Anxiety disorder

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of …

This trial tests whether a culturally adapted program of case manager support can improve survival, reduce hospital readmissions, and boost quality of life for adults recovering from accidental burn injuries in Pakistan. Participants receive up to eight sessions with a case manag…

This study tests an online program called SYNC designed to help youth aged 16-20 in foster care manage stress, build coping skills, and feel more comfortable seeking mental health help. Participants take part in an 8-module online curriculum with support from service providers an…

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether painting roofs with a special reflective coating can lower indoor temperatures and improve mental health. About 800 people in Ahmedabad, India, who live in homes with poor insulation will be randomly assigned to get a cool roof or not. Researchers will me…

This trial tests whether 5-10 minutes of daily mindfulness and compassion training in school can prevent anxiety and depression in children aged 6-16. About 1,750 pupils will take part, with some classes doing the training for 10 weeks and others not. Researchers will track menta…

This study tests a program called BasketballRx, which combines basketball activities with lessons on healthy eating, exercise, sleep, and stress management. The program is designed for teens aged 10 to 15 who are overweight or have obesity, and who identify as Black or Latino. Ov…

This study tests whether a health promotion program can prevent anxiety and depression in older Latino adults who are at risk. 240 participants will either join a program with group walks and social sessions led by a community health worker, or attend a healthy lifestyles educati…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

People on hemodialysis receive needle sticks through a fistula or graft several times a week, and the pain and anxiety can build over time. This trial tests whether slow, deep breathing combined with lemongrass aromatherapy reduces pain and anxiety during needle insertion. Resear…

This study tests whether a therapist-guided virtual reality (VR) program can help adolescents in psychiatric hospitals improve how they regulate their emotions. Participants, aged 11 to 18, are randomly assigned to either personalized VR exposure sessions or a VR relaxation contr…

Researchers are testing a personalized, non-drug treatment for adults with ongoing depression, anxiety, trauma-related symptoms, sleep problems, attention difficulties, or substance-use concerns. Instead of assigning treatment by diagnosis alone, the study selects approaches base…

Researchers are testing a virtual reality therapy for young people with depression and anxiety. The therapy adapts acceptance and commitment therapy to teach skills for viewing thoughts and emotions as temporary events. Up to 75 young people aged 12 to 25 will receive the clinici…

Researchers at the University of Illinois at Chicago are studying which parts of a yoga practice affect anxiety, mood, and thinking in highly anxious college women. About 60 participants complete four sessions that include yoga postures, breathwork, meditation, or watching a yoga…

Researchers are testing a virtual stress-management program for people who care for a spouse or partner with a solid tumor cancer while also holding a job. The program teaches skills such as paced respiration, relaxation, and coping with work and caregiving demands across eight s…

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

Researchers in Greece are testing a nine-session group program called TRANSFORM for people who have finished treatment for blood cancers such as leukemia, lymphoma, and myeloma. The program combines teaching, reflection, coping exercises, and mindfulness to see whether it can spa…

Researchers are adapting a mobile health program that pairs the PositiveLinks app with video counseling from a community health worker. The study enrolls 60 people in Florida who have HIV and mild to moderate anxiety or depression. Participants receive either the enhanced counsel…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study tests whether an online problem-solving therapy, matched to a person's specific symptoms using machine learning, can reduce depression and anxiety better than usual care. About 380 adults with moderate symptoms will take part. The goal is to create a precise, scalable …

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study investigates whether breathing a 50:50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain and anxiety during insertion of a central venous catheter, a common but uncomfortable procedure. Adults aged 18 to 65 who have never used nitrous oxide will be randoml…

This study compares two low-intensity family treatments for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD): internet-delivered cognitive behavioral therapy (CBT) and a parent-led reading program. Both are delivered via telehealth and compared to a relaxati…

This study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This trial tests whether a 20-minute session of mandala coloring while listening to slow instrumental music can reduce cancer fear and anxiety in women undergoing cancer screening. Women aged 30 to 65 attending a screening center will be randomly assigned to either the coloring a…

This trial tests whether a mindfulness app called AmDTx (now DawnDTx) can help reduce symptoms of anxiety and depression in people who are on a waiting list for their first psychiatric consultation. Participants will be randomly assigned to use either the mindfulness app or a pla…

This trial tests whether focusing on warm-colored versus cool-colored visuals during labor can ease pain, anxiety, and discomfort while potentially shortening labor. First-time mothers with a full-term, low-risk pregnancy are randomly assigned to look at either a warm or cool col…

This study tests a topical patch called PEACE that uses gentle vibrations to help people feel less stressed or anxious. 150 adults aged 18 to 85 who have stress or anxiety will wear either the active patch or a sham (fake) patch for 14 days. Researchers will measure changes using…

This trial tests whether acupressure, a technique that applies gentle pressure to specific body points, can reduce pain, fear, and anxiety in children aged 6-12 during removal of K-wires (thin metal pins used to heal elbow fractures). Children will be randomly assigned to receive…

This study from Stanford University tests whether two breathing techniques—cyclic sighing and box breathing—can lower anxiety, compared to hypnosis or listening to an audiobook about stress. Eighty adults will practice daily for 4 weeks and have their brain activity and heart rat…

This trial tests whether using virtual reality (VR) headsets to distract patients can reduce pain and anxiety during bone marrow examinations, which are often uncomfortable and stressful. Participants will either use VR headsets to watch or listen to calming content, or follow th…

This study tests whether a single oral dose of cannabidiol (CBD) can reduce the anxiety people with advanced breast cancer feel before undergoing CT or PET scans. Participants are randomly assigned to receive either CBD or a placebo, and their anxiety levels are measured before a…

This trial tests whether a multisensory foam, which stimulates touch, sight, hearing, and smell with a fun, cooling 'popping candy' effect, can reduce pain, anxiety, and fear in children aged 5 to 10 during a blood draw. Half the children will receive the foam during the procedur…

This study will test whether using technology like virtual reality headsets, tablets with games, or other gadgets can help reduce anxiety and pain in children aged 4 to 17 during minor procedures such as lumbar punctures or heart catheterizations. About 200 kids will be randomly …

This trial tests whether watching robotic fish or live aquarium fish can reduce pain, fear, and anxiety in children aged 5 to 10 during painful medical procedures. Children will be assigned to watch one of the two fish distractions while undergoing the procedure, and their pain, …

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This trial tests whether spending time in nature can reduce anxiety in children aged 9-12 who have experienced adverse childhood events. Participants are assigned to either group nature outings, family outings, or a waitlist. The goal is to see if these nature-based activities im…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This trial tests whether a brief program called CALM, delivered by school nurses, can reduce excessive anxiety in children aged 5 to 12. The program teaches relaxation, facing fears, and changing anxious thoughts over eight weeks. It is compared to a relaxation-only approach and …

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This study explores whether a type of improvised music, designed with calming sound parameters, can reduce anxiety in people with Alzheimer's disease and in healthy adults. Researchers will measure changes in anxiety scores, blood pressure, and heart rate before and after listeni…

This trial tests whether a virtual reality (VR) educational video can reduce anxiety and improve satisfaction in adults starting their first course of external beam radiotherapy for cancer. Half of the 122 participants will watch a VR video through a headset before treatment, whi…

This trial tests whether listening to music for 30 minutes before and after surgery can reduce pain, anxiety, and the need for painkillers in women undergoing gynecologic surgery. Participants will choose from several music genres and report their pain, anxiety, and satisfaction …

This trial tests whether nurse-guided breathing exercises can reduce shortness of breath and anxiety in people with advanced heart failure who come to the emergency department. Participants are randomly assigned to receive either standard care plus guided diaphragmatic and pursed…

This trial tests whether using virtual reality (VR) relaxation before and after gynecologic surgery can reduce anxiety and pain. About 220 women undergoing day or inpatient gynecologic procedures will either use a VR headset with calming scenes or receive standard care. Researche…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This study tests whether a device called CES (cranial electrotherapy stimulation) can reduce anxiety symptoms in 200 active-duty military members and their families. Participants receive either real CES or a sham (placebo) device to see if the gentle electrical pulses truly help.…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with incurable cancer. Participants will receive a pharmaceutical-grade psilocybin along with guided discussions to help them ga…

This trial compares two forms of cognitive-behavioral therapy (CBT) for children and teens with anxiety or obsessive-compulsive disorder (OCD). One approach uses internet-delivered modules with therapist guidance; the other trains parents to lead exposure exercises with their chi…

This study tests a coach-guided digital therapeutic called Toivoa-004, designed to help adults with Long COVID manage symptoms of anxiety and depression. The program delivers cognitive behavioral therapy through a smartphone app and is built to be accessible for people with disab…

People on hemodialysis need their fistula punctured with a needle three times a week, which can be painful and anxiety-provoking. This trial compares three approaches: usual care, applying an ice pack to a specific point on the hand before the needle, and using a numbing gel. Res…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study tests whether showing 3D hologram videos during burn dressing changes can reduce pain, anxiety, and fear in patients. 70 adults will be randomly assigned to either watch a hologram or receive standard care. The hologram projects interactive images into the air without …

This study tests two simple, drug-free methods—vibration and breathing exercises—to see if they can reduce pain and anxiety when a chest tube is removed after surgery. About 70 adults will be randomly assigned to vibration, breathing exercises, or standard care. If effective, the…

This trial tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce anxiety in people with Parkinson's disease. Anxiety affects up to 40% of people with Parkinson's, and standard medications often fall short or cause side …

This early-stage trial is testing whether a non-invasive procedure called focused ultrasound can safely reduce both seizures and anxiety in people with treatment-resistant epilepsy. The ultrasound targets a small region in the brain thought to be involved in both conditions. Rese…

This study compares a structured pulmonary rehabilitation program — including breathing exercises, aerobic conditioning, and education — against standard medical care for people with pericarditis (inflammation around the heart). The goal is to see if the program can reduce chest …

This study is testing a smartphone app called MindTrails-Movement to see if it can help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses a technique called cognitive bias modification for interpretation (CBM-I) to train users to think less negativel…

This study tests whether acceptance and commitment therapy (ACT) helps adults with chronic non-malignant pain (pain lasting 3+ months not caused by cancer). Sixty participants are randomly assigned to ACT, cognitive behavioral therapy (CBT), or standard medical care alone. Both A…

This study tests whether a parent-child therapy program can reduce anxiety in 2- to 3-year-old children who are very fearful or shy. About 90 families will take part in remote sessions. The goal is to see if the therapy helps children feel less anxious and keeps improvements for …

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study investigates whether adding structured exercise groups to standard care improves mood, anxiety, energy, and sleep in adults hospitalized for psychiatric conditions. Participants take part in a 30-minute exercise session led by an occupational therapist, including warm-…

This study tests whether very small, daily doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with advanced illnesses receiving palliative care. Twenty participants will take oral capsules (1-3 mg per day, Monday to F…

This study investigates whether a hemp-derived cannabidiol (CBD) extract can safely reduce anxiety and improve sleep in adults with moderate to severe anxiety. Over four weeks, participants take 50 to 150 mg of CBD daily, with doses adjusted based on tolerance. The trial tracks s…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce pain and anxiety and improve quality of life for burn patients during dressing changes. About 96 adults with second-degree burns will be randomly assigned to receive the stimulation before o…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This trial tests whether an AI-powered chatbot can help reduce anxiety and improve coping in men about to have prostate cancer surgery. Participants will either receive standard preoperative communication or also have access to a large language model (LLM) that answers their ques…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This study tests whether structured hypnotherapy sessions can improve quality of life for women with breast cancer undergoing chemotherapy. Participants in the intervention group receive 10 hypnotherapy sessions alongside standard care, while the control group receives standard c…

This study investigates whether using a stress ball during port catheter needle changes can reduce pain, anxiety, and improve satisfaction in cancer patients. Fifty adult oncology patients will be randomly assigned to either use a stress ball or receive standard care. The goal is…

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This Mayo Clinic study is testing whether eating fermented foods like yogurt, kimchi, and sauerkraut can improve gut microbiome diversity in people with long COVID. Forty adults with long COVID symptoms will either add fermented foods to their diet or continue as usual. Researche…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests a free app called LightBEAM that offers videos, forums, and exercises to help parents manage stress, anxiety, and depression. About 300 Canadian parents of children aged 18 months to 9 years will use the app for 12 weeks. The goal is to see if the app improves pa…

This study tests an experimental nasal spray called fasedienol for quickly reducing anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo and rate their distress levels. The goal is to …

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study tests whether a physical activity program can help pregnant people with symptoms of depression or anxiety feel better. 88 participants will be given a step goal and wear an activity tracker. The program includes weekly reminders and motivational coaching every two week…

This study tests whether a virtual reality (VR) program can help people undergoing bone marrow transplants cope with stress and improve their quality of life. About 80 adult patients with blood cancer will be randomly assigned to either receive the VR program plus usual care, or …

This study looks at whether tapping the skin before a shot (the Helfer Skin Tap Technique) can lower pain and boost comfort during a muscle injection. About 60 adults getting a common painkiller injection will be randomly assigned to either the tap method or standard injection. P…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This study tests whether inhaling essential oils can lower stress and help people relax. Two hundred healthy adults will breathe in either an essential oil or a placebo from an aroma stick during stressful and calming activities. Researchers measure heart rate and self-reported s…

This trial aimed to test an online version of Acceptance and Commitment Therapy (ACT) for adults with disorders of gut-brain interaction (like IBS) who also have anxiety or depression. Participants would have been randomly assigned to either the ACT program or an online education…

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study tests whether an internet-based self-help program called VIVIM can help university students with anxiety and depression. About 108 students will be randomly assigned to use VIVIM or receive usual support from their university counseling service. They will fill out ques…

This study tests a guided mental health chatbot called STARS, designed to help young people aged 18-25 in Lithuania who are feeling anxious or depressed. About 262 participants will use the chatbot and researchers will measure changes in their symptoms. The goal is to see if this…

This trial aimed to see if heart rate variability biofeedback training (using a smartphone app) could reduce stress and anxiety in university students as well as or better than guided meditation. The study planned to enroll second- and third-year physiotherapy students and measur…

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This small study tests whether group drumming sessions can improve emotional well-being for parents of autistic children. Ten parents will take part in drumming groups and report changes in anxiety, depression, and feelings of belonging. The goal is to see if making music togethe…

This study tests whether a mild electrical brain stimulation technique called tDCS can improve musical performance and reduce stage anxiety in 24 young orchestra players aged 18-30. Participants receive either real or fake (sham) stimulation before playing a piece, and their perf…

This study tests whether an 8-session intermodal art therapy program can lower depression, anxiety, and stress while improving emotion regulation in nursing students. Forty-four first- and second-year students from Istanbul Atlas University will be randomly assigned to either the…

This study planned to test whether a lidocaine nerve block (SPG block) could reduce anxiety in adults at electronic dance music festivals, compared to a saline placebo. The trial was withdrawn before enrolling any participants, so no data were collected. The approach was experime…

This study tests a brief digital mental health program for people on waiting lists for psychological treatment. About 80 participants will be randomly assigned to one of four groups: a short program (30-40 minutes), a longer version, or control conditions. The main goal is to see…

This pilot study tests whether using a soft baby carrier for extra physical contact helps mothers with prenatal anxiety or depression feel more connected to their baby. Forty moms in Montreal will either use the carrier or be on a waitlist. Researchers will measure bonding, brain…

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests whether combining a mild electrical brain stimulation (tDCS) with virtual reality meditation can help ease anxiety. 52 adults with generalized anxiety disorder or related conditions will receive 12 sessions over two weeks. Researchers will measure anxiety levels …

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer who are receiving chemotherapy. Twenty-four participants will take part in weekly group music sessions and use personalized playlists at home, alternating periods…

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study aimed to see if having a parent appear on a video call during anesthesia induction could reduce children's anxiety as effectively as the sedative midazolam. It was designed for children aged 4 to 8 undergoing outpatient surgery. However, the study was withdrawn before …

This study tests whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. About 114 women will be randomly assigned to use the glasses or not. Researchers will measure pain on a 0-10 scale and anxiety with a standard questionnaire.

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study looks at whether progressive muscle relaxation exercises can improve sleep, reduce anxiety, and help body image in people with burn injuries. About 100 adults with second-degree burns will either do these exercises twice daily for a week or receive standard care. The g…

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This study tests whether a gentle ultrasound beam aimed at the brain can reduce anxiety. 44 people with high or low anxiety will receive either real or fake ultrasound while their reactions to stressful tasks are measured. The goal is to see if this noninvasive technique can damp…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests a voice-assisted program using Amazon Alexa to help older adults (65+) with depression and their caregivers. Participants use the program for goal setting, reminders, and other mental health support over 12 weeks. Some participants also receive a guide to help th…

This study tests whether inhaling lavender and lemongrass essential oils through a personal necklace can reduce pain and anxiety during active labor. 70 women in labor will be randomly assigned to receive either the aromatherapy or a placebo (sweet almond oil). Researchers will m…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also addressing basic needs like food and housing. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community resources. T…

This study is testing a 5-week program of fun activities—like laughter therapy, reminiscing about the past, and brain games—for seniors living in care facilities. Researchers want to see if it helps improve emotional well-being, reduce anxiety, and calm agitated behavior. The pro…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This small, early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who also had significant anxiety or agitation. The goal was to see if the treatment could reduce these behavioral sy…

This study tests whether a fruit compote made with maqui berry, prebiotics, and probiotics can reduce anxiety and inflammation in 30 university students aged 18-40. Participants eat the compote as part of their normal diet, and researchers measure changes in anxiety levels, stres…

This study aimed to see if placing an ice-filled glove finger in the rectum for 5 minutes before a prostate biopsy could lower pain, anxiety, and stress hormone levels. It planned to include 84 first-time biopsy patients, comparing those who got the ice treatment to those who rec…

This pilot study tests a therapy called Positive Affect Treatment (PAT) for Spanish-speaking adults with depression, anxiety, and low positive affect (a lack of joy or interest). Twelve participants will attend 15 therapy sessions over about 4 months, focusing on pleasant activit…

This study tests whether a single type of cognitive-behavioral therapy (CBT) can work for several anxiety disorders, compared to therapies designed for each specific disorder. About 76 adults with panic disorder, generalized anxiety, social anxiety, OCD, or PTSD will participate.…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study is testing whether listening to calming classical music twice a day can help women with breast cancer feel less anxious and depressed during surgery and chemotherapy. Researchers will also check if music affects certain substances in the blood linked to stress and nerv…

This study looks at whether adding pelvic floor muscle exercises to deep breathing can help reduce pain during periods in women with primary dysmenorrhea. Forty women will be split into two groups: one doing both exercises, the other only deep breathing. Researchers will measure …

This study tests whether a 12-week supervised group exercise program with music can boost emotional well-being in physically inactive women aged 35-60 who feel stressed or down. One hundred women will be randomly assigned to either the exercise group or a waitlist. Researchers wi…

This study looks at whether music therapy can lower anxiety and stress in people with severe mental illness who are staying in a hospital unit. Twelve participants will attend 15 one-hour music sessions where they choose songs and talk with a nurse. Researchers will measure chang…

This study tests whether using a journaling and mood-tracking app called Mirror can reduce symptoms of depression and anxiety in young adults aged 18 to 25. About 500 participants with mild to moderate symptoms will use the app and report their mood changes over 8 weeks. The goal…

This study looks at whether watching immersive videos before open-heart surgery can lower patients' anxiety and improve their recovery. About 200 adults scheduled for elective heart surgery will take part. Researchers will measure anxiety using questionnaires and vital signs befo…

This study tests whether a mindfulness-based childbirth and parenting class can lower anxiety in pregnant women. Sixty women with elevated worry will be randomly assigned to either the mindfulness class or a standard childbirth education class. Researchers will track changes in a…

This study tests whether a 5-week heart rate variability biofeedback program can lower stress and anxiety in 50 dentistry students moving from classroom to clinic. Participants in the training group practice slow breathing with real-time feedback, while a control group receives n…

This study tests whether progressive relaxation exercises and planned education can reduce menopause symptoms, stress, and anxiety in menopausal women. About 144 women will participate, with some receiving the relaxation and education program and others not. The goal is to see if…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This study tests whether placing a colorful, washable walkway mat in front of children's beds can reduce pain and fear and help them start moving sooner after abdominal surgery. About 74 children aged 4–10 will be involved. The mat is designed to distract and encourage kids to wa…

This study tests a videoconference-based coaching program for testicular cancer survivors to help reduce fear of cancer recurrence and improve quality of life. About 70 survivors will be randomly assigned to either a coaching program based on Acceptance and Commitment Therapy (AC…

This study looks at whether following an anti-inflammatory diet for 4 months can improve symptoms of anxiety and depression in 60 adults. Participants will either follow the special diet or their usual eating habits. The study also uses artificial intelligence to analyze speech a…

This study looks at whether using virtual reality goggles or a kaleidoscope can help reduce fear and anxiety in children aged 4 to 6 during a kidney scan (renal scintigraphy). The scan requires the child to lie still, which can be scary. The study will compare these two distracti…

This study tests a special therapy program delivered over the internet for people with mild cognitive impairment or dementia who also feel anxious. The program uses cognitive behavioral therapy (CBT) techniques to help manage worry and fear. Researchers will measure changes in an…

This study tests a remotely delivered 8-week program called ReStoreD for couples where one partner has had a stroke. The program teaches goal-setting, communication, and positive thinking skills to reduce anxiety and depression. Researchers will enroll 400 couples to see if the p…

This study looks at whether a simple hug from a family member before surgery can help lower anxiety and pain afterward. 160 adults having planned surgery will either hug for at least 20 seconds or follow standard care. Researchers will measure anxiety levels and pain scores to se…

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study looks at two simple ways to help children feel less anxious and in less pain when getting a tooth pulled. One method uses a fun video to distract them, and the other uses gentle pressure on a specific point on the hand. The study will include 69 healthy children aged 5…

This study looks at whether fun activities like finger puppets, virtual reality glasses, or smartphone games can lower anxiety and pain in children aged 6 to 12 before and after surgery. About 76 kids having planned surgery will be randomly assigned to one of these play methods. …

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study tests whether a nurse-led education session before surgery can lower patients' anxiety and reduce the risk of agitation when waking up from anesthesia. About 80 adults having elective general surgery will be randomly assigned to receive either the extra education or st…

This Mayo Clinic study tests whether reducing overall smartphone use and avoiding social media apps like Facebook, Instagram, and TikTok can lower anxiety symptoms in adults. One hundred participants with mild anxiety will be asked to change their phone habits, and their anxiety …

This study looks at whether actively caring for plants (like watering and pruning) can lower stress, improve mood, and boost academic motivation in college students. About 87 students will either care for plants on campus, at home, or not engage with plants at all. Over a 16-week…

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study tests whether giving children a palm stimulator or a stress ball to squeeze during a respiratory swab can reduce their pain, fear, and distress. About 35 children aged 6 to 12 will be randomly assigned to use one of these tools or receive standard care. Researchers wil…

This study tests whether a program called Bright IDEAS can help parents of children receiving palliative care feel less anxious, depressed, and stressed. The program teaches parents a step-by-step approach to solving problems. Forty parents will take part in 6-8 sessions and repo…

This study tests whether watching calming nature videos with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be split into two groups: one group uses the VR glasses before and after surgery, while the other receiv…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study looks at whether breathing in aromatherapy scents can help pregnant women feel less pain, worry, and nausea during labor. About 128 women in labor will either receive the scents or standard care. Researchers will compare their symptoms before and after to see if the sc…

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study tests whether adding transcutaneous electrical acupoint stimulation (TEAS) to standard pain relief can reduce pain and inflammation after lung cancer surgery. 90 people scheduled for thoracic surgery will receive either standard care alone or standard care plus TEAS. T…

This study compares two non-invasive devices that stimulate the vagus nerve—one placed on the neck, the other on the ear—to see which better reduces physical discomfort and health-related anxiety in people with somatic symptom disorder. Sixty participants will try both devices in…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This study looks at whether adding 10 grams of fibre to your daily diet for two weeks can improve mental wellbeing, including anxiety, stress, sleep, and mood. Researchers will track changes in 40 healthy adults aged 18-40 using questionnaires. It's a small, early-stage trial to …

This study looks at whether laughter yoga can lower exam anxiety and improve spirituality in nursing students. About 36 students will do laughter yoga twice a week for 4 weeks, while another group does nothing. Researchers will compare anxiety and spirituality scores before and a…

This study looks at whether foot reflexology can reduce anxiety in adults with anxiety disorders. About 44 people will receive either real reflexology or a fake massage twice a week for 5 weeks. Researchers will measure anxiety levels before, during, and after treatment to see if…

This Phase 3 trial tests whether a nasal spray called fasedienol can quickly reduce anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo before speaking. The study also looks at long-t…

This study tests whether showing finger puppets or cartoons to children aged 3-6 before a blood draw can lower their pain and fear. About 120 children will be randomly assigned to one of three groups: finger puppets, cartoons, or standard care (no extra distraction). Researchers …

This study looks at whether spending time with a therapy dog can reduce anxiety and stress in graduate students. Thirty first-year grad students will either interact with a therapy dog or receive general health education. Researchers will measure stress through saliva cortisol le…

This study looks at whether two Akashic Records sessions can improve mental health in adults who have felt stressed, anxious, or down in the past year. Participants will attend private video sessions with a therapist and complete surveys about their mood and resilience. The goal …

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study tests a 16-week cognitive behavioral therapy (CBT) program called the C.A.T Project for Pakistani teenagers aged 14 to 17 with moderate to severe anxiety. The program helps teens change unhelpful thoughts and behaviors using relaxation, problem-solving, and parent educ…

This study tests whether a 30-minute music session can reduce stress, anxiety, and pain in adults recovering from heart surgery. Researchers will measure stress hormones, vital signs, and patient-reported feelings in 120 participants. The goal is to see if music offers a simple, …

This study tests whether using a virtual reality headset (HypnoVR) can help reduce pain and anxiety during labor. Seventy women in Tunis will be randomly assigned to use the headset or receive standard care. Researchers will measure pain and anxiety levels before and after the in…

This study tests whether using a stress ball during a prostate biopsy can help reduce anxiety and pain. Researchers will enroll 66 men undergoing their first prostate biopsy. Participants will squeeze a stress ball during the procedure, and their pain and anxiety levels will be m…

This study tests a stepped care cognitive behavioural therapy (CBT) program for children aged 7-12 with mild to moderate anxiety, delivered in primary care settings. All children start with a brief group intervention, and those needing more support receive additional individual C…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ages 8–12) and lower parenting stress for their parents. 66 families will either take part in laughter yoga sessions or be placed on a waiting list. The st…

This pilot study tests whether a smartphone app called AmDTx can help lung cancer patients manage anxiety before and after surgery. The app includes mindfulness training and a relaxing puzzle game. Only 6 participants are enrolled, and the main goal is to see if people will actua…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain sca…

This study tests a specially designed coverall for intensive care patients who need to move after surgery. The goal is to see if the coverall helps reduce anxiety, improve comfort, protect physical privacy, and increase satisfaction. Thirty patients will try both the coverall and…

This study planned to compare three different medications given as nose sprays to children aged 2 to 6 years who needed stitches for a cut. The goal was to see which one worked best for pain and anxiety during the procedure. However, the trial was withdrawn before any children we…

This study tests whether two types of breathing exercises—pranayama and deep breathing—can help reduce pain and anxiety in people recovering from abdominal surgery. 120 adults who had elective abdominal surgery will practice these exercises every 2 hours starting 4 hours after th…

This study tests whether using a kaleidoscope can reduce pain, anxiety, and fear in children aged 6-14 with cancer who are getting subcutaneous injections. The kaleidoscope is used as a distraction during the procedure. The study involves 72 children and compares their pain and f…

This study tests whether showing educational videos to children aged 4-7 and their parents before a blood draw can lower the child's pain, fear, and anxiety. About 76 children will take part, and researchers will measure their distress using standard scales. The goal is to find a…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…

This study surveys 1,500 former Norwegian elite athletes to map their mental and physical health after retirement. Researchers focus on differences between weight-sensitive sports, such as weight-class, aesthetic, and endurance sports, and less weight-sensitive ones. They will ex…

This study looks at how often older adults (65 and older) experience anxiety and depression after having non-cardiac surgery. Researchers will follow a group of patients in China, using questionnaires to measure their mental health before and after surgery. The goal is to underst…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study investigates the link between autism and physical symptoms like gastrointestinal issues, autoimmune diseases, and heart problems. Researchers will compare autistic individuals, people with anxiety or depression, and healthy controls to understand how these symptoms are…

This study tests whether seeing a picture of a supportive friend or family member helps people with social anxiety unlearn fear more effectively. Researchers will compare fear responses in 100 participants (50 with social anxiety, 50 healthy) after pairing threatening cues with e…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety feel less afraid. Researchers will compare 50 healthy adults and 50 adults with social anxiety disorder. Participants will learn to associate a neutral image with a mild electr…

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study looks at how cannabis ads that claim to help with anxiety or depression affect what people buy. About 2,000 light-to-moderate cannabis users with mild to severe anxiety or depression will shop in a realistic online store. Some see ads with mental health claims, others …

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study looks at adults with temporomandibular disorders (TMD) — problems with the jaw joint and muscles — to measure how chronic pain, anxiety, depression, and perceived stress relate to each other. Researchers will use standard questionnaires to assess pain severity, depress…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study looks at whether women who took part in a thorough medical investigation after a pregnancy loss (the COPL cohort) had better mental health outcomes one year later compared to those who received standard care. Researchers will analyze data from Danish national registrie…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study is testing whether a simple saliva test can help doctors choose the right psychiatric medications for children and teens aged 6 to 24. The test looks at the child's DNA to predict how they might respond to different drugs. Researchers hope this will lead to fewer side …

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study looks at whether having a licensed counselor available can improve the mental well-being of medical residents (doctors in training). The researchers will measure changes in well-being, depression, and anxiety. 21 internal medicine residents from the University of Nevad…

This study looks at whether anxiety and depression are connected to carpal tunnel syndrome in medical students. Researchers will measure the median nerve in the wrist and check students' anxiety and depression levels using questionnaires. The goal is to see if there is a link bet…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study is testing a digital platform designed to help community health workers (non-specialist providers) feel more confident and skilled when counseling people with anxiety or depression. About 55 English-speaking adults who have already completed a specific training program…

This study looks at whether a fear-inducing virtual reality (VR) experience can change how much empathy people feel. About 110 young adults (ages 18-25) will either experience a scary VR scenario, like walking a plank high above a city, or a neutral one. Researchers will measure …

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study tests whether giving doctors a summary of their patient's survey answers before a consultation helps people on sick leave return to work. About 1180 adults in Norway are taking part. The goal is to see if this simple nudge improves recovery and reduces time off work.

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study involves 2,200 women aged 50–67 to see if personalized mammography screening, based on genetic and lifestyle risk factors, is safe and acceptable. Half the women receive standard biennial mammograms, while the other half get a risk assessment and a tailored screening s…

This study looks at how jaw surgery changes not just your bite and appearance, but also your emotions, jaw muscles, and joint health. Researchers will follow 100 patients before and after surgery, using scans, muscle tests, and questionnaires to track these changes. The goal is t…

This study explores whether a personalized therapy method called Process-based Therapy is practical in regular mental health clinics. About 40 adults with depression or anxiety will try this approach, and researchers will measure how satisfied patients and therapists are with it.…

This study explores whether highlighting certain words in questionnaire instructions (like 'bothered by') affects how people with depression or anxiety respond. Two hundred U.S. adults who have been treated for these conditions in the past year will take the same survey twice in …

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study investigates whether psychological factors like fear of movement, self-confidence, and mood can predict how much pain and disability improve after manual therapy in people with chronic low back pain. Sixty adults aged 18-65 with pain lasting over 3 months will be split…

This study tests whether a single session of transcranial direct current stimulation (tDCS) can improve the brain's ability to update fear and safety associations in people with anxiety disorders. 140 participants will be randomly assigned to receive either active stimulation tar…

This study is developing and testing an online training program to teach therapists how to deliver exposure therapy to people with anxiety disorders and OCD. About 56 practicing therapists will try the program and give feedback to improve it. The goal is to see if the training re…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study looks at whether a supplement made from black rice extract can increase levels of BDNF, a protein important for memory and mood. Researchers will give 12 healthy adults either the supplement or a placebo and measure BDNF in their blood. The goal is to see if this natur…

This study tests a training program for occupational therapists who work with adults who have had a brain injury. The goal is to help therapists better spot and treat anxiety and depression in their patients. Twenty therapists will take part, and researchers will see if they star…

This study tests a new training program called CARE, designed to help therapists build a stronger bond with patients who come from a different cultural background. Forty Asian American participants will receive up to 15 online therapy sessions from therapists trained in this appr…

This study is surveying 2500 adults from Croatia, Greece, Italy, Slovenia, and Spain to explore how diet, exercise, sleep, stress, and social habits relate to physical and mental health. Participants complete an online questionnaire about their lifestyle and well-being. The goal …

This study looks at whether AI chatbots can improve how much adults know about anxiety and how they feel about it. About 200 people will use either a chatbot or read standard materials for one week. The goal is to see if chatting with AI helps people learn more and feel more conf…

This study compares two types of training for midwifery students: trauma-informed supportive care and universal continuous supportive care. The goal is to see if these programs improve students' confidence in their clinical skills and reduce their anxiety and secondary traumatic …

This study in Nepal tests whether using rapid point-of-care tests for sexually transmitted infections can reduce the overuse of antibiotics for vaginal discharge. About 1,500 women will be split into three groups: standard care, test-guided treatment, or test-guided treatment plu…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

Researchers at UCLA are studying whether naltrexone, a drug that blocks opioid receptors, can stop reminders of a social support figure from helping people overcome fear. Sixty healthy adults aged 18-35 will receive either naltrexone or a placebo, then undergo a fear extinction p…

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…

This study looks at how regular exercise influences sleep quality, chronotype (whether you're a morning or evening person), and depression symptoms in university students. Researchers will track 54 students from Aydın Adnan Menderes University who exercise regularly, using questi…

This study looks back at 376 patients who received psychedelic-assisted therapy with LSD or psilocybin for depression, anxiety, PTSD, or substance use disorders. Researchers want to see if the intensity of the psychedelic experience is linked to better outcomes. All data comes fr…

This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial …

This study interviews 18 physiotherapists in private practice to understand how they screen for anxiety and depression in patients with chronic neck, shoulder, and low back pain. The goal is to identify what helps or hinders these mental health checks. The study does not test any…