Skull disorder

This study compares a new biodegradable nasal dressing that slowly releases a steroid (mometasone furoate) to a standard steroid-releasing stent, both used after sinus surgery. About 110 adults with chronic sinusitis (with or without nasal polyps) will receive the new dressing in…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests whether using limited surgery followed by proton therapy can control craniopharyngioma, a rare brain tumor, in children and young adults. The goal is to reduce radiation side effects by using a tighter radiation margin. Some patients who have complete tumor remov…

This study tests a precise type of proton radiation (IMPT) for people with chordoma or chondrosarcoma in the spine, sacrum, or skull base. The goal is to control the tumor while reducing damage to healthy tissue. Some participants may also have surgery. The study includes 64 adul…

This study tests a newer form of radiation called intensity-modulated proton therapy in children and young adults with craniopharyngioma, a rare brain tumor. The goal is to see if this precise radiation can better control the tumor while causing fewer side effects than older radi…

This phase II trial tests two targeted drugs, vemurafenib and cobimetinib, in 24 people with a rare type of brain tumor called papillary craniopharyngioma that has a specific genetic mutation (BRAF V600E). The drugs work by blocking enzymes that help tumor cells grow. The main go…

This Phase II trial is studying whether proton beam therapy, with or without standard photon radiation, can effectively treat skull base chordoma, a rare tumor at the base of the skull. Nineteen participants who had surgery to remove as much tumor as possible are receiving daily …

This study tests a new totally implantable cochlear implant system (TICI G2) that has a microphone under the skin, so you can hear without any external devices. Researchers will enroll 18 adults with sensorineural hearing loss to see how well the internal microphone works over ti…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This study tests whether online training and regular feedback reports can help doctors prescribe fewer antibiotics for common infections like ear infections, strep throat, sinusitis, and pneumonia in children. About 420 children aged 6 months to 12 years are included. The goal is…

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This study tests a new treatment for chronic sinusitis, a long-lasting sinus infection that doesn't get better with standard care. Researchers will take healthy bacteria from a donor's sinuses and transfer them into the sinuses of 80 patients, after a special sinus wash. The goal…

This study tests a drug called tocilizumab in children with a rare brain tumor called adamantinomatous craniopharyngioma. First, a small group gets one dose before surgery to see if the drug reaches the tumor. If it does, more children will receive the drug every two weeks for ab…

This study tests whether digital tools can help people with allergic rhinitis (hay fever) better control their symptoms. About 240 adults will use a smartphone platform that tracks symptoms, sends reminders, and gives personalized advice. Researchers will compare their progress t…

This study compares two ways to rebuild bone in the gum area of children with a cleft palate. One method uses a custom 3D-printed mold to shape the patient's own bone into a plug, while the other uses small bone chips. The goal is to see which approach fills the bone gap better a…

This study compares the safety of routine telephone or video follow-ups versus in-person visits for patients with non-functioning pituitary tumors. Over two years, 812 participants will be randomly assigned to remote or in-person check-ups. The goal is to see if remote follow-up …

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This study tests a new surgical method that uses a tiny camera (endoscope) to repair broken facial bones through small, hidden cuts instead of large incisions. The goal is to see if this approach works as well as standard surgery while reducing scarring and nerve damage. Thirty a…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study tests whether a very low dose of radiation (4 Gy) can control slow-growing B-cell lymphoma in the eye socket. About 50 adults with stage I-IV indolent lymphoma or mantle cell lymphoma will receive this targeted treatment. The goal is to shrink or stop the cancer while …

This early study tests a new approach for people with chronic sinusitis that keeps coming back. A balloon coated with the drug paclitaxel is inflated in the nasal passages to deliver medication directly to the tissue. The goal is to see if it is safe and can reduce symptoms and t…

This study tests an investigational drug called 611 in 243 adults with chronic sinusitis and nasal polyps that haven't been well-controlled by other treatments. The goal is to see if 611 can shrink polyps and ease nasal congestion over 24 weeks. Participants receive either the dr…

This study tests whether a special PET scan using a radioactive form of methionine (a natural amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 503 participants will be scanned to see if the metho…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests whether a new type of PET/CT scan, using a radioactive tracer called 68Ga-DOTATOC, can find neuroendocrine tumors (NETs) and similar tumors more safely and accurately than current imaging methods. About 800 people with known or suspected NETs will receive the sca…

This study compares a new, non-invasive PET-MRI scan to the standard invasive test (IPSS) for finding pituitary tumors in people with Cushing's disease. About 43 adults with confirmed Cushing's will get both tests to see which is more accurate. The goal is to make diagnosis safer…

This early-phase study tests a new radioactive tracer called [68Ga]Ga-NOTA-RF for PET scans in 30 people with pituitary tumors. The goal is to see if this tracer can better highlight tumors and help doctors tell different tumor types apart. Participants receive an injection of th…

This study aims to see if a simple, inexpensive saliva test can accurately diagnose Cushing's syndrome, a condition where the body makes too much cortisol. Researchers will compare two automated saliva test methods in 380 adults who are already being checked for the condition. Th…

This study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…

This study tests an experimental drug called itepekimab in 66 adults with chronic sinusitis who have not improved with standard treatments. Participants receive either the drug or a placebo for 24 weeks. The goal is to see if itepekimab can reduce sinus inflammation and ease symp…

This study looks at whether special high-dissolving foods can improve feeding quality of life for children aged 6 months to 18 years after craniofacial surgery. Half of the 160 participants will receive these foods after surgery, while the other half will follow standard care. Re…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

This study compares three ways to manage the airway during sinus surgery: a laryngeal mask, a breathing tube, and a breathing tube with lidocaine to numb the throat. Researchers want to see which method causes the least coughing and helps patients wake up more calmly. The trial i…

This study aimed to see if using a connected toothbrush (Ara® KOLIBREE) for one month before alveolar bone graft surgery could improve oral hygiene in children aged 5 to 12 with cleft lip and palate. The trial was withdrawn before enrolling any participants, so no results are ava…

This study tests experimental sound coding strategies that may improve hearing for adult cochlear implant users. About 120 participants will compare the new strategies to their current settings, focusing on understanding speech in noisy environments. The goal is to find ways to m…

This study tests a new cochlear implant that slowly releases dexamethasone, a drug that reduces inflammation after surgery. The goal is to see if it works better than a standard implant for adults with severe hearing loss. About 48 adults will be randomly assigned to get either t…

This pilot study tests whether adding epinephrine to a standard nerve block (pterygopalatine ganglion block) reduces bleeding during functional endoscopic sinus surgery (FESS) in people with chronic rhinosinusitis. Eighty adults undergoing bilateral FESS will receive the nerve bl…

This study tests whether a nerve block placed in the face can reduce pain and the need for strong opioid drugs after cleft palate surgery in children. The goal is to help kids start eating and drinking sooner and go home faster. The study involves 40 children having cleft palate …

This study compares two approaches—a nerve block and a sedative drug—to reduce pain and improve the surgical field during trans-nasal endoscopic pituitary surgery. About 69 adults will be randomly assigned to receive either a sphenopalatine ganglion block, dexmedetomidine, or sta…

This pilot study tests whether a small procedure done in the doctor's office (called EPIC) can work as well as standard sinus surgery for people with chronic sinusitis and nasal polyps. The EPIC procedure is done under local anesthesia and has a shorter recovery time. The study o…

This study tests whether a smartphone-based AI tool can help doctors give a pain-blocking injection to babies having cleft lip repair. The goal is to reduce pain during surgery and the need for extra pain medicine. The study includes 120 infants aged 5-18 months and compares the …

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study aimed to find out how often chronic sinusitis occurs in children treated for head and neck cancer, and how it affects their quality of life. Researchers planned to compare these children to those treated for cancer elsewhere in the body using a questionnaire called SNO…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This phase 1 study tests a new PET imaging tracer called 89Zr-cRGDY in 17 people with malignant brain tumors or pituitary adenomas. The tracer is given in a very small dose to see how it spreads and clears from the body. The goal is to improve brain tumor imaging, not to treat th…

This study aims to develop a new way to measure how well the sinuses work in people with chronic sinusitis. About 30 adults with chronic sinusitis and a recent bacterial infection will take the drug ivacaftor. The main goal is to see if a special test can detect changes in sinus …

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This project works to make sure children with common respiratory infections get the right antibiotics for the right amount of time. It involves over 259,000 kids across many clinics. The goal is to learn the best ways to help doctors follow antibiotic guidelines and reduce unnece…

This study looks at tumor samples from 250 children with a rare brain tumor called craniopharyngioma. Researchers want to find specific targets in the tumor that could lead to better, less harmful treatments. The goal is to understand the tumor's biology so future therapies can b…

This study investigates why some people develop chronic sinusitis with nasal polyps, focusing on how epigenetic changes and viruses might trigger the disease. Researchers will analyze tissue samples from 60 participants, including patients with active disease, those in remission,…

This study follows 1500 patients with pituitary gland disorders to see how they fare over time, whether treated with medication, surgery, or just monitoring. Researchers will track tumor regrowth after surgery to find clues that predict recurrence. The goal is to learn, not to te…

This study compares two dental devices—the quadhelix and mini-hyrax expanders—in 24 children with cleft lip and palate who need their upper jaw widened before bone graft surgery. Researchers will use 3D scans and models to measure how much the jaw expands. The goal is to see whic…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study looks at 500 adults having pituitary tumor surgery through the nose. Researchers want to find out who gets headaches soon after surgery and build a tool to predict that risk. Participants report their pain daily and fill out surveys for up to 3 months after surgery.

This study tests whether 3D-printed, custom-made titanium plates help surgeons rebuild the jaw more accurately and quickly than standard plates. About 92 adults with jaw tumors, deformities, or other conditions will be randomly assigned to receive either type of plate during surg…

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study was designed to see how chronic sinusitis affects the tiny hair-like cells (cilia) that help clear mucus from the nose. Researchers planned to use special glowing nano-sticks to measure how well these cells work. However, the study was withdrawn before any participants…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study looks at the genes of 1,200 adults to find out why some people get chronic sinusitis. Participants must have a CT scan showing either normal sinuses or sinus disease. The goal is to identify genetic variations linked to the condition, which could lead to better underst…

This study tests whether giving patients an information sheet during a doctor's visit for a respiratory infection (like bronchitis, sinusitis, or sore throat) can lower antibiotic prescribing and improve communication. About 1,100 adults in Danish general practices will either re…

This study surveys 530 prolactinoma patients and their doctors to understand real-world treatment experiences, side effects, and preferences. The goal is to identify gaps in care and guide future research for better, more personalized treatment strategies. No new treatments are t…

This study brings together medical teams that treat children with cleft lip and/or palate. They will collect information on speech, hearing, dental health, and quality of life from about 1,000 patients. The goal is to compare results across centers and find ways to improve care. …

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study is testing a new web-based tool designed to help people with chronic sinusitis make better decisions about their treatment, including whether to have surgery. About 50 patients from USC clinics will use the tool or receive standard information. Researchers will measure…