New nerve block or drug: which eases pain after pituitary surgery?

NCT ID NCT06639659

Ongoing Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches—a nerve block and a sedative drug—to reduce pain and improve the surgical field during trans-nasal endoscopic pituitary surgery. About 69 adults will be randomly assigned to receive either a sphenopalatine ganglion block, dexmedetomidine, or standard general anesthesia. The goal is to see which method provides better pain relief and less bleeding during and after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sphenopalatine ganglion block (nerve block procedure) and dexmedetomidine (drug)
What this could lead to: If successful, this could point to a better way to manage pain and reduce bleeding during pituitary surgery, improving recovery and comfort.
What could go wrong: This is a small, early-stage trial with only 69 participants, so results may not apply to everyone. Both methods have risks, such as side effects from the drug or complications from the nerve block.

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Conditions

The condition(s) this trial relates to.

pituitary tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPHENOPALATINE GANGLION NERVE BLOCK TRANSNASAL ENDOSCOPIC PITUTARY SURGERY

Contacts and locations

Locations

Zagazig Univesity Hospital

Zagazig, Egypt

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