Balloon coated with cancer drug could ease sinusitis

NCT ID NCT05883462

Ongoing Disease control Sponsor: Airiver Medical, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests a new approach for people with chronic sinusitis that keeps coming back. A balloon coated with the drug paclitaxel is inflated in the nasal passages to deliver medication directly to the tissue. The goal is to see if it is safe and can reduce symptoms and the need for repeat procedures. The trial involves 45 adults and is the first time this device is being tested in humans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: paclitaxel-coated nasal balloon
What this could lead to: If it works, this could offer a new, less invasive option to manage recurrent sinusitis and delay or avoid repeat sinus surgeries.
What could go wrong: This is a very early, first-in-human study with only 45 people. The drug coating may cause side effects, and the balloon procedure itself carries risks like bleeding or eye complications. Success is far from guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS

Contacts and locations

Locations

Sanatorio Americano Hospital

Asunción, Paraguay

More trials for these conditions

Other studies related to the condition(s) this trial covers.