Can a Two-Drug combo beat aspirin alone for preventing clots after joint surgery?
NCT ID NCT04075240
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This large, completed phase 3 trial enrolled over 5,400 people undergoing total hip or knee replacement to compare two approaches for preventing venous thromboembolism (blood clots). Participants received either aspirin alone or a short course of rivaroxaban followed by aspirin. The study measured how many developed symptomatic clots or experienced bleeding. The goal was to find a safer, more effective prevention strategy for this common surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- rivaroxaban (Xarelto) and aspirin
- What this could lead to
- If successful, this could show that adding a short course of rivaroxaban to aspirin is a safe and effective way to prevent dangerous blood clots after joint replacement surgery.
- What could go wrong
- This trial is completed, so results are known. However, the benefit may be modest, and adding rivaroxaban increases bleeding risk. The findings may not apply to people with prior clots or other risk factors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Queen Elizabeth II HSC
Halifax, Nova Scotia, B3H 3A7, Canada
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