New proton therapy strategy aims to shrink side effects for young brain tumor patients

NCT ID NCT01419067

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using limited surgery followed by proton therapy can control craniopharyngioma, a rare brain tumor, in children and young adults. The goal is to reduce radiation side effects by using a tighter radiation margin. Some patients who have complete tumor removal by surgery are simply watched without radiation. The trial tracks how long patients stay free of tumor growth and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: proton therapy
What this could lead to: If successful, this approach could offer a way to control craniopharyngioma with fewer long-term side effects than standard radiation.
What could go wrong: This is a phase II trial with a moderate number of participants, so results may not apply to everyone. There is still a risk of tumor progression or side effects from treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

craniopharyngioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRANIOPHARYNGIOMA

Contacts and locations

Locations

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
University of Florida Health Proton Therapy Institute

Jacksonville, Florida, 32206, United States

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