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Could a common virus trigger mental illness? massive study investigates

NCT ID NCT07453420

Knowledge-focused Sponsor: Shalvata Mental Health Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times

Summary

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether infections can cause relapses in people who already have a mental illness. Researchers will examine factors like age, sex, and social background that might make someone more vulnerable or resilient.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify who is most at risk for mental illness after infections and point to protective factors.
What could go wrong
This is an observational study using existing data, so it cannot prove cause and effect. Results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The Israel cohort consists of two databases from the Clalit Health Services (CHS) registries from Israel. The CHS is the largest of four operating healthcare organisations to provide healthcare to all citizens of Israel, and covers more than 50% of Israel's population. The CHS databases undergo periodic updating processes and have been validated by the registry algorithm as well as by many scientific organisations utilising the database. The diagnoses of chronic diseases are based on real-time input from healthcare providers, pharmacies, medical care facilities, and administrative computerised operating systems.

Ages

0 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

In CHS 1: Inclusion criteria: \- Individuals insured by the CHS since birth and with at least 10 years of follow up. Exclusion criteria: \- Termination of insurance and lack of successive medical follow up. In CHS 2: Inclusion criteria: * Active diagnosis of schizophrenia in CHS registries during stages of analyses * Place of residence is at the CHS hospital catchment areas (to ensure psychiatric hospitalisation is fully registered). Exclusion criteria: \- Lack of active diagnosis and place of residency outside of CHS catchment area.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder bipolar disorder Infections major depressive disorder psychiatric disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Bipolar Depression - major depressive disorder Schizophenia disorder

Contacts and locations

Locations

  • University of Haifa

    Haifa, Israel

More trials for these conditions

Other studies related to the condition(s) this trial covers.