trial relates to.

chronic periodontitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrabony defect Intrabony defects in chronic periodontitis

Contacts and locations

Locations

  • Faculty of Dental Medicine for Girls, Al- Azhar University

    Cairo, Cairo Governorate, Egypt

  • Ola Jamal

    Cairo, Cairo Governorate, Egypt

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