Lung neoplasm

Researchers are testing whether a doctor can remotely steer a robotic bronchoscope over a 5G network to freeze small lung tumors from inside the airway. The study enrolls about 15 adults with non-small cell lung cancer or controlled metastatic lung tumors, each no larger than 3 c…

Researchers are testing whether giving targeted therapy before and after surgery helps people with stage III non-small cell lung cancer that has specific rare gene changes. The study includes 190 adults whose tumors have alterations in genes like EGFR, ALK, ROS1, MET, RET, or KRA…

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing whether adding stereotactic radiation to two drugs, envafolimab and endostar, helps people with stage IV non-small cell lung cancer. Participants have tumors without common EGFR, ALK, or ROS1 mutations and have not received prior systemic treatment. Everyo…

This trial tests a device that uses pulsed electric fields to destroy lung tumors. It is for people with early-stage non-small cell lung cancer or lung metastases that cannot be removed with surgery or treated with radiotherapy. Participants receive the ablation under general ane…

This early-phase study is testing a combination of two experimental drugs, Ris-Rez and ivonescimab, in about 184 adults with advanced solid tumors that have spread. The main goals are to find a safe dose, understand side effects, and see if the combo can shrink tumors. It's a fir…

This study tests whether a very thin freezing needle can safely biopsy and destroy suspicious lung nodules in one procedure. About 30 adults with small lung nodules who are not candidates for or decline surgery will undergo the combined approach under CT guidance. Researchers wil…

This phase 2 trial tests whether zipalertinib, an oral drug that targets cancer cells with atypical EGFR mutations, can eliminate remaining cancer cells in people with early-stage non-small cell lung cancer. Participants who have completed standard treatment and show signs of min…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This study tests whether adding a cancer vaccine (CIMAVAX-EGF) to standard targeted drugs (sotorasib or adagrasib) can help control advanced lung cancer with a KRAS G12C mutation. About 29 adults with stage III or IV non-small cell lung cancer will receive the combination. The go…

This trial tests a type of radiation called brain-avoidant proton craniospinal irradiation (BRAVO-pCSI) in people with leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. The study includes adults with breast cance…

This early-phase trial tests whether a special MRI scan using hyperpolarized xenon gas can help doctors plan radiation treatment for non-small cell lung cancer. The goal is to deliver enough radiation to the tumor while avoiding healthy lung tissue, which could reduce side effect…

This trial tests a new approach to pulmonary rehabilitation, a standard programme of exercise and education for people with chronic lung disease. The twist is that informal carers, often family members, join the education and support sessions. The goal is to see if this carer-inc…

This trial tests whether a ventilation strategy based on mechanical power—a measure of energy delivered to the lungs—can reduce postoperative pulmonary complications like pneumonia and collapsed lungs in adults undergoing lung resection surgery. Participants are randomly assigned…

This study tests whether adding a new drug, obrixtamig, to standard chemotherapy can help people with a rare and aggressive lung cancer called large-cell neuroendocrine carcinoma (LCNEC). The trial will include 75 adults with advanced LCNEC that cannot be cured by surgery. Resear…

This trial tests whether a structured exercise program can strengthen the immune system's attack on non-small cell lung cancer. Patients receiving chemo-immunotherapy before surgery will either follow an exercise plan with a stationary bike or receive standard recommendations. Th…

This trial investigates whether specially engineered T cells can safely target and fight lung cancer. Participants have advanced or relapsed lung cancer and receive a single infusion of their own T cells that have been trained to recognize cancer-specific markers. The study aims …

This trial tests whether tirzepatide, a medication used for weight management, can reduce the rapid weight gain and metabolic changes caused by lorlatinib, a targeted therapy for ALK-positive non-small cell lung cancer. Adults already taking lorlatinib will receive weekly tirzepa…

This trial is testing two different radiation schedules for people with peripheral lung cancer or a single lung metastasis. One group receives the standard five-session treatment, while the other gets an experimental three-session approach. The goal is to see if the shorter sched…

This study tests whether giving a dye called Cytalux a few days before surgery works as well as giving it closer to the operation. The dye makes tumors glow under a special light, helping surgeons remove them more completely. About 106 adults with suspected lung cancer or confirm…

This trial tests whether combining an EGFR-targeted pill (EGFR-TKI) with an antibody-drug conjugate (trastuzumab rezetecan) can shrink tumors in people with advanced non-small cell lung cancer that has both an EGFR mutation and HER2 alterations. Participants receive the combinati…

This phase 2 trial is testing a novel combination for people with metastatic pancreatic cancer that has progressed after standard first-line chemotherapy. The approach combines a device that alternately freezes and heats the tumor (multimodal thermal therapy) with a personalized …

This trial is testing whether giving radiotherapy to the main lung tumour, in addition to standard chemotherapy or immunotherapy, can reduce cancer spread and help people with metastatic non-small-cell lung cancer live longer. Around 420 adults with newly diagnosed stage IV lung …

This trial tests whether MRI-guided stereotactic body radiotherapy (SBRT) can safely treat ultra-central lung tumors—growths located near the windpipe and major airways. Using an MR-LINAC machine, doctors can adjust the radiation beam in real time as the patient breathes, potenti…

This trial compares two treatments for early-stage lung cancer in patients who cannot have surgery: microwave ablation delivered through a bronchoscope versus standard stereotactic body radiotherapy. The goal is to see which approach better controls the tumor over two years, with…

This study tests a new treatment for people with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. It combines low-dose radiation to the chest with an immunotherapy drug (adebrelimab) and chemotherapy, followed by maintenance immunotherapy for up to t…

This study is for people with a specific type of lung cancer (EGFR-positive adenocarcinoma) that has spread to the lining of the chest, causing fluid buildup. Researchers are testing whether combining a daily targeted pill (furmonertinib) with focused chest radiation can safely c…

This phase II trial tests the drug cemiplimab, an immunotherapy, given before and after surgery for people with early-stage non-small cell lung cancer that has high levels of a protein called PD-L1. About 33 participants will receive cemiplimab for three cycles, then undergo surg…

This pilot study tests whether an inhaled drug called cromolyn sodium, already used for asthma, is safe and feasible for people with locally advanced lung cancer. The drug works by calming mast cells, which may play a role in tumor growth and treatment resistance. About 5 to 10 p…

This study tests a new approach for lung cancer patients who are at high risk of incomplete tumor freezing during cryoablation. Before the freezing procedure, doctors will block small blood vessels near the tumor using a temporary, absorbable material. The goal is to make the fre…

This early-stage study tests a new treatment called DCTY1102 for people with advanced cancers (like pancreatic, colorectal, or lung cancer) that have a specific genetic change (KRAS/NRAS G12D mutation) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own …

This early-stage trial tests a new drug called CRPA1A2, which helps the body's immune cells attack cancer cells. It is for people with certain advanced solid tumors (like lung, esophagus, head and neck, or liver cancer) that have not responded to other treatments. The study will …

This study tests whether adding radiation to immunotherapy and chemotherapy can help people with advanced small-cell lung cancer that has spread to the liver. It includes 30 adults aged 18-75 whose cancer did not respond to or stopped responding to prior treatments. The goal is t…

This study tests whether a special omega-3-enriched nutritional drink can improve nutrition in people with advanced lung or colorectal cancer who are at risk of malnutrition. About 118 participants will either get the drink plus dietary advice, or just dietary advice alone. The g…

This phase 2 trial tests a new drug called vebreltinib combined with standard chemotherapy as a first treatment for people with advanced non-small cell lung cancer that has MET overexpression and no other known genetic drivers. The study will enroll 19 participants to see if the …

This early study tests a robotic bronchoscopy system that aims to detect, sample, and treat small lung tumors in a single procedure. About 30 adults with suspicious lung nodules up to 3 cm who cannot or choose not to have surgery will participate. The system uses advanced imaging…

This study tests a new treatment called Y-90 FAPI for people with advanced non-small cell lung cancer that has stopped responding to standard therapies. The treatment delivers radiation directly to cancer cells by targeting a protein found on tumor-supporting cells. The goal is t…

This early-stage trial tests injecting the chemotherapy drug cisplatin directly into lung tumors using a thin tube with a camera. The goal is to see if this approach is safe and can kill more cancer cells while causing fewer side effects than standard IV chemo. The study will enr…

This study tests whether adding capivasertib to osimertinib can help people with a specific type of advanced lung cancer whose disease has worsened after initial treatment. About 53 adults with EGFR-mutant NSCLC and additional PIK3CA/AKT1/PTEN gene changes will receive the two dr…

This phase 2 trial tests a sequence of targeted therapy (garsorasib), immunotherapy (ivonescimab), and chemotherapy before and after surgery for people with a specific type of lung cancer (KRAS G12C mutation) that can be removed. The goal is to see if this approach increases the …

This Phase 2 trial tests a combination of two drugs, tunlametinib and cetuximab β, in 55 people with advanced non-small cell lung cancer that has a KRAS mutation and has not responded to prior treatments. The goal is to see if the combo can shrink tumors and control the disease. …

This study compares two types of targeted therapy (first-generation vs third-generation EGFR TKIs) for people with advanced lung cancer that has a specific rare mutation called EGFR exon 19 deletion-insertion. About 94 participants will be randomly assigned to one of the two trea…

This study tests a combination of two drugs—CVL237 tablets and serplulimab injection—in people with advanced solid tumors that have lost or have low levels of a protein called PTEN. The trial aims to find the safest dose and see if the combo can shrink tumors or delay their growt…

This study compares two treatments for high-risk patients with early-stage non-small cell lung cancer: minimally invasive surgery (wedge resection) and stereotactic body radiation therapy (SBRT). The goal is to see which approach leads to longer disease-free survival and better q…

This early-stage trial is testing a new oral drug called HS-10504 combined with several other drugs given by IV in people with advanced non-small cell lung cancer that has worsened after previous treatment. The study will enroll about 400 participants and aims to find safe doses …

This study is testing a device called the HybridTherm® system, which uses freezing and radiofrequency heat to destroy small lung tumors during a routine bronchoscopy. The procedure is done before the patient's planned surgery to remove the tumor. The main goals are to see if the …

This study tests two drugs, sacituzumab govitecan and ivonescimab, alone or together, in people with advanced non-small cell lung cancer that has specific gene changes. The goal is to see if the combination works better than either drug alone at shrinking tumors and delaying canc…

This study compares two ways of performing robotic lung surgery for early-stage non-small cell lung cancer. In one method, the surgeon controls all tools from a console (totally robotic). In the other, a bedside assistant helps with handheld staplers. The trial will measure costs…

This study tests a combination of anlotinib pills and standard chemotherapy for people with a rare, advanced lung cancer that lacks the SMARCA4 gene. About 28 adults will receive the treatment in 21-day cycles to see how long it keeps the cancer from growing and what side effects…

This phase 2 trial tests the drug golidocitinib in 16 people with advanced lung cancer who have severe blood problems caused by immunotherapy. The goal is to see if the drug can safely improve blood counts and reduce symptoms. Participants take the drug until their blood levels r…

This study tests two experimental drugs, ANS014004 and PLB1004, given together to people with a specific type of advanced lung cancer (EGFR mutation-positive NSCLC). The goal is to find a safe dose and see if the combination can shrink tumors or stop them from growing, especially…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes pill) to standard cancer treatment can help people with advanced lung cancer and diabetes live longer or slow their tumor growth. About 200 adults will take either the SGLT2 inhibitor or other diabetes drug…

This study tests a therapy that takes a patient's own immune cells, grows and strengthens them in a lab, and then gives them back to fight cancer. It is for people with advanced lung, liver, colorectal, or breast cancer that has spread. The goal is to see if this approach is safe…

This phase 2 trial tests a combination of two drugs—sacituzumab tirumotecan and bevacizumab—in 31 adults with advanced non-squamous lung cancer that has worsened after initial treatment. The goal is to see if the combo can shrink tumors or slow the disease. Participants receive t…

This study looks back at medical records of 600 Chinese patients with advanced non-small cell lung cancer that has a KRAS G12C mutation. All patients took the drug IBI351 between August 2024 and August 2025. Researchers will check how many patients' tumors shrank or disappeared, …

This phase 2 trial tests a combination of two drugs, Sacituzumab tirumotecan and bevacizumab, in 50 people with a specific type of lung cancer (EGFR-mutant nonsquamous NSCLC) that has spread to the brain and no longer responds to standard targeted therapy. The goal is to see if t…

This Phase 3 trial compares a new drug called JYP0322 with standard platinum-based chemotherapy in 207 people with advanced ROS1-positive non-small cell lung cancer who have already been treated with ROS1-targeted therapy. The main goal is to see if JYP0322 delays cancer growth b…

This study tests a robotic bronchoscope to inject a dye near small lung nodules before they are removed surgically. The dye helps surgeons see the nodule during operation, making removal more accurate. Fifty patients with hard-to-find nodules will be enrolled, and researchers wil…

This phase II trial tests whether combining cryoablation (freezing the tumor) with the immunotherapy drug serplulimab can treat early-stage non-small cell lung cancer in people who cannot have surgery or radiation. Twenty-five adults with stage Ia NSCLC will receive one cryoablat…

This phase 3 trial tests QL2107, a biosimilar (copy) of the cancer drug Keytruda, in 122 adults with non-small cell lung cancer that has been surgically removed. The goal is to see if the body processes QL2107 the same way as Keytruda when given as an extra treatment after surger…

This study tests a gene therapy called Gendicine, given as a mist to breathe in, for people with multiple ground-glass lung nodules — spots that may turn into cancer. About 38 adults will receive the treatment and be monitored with CT scans to see if the nodules shrink or disappe…

Researchers are building an artificial intelligence system that analyzes chest CT images and offers decision support to doctors reading those scans for lung cancer. They use deidentified CT exams from routine care to develop and lock the AI models. In the prospective stage, about…

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Researchers at Penn State University are testing three software innovations designed to improve bronchoscopy guidance during lung cancer evaluations. The study enrolls a small number of adults who are already scheduled for a clinical bronchoscopy to examine abnormal lung tissue o…

Researchers are testing a new imaging agent called 111In-TJD-31 that targets placental alkaline phosphatase (ALPP), a protein found on many solid tumor cells but rarely in healthy adult tissue. The study enrolls 8 participants: 2 healthy volunteers who give blood samples and 6 pa…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

Researchers are testing artificial intelligence models that analyze CT scans to find lung nodules and estimate whether they are benign or malignant. The study enrolls adults who have at least one non-calcified lung nodule measuring 3 to 30 mm. Participants receive no drugs or pro…

Researchers are testing whether an electronic nose that analyzes exhaled breath can serve as a noninvasive prescreening tool for several diseases at once. The study plans to enroll up to 20,000 adults and will first standardize the breath-sampling procedure, then evaluate how wel…

This trial tests whether a new imaging method, using femtosecond laser light and artificial intelligence, can accurately predict high-risk features in lung cancer, such as spread to lymph nodes. Researchers will compare the AI's predictions with actual pathology results from surg…

This trial tests whether adding a small probe called the Iriscope to standard bronchoscopy improves the diagnosis of lung nodules. Doctors usually guide the biopsy with real-time X-rays, but sometimes they cannot see the nodule directly. The Iriscope slides into the bronchoscope …

This trial tests whether a femtosecond laser imaging technique, combined with artificial intelligence, can accurately distinguish benign from malignant lung tissue in surgical specimens. Researchers will compare the AI-assisted diagnosis against standard pathology results. The st…

This trial is testing two new imaging tracers, called CM500, to see if they can help detect solid tumors anywhere in the body. The tracers are given by injection and then used with PET scans to create detailed images. The study includes healthy volunteers and people with various …

This study explores whether a special MRI scan, done without any contrast dye, can tell the difference between benign and cancerous lung nodules that were flagged as suspicious on a routine lung cancer screening CT. Adults aged 50 to 80 with a history of heavy smoking and a Lung-…

This pilot study will offer low-dose CT scans to about 500 high-risk smokers aged 50-80 in Kuwait to see if this screening approach is practical and acceptable. The goal is to measure how many people agree to screening, identify barriers, and evaluate the use of AI to help read t…

This trial is testing whether a breath analysis device can detect unique chemical patterns—called volatile organic compounds—that may signal the presence of cancer. Researchers will collect breath samples from 1,000 people with various cancers and 1,000 healthy volunteers, then u…

This pilot study explores whether a breath sample collected with the VosCryo device can provide enough cellular material to help diagnose advanced lung cancer. Researchers will compare breath samples from 12 people with late-stage lung cancer and 12 healthy relatives to see if th…

This study tests whether an artificial intelligence (AI) model called Sybil can predict a person's risk of developing lung cancer based on a CT scan of the chest. The study enrolls people aged 18 to 80 who have a family history of lung cancer. Participants receive a CT scan, and …

This study tests an artificial intelligence (AI) prototype designed to quickly evaluate tissue samples taken during a bronchoscopy, a procedure used to diagnose lung cancer. The AI analyzes microscope images of the samples to determine if they are adequate for diagnosis and wheth…

This study tests a new radioactive tracer called 68Ga-MY for PET scans. It targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will get both a standard FDG scan and a 68Ga-MY scan. Researchers will compare the…

This study will check if low-dose CT scans can find lung cancer early in 1,716 high-risk smokers in India. Participants get a baseline scan, and if anything looks suspicious, they are referred to a team of specialists for follow-up. The goal is to see if this screening method wor…

This study will test a new, disposable freezing catheter (Celsio) in 30 people who need a lung procedure. The catheter uses extreme cold to help diagnose or treat conditions like lung cancer and interstitial lung disease. Unlike current devices, it does not need a bulky console o…

This study will enroll 2,000 people aged 50 or older in Mexico, Costa Rica, Colombia, and Argentina who are at high risk for lung cancer due to smoking, wood smoke exposure, family history, or COPD. Participants will get a chest X-ray analyzed by artificial intelligence and a low…

This study tests whether a special dye, given before a bronchoscopy, can make lung tumors glow so doctors can see them more clearly. About 20 adults with a suspicious lung nodule or lymph node will receive the dye and then have a bronchoscopy with a special camera. The goal is to…

This study tests whether a new MRI contrast agent, gadopiclenol, can detect brain metastases earlier than standard methods in 180 patients with advanced lung, breast, or skin cancer. Participants will receive screening brain MRIs to compare diagnosis timing and accuracy. The goal…

This study will test whether low-dose CT scans can help find lung cancer early in high-risk smokers aged 50-79 in Hong Kong. About 15,000 participants will be randomly assigned to receive three rounds of CT scans or usual care. The main goal is to see if screening reduces lung ca…

This study tests a new PET imaging agent, 68Ga-cPP-BCH, to detect PD-L1 protein levels in tumors of people with lung cancer, melanoma, or other solid tumors. The goal is to see if this scan can identify who might benefit from anti-PD-1/PD-L1 immunotherapy without needing a tissue…

This study looks at whether low-dose CT scans can help find lung cancer early in people aged 40 to 80 who have never smoked. About 2,500 participants will fill out questionnaires, give blood and urine samples, and have lung function tests and CT scans. Researchers will track how …

This study will test whether a new type of PET scan (18F-FAPI) can more accurately detect lung cancer and help predict patient outcomes. About 120 adults already diagnosed with lung cancer will receive the scan. The goal is to see if this imaging method is better than current tec…

This study aims to see if a blood test, taken before lung cancer surgery, can predict which patients will develop serious lung complications afterward. Researchers will analyze immune cells and proteins in the blood of 100 adults undergoing lung surgery. If the test works, it cou…

This study tests if using a confocal laser microscope along with a freezing probe (cryoprobe) makes lung biopsies safer and more accurate. Forty adults with lung spots will be split into two groups: one gets the standard ultrasound-guided biopsy, the other gets the new laser-guid…

This study tests whether artificial intelligence (AI) software can help radiologists find lung cancer on low-dose CT scans more accurately. About 1,120 adults at risk for lung cancer will be randomly assigned to have their scans read with or without AI assistance. The goal is to …

This study compares a new robot-assisted system to the standard manual method for taking a tissue sample (biopsy) from a lung nodule. The goal is to see if the robot is as safe and effective at diagnosing lung cancer or other conditions. About 158 adults with suspicious lung nodu…

This study compares 3D models from non-contrast CT scans to standard contrast CT scans for planning minimally invasive lung cancer surgery. Researchers will check if the 3D models accurately show blood vessels, airways, and tumor location during surgery. If they work, patients mi…

This study will test whether a special CT scan (dual-energy CT) can be as good as MRI for mapping tumors and healthy organs before radiation therapy. Researchers will enroll 80 people with brain, bone, head/neck, or lung cancer. If DECT works well, it could save time and money co…

Researchers at Johns Hopkins University are testing whether a short animated video and brochure, sometimes followed by a phone call, can help people at higher risk of lung cancer get low-dose CT screening. The trial enrolls adults aged 50 to 80 with a significant smoking history …

This trial tests whether a community-based program called Witness Project Lung can increase lung cancer screening among Black adults aged 50 to 80 who smoke or quit within the past 15 years. The program uses peer role models, videos, and tailored materials to educate participants…

This study tests a vaccine called SurVaxM in 80 current or former heavy smokers at high risk for lung cancer. The vaccine trains the immune system to recognize and attack cells that produce a protein called survivin, which is common in cancer cells. The goal is to see if the vacc…

This study tests whether home-based breathing exercises and stationary bike workouts can improve lung health in 200 current and former smokers aged 50 and older. Participants will use a handheld breathing device and a stationary bike for 12 weeks. The goal is to see if these exer…

This study compares two ways to share lung cancer screening information with people who call tobacco quitlines. Participants are quitline clients aged 50 to 80 with a heavy smoking history. One approach offers extra coaching and navigation support. The goal is to see which method…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This study looks at whether the shingles vaccine can prevent shingles and improve survival in 500 lung cancer patients. Participants will either receive the vaccine or not, and researchers will track shingles cases and survival rates over time. The goal is to see if the vaccine o…

This trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve sleep quality in adults undergoing surgery for lung cancer. Participants with poor sleep before surgery will receive either active rTMS or a sham (inactive) treatment over five …

This study aims to create a brief behavioral intervention for older adults (60+) with lung cancer, addressing aging-specific concerns like depression, anxiety, pain, and shortness of breath. In the first phase, patients, caregivers, and providers give feedback on the program. In …

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study tests a program called LiveWell, which teaches emotional coping skills to people with metastatic lung cancer who are feeling anxious or depressed. About 80 participants will either take the program or receive usual care. The goal is to see if the program is practical, …

This randomized trial tests whether immersive virtual reality (VR) can reduce anxiety in people with lung cancer during immunotherapy or chemo-immunotherapy infusions. Half of the 60 participants will use a VR headset showing calming nature scenes during four infusion visits, whi…

Shortness of breath, or dyspnea, affects most lung cancer patients and often persists despite standard treatments. This pilot study tests a stepped-care behavioral intervention called INSPIRE, which starts with brief coping skills and adds more intensive psychological support onl…

This trial tests whether a digital platform that sends symptom check-ins and self-care tips via text message can help people with head and neck or lung cancer report their health more consistently. Participants either receive standard symptom questionnaires or get extra monitorin…

This study tests whether giving a nerve block at two rib levels instead of one can better control pain after video-assisted thoracoscopic surgery for lung cancer. Eighty-eight adults scheduled for lung surgery will receive either a standard single-point block or a two-point block…

This study tests a short behavioral program called BREEZE+ to help people with advanced lung cancer manage breathlessness. The program includes three nurse-led sessions and a digital app that teaches breathing and relaxation skills. Researchers will compare this to usual care in …

This trial compares standard radiation therapy with a new method that specifically avoids damaging small airways in the lungs. The goal is to see if this airway-sparing approach helps patients with stage III non-small cell lung cancer retain better breathing function after treatm…

This study tests a home-based app for lung cancer patients on combination drug therapy. The app helps patients track symptoms, get personalized advice, and receive nurse support during treatment breaks. Researchers will see if it reduces symptom burden and improves quality of lif…

This study tests whether a smartphone reminder app can help lung cancer patients stay physically active during radiation therapy. About 32 adults with lung cancer will use the app or standard care, and their daily step counts will be compared. The goal is to see if simple digital…

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests a new program called ADAPT, which is a type of talk therapy for lung cancer patients and their spouses. The goal is to help both partners feel less afraid of the cancer coming back. About 72 couples will try the program during chemotherapy or radiation and answer…

This study looks at whether a special oxygen device (high-flow nasal cannula) can prevent dangerously low oxygen levels in children aged 1 to 6 years who are sedated for a lung exam called bronchoscopy. About 430 children will be randomly assigned to receive either the high-flow …

This study is testing a program called Care and Connect, where trained volunteers provide support and information to people with lung cancer. The goal is to see if this program helps reduce distress and makes it easier for patients to get the care they need. About 50 adults with …

This study will test whether mindfulness-based breathing exercises can help lung cancer patients who are undergoing chemotherapy feel less breathless and improve their quality of life. Sixty patients will be split into two groups: one will practice these breathing exercises for e…

This study tests whether doing special breathing exercises for a few weeks before lung cancer surgery can reduce problems like pneumonia and help patients leave the hospital sooner. 70 people scheduled for lung cancer surgery will be randomly assigned to standard care or standard…

This study tests a home-based program of exercise and breathing techniques for people with lung cancer who are scheduled for surgery. The program lasts 8 weeks before surgery and 4 weeks after, using a smartphone app to guide patients. Researchers want to see if it improves fitne…

This study tests a special breathing tube with a built-in camera for people undergoing repeat lung surgery. The tube helps doctors see exactly where it is placed, which may reduce problems like mispositioning. The trial will compare this video tube to the standard tube in 500 pat…

This study tests whether a combination of two anti-nausea drugs (rolapitant and palonosetron) can prevent vomiting and severe nausea in 238 lung cancer patients receiving both chemotherapy and radiation. The goal is to improve comfort during treatment. Participants will be follow…

This study looks at whether a two-week program of walking and breathing exercises before surgery for non-small cell lung cancer can help reduce pain, speed up recovery, shorten hospital stays, and improve quality of life. About 62 adults scheduled for surgery will be split into t…

This study compares a newer anesthesia method where patients breathe on their own during lung surgery to the standard method using a breathing tube and machine. About 1,600 people having minimally invasive lung nodule removal will be randomly assigned to one of the two methods. T…

This study tests whether using a lung perfusion PET/CT scan to guide radiation planning can reduce lung injury compared to standard anatomical planning. About 418 adults with lung tumors receiving stereotactic body radiotherapy (SBRT) will be randomly assigned to one of the two p…

This study tests whether gentle, hands-on osteopathic techniques can stimulate the vagus nerve in people with advanced lung cancer. Researchers will measure heart rate variability, a sign of nerve health, and check if these safe, non-invasive treatments reduce anxiety during chem…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study will screen 477 current or former smokers in Brazil for lung cancer using CT scans. It aims to see how often the scans give false alarms (false positives) in a region where lung infections are common. The goal is to improve screening accuracy and reduce unnecessary fol…

Researchers are testing an experimental cryoablation catheter that freezes lung tissue, using donated human lungs kept alive outside the body. The goal is to see whether the device can reach and cool tumors through the airways, which could offer a less invasive option than surger…

Some people who have keyhole lung cancer surgery develop lasting breathlessness and struggle with gentle exercise, even if their breathing was fine before. Researchers suspect the right side of the heart, which pumps blood to the lungs, may be weakened by the extra pressure it fa…

This study will enroll 1,500 current or former smokers aged 50-80 to see if an artificial intelligence (AI) model can help doctors better detect lung nodules and predict cancer spread. Participants will undergo CT scans, and the AI's results will be compared to standard radiologi…

Researchers are collecting blood and tumor tissue samples from 30 adults with relapsed small-cell lung cancer who are receiving a standard DLL3 T cell engager therapy. The goal is to track changes in tumor markers over time and see if those changes relate to how well the treatmen…

This study uses a special PET scan to track a tracer called 89Zr-trastuzumab in people with advanced lung cancer that has HER2 changes. The goal is to see if the tracer builds up differently in tumors with HER2 mutations versus those with too much HER2 protein. About 20 adults wi…

This study is looking at whether analyzing blood, urine, and stool samples can help predict which lung cancer patients are more likely to develop radiation pneumonitis—a type of lung inflammation—after receiving immunotherapy and radiation therapy. The researchers will collect sa…

This trial tests a new communication workflow called CORRECT that helps radiologists and radiation oncologists work together more effectively when planning radiation therapy for lung and head-and-neck cancers. About 194 patients will be involved, and doctors will use a shared sys…

This study surveys people with lung tumors before and after a procedure called percutaneous ablation, which uses heat or cold to destroy cancer cells. Participants will rate symptoms like pain, fatigue, and shortness of breath on a simple scale. The goal is to understand how pati…

This trial tests whether using a personalized 3D lung model during preoperative consultations helps patients better understand their lung surgery options and feel more involved in decision-making. Adults scheduled for thoracoscopic lung resection for suspected or confirmed lung t…

This study will enroll over 3,200 adults in Delhi and surrounding areas to understand how air pollution, especially fine particles (PM2.5), combines with other factors like smoking and genetics to increase lung cancer risk. Researchers will also look for biomarkers and identify g…

This study will develop an artificial intelligence model that uses a patient's series of CT scans over time to predict whether a lung nodule will grow or become cancerous. Researchers will analyze scans from nearly 5,000 people to train the AI to recognize different growth patter…

This study looks at a specific type of lung cancer called lung adenocarcinoma and how it can spread through tiny air spaces in the lungs. Researchers will collect tumor and healthy tissue samples from 140 patients to find genetic markers that might predict this spread. The goal i…

This study looks at medical records of 3,000 adults with lung cancer to see if the stage at diagnosis is shifting to earlier, more curable stages. Researchers will track how often cancer is found through screening programs, chest X-rays, or heart scans. No new treatments or tests…

This study tests whether a specially designed educational toolkit, called the Lung Toolkit, can improve knowledge about lung cancer and screening among American Indian and Alaskan Native adults aged 50 to 80 who smoke cigarettes. The toolkit includes a website with resources and …

This study aims to find better ways to help Veterans quit smoking when they come in for lung cancer screening. Since smoking causes most lung cancers, combining screening with stop-smoking support could save more lives. The project will test new processes at a few VA sites and me…

This study compares a new electromagnetic navigation system to standard CT scans for guiding surgeons to small lung nodules during surgery. About 400 adults with nodules up to 2 cm will be randomly assigned to one method. The goal is to see which approach helps surgeons find and …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study will look back at medical records of 300 people with advanced non-small cell lung cancer (NSCLC) whose disease got worse after first-line immunotherapy. Researchers want to see which second-line treatments were used and how well they worked in real-world practice. The …

This study looks at whether people with peripheral vascular disease (narrowed leg arteries) might also be at high risk for lung cancer because of shared smoking history. Researchers will check if these patients qualify for lung cancer screening and refer them for a low-dose CT sc…

This observational study will enroll 300 people with suspected lung lesions to see if 3D ultrasound can measure them as accurately as CT scans. Participants will undergo both ultrasound and CT imaging, and researchers will compare the results. If the 3D ultrasound works well, it …

This study tests whether the Apple Vision Pro headset can help surgeons see blood vessels more clearly during lung surgery. Twenty adults scheduled for lung surgery will have a CT scan before the operation, and the surgeon will wear the headset to view 3D images during the proced…

This early-stage study looks at how the drug anecatibin fumarate is processed in the body of people with and without liver problems. It will include 24 adults with lung cancer. The goal is to understand safety and drug levels, not to test if the drug works.

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This pilot study will check if tumor DNA in spinal fluid can predict brain metastases in 40 patients with stage III or IV non-small cell lung cancer. Participants will undergo a lumbar puncture to collect cerebrospinal fluid, plus blood draws and an MRI six months later. The goal…

This study will test if a simple, low-intensity cycling exercise combined with a handheld monitor can predict serious complications in lung cancer patients before surgery or other treatments. Researchers will include 500 adults with suspected lung cancer. The goal is to make risk…

This study looks at sputum and blood samples from 50 adults with advanced non-small cell lung cancer who are starting immunotherapy. Researchers want to find immune cell changes that could predict which patients will respond well to treatment. The goal is to better understand the…

This study looks at whether an extra cleaning step during a common lung cancer staging procedure (EBUS) can reduce contamination of tissue samples. Researchers will collect samples from 204 adults with suspected lung cancer. The goal is to see if better cleaning leads to more acc…

This study will enroll 63 people with advanced non-small cell lung cancer whose disease has been stable for at least 6 months. Participants will take part in a 3-month rehabilitation program that includes physical activity. Researchers will measure quality of life, hand grip stre…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study tests whether extended reality (XR) can help doctors more accurately locate small lung nodules during CT scans. About 30 adults scheduled for lung nodule surgery will participate. The goal is to see if XR guidance improves precision and reduces complications.

This large observational study will enroll 14,300 people aged 40-74 to see if combining a non-contrast CT scan with a blood test that looks for DNA changes can detect lung cancer earlier. The goal is to develop a more accurate screening method. Participants must have a lung cance…

This study will examine immune cells found in fluid from the lungs of 60 people with advanced lung cancer. Researchers want to see if these cells can help predict how well standard cancer treatments work. Participants will have a bronchoscopy as part of their regular care, and th…

This study uses artificial intelligence to analyze CT scans, pathology slides, and genetic reports from 1,000 lung cancer patients with EGFR mutations. The goal is to build a model that predicts how well targeted therapy will work after surgery. If successful, it could help docto…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study will analyze genetic data from 100,000 people to see if variations in aldehyde-metabolizing genes (ADH1B and ALDH family) are linked to lung cancer risk, especially in people who have never smoked. The goal is to understand how these genes might influence the developme…

This study will use artificial intelligence and 3D CT scans to predict how well a person's lungs will work after different treatments for early-stage lung cancer. About 192 adults with stage IA non-small cell lung cancer will be followed for two years after surgery or a minimally…

This study looks at how low body temperature during lung cancer surgery (using a tiny camera) affects pain and complications after the operation. About 144 adults having this surgery will have their temperature tracked continuously. The goal is to understand if getting cold durin…

This study will measure specific immune cells in the blood of 200 non-small cell lung cancer patients before and after surgery. The goal is to see if these markers can help predict if the cancer will come back or how long patients will live. Participants must have early-stage lun…

This study will follow 100 lung cancer patients after surgery to see if levels of CEA and ctDNA in the blood can predict whether the cancer comes back. Participants will have regular blood tests and imaging over two years. The goal is to catch recurrence earlier and tailor follow…