Skull disorder

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

This study tested a surgical technique called a dermal roll flap to support the nostril base in 45 people who had a previous cleft lip repair. The flap uses extra skin from the lip to lift and stabilize the nostril on the cleft side. Researchers measured changes in nostril positi…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study tested a new, simple device to reduce the size of wide gaps in the jawbone (alveolar clefts) in 15 people aged 12-25 with repaired cleft lip and/or palate. The device slowly pulls the bone together before a bone graft, aiming to make the graft more successful. The stud…

This study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well …

This study tested a new way to rebuild the lower jaw after removing benign tumors. Surgeons used virtual 3D planning to create custom-made plates and combined them with a piece of the patient's own rib bone. Thirty people took part, and the team checked how well the wounds healed…

This study tested whether combining two FDA-approved cancer drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the best dose and see if it improves surv…

This study tested a new way of delivering radiation for people with non-secreting pituitary adenomas that came back or remained after surgery. Instead of a single high dose, the radiation was given in five smaller daily doses. The goal was to see if this approach could control tu…

This study looked at whether rinsing the nose with diluted povidone-iodine (a common antiseptic) after sinus surgery helps people with chronic sinusitis recover better than standard saline or mucomyst rinses. Forty-eight adults who had sinus surgery used one of the three rinses d…

This study tested whether a dietary supplement called Imunoglukan P4H® (made from pleuran, a mushroom extract, plus vitamin C) could help people with chronic sinusitis. 85 patients over age 12 took the supplement alongside standard treatments like nasal sprays and saline rinses. …

This study tested a modified jaw surgery (Le Fort I osteotomy) in 9 adults with cleft lip and palate who also had a misaligned bite and a bone gap in the upper jaw. The surgery aimed to improve facial structure and reduce the size of the bone defect. Researchers measured changes …

This study tested whether adding extra dental checkups and video calls with a dentist could improve oral hygiene in children with cleft deformities. Sixty children aged 3 to 15 took part. The program included a longer dental visit and teleconsultations every two months. Researche…

This study tested a new method to repair a type of cleft palate that affects the upper gum (unilateral alveolar cleft). Ten patients received a 'sticky bone' graft combined with a special growth factor membrane. The researchers checked for inflammation, fluid leaking into the nos…

This study tested a new device called the Leaf Self Expander to widen the upper jaw in 20 children with cleft lip and palate. The device was compared to the standard rapid maxillary expander. Researchers used 3D scans to measure changes in bone and tooth position. The goal was to…

This completed Phase 1/2 trial tested whether metformin (a diabetes drug) and pirfenidone (an anti-scarring drug) can reduce fibrosis in people with oral submucous fibrosis, a condition that causes mouth stiffness and raises cancer risk. 45 participants received either metformin,…

This study looked at whether a second surgery could improve the look of the lip and nose in 25 people born with a cleft lip who already had one repair. The goal was to see if patients were happier with their appearance and function after the extra surgery. Results were measured u…

This study tested a special device placed inside the mouth to slowly pull bone across a wide gap in the gum (alveolar cleft) in 8 patients aged 7 to 20. The goal was to close the gap without needing a bone graft. Researchers measured changes in the cleft size, tooth movement, and…

This study tested a new surgical technique for repairing a common complication after cleft palate surgery: a hole (fistula) in the roof of the mouth. In 36 patients, half received the standard two-layer repair, while the other half also had a small piece of fat from the cheek pla…

This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The…

This study tested two different bone graft materials to repair a common birth defect called alveolar cleft (a gap in the upper jaw). Fourteen children aged 8 to 12 received either a standard graft or one mixed with a special blood product. The goal was to see which material led t…

This study tested a drug called pegvisomant in children aged 2 to 18 with gigantism, a condition where the body makes too much growth hormone. The goal was to see if the drug could safely lower hormone levels and slow down abnormal growth. Participants received daily injections a…

This study tested an experimental drug called SPI-62 in 26 adults with Cushing's syndrome caused by a non-adrenal tumor. The goal was to see if SPI-62 could lower cortisol levels safely. Participants received either SPI-62 or a placebo for 24 weeks, with an option to continue lon…

This study tested whether using a special PET scan (FAZA) to find oxygen-starved (hypoxic) tumor cells can help guide proton therapy for chordomas of the skull base, spine, or sacrum. 64 adults who had surgery or were getting radiation received a higher radiation dose to the hypo…

This study compared two types of sinus surgery for people with chronic sinusitis and nasal polyps that involve a type of inflammation called eosinophilic. One surgery (MRESS) removes more tissue, including the middle turbinate, while the standard surgery (FESS) preserves it. The …

This completed trial tested whether a gelatin sponge works as well as a bone matrix for lifting the sinus floor during dental implant placement. Fourteen patients with low bone height in the upper jaw received one of the two materials. The study measured bone gain and implant sta…

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers a…

This completed study tested a special dental expander combined with tiny bone perforations (MOPs) to widen the upper jaw in 14 adults aged 17-23 with a narrow jaw and crossbite. The goal was to see if this less invasive method could effectively expand the jaw without major surger…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested whether a special scan called [11C]-Methionine PET/MRI can better locate tiny pituitary tumors that cause Cushing's disease. Standard MRI often misses these tumors, leading to risky exploratory surgery. The study involved 33 adults with confirmed Cushing's disea…

This study looked at whether nasal drops made from Pistacia lentiscus oil (a natural plant oil) can help prevent chronic sinusitis from coming back. 100 adults with frequent sinus infections were followed for 12 months. One group used the oil drops plus a saltwater rinse, while t…

This study tested whether a special nerve block given during cleft palate repair can lower pain and reduce the need for opioids in children. Forty children having their first cleft palate surgery received the nerve block. Researchers measured pain scores and opioid use to see if …

This study tested whether a numbing injection behind the nose (sphenopalatine ganglion block) could reduce confusion and agitation after sinus surgery. 100 adults received either the nerve block or a placebo. The goal was to see if the block helped patients wake up more calmly an…

This study tested whether rinsing the sinuses with hot saline (50°C) during surgery for chronic sinusitis reduces bleeding and improves the surgeon's view. 59 adults were split into three groups: hot saline, room-temperature saline, or no rinse. The goal was to see if the hot rin…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study tested whether a single dose of dexmedetomidine, given during surgery, can prevent severe agitation in children aged 1-7 after cleft palate repair. Sixty children were randomly assigned to receive either the drug or a placebo (saline). The main goal was to measure emer…

This study tested two different nasal packs used after nose surgery to see which one patients liked better and which led to better healing. Twenty adults who had nasal surgery received either a VELNEZ or NASOPORE pack. Researchers checked for pain, bleeding, and how well the pack…

This study tested different doses of melatonin (3, 5, and 10 mg) compared to a placebo in 160 adults undergoing sinus surgery. The goal was to see which dose best reduces anxiety and pain while keeping heart rate and blood pressure stable. Results could help doctors choose the ri…

This study tested whether soaking feet in warm water for 20 minutes before pituitary tumor surgery helps patients feel less anxious and keeps vital signs stable. 100 adults were enrolled, with one group receiving the foot bath and the other standard care. Researchers measured anx…

This study tested whether adding a gentle hands-on therapy called craniosacral osteopathic treatment to standard care can improve symptoms and quality of life for people with chronic sinusitis. Fifty adults with the condition were randomly assigned to receive either standard medi…

This study tested a nitric oxide nasal spray against a saline placebo in 162 adults with recurrent acute sinusitis. Participants used the spray at the first sign of a new episode for two weeks. The goal was to see if the nitric oxide spray speeds up symptom relief and reduces the…

This study looked at two ways to numb a nerve bundle in the face during pituitary gland surgery. The goal was to see which method reduces the amount of anesthesia needed during the operation. Sixty adults having this type of surgery took part. The results help doctors choose the …

This small study tested a herbal tea made from berry and mango leaves in 10 adults with acute sinusitis. Participants drank the tea three times a day alongside their usual care for one month. Researchers measured changes in quality of life using a standard symptom questionnaire. …

This study looked at two methods to treat concha bullosa, a condition where the middle turbinate in the nose is enlarged and can block sinuses. 62 adults with chronic sinusitis were randomly assigned to have the turbinate crushed or partially removed during sinus surgery. After o…

This study looked at whether smell training with scented oils can help people regain their sense of smell after endoscopic skull base surgery. 41 adults with benign skull base tumors participated. Half used scented sticks and half used unscented sticks for training. Researchers m…

This study tested an experimental implant called LYR-210 in 182 adults with long-term sinus inflammation (chronic rhinosinusitis). The goal was to see if it could reduce key symptoms like nasal congestion, discharge, and facial pain better than a placebo. Participants received th…

This study tested a gel called PuraSinus to see if it makes follow-up cleanings after sinus surgery less painful. 30 adults with chronic sinus disease took part. The gel was compared to standard nasal dressings. The goal was to reduce pain and discomfort during these cleanings.

This study tested whether Ectoin nasal spray helps relieve symptoms of acute sinusitis compared to another medication (Sinupret forte). 66 adults used the spray or took the other drug for 14 days. Doctors checked symptoms at day 7 and day 14, and patients kept a daily diary. The …

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at how well Global D implants work for orthognathic (jaw) surgery and whether they improve patients' quality of life. 198 people who had their first jaw surgery received these implants. Researchers measured quality of life before and after surgery using a specia…

This study tested two ways to remove bone during a minimally invasive sinus surgery called the prelacrimal approach. One method uses a modern ultrasonic device (piezosurgery), the other uses a traditional hammer and chisel. The trial included 40 adults with various non-cancerous …

This study tested two methods to keep blood pressure stable and reduce pain during pituitary tumor surgery. Sixty adults received either a numbing injection near the cheekbone or numbing medicine placed inside the nose. The goal was to see which approach better controls blood pre…

This study tested whether injecting the numbing drug ropivacaine into the nose can reduce pain after endoscopic sinus surgery. 184 adults having sinus surgery were randomly given either ropivacaine or a saltwater placebo injection. The main goal was to measure pain intensity and …

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study tested an experimental drug called brensocatib in 288 adults with long-term sinus inflammation but no nasal polyps. Participants took either 10 mg, 40 mg, or a placebo daily for 24 weeks. The goal was to see if the drug could improve daily symptoms like congestion, run…

This Phase 2 study tested dupilumab (Dupixent) in 33 adults with chronic sinusitis but no nasal polyps. Participants received injections every two weeks for six months. The main goal was to see if the drug improves sinus symptoms and quality of life compared to a placebo.

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study tested whether a nanoemulsified sesame oil nasal spray can improve symptoms and healing after sinus surgery in people with chronic sinusitis. Sixty patients used different nasal solutions after surgery, and researchers measured symptom scores and endoscopic healing. Th…

This study tested whether adding the sedative drug dexmedetomidine to anesthesia improves the view for surgeons during endoscopic sinus surgery. Fifty adults with rhinosinusitis were enrolled. The goal was to see if the drug could make the surgical field clearer, potentially maki…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study tested a new way to measure nose and lip shape in 14 infants with cleft lip and palate using 3D facial scans. Researchers compared these scans to standard photos and manual measurements to see if the digital method is accurate. The goal is to find a better, less invasi…

This study looked at 49 people with masses in the sellar region of the brain (near the pituitary gland). Researchers compared MRI scans before surgery with the final diagnosis after surgery to see how well imaging predicts the type of tumor. The goal was to improve diagnosis and …

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at whether a special honey (Trigona sp.) helps heal wounds after cleft palate surgery better than a standard antibiotic dressing. Twenty-four children aged 18 months to 6.5 years participated. Researchers measured a healing marker in saliva before and after surg…

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This small pilot study tested a new way to place dental implants in the upper jaw when there is not enough bone height. Surgeons used a special drill and a tiny camera to watch the sinus membrane during the procedure. The goal was to see how often the membrane gets torn, which ca…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This study looked at 50 people who had jaw surgery to fix facial deformities. Researchers compared two surgical methods to see which one led to better nose and lip shape and less swelling after the operation. The goal was to find the technique that gives the best cosmetic results…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This completed study looked at whether substances in nasal fluid can help doctors objectively measure the severity of respiratory conditions like asthma, COPD, hayfever, and sinusitis. Researchers collected samples from 111 adults (including healthy volunteers) using a small nasa…

This study followed 80 people with newly diagnosed Cushing's disease for three years to see how the disease affects the heart, bones, metabolism, and quality of life. Researchers used blood tests, heart scans, bone density tests, and questionnaires to track complications before a…

This study tested whether a type of eye scan called OCT-angiography can predict how well vision will recover after surgery to remove a pituitary tumor. Researchers compared the scan results with standard vision tests in 21 patients. The goal was to see if the scan could serve as …

This study looked at how routine cleft repair surgery changes blood flow in the roof of the mouth. Researchers used a non-invasive probe to measure oxygen levels in the tissue before and after surgery in 77 patients. The goal was to understand the surgery's effect on tissue healt…

This study tested whether a French translation of the SN-5 questionnaire, which measures quality of life in children with chronic rhinosinusitis, works as well as the original English version. Researchers asked 89 children (ages 2–12) and their parents to fill out the questionnai…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study measured normal nasalance scores in 131 French-speaking children aged 8 to 10 using a non-invasive device called a Nasometer. The goal is to create reference values that help doctors diagnose velopharyngeal dysfunction, a common issue in children with cleft palate, wit…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study used brain scans to understand how speech therapy helps children with cleft palate who have trouble speaking clearly. Researchers looked at brain connections and structure before and after therapy in 164 children aged 4 to 16. The goal was to see if therapy changes abn…

This study followed 215 people with chronic sinusitis who received a corticosteroid-releasing sinus stent during sinus surgery. Researchers tracked safety and symptom changes over 6 to 12 months using a standard symptom questionnaire. The goal was to confirm the stent's long-term…

This study looked at 500 children who had surgery for a rare brain tumor called craniopharyngioma. Researchers used MRI scans to grade how much the tumor damaged a key brain area (the hypothalamus). They found that more damage was linked to higher rates of growth hormone deficien…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study looked at how mepolizumab, a biologic drug, changes inflammation in people with severe eosinophilic asthma. Researchers measured immune and metabolic markers in the nose, lungs, and blood of 15 adults. The goal was to better understand the drug's full impact beyond jus…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and imp…

This study looked at 134 adults with chronic sinusitis to see if sleep problems and daytime tiredness predict declines in thinking skills and daily functioning. Participants filled out questionnaires about their symptoms and quality of life. The goal was to better understand how …

This study used computer simulations to analyze airflow in the noses of 12 adults with a cleft lip nasal deformity who were scheduled for surgery. The goal was to better understand how the deformity affects breathing and to help doctors plan more effective surgeries. The research…

This study tested whether analyzing the DNA and RNA of a child's tumor could help doctors choose personalized treatments. It included 186 children with relapsed or hard-to-treat cancers like neuroblastoma and brain tumors. The goal was to see if this approach was feasible and saf…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This completed study looked at 111 newborns who had cleft lip repair surgery. Researchers compared those who received a regional nerve block for pain relief to those who did not. The goal was to see if the nerve block reduced the amount of opioid pain medicine needed during and a…

This completed study tested whether a virtual reality training program could improve the ability to locate sounds in people with hearing loss. 79 participants performed sound localization tasks with and without visual feedback. The goal was to see if training could reduce pointin…