New blood clot pill could replace daily shots for joint replacement patients

NCT ID NCT07124819

Completed Prevention Sponsor: Avexima Diol LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compared an experimental oral anticoagulant called Dimolegin to the standard injectable drug Clexane for preventing venous thromboembolism (VTE) in 215 adults undergoing hip or knee replacement surgery. The goal was to see if the pill is as effective and safe as the injection in reducing blood clots, clot-related deaths, and bleeding events. If successful, Dimolegin could offer a more convenient, needle-free option for post-surgery clot prevention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dimolegin (oral anticoagulant)
What this could lead to: If it works, this could offer a convenient pill alternative to daily injections for preventing dangerous blood clots after joint replacement surgery.
What could go wrong: This is a completed phase 3 trial with 215 participants, but results are not yet published. The new drug may not be as effective or safe as the standard treatment, and bleeding risks are a concern.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

venous thromboembolism prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHROPLASTY REPLACEMENT, KNEE ARTHROPLASTY, REPLACEMENT, HIP PREVENTION VENOUS THROMBOEMBOLISM (VTE)

Contacts and locations

Locations

Bryansk City Hospital No. 1

Bryansk, Russia
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Moscow, Russia
National Research Ogarev Mordovia State University

Saransk, Russia
Privolzhsky Research Medical University

Nizhny Novgorod, Russia
Rostov State Medical University

Rostov-on-Don, Russia
Ryazan State Medical University named after academician I.P. Pavlov

Ryazan, Russia
Samara Regional Clinical Hospital named after V.D. Seredavin

Samara, Russia
Saratov State Medical University named after V. I. Razumovsky

Saratov, Russia

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