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Virtual reality test reveals hidden memory damage in cured Cushing's patients

NCT ID NCT02603653

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and improve how we measure them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Feb 2016

Finished

Aug 2017

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients : * history of Cushing's Disease * aged : 18 - 60 years * Biological remission of Cushing's disease for at least one year * Affiliation to Social Security * Informed consent signed by patient and investigator (at the latest the inclusion's day, before study's exams) For controls : * People aged 18 to 60 years matched to patients for age, sex and educational level * Affiliation to Social Security * Informed consent signed by patient and investigator (at the latest the inclusion's day, before study's exams) Exclusion Criteria: For patients : * Persistent hypercortisolism (even mild) * Current treatment of hypercortisolism with drugs * Obesity (BMI \>30 kg/m²) * Alcohol or drug addiction present or past * Growth hormone deficit * Diabetes mellitus with hemoglobin A1c \> 7.5% and/or fasting blood glucose \> 1.4 g/L * History of pituitary radiotherapy * History of cerebrovascular or neuro-cerebral disease * untreated dysthyroidism * Current psychotropic drug treatment * Pregnancy * Use of glucocorticoids in the last 3 months before study (aside hydrocortisone replacement therapy) * Excessive hydrocortisone replacement therapy (unadjusted to weight and/or with evening administration) For controls : * Obesity (BMI \>30 kg/m²) * Alcohol or drug addiction present or past * Current psychotropic drug treatment * History of cerebrovascular or neuro-cerebral disease * Current pregnancy * Chronical use of corticoid (\> 1 month), current or past * Use of glucocorticoids in the last 3 months before study (aside hydrocortisone replacement therapy) * Diabetes mellitus with hemoglobin A1c \> 7.5% and/or fasting blood glucose \> 1.4 g/L * Obesity (BMI \>30 kg/m²) * untreated dysthyroidism

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Conditions

The condition(s) this trial relates to.

ACTH-dependent Cushing syndrome Cushing disease due to pituitary adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cushing's disease

Contacts and locations

Locations

  • Hôpital du Haut-Lévêque

    Pessac, 33604, France

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