New device sucks out dangerous blood clots in leg veins

NCT ID NCT05003843

Ongoing Disease control Sponsor: Penumbra Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a device called the Indigo Aspiration System that suctions out blood clots in people with deep vein thrombosis (DVT) in the leg. The goal is to see if it safely and effectively removes the clot and restores blood flow. About 229 participants with recent DVT symptoms are being treated with this device and followed for complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Indigo Aspiration System (a device that suctions out blood clots)
What this could lead to: If successful, this could provide a safer, more effective way to quickly remove large blood clots in the leg veins, potentially reducing long-term damage and complications.
What could go wrong: This is a single-arm study without a comparison group, so benefits may be overstated. Risks include bleeding, device-related injury, or the clot returning.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VEIN THROMBOSIS DVT

Contacts and locations

Locations

BUMC - Dallas (Scott & White)

Dallas, Texas, 75246, United States
Baptist of Miami

Miami, Florida, 33176, United States
Christ Cincinnati

Cincinnati, Ohio, 45219, United States
Christiana Care

Newark, Delaware, 19713, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Hackensack Medical Center

Hackensack, New Jersey, 07601, United States
Holston Valley Medical

Kingsport, Tennessee, 37660, United States
Indiana University Health

Indianapolis, Indiana, 46290, United States
Jewish Barnes Hospital

St Louis, Missouri, 63110, United States
Kaleida University at Buffalo

Buffalo, New York, 14203, United States
LSU Hospital Shreveport

Shreveport, Louisiana, 71103, United States
Lafayette General/Cardiovascular Institute of the South

Lafayette, Louisiana, 70503, United States
Lancaster General Hospital

Lancaster, Pennsylvania, 17602, United States
Lenox Hill Hospital

New York, New York, 10075, United States
Long Beach Medical Center

Long Beach, California, 90806, United States
Lovelace Heart

Albuquerque, New Mexico, 87102, United States
MUSC

Charleston, South Carolina, 29425, United States
McLaren Greater Lansing

East Lansing, Michigan, 48910, United States
MedStar Washington

Washington D.C., District of Columbia, 20010, United States
Memorial Jacksonville

Jacksonville, Florida, 32216, United States
Mount Sinai Miami

Miami Beach, Florida, 33140, United States
Mount Sinai NY

New York, New York, 10029, United States
NC Heart and Vascular Research

Raleigh, North Carolina, 27607, United States
NYU

New York, New York, 11220, United States
Nebraska Methodist

Omaha, Nebraska, 68118, United States
Northwestern Memorial

Chicago, Illinois, 60611, United States
Protestant Memorial Medical Center, Inc

Belleville, Illinois, 62226, United States
Radiology and Imaging Specialists

Lakeland, Florida, 33805, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Sarasota Memorial

Sarasota, Florida, 34239, United States
Sentara

Norfolk, Virginia, 23507, United States
Sharp Grossmont

La Mesa, California, 91942, United States
St. Joseph Mercy Ann Arbor Hospital

Ann Arbor, Michigan, 48197, United States
St. Vincent

Indianapolis, Indiana, 46260, United States
Stony Brook University

Stony Brook, New York, 11794, United States
TriHealth

Cincinnati, Ohio, 45242, United States
UCLA

Los Angeles, California, 90095, United States
UMass Memorial Medical Center

Worcester, Massachusetts, 01655, United States
UPenn

Philadelphia, Pennsylvania, 19104, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Weill Cornell Medicine

New York, New York, 10021, United States

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