Can a Two-Drug combo beat aspirin alone for preventing clots after joint surgery?
NCT ID NCT04075240
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This large, completed phase 3 trial enrolled over 5,400 people undergoing total hip or knee replacement to compare two approaches for preventing venous thromboembolism (blood clots). Participants received either aspirin alone or a short course of rivaroxaban followed by aspirin. The study measured how many developed symptomatic clots or experienced bleeding. The goal was to find a safer, more effective prevention strategy for this common surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rivaroxaban (Xarelto) and aspirin
What this could lead to
If successful, this could show that adding a short course of rivaroxaban to aspirin is a safe and effective way to prevent dangerous blood clots after joint replacement surgery.
What could go wrong
This trial is completed, so results are known. However, the benefit may be modest, and adding rivaroxaban increases bleeding risk. The findings may not apply to people with prior clots or other risk factors.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Queen Elizabeth II HSC
Halifax, Nova Scotia, B3H 3A7, Canada