Can newer blood thinners beat aspirin for clot prevention in blood cancer patients?

NCT ID NCT05198960

Recruiting now Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether direct oral anticoagulants (DOACs) like apixaban or rivaroxaban are better than low-dose aspirin at preventing blood clots in people with JAK2V617F-positive myeloproliferative neoplasms (blood cancers). The study plans to enroll 1308 high-risk patients. The goal is to see if these newer blood thinners reduce the risk of dangerous clots without causing too much bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Apixaban or Rivaroxaban (blood thinners)
What this could lead to: If successful, this could offer a more effective way to prevent dangerous blood clots in people with certain blood cancers, potentially reducing strokes and heart attacks.
What could go wrong: This is a large phase 3 trial, but blood thinners carry a risk of serious bleeding. It is unclear if the benefits will outweigh this risk in this specific patient group.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera cellular phase chronic idiopathic myelofibrosis essential thrombocythemia Hemorrhage primary myelofibrosis venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL THROMBOCYTHEMIA HIGH RISK PATIENTS JAK2 V617F POLYCYTHEMIA VERA PREFIBROTIC/EARLY PRIMARY MYELOFIBROSIS

Contacts and locations

Locations

CH Bretagne Atlantique Vannes
RECRUITING

Vannes, 56017, France
CH Le Mans
NOT_YET_RECRUITING

Le Mans, 72000, France
CH Libourne
NOT_YET_RECRUITING

Libourne, 33500, France
CH Paul-Brousse (APHP)
NOT_YET_RECRUITING

Villejuif, 94800, France
CH d'Annecy
NOT_YET_RECRUITING

Annecy, 74374, France
CH d'Argenteuil
NOT_YET_RECRUITING

Argenteuil, 95100, France
CH d'Avignon
RECRUITING

Avignon, 84000, France
CH de Béziers
NOT_YET_RECRUITING

Béziers, 34500, France
CH de Morlaix
RECRUITING

Morlaix, 29600, France
CH de Perpignan
NOT_YET_RECRUITING

Perpignan, 66000, France
CH de Périgueux
RECRUITING

Périgueux, 24019, France
CH de Rochefort
NOT_YET_RECRUITING

Rochefort, 17300, France
CH de Roubaix
RECRUITING

Roubaix, 59100, France
CH de Versailles
NOT_YET_RECRUITING

Versailles, 78150, France
CH de la Côte Basque Bayonne
NOT_YET_RECRUITING

Bayonne, 64100, France
CHD Vendée La Roche Sur Yon
RECRUITING

La Roche-sur-Yon, 85925, France
CHIC de Quimper
RECRUITING

Quimper, 29107, France
CHR d'Orléans
RECRUITING

Orléans, 45100, France
CHU Bordeaux
RECRUITING

Bordeaux, 33604, France
CHU Brest
RECRUITING

Brest, 29609, France
CHU Grenoble Alpes
RECRUITING

Grenoble, 38043, France
CHU La Réunion - Site Nord Félix GUYON
NOT_YET_RECRUITING

Saint-Denis, 97405, France
CHU La Réunion - Site Sud
NOT_YET_RECRUITING

Saint-Pierre, 97410, France
CHU Le Havre
NOT_YET_RECRUITING

Le Havre, 76083, France
CHU d'Angers
RECRUITING

Angers, 49933, France
CHU de Clermont-Ferrand
NOT_YET_RECRUITING

Clermont-Ferrand, 63003, France
CHU de Limoges - Hôpital Dupuytren
RECRUITING

Limoges, France
CHU de Montpellier
NOT_YET_RECRUITING

Montpellier, 34295, France
CHU de Nancy
RECRUITING

Nancy, 54511, France
CHU de Nantes - Hôtel-Dieu
NOT_YET_RECRUITING

Nantes, 44093, France
CHU de Rennes
NOT_YET_RECRUITING

Rennes, 35033, France
CHU de Tours
RECRUITING

Tours, 37044, France
Centre Henri Becquerel de Rouen
RECRUITING

Rouen, 76038, France
Centre Léon Bérard Lyon
NOT_YET_RECRUITING

Lyon, 69000, France
Clinique Sainte Anne Strasbourg
NOT_YET_RECRUITING

Strasbourg, 92210, France
Hôpital Cochin (APHP)
NOT_YET_RECRUITING

Paris, 75679, France
Hôpital Henri Mondor (APHP)
RECRUITING

Créteil, 94010, France
Hôpital Privé du Confluent Nantes
NOT_YET_RECRUITING

Nantes, 44202, France
Hôpital St-Louis (APHP)
RECRUITING

Paris, 75010, France
Hôpital privé Cesson-Sévigné
NOT_YET_RECRUITING

Cesson-Sévigné, 35510, France
Institut de Cancérologie Lucien Neuwirth St-Priest-en-Jarez
RECRUITING

Saint-Priest-en-Jarez, 42271, France
Médipôle Hôpital Mutualiste Villeurbanne
RECRUITING

Villeurbanne, 69616, France

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