Can dupixent ease sinusitis without polyps? new trial hints at answer

NCT ID NCT04362501

Completed Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 2 study tested dupilumab (Dupixent) in 33 adults with chronic sinusitis but no nasal polyps. Participants received injections every two weeks for six months. The main goal was to see if the drug improves sinus symptoms and quality of life compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dupilumab (Dupixent)
What this could lead to: If successful, this could provide a new treatment option for people with chronic sinusitis who don't have nasal polyps, improving symptoms and quality of life.
What could go wrong: This is an early Phase 2 trial with only 33 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome chronic rhinosinusitis sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC SINUSITIS

Contacts and locations

Locations

Johns Hopkins University School of Medicine

Baltimore, Maryland, 21224, United States

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