Venous thromboembolism

This study tests a new medical device called the GORE VIAFORT stent, which is a small mesh tube placed inside a blocked or narrowed vein in the leg or pelvis to keep it open. The goal is to improve blood flow and reduce symptoms like pain, swelling, and leg ulcers. About 165 adul…

This study compares two methods for monitoring the blood thinner heparin in hospitalized patients with blood clots. One method uses a standard clotting test (PTT), while the other uses a newer test (anti-Xa). The goal is to see which method helps patients reach the right blood th…

This study is tracking 100 patients in Japan who receive the ClotTriever device to treat severe deep vein thrombosis (DVT). The device is used to remove blood clots from deep veins. Researchers are checking how safe the device is and how well it clears the clot in everyday hospit…

This study tests whether a structured 5-part nursing care bundle can reduce dangerous blood clots (venous thromboembolism) after total hip replacement surgery. The bundle includes patient education, ankle exercises, early walking, fluid management, and compression stockings. Abou…

This study looks at children with congenital heart disease who take the blood thinner rivaroxaban after a Fontan procedure. The goal is to see how often serious or minor bleeding happens. Researchers will collect data from regular doctor visits for up to 2 years. No extra tests o…

This study is testing a device called the Indigo Aspiration System that suctions out blood clots in people with deep vein thrombosis (DVT) in the leg. The goal is to see if it safely and effectively removes the clot and restores blood flow. About 229 participants with recent DVT …

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study tests a device called the Cleaner Pro Thrombectomy System, which is threaded through a blood vessel to suction out clots in the lungs of people with acute pulmonary embolism. The trial aims to see if the device safely reduces heart strain and avoids major complications…

This study tests whether using a person's individual risk of another blood clot or major bleeding can help doctors decide how long they should take blood thinners after a first clot. About 600 adults who had a first deep vein thrombosis or pulmonary embolism will fill out a quest…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study compares two common blood thinners—aspirin and enoxaparin (Lovenox)—to see which works better at preventing dangerous blood clots after surgery for bone cancer or cancer that has spread to the bone. About 2,868 adults having pelvic or leg surgery for these conditions w…

This study looks at whether a detailed full-body scan called FDG PET/CT can find hidden cancers in people aged 50 and older who have had an unexplained blood clot. About 1,276 participants will get either the scan or standard cancer checks. The goal is to see if the scan catches …

This study tests whether a fast, bedside ultrasound (called POCUS) can diagnose deep vein thrombosis (DVT) in the leg as accurately as the standard, more time-consuming ultrasound. About 50 adults with DVT symptoms will get both tests, and researchers will compare the results and…

This study tests whether a simple handgrip exercise can lower the risk of deep vein thrombosis (DVT) in adult hospital patients with a PICC line. Participants squeeze a soft ball for 10 seconds, rest, and repeat for 10 minutes, three times a day. The trial will track 2,500 patien…

This study tests whether a special nursing care protocol can prevent deep vein thrombosis (DVT) in patients recovering from on-pump cardiac surgery. The protocol includes using devices to improve blood flow, blood thinners, early patient movement, hydration, and education. Resear…

This study tests a new drug called KN060, given as a single intravenous dose, to prevent blood clots in people having total knee replacement surgery. It compares KN060 to the standard treatment enoxaparin, which requires daily injections. The trial involves 241 adults and is curr…

This study examines medical records from 10,000 people who had sepsis (blood poisoning) and developed dangerous blood clots (VTE) while in the ICU. Researchers want to see how many also had a serious blood disorder called DIC, which can cause clots throughout the body. By looking…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study looks at why some children and teens feel short of breath or have trouble exercising after their first blood clot in the leg (deep vein thrombosis) or lung (pulmonary embolism). Researchers will measure exercise capacity and breathing using special tests. The goal is t…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study explores whether an Apple Watch can track walking, heart rate, breathing, and sleep in people with glioblastoma, a serious brain cancer. The goal is to see if the watch can detect symptom changes before they become serious, like seizures or blood clots. Twenty-five pat…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study reviews medical records of 234 women who had gynecological surgery to see which method of preventing blood clots (like using compression devices or blood thinners) works best and is most cost-effective. Researchers will compare different prevention strategies to find t…

This study tests a modified clinical program to help doctors better prevent blood clots (VTE) in cancer patients starting treatment. About 25 patients and their doctors will take part. The program includes education for doctors and a structured risk assessment to decide if blood-…

This study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running heart health studies to find patterns and risk factors. The goal…