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Blood thinner showdown: which is safer for clot patients?

NCT ID NCT03266783

Completed Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two blood thinners, rivaroxaban (Xarelto) and apixaban (Eliquis), in 2760 adults with new blood clots in the legs or lungs. The goal was to see which drug causes fewer bleeding problems. Results could help doctors choose the safer option for treating venous thromboembolism.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
rivaroxaban and apixaban (blood thinners)
What this could lead to
If one drug proves safer, doctors may prescribe it more often to reduce bleeding complications in VTE patients.
What could go wrong
This is a single completed trial; results may not apply to all patients. Bleeding risk differences could be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

  • Alberta Health Sciences

    Edmonton, Alberta, Canada

  • CHU de Québec-Université Laval

    Québec, Quebec, Canada

  • Hamilton General Hospital

    Hamilton, Ontario, Canada

  • Hôpital Sacré-Coeur de Montréal

    Montreal, Quebec, Canada

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Juravinski Hospital

    Hamilton, Ontario, Canada

  • Kingston General Hospital

    Kingston, Ontario, Canada

  • London Health Sciences Center

    London, Ontario, N6A 5W9, Canada

  • McGill University Health Center

    Montreal, Quebec, H4A 3J1, Canada

  • QEII Health Science Centre

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • St. Joseph's Healthcare Hamilton

    Hamilton, Ontario, Canada

  • St. Mary's Hospital

    Montreal, Quebec, Canada

  • St. Paul's Hospital

    Vancouver, British Columbia, Canada

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • The Royal College of Surgeons in Ireland/Mater Misericordiae University Hospital

    Dublin, Ireland

  • The University of Sydney

    Darlington, New South Wales, 200606, Australia

  • UHN - Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • University of Calgary

    Calgary, Alberta, Canada

  • University of Sherbrooke

    Sherbrooke, Quebec, Canada

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