Which blood thinner works best after joint surgery? huge study reveals answers

NCT ID NCT02810704

Completed Prevention Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared three common blood thinners—aspirin, warfarin, and rivaroxaban—to prevent dangerous blood clots after hip or knee replacement surgery. Nearly 19,000 adults took part. The goal was to find which option best balances preventing clots with avoiding bleeding side effects.

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Conditions

The condition(s) this trial relates to.

thrombophilia due to thrombin defect venous thromboembolism Venous Thrombosis pulmonary embolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY EMBOLISM VENOUS THROMBOSIS

Contacts and locations

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Locations

Anderson Orthopaedic Institute (VA)

Alexandria, Virginia, 22306, United States
Arthritis Surgery Research Foundation

South Miami, Florida, 33143, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Boston University Medical Center

Boston, Massachusetts, 02118, United States
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Indiana University

Indianapolis, Indiana, 46037, United States
Johns Hopkins University

Baltimore, Maryland, 21218, United States
Lahey Clinic

Burlington, Massachusetts, 01805, United States
Lifespan Health

East Providence, Rhode Island, 02914, United States
London Health Sciences Centre

London, Ontario, N6A 4V2, Canada
Mayo Clinic

Scottsdale, Arizona, 85259, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
New York University

New York, New York, 10016, United States
Northwell Health

New York, New York, 10075, United States
Penn State Hershey Med Center

Hershey, Pennsylvania, 17033, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Sinai Hospital

Baltimore, Maryland, 21215, United States
Stanford University Hospital

Stanford, California, 94305, United States
UCLA

Los Angeles, California, 90404, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Ottawa

Ottawa, Ontario, K1H 8L6, Canada
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Utah

Salt Lake City, Utah, 84132, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
University of Washington

Seattle, Washington, 98133, United States
Virginia Commonwealth University Medical Center

Richmond, Virginia, 23284, United States
West Virginia University

Morgantown, West Virginia, 26506, United States

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