Venous thromboembolism

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This trial compared two blood thinners—apixaban (a pill) and enoxaparin (a shot)—in 126 bladder cancer patients after bladder removal surgery. The goal was to see which one patients were more likely to take as prescribed, which they preferred, and what it cost them. Participants …

This study compared two blood thinners, rivaroxaban (Xarelto) and apixaban (Eliquis), in 2760 adults with new blood clots in the legs or lungs. The goal was to see which drug causes fewer bleeding problems. Results could help doctors choose the safer option for treating venous th…

This pilot study tested whether a shorter course of blood thinner (LMWH) followed by aspirin is as good as the standard 6 weeks of LMWH for preventing blood clots after childbirth. The study enrolled 30 women at moderate to high risk of clots. The main goal was to see if women wo…

This large, completed phase 3 trial enrolled over 5,400 people undergoing total hip or knee replacement to compare two approaches for preventing venous thromboembolism (blood clots). Participants received either aspirin alone or a short course of rivaroxaban followed by aspirin. …

This study tested a soft robotic sock called VACOM in 19 stroke patients who had trouble moving their ankle. The sock gently moves the ankle to prevent stiffness and improve blood flow, aiming to reduce the risk of blood clots and contractures. The trial is complete, but results …

This study tested whether the blood thinner pill rivaroxaban works as well as standard injections (enoxaparin) in children aged 6 months to 18 years with deep vein clots. Sixty children were randomly assigned to either the pill or injections for 3 months. The main goal was to see…

This study looked at whether the blood thinner Xarelto (rivaroxaban) can prevent dangerous blood clots in the legs or lungs after hip or knee replacement surgery. 150 patients were randomly assigned to receive either Xarelto or no blood thinner after surgery. The researchers trac…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study looked at how well the JETi device works in real-world settings to remove blood clots from deep leg veins (venous thrombosis). The device uses suction and tiny water jets to break up and remove clots. In 121 patients, the device successfully cleared at least 75% of the…

This completed trial tested a device called Ceragem Master V6 to see if it improves blood circulation in people at risk for deep vein thrombosis (DVT) and in healthy adults. 59 participants used the device once, and researchers measured changes in blood flow speed and vein size u…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This completed trial tested a device called CGM MB-1701 to see if it can improve blood flow in people at risk for deep vein thrombosis (DVT). The study enrolled 60 adults who did not have DVT at the start. Researchers measured changes in blood flow speed in the leg vein after usi…

This study tested a hospital policy of giving tranexamic acid to adults undergoing major non-cardiac surgery to reduce the need for blood transfusions. Over 8,400 patients took part across multiple hospitals. The goal was to see if this approach safely lowers transfusion rates an…

This study tested a device called the JETi system to remove blood clots from veins or arteries in the arms or legs. It included 12 adults of Asian descent in Hong Kong. The goal was to see how well the device cleared clots and if it caused serious side effects like bleeding or re…

This study tested whether giving the drug tirofiban during stent or flow diverter procedures for unruptured brain aneurysms could reduce the number of small brain injuries seen on MRI after surgery. 192 adults aged 18-80 took part. The goal was to see if tirofiban works better th…

This study compared two common blood thinners, rivaroxaban and apixaban, in 72 adults with newly diagnosed blood clots in the legs or lungs. The main goal was to see if a larger trial is possible by checking how many patients could join and complete follow-ups. Researchers also t…

This study looked at whether a low dose of the blood thinner apixaban (2.5 mg twice daily for 12 months) can safely prevent blood clots from returning in people who already had a clot triggered by a temporary risk factor. 600 high-risk adults took either apixaban or a placebo. Th…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This pilot study tested whether giving the blood thinner enoxaparin after a C-section is feasible and safe. 64 women who had a C-section were randomly assigned to receive enoxaparin or no treatment for 14 days. The main goal was to see if enough women would join and complete the …

This study tested whether a mobile app called ThinkSono Guidance can help healthcare workers who are not ultrasound experts (like nurses or general doctors) take good-quality ultrasound images of leg veins to check for blood clots. Over 600 adults with symptoms of deep vein throm…

This study tested a new approach to diagnose whether a blood clot has returned in the leg. Instead of relying on older methods, doctors used color Doppler ultrasound and a D-Dimer blood test to safely rule out a new clot. Over 400 people with a history of deep vein thrombosis too…

This study looks at whether ultrasound can correctly diagnose a repeat deep vein thrombosis (DVT) in the same leg. Researchers will check if the clot changes after 3 months of blood thinner treatment. The goal is to reduce false alarms and unnecessary treatment. The study involve…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This trial tests whether a short 5-day course of the blood thinners rivaroxaban (Xarelto) or apixaban (Eliquis) can prevent blood clots that sometimes form after laser treatment for varicose veins. Adults with symptomatic vein reflux undergoing laser ablation of the great sapheno…

This study tested an experimental drug called REGN7508 in 179 adults having knee replacement surgery. The goal was to see if it could prevent blood clots in the legs or lungs better than standard care. Researchers also monitored side effects and how the drug moved through the bod…

This study tested a new drug called SHR-2004 to prevent dangerous blood clots in people undergoing elective total knee replacement. Over 1,100 adults participated, receiving either SHR-2004 or a standard blood thinner. The goal was to see if SHR-2004 could reduce clots in the leg…

This study tested two experimental drugs, REGN9933 and REGN7508, to see if they can prevent venous thromboembolism (blood clots) in adults who need a PICC line for at least 14 days. The drugs are monoclonal antibodies that target a clotting factor. 195 participants received a sin…

This study compared three common blood thinners—aspirin, warfarin, and rivaroxaban—to prevent dangerous blood clots after hip or knee replacement surgery. Nearly 19,000 adults took part. The goal was to find which option best balances preventing clots with avoiding bleeding side …

This study looked at 86 women with Factor V Leiden or Factor II mutations who had no history of blood clots. Researchers compared how long doctors prescribed blood thinners after childbirth (less than 2 weeks vs. 6 weeks) to see if shorter treatment was still effective at prevent…

This study compared an experimental oral anticoagulant called Dimolegin to the standard injectable drug Clexane for preventing venous thromboembolism (VTE) in 215 adults undergoing hip or knee replacement surgery. The goal was to see if the pill is as effective and safe as the in…

This completed trial tested whether a nurse-led program of early movement, leg-sleeve squeezes, and blood tests could prevent deep vein thrombosis (DVT) in adults after brain or spine surgery. Over 1,200 participants were randomly assigned to either the nurse-led program or stand…

This study tested whether adding a leg compression device to elastic stockings reduces blood clots in intensive care patients at high risk of bleeding. Over 400 patients were randomly assigned to receive either the device plus stockings or stockings alone. The main goal was to se…

This study compared two blood-thinning drugs, Bemiparin and Enoxaparin, to prevent venous thromboembolism (dangerous blood clots) in 7020 women after vaginal or cesarean delivery. All participants had risk factors for clots and received daily injections for up to 7 days after giv…

This study tested whether a small, wearable device called geko can help prevent dangerous blood clots in the legs of critically ill adults. The geko device uses mild electrical pulses to stimulate leg muscles, improving blood flow. Researchers compared it to standard compression …

This study tested whether a special nursing plan (called ERAS) could help women recover after surgery for cervical cancer. 160 women were split into two groups: one got the ERAS nursing plan, the other got standard care. The goal was to see if the ERAS plan could lower the risk o…

This study tested whether starting physiotherapy early is practical and helpful for patients hospitalized with a first-time deep vein thrombosis (DVT) in the leg. Twenty-four adults participated, and researchers measured how many joined, stayed, and completed quality-of-life surv…

This study looks back at the medical records of over 100,000 hospitalized patients to identify which health conditions and factors are linked to a higher risk of death in people with venous thromboembolism (VTE) — blood clots in the veins, including deep vein thrombosis and pulmo…

This study looked at how doctors make decisions about dosing the blood thinner warfarin based on a patient's genetic background. Researchers used virtual reality to simulate patient visits with different racial and socioeconomic backgrounds. 196 internal medicine residents partic…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study reviews existing medical records to understand how blood clots (VTE) are treated in people with active cancer or a history of cancer. Researchers will look at which blood thinners are used, how often clots come back, and the costs involved. No new treatments are given—…

This study looks at healthcare claims from over 78,000 people to see if it can reproduce the results of the EINSTEIN-DVT trial, which compared two blood thinners (rivaroxaban and warfarin) for treating blood clots. The goal is not to test a new drug, but to learn whether real-wor…

This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better pr…

This study examines the best time to start blood thinners in women who have had severe bleeding after childbirth. Researchers are looking at whether starting blood thinners within 24 hours or later affects the risk of blood clots or further bleeding. The goal is to find a balance…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This study examined blood samples from 119 adults with sickle cell disease, sickle cell trait, or no condition to understand why some develop dangerous blood clots. Participants gave blood and had health check-ins over two years. The goal was to find biomarkers that could lead to…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This study used data from over 12,000 ICU patients to create a computer model that can predict which patients are at risk for venous thromboembolism (VTE) – dangerous blood clots. The model was designed to be easy for doctors to understand and use. The goal is to improve preventi…

This completed study from Israel examined 4,500 ICU patients to see if intermittent pneumatic compression (IPC) devices, which are used to prevent dangerous blood clots, might also cause pressure sores. The researchers focused on sores around the ankles and other bony areas. The …

This study looked at how often air bubbles accidentally get into the bloodstream during bronchoscopy, a common lung procedure. About 500 adults having diagnostic or therapeutic bronchoscopy were monitored with heart and brain ultrasound to detect these bubbles. The goal was to fi…

This study looks at data from children under 18 in Japan who were prescribed either rivaroxaban or warfarin for blood clots. Researchers want to see how often major bleeding happens in real-world use. No new treatments are given—only existing medical records are reviewed.

This study looked at whether sending alerts to pharmacists instead of doctors helps improve how blood thinners (anticoagulants) are prescribed. Researchers tested two types of alerts with 306 healthcare providers. The goal was to see which method leads to faster and safer prescri…

This completed study followed 1,000 adults with venous thromboembolism (blood clots) across China for several years. Researchers tracked who had another clot, who had bleeding problems, and who died. The goal was to learn which patients need long-term blood-thinning medication an…

This study looked at whether a blood test done before hip or knee replacement surgery can predict the risk of developing deep vein thrombosis (DVT), a dangerous blood clot. Researchers measured thrombin generation in 146 patients. The goal was to see if the test could identify wh…

This study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. Researchers asked about their quality of life, confidence in managing their condition, and how they view the care they receive. The goal is to better understand the real-life challenges thes…

This study tested whether a special PET/CT scan can predict which patients with deep vein thrombosis (DVT) will later develop post-thrombotic syndrome (PTS), a condition causing chronic leg pain, swelling, and ulcers. Researchers imaged 51 patients shortly after their DVT and fol…

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This completed study examined stored DNA from 150 adults over 50 who had a history of venous thromboembolism (blood clots). Researchers looked for specific gene mutations linked to a condition called clonal hematopoiesis of indeterminate potential (CHIP). The goal was to see how …

This completed study looked at whether intimate partner violence (IPV) increases the risk of blood clots in women taking combined oral contraceptives. Researchers compared 997 women who had a first blood clot with similar women who did not, using a questionnaire to screen for IPV…

This study looked at how well the Wells score, a tool used to predict deep vein thrombosis (blood clots), works for hospitalized patients who are already receiving blood thinners. Researchers compared the score's accuracy between patients with and without thromboprophylaxis and c…

This study looked at whether levels of nucleosomes and free DNA in the blood change from month to month in healthy people and in those who have had a blood clot (venous thromboembolism). Researchers measured these markers monthly for six months in 15 healthy volunteers and 15 pat…

This study looked at medical costs for cancer patients who had a blood clot (VTE) and were treated with either apixaban or low molecular weight heparin. Researchers analyzed insurance claims from over 7,300 patients to compare total healthcare costs, including hospital stays and …

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…

This study tracked 81 adults with pelvic or hip socket fractures to see how often they developed blood clots in their legs or lungs, even while receiving standard clot-preventing medication. All participants got ultrasound scans to find clots that might not cause symptoms. The go…

This study looked at 744 people who had a blood clot before and were suspected of having another one. Researchers tested three different checklists (called clinical decision rules) to see how well they could tell if a new clot was really there. The goal was to help doctors avoid …

This completed study followed 300 patients with venous thromboembolism (blood clots in veins) to track how often clots return or cause bleeding. Researchers hope to find new risk factors and compare newer blood thinners. The study only observes, so it cannot test treatments direc…