Could a simple nasal spray replace antibiotics for sinusitis?
NCT ID NCT06264141
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a nitric oxide nasal spray against a saline placebo in 162 adults with recurrent acute sinusitis. Participants used the spray at the first sign of a new episode for two weeks. The goal was to see if the nitric oxide spray speeds up symptom relief and reduces the need for steroid sprays or antibiotics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nitric oxide nasal spray
- What this could lead to
- If it works, this could offer a fast-acting, drug-free option to ease sinusitis symptoms and cut down on antibiotic use.
- What could go wrong
- This is a small Phase 2 study, so results may not hold up in larger trials. The spray is compared to saline, not standard care, and benefits may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alpha Recherche Clinique LeBourneuf
Québec, Quebec, G2J 0C4, Canada
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Alpha Recherche Clinique Val-Belair
Québec, Quebec, G3K 2P8, Canada
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Cliantha Research
Mississauga, Ontario, L4W 1V7, Canada
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Clinical Research of Ontario
Scarborough Village, Ontario, M1S 4T7, Canada
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Intermed Groupe Santé
Chicoutimi, Quebec, G7H 7Y8, Canada
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Okanegan Clinical Trials
Kelowna, British Columbia, V1Y 1Z9, Canada
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Richmond Clinical Trials (Okanagan Clinical Trials Satelite Site)
Richmond, British Columbia, V6V 2L1, Canada