Venous thromboembolism

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This trial is testing a device designed to remove blood clots from the deep veins of the legs, a condition called deep vein thrombosis (DVT). The study will enroll about 167 adults with acute or subacute DVT to see if the device can safely and effectively clear the blockage. Part…

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. The trial will include about 1,600 participants with or without cancer who have deep vein thrombosis …

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This pilot study tests whether omeprazole, a common heartburn drug, can reduce gastrointestinal bleeding in adults 65 and older who take blood thinners for blood clots. Researchers will enroll 360 participants to see if a larger trial is feasible. The study focuses on recruitment…

This study tests an experimental drug called REGN7508 (cenvacibart) against aspirin to prevent blood clots in 2000 adults having knee replacement surgery. The drug targets a clotting factor to reduce clot risk. Researchers will compare how many people develop clots or die from cl…

This study tests whether removing a blood clot from a specific thigh vein (the profunda femoris vein) during standard treatment for a large leg vein clot can prevent long-term complications like pain and swelling. About 140 adults with recent leg clots will be randomly assigned t…

This study tests an experimental drug called REGN7508 (cenvacibart) to prevent venous thromboembolism (blood clots) in adults after elective total knee replacement. About 2,000 participants will receive either REGN7508, apixaban, or enoxaparin to compare effectiveness and safety.…

This study tests whether a newer blood thinner (rivaroxaban) works as well as the standard drug (warfarin) for preventing clots and bleeding in people who have a mechanical aortic valve. About 1,300 adults who had valve surgery at least 3 months ago will take one of the two pills…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This study is testing a device called the Cleaner Vac® Thrombectomy System, which uses suction to remove blood clots from deep veins in the leg. About 185 adults with deep vein thrombosis (DVT) will be enrolled. The goal is to see if the device can safely and effectively clear th…

This study tests whether enoxaparin, a blood thinner, can prevent blood clots caused by central venous catheters in critically ill children. Researchers will enroll 258 children up to 17 years old and adjust the dose based on age. The goal is to see if age affects how well the dr…

This study compares two medical devices used to remove large blood clots from the leg veins. About 180 adults with acute deep vein thrombosis (DVT) will receive either the ClotTriever System or an aspiration device. The goal is to see which device clears clots better and reduces …

This study tests whether giving tranexamic acid (TXA) before and after major colorectal surgery can reduce bleeding and the need for blood transfusions. About 394 adults having inpatient colorectal surgery will either receive TXA or not. The trial also checks if TXA raises the ri…

This study compares two approaches for low-risk patients with small blood clots in the lungs (isolated subsegmental pulmonary embolism). Half will receive standard blood-thinning medication (rivaroxaban), while the other half will get a placebo and be closely monitored. The goal …

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study looks for the best way to treat people who have a blood clot (like in the leg or lung) and also take daily aspirin or similar drugs for heart disease. Both conditions need blood thinners, but taking them together raises the risk of dangerous bleeding. The trial will co…

This study follows 82 people who receive the Celect Platinum Vena Cava Filter, a device placed in a large vein to catch blood clots and prevent them from reaching the lungs. Researchers will track safety and performance for up to 5 years, checking for problems like filter movemen…

This study tests whether a specially adjusted dose of the blood thinner apixaban can safely treat blood clots in cancer patients who also have low platelet counts. About 30 adults with active cancer and a recent clot will receive the adjusted dose. The goal is to see if this appr…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This phase 3 trial is testing whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban are better than low-dose aspirin at preventing blood clots in people with JAK2V617F-positive myeloproliferative neoplasms (blood cancers). The study plans to enroll 1308 high-ris…

This study tests a new approach to remove blood clots from deep leg veins in people with acute deep vein thrombosis (DVT). The standard method accesses the vein behind the knee, while the new method uses veins in the calf or the opposite leg. Researchers want to see if the new ap…

Hospital-acquired blood clots are a leading cause of death in U.S. hospitals. This study tests an AI tool called VTE-AI that automatically identifies patients at high risk for clots and alerts doctors if prevention hasn't been ordered. Over 2,200 patients across four hospitals wi…

This study tests whether the blood thinner rivaroxaban can prevent dangerous blood clots in people with idiopathic membranous nephropathy, a kidney disease that raises clot risk. About 134 participants at high risk for clots but low risk for bleeding will receive either rivaroxab…

This study compares two different dosing schedules of the blood thinner apixaban (Eliquis) against no blood thinner in about 996 cancer patients at moderate risk for blood clots. Participants take either 2.5 mg twice daily, 5 mg once daily, or no anticoagulant for 6 months. The g…

This Phase 3 trial tests whether Kinisoquin™, a supplement-like drug made from isoquercetin plus vitamins C and B3, can prevent dangerous blood clots in 480 people with advanced pancreatic cancer. Participants receive either Kinisoquin™ or a placebo alongside their first chemothe…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests an experimental drug called SRSD107 to see if it can prevent blood clots in people having knee replacement surgery. About 450 adults aged 60 to 80 will receive either SRSD107 or the standard blood thinner enoxaparin. The goal is to compare how well each drug prev…

This study compares two different doses of the blood thinner bemiparin to see which works better at preventing dangerous blood clots in people with severe obesity after surgery. About 2,400 participants will be enrolled. The goal is to find the safest and most effective dose for …

This study compares two types of blood thinners taken as pills (apixaban and rivaroxaban) against a standard daily injection (enoxaparin) to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will be ra…

This study tests whether a shared decision-making process, which uses personalized risk scores, can help patients with unprovoked blood clots choose the best duration of blood-thinning medication. The goal is to reduce the chance of another clot or serious bleeding while improvin…

This study tests whether apixaban (a pill taken twice a day) is a safe and more satisfying alternative to enoxaparin (a daily shot) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researc…

This study tests whether taking a blood thinner (rivaroxaban) plus aspirin after a vein-stenting procedure keeps the vein open longer and prevents new clots. About 172 people with deep vein thrombosis and narrowed iliac veins will receive the combination for 6 months (rivaroxaban…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study looks at whether blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 patients across multiple hospitals will take part. In half the hospitals, doctors will follow their usual approach; in the other h…

This study is testing a new wearable ultrasound sensor that sticks to the skin like a patch. The goal is to see if it can help doctors find and monitor deep vein thrombosis (blood clots) and heart conditions early, without needing bulky machines. About 300 adults with heart failu…

This study is testing a new device that can find blood clots moving through the bloodstream in people with thromboembolism (blood clots in veins or arteries). About 30 adults with known or high risk of clots will be enrolled. The device uses a special ultrasound technique to dete…

This trial tests whether doing ultrasound scans twice a week on critically ill patients can catch deep-vein thrombosis (DVT) early. The goal is to prevent pulmonary embolism (a clot in the lung) and reduce deaths within 90 days. The study will enroll 1,800 adults in the ICU who a…

This trial tests whether taking a low-dose aspirin pill every day for six weeks after delivery can prevent dangerous blood clots in the legs or lungs as effectively as the standard daily heparin injections. The study enrolls people who have given birth and have one or more risk f…

This study is testing whether giving new mothers a low-dose blood thinner for just 7-10 days after delivery can prevent blood clots in the legs or lungs. About 9,200 women with certain risk factors (like emergency C-section, obesity, or pre-eclampsia) will either receive the drug…

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This phase 3 trial tests an experimental drug called REGN7508 to prevent blood clots in people with solid tumors who are receiving cancer treatment. About 1,120 participants will receive either the drug or a placebo. The study measures how well the drug prevents clots and checks …

This study looks at the best way to prevent blood clots in people who have a leg cast or splint after an injury. For those at high risk of clots, it compares pills to standard injections. For low-risk people, it checks if any medication is better than just advice. Over 10,000 par…

This study looks at whether giving blood thinners (LMWH) for 6 weeks after childbirth can prevent dangerous blood clots in women who have a moderate risk. About 2,400 women will be randomly assigned to receive either the blood thinner or standard care without it. The goal is to s…

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This study tests whether a special scoring tool (the Lyon-VTE score) can better prevent dangerous blood clots in pregnant women at high risk compared to standard care. About 600 pregnant women with a personal history of blood clots or a clotting disorder will be randomly assigned…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after surgery. About 8,600 adults having high-risk operations (like cancer or joint surgery) will be randoml…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This study is testing whether the blood thinner apixaban can safely prevent blood clots in people newly diagnosed with a fast-growing brain tumor called grade 4 glioma. About 40 adults will take apixaban while receiving standard radiation and chemotherapy. The main goal is to see…

This study tests whether taking blood thinners for 12 weeks can prevent dangerous blood clots in people with autoimmune hemolytic anemia (AIHA), a rare disease where the immune system destroys red blood cells. About 72 adults with newly diagnosed or relapsed AIHA will receive eit…

This study compares two blood thinners—rivaroxaban (a pill) and enoxaparin (a shot)—to see which works better at preventing dangerous blood clots in the legs after emergency abdominal surgery. About 212 adults will take one of the two medicines daily for 7 days after surgery. Res…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study tests whether a structured walking program, added to standard care, can improve quality of life and reduce long-term complications in people who have had a first deep vein thrombosis (DVT) in the leg. Researchers will enroll 152 adults and compare those who receive the…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study surveys doctors who use the Liberant system to remove fresh blood clots from leg arteries and veins. About 50 patients aged 22 or older will be treated within 72 hours of their procedure. The goal is to confirm the device is safe and works as intended.

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study is testing a new, non-invasive device that uses electrical signals to measure blood flow in the legs. It includes 20 healthy volunteers and 20 patients with deep vein thrombosis (DVT) who are undergoing clot-busting treatment. The goal is to collect data to improve the…

This study is testing a portable device that measures electrical signals and light absorption to monitor blood flow in tissue flaps used for breast reconstruction. Ten women undergoing this surgery will have the device attached to the flap during the operation. The goal is to see…

This study compares how a 60-minute treadmill walk changes blood clotting in people who have had a blood clot (venous thromboembolism) and those who haven't. Researchers will measure clotting markers before and after exercise in 94 participants. The goal is to better understand h…

This study is collecting blood and urine samples from 150 cancer patients who have had blood clots. The goal is to learn more about why clots happen in cancer and how to prevent them. Participants will be followed over time to track clot recurrence and bleeding risks.

This study is looking at whether women who have had a blood clot while using hormones (like birth control pills or during pregnancy) have family members who are also more likely to have had a clot. Researchers will compare the family history of these women with that of women who …

This study looks at 665 people who had a pulmonary embolism (a blood clot in the lung) and are at intermediate risk of another clot. Researchers will use a special 3D lung scan (V/Q SPECT/CT) to measure leftover blockages in lung blood vessels. The goal is to see if this scan can…

This study follows 3,400 people who have had a blood clot (venous thromboembolism) to see how often clots return and what raises the risk. It focuses on two groups: patients under 50, and cancer patients of any age. Researchers will track recurrences over 1 to 5 years and also mo…

This study is testing a new radioactive tracer designed to attach to active blood clots and make them visible on a PET scan. Researchers will take blood samples from 10 healthy volunteers, create clots in the lab, and see how well the tracer binds to them. The goal is to develop …

This study looks at how a common blood thinner (LMWH) works in pregnant women. Pregnancy naturally makes blood clot more easily, which can be risky. Researchers will use a special test to measure clotting in 50 pregnant women across all trimesters and after birth, to find the bes…

This study follows 260 cancer patients who are on long-term blood thinners for blood clots (VTE). Researchers will ask participants about their quality of life, how well they stick to their medication, and their healthcare costs over 12 months. The goal is to learn what helps or …

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study looks at how often lung cancer patients on immune checkpoint inhibitors develop blood clots (in veins or arteries) and what factors increase that risk. Researchers will follow 2,400 adults with lung cancer who are starting immunotherapy, comparing those who get clots w…

This study is a registry that follows up to 10,000 people who have been diagnosed with a blood clot (deep vein thrombosis or pulmonary embolism) and started blood-thinning medication within 14 days. Researchers at the Mayo Clinic will track how many patients have another clot or …

This study looks at whether using a blood test (anti-Xa) to adjust the dose of a blood thinner (enoxaparin) works better than dosing based on weight alone for preventing dangerous blood clots in burn patients. About 25 adults with serious burns will be enrolled. The goal is to se…

This study aims to validate the Caprini score, a tool that estimates blood clot risk, in 3,000 people undergoing varicose vein surgery. Participants will be followed for four weeks after procedures like laser treatment or vein stripping to see if the score accurately predicts who…

This study follows 900 people having lung cancer surgery to learn why some develop blood clots in their legs (deep vein thrombosis) within 30 days after surgery. Researchers will collect medical data and use machine learning to build a tool that predicts each person's risk. The g…

This early-stage study looks at how two common blood thinners, rivaroxaban and apixaban, behave in people with compensated liver cirrhosis. 24 participants receive a single dose of one drug, and researchers measure drug levels and blood clotting markers over 12 hours. The goal is…

This study follows 178 patients hospitalized with a first-time deep vein thrombosis (DVT) in the leg. Researchers will take blood samples and perform ultrasounds to see if certain markers, like suPAR, can predict long-term complications such as post-thrombotic syndrome. The goal …

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study compares two common methods (a snare device and rigid forceps) for removing IVC filters, which are small devices placed in a vein to catch blood clots. Researchers want to see which method is more successful and faster. About 100 adults with a history of DVT who need t…

This study is testing a computer model called the CLOVER score, which uses machine learning to predict whether a person with a blood clot might have an undiagnosed cancer. Researchers will check the model's accuracy in 500 patients over two years. If it works well, doctors could …

This study looks at whether common blood thinners like heparin can mess up lab tests for another blood thinner, argatroban. Doctors often switch patients from heparin to argatroban, but current tests can't tell the two drugs apart. Researchers will analyze blood samples from 70 a…

This study looks at 500 people with advanced lung cancer to see if certain genetic changes (mutations) increase the risk of blood clots. Researchers will measure blood markers and track participants for 6 months. The goal is to learn which patients are at higher risk so doctors c…

This study will use daily bedside ultrasound to look for blood clots caused by central venous catheters in 100 adults after major surgery. Half the patients had cancer surgery, half had non-cancer surgery. The goal is to learn how often clots form and what factors increase the ri…

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This study tests a new, non-invasive way to measure blood flow in the legs of people who may have deep vein thrombosis (a blood clot). Researchers will use an air-filled bladder under a compression cuff to see how well blood moves. The goal is to improve detection of clots withou…

This study is a large registry that collects detailed information from 120,000 patients with venous thromboembolism (blood clots). The goal is to help doctors better understand the disease and identify who is at highest risk for complications like bleeding or another clot. By inc…

This study looks at why cancer patients have a much higher risk of developing blood clots. Researchers will collect blood clots from 120 patients (with and without cancer) who undergo a procedure to remove clots. They will analyze the clots for cancer cells and other factors to b…

This study is a registry that follows up to 5,000 adults who have an IVC filter placed or removed. An IVC filter is a small device placed in a large vein to prevent blood clots from traveling to the lungs. The goal is to collect data on how well the filter works and any complicat…

This study tests whether a set of quality improvement tools—including guidelines, care protocols, and a mobile app—can help hospitals in China better prevent blood clots in patients. About 5,800 hospitalized adults will take part across multiple hospitals. The goal is to see if t…

This study looks at whether giving low-risk blood clot patients a 4G tablet for remote check-ups, education, and questionnaires is practical and satisfying for patients and doctors. Fifty participants will use the tablet for up to a year while following standard treatment. The go…