Osteoarthritis

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This trial tests whether blood-flow-restriction (BFR) training, done before knee replacement surgery, can reduce pain and boost strength. BFR uses a cuff to partially block blood flow during low-weight exercise, which may build muscle without heavy loads. About 19 people schedule…

This study tracks 245 adults aged 18 to 60 who receive a Vivacit-E liner during hip replacement surgery. The liner is a plastic cup that fits inside the hip socket to allow smooth movement. Researchers measure how long the liner stays in place without needing removal, and they ch…

This trial tests whether a single injection of ICM-203, a gene therapy, can safely help people with mild-to-moderate knee osteoarthritis. The therapy delivers a gene into the knee joint that may encourage cartilage growth, reduce inflammation and pain, and improve daily movement.…

This trial tests whether digital tools can help people with mild to moderate hip or knee osteoarthritis manage their condition without surgery. Participants receive one of three options: usual care with a handout, a physical activity prescription from a doctor using a smartphone …

This trial tests whether applying insulin gel to the skin, combined with therapeutic ultrasound (a technique called phonophoresis), can reduce pain and improve function in people with shoulder joint inflammation. Researchers compare a standard insulin gel with a nano-formulated v…

This study looks at whether the amount of tension applied to a new ACL graft during knee surgery influences the development of arthritis over at least 15 years. About 168 people with a torn ACL in one knee will be followed, comparing two common tension settings. The goal is to se…

This trial compares two common surgeries for end-stage ankle arthritis: ankle fusion (arthrodesis) and ankle replacement (arthroplasty). It aims to see which procedure better improves daily function, reduces pain, and enhances quality of life. Adults with ankle arthritis who are …

This study compares a new sensorimotor ankle rehabilitation training (SMART) program to standard care for people with a first-time ankle sprain. The goal is to see if SMART reduces re-injury rates and improves quality of life over one year. Researchers will enroll 150 participant…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…

This trial tests whether a plastic meniscus implant can outperform non-surgical treatments for people with persistent knee pain after a partial meniscus removal. Participants who had the surgery more than six months ago and are between 30 and 75 years old are randomly assigned to…

This trial investigates whether people with knee osteoarthritis who also have a bowleg deformity (tibia vara) experience different pain relief after a partial knee replacement compared to those without the deformity. The study will measure medial knee pain using a standard pain s…

This trial compares three different knee replacement implants—Journey II, Stryker Triathlon, and Zimmer Persona—in people aged 50 to 75 with knee osteoarthritis. Researchers measure how well each implant restores knee movement, walking patterns, and function after surgery. The go…

This trial compares standard knee replacement surgery to surgery using custom cutting blocks designed from each patient's anatomy. The goal is to see if these personalized tools lead to better knee function, less bleeding, shorter surgery time, and lower overall costs. About 95 p…

This trial compares two surgical procedures for thumb arthritis at the base of the thumb. One is a newer technique called Mini TightRope suspensionplasty, which uses a small suture-button system to stabilize the joint. The other is the standard ligament reconstruction and tendon …

This study tests whether a three-month resistance training program using ankle weights can improve leg strength, balance, pain, and quality of life in people who have had knee replacement surgery for osteoarthritis. Twenty-four participants are randomly assigned to either the res…

This trial tests whether a collagen-based injection (Fibroquel) works as well as a standard hyaluronic acid injection (Synvisc) for knee osteoarthritis. About 32 adults with moderate knee OA will receive three weekly injections of one treatment. The study measures knee function a…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tests whether a mobile-friendly gamified app, called Game-App-KNEE, can improve functional outcomes and recovery for people who have had total knee replacement surgery. Participants use the app daily for three months after discharge, while a control group receives only…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. Participants were randomly assigned to have knee surgery or follow a physical therapy program. The main goal was to measure changes in knee function and pai…

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It included 252 adults with knee pain, arthritis, or deformities who were already scheduled for knee replacement. R…

This early-stage trial tested a new injection for wrist osteoarthritis that combines the patient's own fat (microfat) and platelet-rich plasma (PRP). The goal was to see if this mixture is safe and can reduce pain and improve wrist function, potentially delaying the need for surg…

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study tested an experimental protein called LNA043, given as injections into the knee, to see if it can help regrow cartilage in people with knee osteoarthritis or cartilage injuries. 142 adults participated in two parts: one for cartilage lesions and one for osteoarthritis.…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study tested a treatment for people with damaged knee cartilage caused by arthritis or injury. The treatment used the patient's own cartilage cells grown in a lab and then implanted into the knee. The goal was to see if it could reduce pain and improve knee function over 48 …

This completed trial tested Chondron, a treatment made from a patient's own cartilage cells, for knee cartilage defects caused by osteoarthritis or injury. Ten participants received the cells during arthroscopic surgery. The study measured pain and knee function over 96 weeks to …

This study tested a new shoulder implant called the Catalyst CSR System in 87 people with shoulder arthritis or bone damage. The implant is designed to preserve more natural bone than traditional replacements. Researchers measured pain, movement, and implant safety over two years…

This study looked at whether weight-loss surgery (sleeve gastrectomy) is better than diet and medication for adults aged 65 and older with severe obesity and related health problems like type 2 diabetes, high blood pressure, sleep apnea, and knee arthritis. Sixty patients chose e…

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. T…

This phase 2 trial tested an experimental drug called LRX712, given as injections into the knee, to see if it can help regrow cartilage in people with mild to moderate knee osteoarthritis. 45 participants received either the drug or a placebo over 8 weeks. The main goal was to me…

This early-phase trial tested a stem cell product called CARTISTEM in 12 adults with knee cartilage defects. The stem cells, derived from human umbilical cord blood, were implanted into the knee to see if they could safely help repair damaged cartilage. The study measured knee fu…

This study followed 218 people who received a cementless POLARSTEM hip implant to treat osteoarthritis. Researchers tracked how well the implant worked and how long it lasted over up to 10 years. The goal was to see if this implant is a safe and effective option for hip replaceme…

This study tested a new drug called lorecivivint (SM04690) injected into the knee for people with moderate to severe knee osteoarthritis. 101 participants received two injections six months apart and were followed for a year. The goal was to see if the drug is safe and improves b…

This study tested a new shoulder implant called PyroTITAN HRA in 156 people with arthritis. The implant resurfaces the ball part of the shoulder joint to relieve pain and improve function. Researchers tracked how long the device lasted and whether it caused problems, aiming to se…

This study tested a new implant called Agili-C for people with knee cartilage damage or early arthritis. 251 participants received either the implant or standard surgery. The goal was to see if the implant improved pain and function over 5 years. Results suggest it may be a helpf…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for sev…

This study tested whether a daily plant protein supplement (Nutrilite All-Plant Protein Booster) could improve muscle function and reduce arthritis symptoms in 139 adults aged 50 to 70 with mild to moderate sarcopenia and osteoarthritis. Participants took either the protein suppl…

This study tested a robotic system called CORI that helps surgeons plan and perform knee replacement surgery. The goal was to see if the robot helps place the new knee joint more accurately. 126 adults who needed a partial or total knee replacement took part. The results showed t…

This study looked at how well a specific knee replacement, the Medacta GMK Sphere, works over time. Researchers measured how often patients forgot about their artificial knee in daily life, two and five years after surgery. The study involved 260 adults with osteoarthritis who ne…

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and …

This study followed 76 adults who received a total shoulder replacement using the MIRAI modular prosthesis. Researchers measured how well the shoulder functioned and how stable the implant was over five years. The goal was to see if the implant helps patients move better and last…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tested whether a self-assessment questionnaire for the shoulder, knee, or ankle can help people decide if they need an orthopedic specialist visit. 150 adults who already requested an orthopedic exam filled out the questionnaire. Researchers will analyze the answers to…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain an…

Researchers are testing whether combining extracorporeal shockwave therapy with injections of hyaluronic acid or platelet-rich plasma eases pain and improves knee function better than shockwave therapy alone in people with moderate to severe knee osteoarthritis. The trial enrolls…

This trial tests whether S(+) ibuprofen, a purified form of the common painkiller, can reduce pain in people with knee or hip osteoarthritis better than a standard ibuprofen product. Researchers will compare the two treatments in about 176 adults aged 18 to 75. Participants will …

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This trial asks whether adding kinesio taping to platelet-rich plasma (PRP) injections can improve pain, function, and quality of life in women with knee osteoarthritis. Sixty women aged 50 to 65 with mild-to-moderate knee osteoarthritis will receive either therapeutic kinesio ta…

This study looks at whether adding cognitive behavioral therapy (CBT) and exercise to knee replacement surgery helps reduce pain and improve function. About 282 adults with knee osteoarthritis are randomly assigned to one of three groups: a non-surgical program with CBT and exerc…

This study looks at how a 3-month program of exercise and education affects pain and quality of life in people with hand osteoarthritis. Researchers will analyze data from 2,000 participants in the Swedish Osteoarthritis Registry. The goal is to see if this first-line treatment h…

This trial compares two ways of using radiofrequency energy to block knee nerves in people with osteoarthritis-related knee pain that hasn't improved with other treatments. One method uses a single probe (monopolar), the other uses two probes (bipolar). The study will measure pai…

This study tests a device called RELAY that delivers both local anesthetic and mild electrical pulses to nerves after shoulder or foot surgery. The goal is to provide up to 28 days of pain relief, much longer than current options. About 50 adults undergoing specific surgeries wil…

This study compares Mobithron, a supplement containing hyaluronic acid, collagen, and Boswellia, to standard glucosamine for easing pain and improving function in people with knee osteoarthritis. Adults aged 50 to 75 with knee osteoarthritis take either Mobithron or glucosamine d…

This study compares two hands-on therapy techniques—joint distraction and passive end-range overpressure—for people with knee osteoarthritis. Participants, aged 40 to 60 with moderate knee pain, receive one of the two treatments over four weeks. The goal is to see which approach …

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study tested whether a gentle electrical current, called frequency specific microcurrent, can lower inflammation and pain in obese adults with osteoarthritis. Ten participants received one hour of treatment and had blood drawn to measure inflammatory markers. They also fille…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study tested whether using a blue laser before a standard red laser can help reduce muscle and joint pain in 44 adults with chronic neck or shoulder pain. Participants received a 13-minute treatment combining both lasers. The goal was to see if at least 65% of people got a 3…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This completed study tested two different physical therapy programs in 84 adults aged 40-60 with grade II knee osteoarthritis. One group received the Macquarie injury management protocol (soft tissue work plus exercises), while the other did a targeted knee exercise program. Rese…

This study compares two common surgeries for thumb arthritis: total joint replacement (arthroplasty) and trapeziectomy (removing a small bone). Researchers will analyze data from 1,000 patients aged 45 and older in a Swedish registry, tracking pain, function, and complications fo…

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested two ways of applying radial pressure wave therapy to the knee in 82 people with knee osteoarthritis. The goal was to see if targeting specific joint lines works better than treating the most painful spots. Participants received three sessions and were followed f…

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested three different injections for people with painful jaw arthritis: platelet-rich plasma (PRP), hyaluronic acid, and a steroid called triamcinolone acetonide. 64 adults received one of these or a placebo saline injection. Researchers measured pain and mouth openin…

This study tested a system that combines a wearable knee sensor with an exercise app to help people with knee osteoarthritis. The program provides personalized exercises and real-time feedback to ensure correct form. Thirty adults with knee osteoarthritis participated, and resear…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study tested whether injecting a collagen product called CartiZol into the knee can reduce pain in people with osteoarthritis, cartilage damage, or injury-related arthritis. 200 adults with knee pain received either the collagen injection or a placebo (saline). The main goal…

This study tested whether a collagen injection into the knee could relieve pain and improve function better than a standard hyaluronic acid injection in 100 adults with knee osteoarthritis. Participants received one injection and were followed for up to 52 weeks. The goal was to …

This study looked at whether a numbing injection around knee nerves (genicular nerve block) can reduce pain and improve quality of life and joint position sense in people with chronic knee osteoarthritis. 40 adults aged 55-75 with moderate knee arthritis took part. The goal was t…

This study tested a step-by-step treatment plan for people with knee osteoarthritis pain. Participants first received duloxetine (Cymbalta), a drug that helps with pain, and then, if needed, an injection of hyaluronic acid mixed with a steroid into the knee joint. The goal was to…

This study looked at whether doing physical therapy online (telerehabilitation) works as well as going to a clinic in person after shoulder replacement surgery. 93 patients were randomly assigned to either online or in-person therapy. Researchers measured shoulder movement, pain,…

This study tested an experimental drug called DFV890 in 115 adults aged 50-80 with painful knee osteoarthritis. Participants received either the drug or a placebo to see if it reduced pain and inflammation. The goal was to find a new way to ease symptoms and improve daily functio…

This study tested whether a clinical Pilates program can reduce symptoms of hip osteoarthritis. Fifty-two adults with hip OA were assigned to either clinical Pilates or standard therapeutic exercises twice a week for 12 weeks. Researchers measured pain, movement, balance, and qua…

This study tested whether eccentric muscle training (lengthening exercises) improves walking performance in people with knee osteoarthritis compared to standard concentric training (shortening exercises). Forty adults aged 40-85 with knee osteoarthritis participated in 6 weeks of…

This study tested two physical therapy methods for people with moderate knee osteoarthritis (grade II). One group received hands-on manual therapy (joint mobilization, massage), while the other got standard exercises and electrotherapy. Over 6-8 weeks, researchers measured pain, …

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested two treatments for jaw joint arthritis (TMJ osteoarthritis): platelet-rich plasma (PRP) and autologous conditioned serum (ACS), both made from the patient's own blood. 75 adults who had not improved with standard care received one of these injections after a joi…

This Phase 3 trial tested an experimental drug called RTX-GRT7039, given as an injection into the knee joint, to see if it reduces pain from osteoarthritis. 469 adults with knee osteoarthritis who did not get enough relief from standard treatments took part. The study compared th…

This Phase 3 trial tested whether a single injection of RTX-GRT7039 into the knee can reduce pain in adults with knee osteoarthritis who haven't gotten enough relief from standard treatments. 466 participants received either the drug or a placebo injection. The study measured pai…

This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …

This phase 3 trial tested the safety of an experimental drug called RTX-GRT7039, given as a knee injection to 714 adults with moderate to severe osteoarthritis pain that wasn't helped by standard treatments. The study focused on side effects and did not measure how well the drug …

This study tested a WeChat mini-program that provides personalized rehab plans, progress tracking, and emotional support for people recovering from hip or knee replacement surgery. 140 adults aged 18-80 used the app alongside standard care, or standard care alone. The goal was to…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether changing the angle of a leg exercise machine (N-K Table) from 0° to 50° helps people with knee osteoarthritis activate their thigh muscles more. Forty-three women aged 50-65 with knee osteoarthritis did isotonic knee extensions at both angles. Muscle act…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study looked at whether adding Tai Chi exercises to standard physical therapy helps older adults (ages 60-80) with knee osteoarthritis. 96 participants were split into three groups: standard therapy alone, therapy with virtual reality training, or therapy with Tai Chi. The g…

This study looked at whether adding a nerve block (PENG block) to a standard steroid injection into the hip joint can better relieve pain from hip osteoarthritis. Researchers followed 50 patients whose pain persisted despite other treatments. The goal was to see if the combinatio…

This study tested whether a self-administered oxytocin nasal spray could reduce pain and improve function in older adults with knee osteoarthritis. Over 4 weeks, 83 participants used either the spray or a placebo. The goal was to see if oxytocin, a natural pain-relieving hormone,…

This study tested whether a custom knee brace connected to a mobile app and motion sensors can improve symptoms and daily function for people with knee osteoarthritis. 36 adults aged 45-75 with mild to moderate knee OA wore their assigned brace for 6 months and completed surveys …

This early-stage study tested a new drug called APPA-1 in 40 healthy volunteers and people with osteoarthritis. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked at how food and gender affect the drug. This is a first step to see …

This study tested a new treatment for knee osteoarthritis using stem cells from umbilical cord tissue. 31 people aged 55-70 with moderate knee arthritis received the stem cells either with or without a minor knee surgery (arthroscopy). The goal was to see if the treatment could r…

This study compared two hands-on therapies—Strain Counter Strain and Myofascial Release—for people with knee osteoarthritis. 44 adults aged 40 to 65 with grade 2 knee osteoarthritis took part. The goal was to see which technique better reduces pain and improves daily function and…

This study looked at whether adding craniosacral therapy (a gentle, hands-on technique) to a home exercise program could reduce pain and improve function in people with knee osteoarthritis. Twenty-one adults participated, with one group receiving the therapy weekly for six weeks …

This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…

This study tested a single injection of lorecivivint into the knee joint of 501 people with moderate-to-severe knee osteoarthritis. The goal was to see if it reduces pain and improves function over 56 weeks compared to a placebo. Participants reported their pain levels weekly, an…

This study tested whether L-carnitine, a natural supplement, can reduce pain, stiffness, and improve physical function in people with mild to moderate knee osteoarthritis. 66 participants took either L-carnitine or a placebo three times daily for 8 weeks. The goal was to see if L…

This study tested a single injection of a drug called lorecivivint in the knee joint of 496 people with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo (fake injection) over 28 weeks. Participants reported…

This study looked at whether telehealth follow-up (phone or video calls) after total knee replacement helps patients regain function, take care of themselves, and do daily activities better than standard discharge instructions. About 60 adults who had knee replacement surgery wer…

This pilot study tested whether listening to a 12-minute guided mindfulness meditation before total knee replacement surgery could improve patients' mental well-being and physical recovery. Thirty adults scheduled for knee replacement were randomly assigned to receive the meditat…

This study tested whether injecting a person's own processed fat (MFAT) into the knee works better than a standard steroid shot for osteoarthritis pain. Forty adults with moderate knee arthritis received either MFAT or a steroid injection. Researchers tracked pain and symptom cha…

This study looked at whether showing patients pictures of their damaged cartilage and new knee joint after surgery helps them feel better and move better early on. About 80 adults with severe knee arthritis who had a knee replacement took part. The goal was to see if seeing the p…

This study looked at two ways to manage pain after knee replacement surgery: a shot around the knee joint and a nerve block in the thigh. The goal was to see which method helps patients recover better and feel less pain. Sixty adults who had knee replacement took part, and their …

This study tested a dietary supplement containing Boswellia serrata, curcumin, and MSM in 100 adults with joint pain or stiffness. Participants took either the supplement or a placebo for a period, and researchers measured inflammation markers and arthritis symptoms using a stand…

This early-stage study tested a single injection of a new drug (SAR446959) into the knee joint of 32 adults aged 45-65 with knee osteoarthritis. The main goal was to check safety and how the drug moves in the body, not to prove it works. Participants were monitored for about 6 mo…

This study looked at whether adding deep breathing or simple yoga poses to standard physical therapy could help people with knee osteoarthritis feel less afraid of moving. 40 adults aged 40-60 with severe knee pain took part. The results showed that both approaches helped reduce …

This study tested whether taking UC-II, glucosamine, and curcumin together can reduce knee pain and inflammation. Thirty-two adults with chronic knee pain were randomly assigned to receive the supplement or a placebo for a set period. Researchers measured pain levels, knee functi…

This study tested a drug called MT-5547 (fasinumab) in 626 Japanese adults with moderate to severe osteoarthritis pain in the knee or hip. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if the drug reduces pain and improves daily fu…

This study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…

This early-stage study tested the safety of an experimental drug called CYT-108 for people with mild to moderate knee osteoarthritis. Nineteen participants received either the drug or a placebo injection into the knee, and researchers monitored them for 26 weeks. The goal was to …

This study tested a gel called Pandora, made of hyaluronic acid and tranexamic acid, injected into the knee to reduce pain and improve movement in people with knee osteoarthritis. 252 adults aged 35–85 with moderate knee arthritis received either one injection, three weekly injec…

This study tested whether injecting platelet-rich plasma (PRP) with or without platelet-rich fibrin (PRF) can reduce pain and improve jaw movement in adults with temporomandibular joint osteoarthritis. 42 participants received either a combination of PRP and PRF, PRP alone, or PR…

This study tested a single injection of EVI-01, a hyaluronic acid gel, in 120 people with painful knee osteoarthritis. The goal was to find the best dose that reduces pain and improves function while being safe. Participants were randomly assigned to receive one of two doses of E…

This completed study tested whether taking melatonin (3 mg each night for 12 weeks) can safely reduce pain in people with knee osteoarthritis. Researchers enrolled 340 adults aged 40-80 with moderate knee pain. Half received melatonin and half received a placebo pill. The main go…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study looked at whether giving a single high dose of vitamin C through an IV, along with nerve blocks, could reduce pain and help people recover faster after total knee replacement. 73 adults aged 50 to 80 took part. The researchers measured pain levels, soreness, and how mu…

This study tested whether showing people a photo of their new knee right after surgery helps them regain movement faster. 59 adults having knee replacement were randomly assigned to get a photo or not. Researchers measured knee bending at 6 weeks to see if the photo group did bet…

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study tested whether a Fitbit activity tracker, a smartphone app, and phone calls with a physical therapist could help people with knee osteoarthritis become more active and sit less. Fifty-one participants were split into two groups: one received the program right away, the…

This study tested an 8-week mindfulness program (MBSR) in 40 adults with painful hip or knee osteoarthritis. Participants learned to focus on the present moment to better manage chronic pain. The goal was to see if mindfulness could reduce pain and improve daily function compared…

This study tested a single injection of polyacrylamide hydrogel (Arthrosamid®) into the knee joint of 387 people with knee osteoarthritis. Researchers measured pain and physical function over 12 months. The goal was to see if the gel could reduce pain and improve everyday movemen…

This study tested whether injecting oxygen-ozone into the thumb joint, along with wearing a splint, reduces pain and improves hand function in people with thumb osteoarthritis. 43 adults took part. The goal was to see if this combination works better than using a splint alone.

This study tested whether a shot of platelet-rich plasma (PRP) from a person's own blood works better than a common steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received either a PRP or steroid injection. Researchers measure…

This completed trial looked at whether giving two doses of dexamethasone (a steroid) along with tranexamic acid (a drug to reduce bleeding) around the time of hip or knee replacement surgery improves recovery. 92 patients were randomly assigned to receive either one or two doses …

This study tested whether Baduanjin, a gentle mind-body exercise, can reduce pain, improve balance, and lessen fear of movement in people with knee osteoarthritis. Sixty adults aged 40 to 70 with moderate knee OA took part. They were split into three groups: one did standard exer…

This study tested whether adding a gentle joint-gliding technique called Mulligan's mobilization to simple isometric exercises could help people with knee osteoarthritis. Fifty adults with moderate knee arthritis received either the mobilization plus exercises or a sham version f…

This study tested a device that gently stimulates a nerve in the ear to reduce pain and inflammation in people with a severe form of hand osteoarthritis. 148 participants used either the active device or a sham (fake) device daily for 12 weeks. The goal was to see if the real dev…

This completed study compared three common treatments for knee osteoarthritis (gonarthrosis) in 82 adults aged 40–65. Participants received either platelet-rich plasma (PRP) injections, topical diclofenac gel, or a structured exercise program for 6 weeks. The goal was to see whic…

This study follows adults over 60 who are having a hip replaced due to osteoarthritis. The goal is to see how the surgery affects their balance and their confidence in performing daily activities without falling. Researchers will measure balance using a detailed physical test and…

This study uses ultrasound to measure the thickness of ankle cartilage in people with spinal cord injuries and compares it to healthy individuals. The goal is to see if cartilage damage starts early, which could help prevent osteoarthritis. Researchers will also assess participan…

This registry study collects detailed information from 45,000 adults undergoing fast-track hip or knee replacement at eight Danish hospitals. Researchers track patient health before surgery and complications afterward, including hospital stays, readmissions, and deaths within 90 …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at 40 people with knee osteoarthritis who received injections of platelet-rich plasma (PRP) made from their own blood. Researchers measured pain, function, and inflammation markers to see how PRP might help. The goal was to better understand the treatment's effe…

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study tested a new way to measure heart fitness (VO2 max) in 30 people before and after hip replacement surgery. Participants wore a small chest sensor to estimate VO2 max without exercise. The goal was to see if this method can track natural recovery over 12 weeks. It is a …

This study looked at 72 people with hip osteoarthritis to see if X-ray findings match how they feel day-to-day. Researchers measured pain, stiffness, physical function, and balance, then compared those to X-ray severity scores. The goal was to better understand the connection bet…

This study looked at why the quadriceps (thigh) muscle sometimes stops working properly after total knee replacement surgery. Researchers measured muscle inhibition in 20 patients during their hospital stay and tracked their recovery for 6 weeks. The goal was to understand how th…

This study explored the connection between knee pain and the ability to sense the position of the lower back in 56 adults with knee osteoarthritis. Participants had their knee pain measured and performed a test to see how accurately they could feel their back's position. The goal…

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. The…

This study looked at 44 adults with osteoarthritis who took mineral baths (balneotherapy) for three weeks. Researchers used heart ultrasound before and after to see if the baths changed heart function. The goal was to better understand how balneotherapy affects the heart, especia…

This study tested whether custom carbon fiber braces can reduce harmful forces on the ankle joint after a fracture, which may lower the risk of developing arthritis. Twenty-two adults with healed ankle fractures walked with and without different brace designs while researchers me…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study followed 432 people who had ACL reconstruction surgery to see who develops osteoarthritis years later. Researchers measured knee joint space on x-rays and looked at injury details, surgical factors, and patient traits. The goal is to identify risk factors that could he…

This study looked at 368 patients with severe ankle arthritis who chose surgery. Researchers used surveys, step counts, and motion-capture walking tests to compare how well different surgical procedures improved function and quality of life. The goal was to find out which surgery…

This study followed 472 adults aged 18-75 who received a specific type of hip replacement to see how long the implants lasted. Researchers used patient surveys and survival curves to measure device performance. The goal was to gather long-term data, not to test a new treatment.

This study looked back at 54 people who had a hip replacement with a specific part called the CL TRAUMA cemented stem. The goal was to see if the part was safe and worked well. Researchers measured how well patients could move and if they had pain using a standard hip score.

This study tested four different cuff designs for carbon fiber ankle-foot orthoses (braces) in 35 healthy adults and people with ankle arthritis or injury. Researchers measured comfort, pain, foot pressure, and walking mechanics to see which cuff design people liked best. The goa…

This study looked at 100 people who had reverse total shoulder replacement to see if doing exercises at home works as well as going to a physical therapist. Patients were split into two groups: one did formal PT starting a few days after surgery and continuing weekly for three mo…

This study followed 162 people who received a G7 hip cup system during hip replacement surgery. Researchers measured pain, function, and hip movement using standard scores. The goal was to see how the device performs in everyday patients with arthritis or other joint problems.

This study looked at fat cells from bone marrow and belly fat in 45 post-menopausal women having knee replacement surgery for osteoarthritis. Researchers measured gene activity to see if bone marrow fat releases more joint-damaging factors. The goal is to understand how fat contr…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study checked whether a Turkish version of the General Rehabilitation Adherence Scale works well for people with osteoarthritis. Researchers gave the questionnaire to 88 patients receiving physiotherapy. The goal was to see if the translated scale is valid and reliable for u…

This completed study followed 120 adults over 40 who had knee replacement surgery for osteoarthritis. Researchers compared four different knee implants to see how well patients moved, walked, climbed stairs, and felt about their recovery over two years. The goal was to identify w…

This study looked at whether hip precautions—like not bending too far or crossing legs—are needed after hip replacement surgery. Over 1,100 patients were randomly assigned to follow precautions or not for six weeks. Researchers tracked dislocations, return to daily activities, an…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study looked at how video-guided acupuncture imagery treatment (VGAIT) changes brain activity in people with knee osteoarthritis. Researchers used brain scans to compare real acupuncture, sham acupuncture, and guided imagery in 125 adults aged 40-70. The goal was to understa…

This study looked at how pain in one knee affects the forces on the other knee during walking. Researchers measured walking patterns in 55 adults with knee osteoarthritis and healthy volunteers. The goal was to understand how the body adjusts movement to protect a painful joint, …

This study looked at 40 people who had a total hip replacement through a small incision in the front of the hip. Researchers compared two types of metal stems (AMIStem and Quadra) to see how bone density around the implant changed one year after surgery. The goal was to find out …

This study compared how well an AI chatbot (ChatGPT) answered common questions from people with knee or hip osteoarthritis versus answers from real doctors. 286 patients rated the responses for preference, length, and difficulty. The goal was to see if AI could provide acceptable…

This study looked at whether physical rehabilitation after hip or knee replacement surgery is better than no rehabilitation for helping people with daily activities like walking and getting in and out of a car. 169 adults who had hip or knee replacement due to osteoarthritis took…

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This study tested two ways of teaching older adults with knee osteoarthritis about their pain. One group learned about the biology of pain and how to manage it, while the other received standard information about joint damage. Researchers measured whether the type of education af…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This large observational study followed over 288,000 people with hip or knee osteoarthritis who received core treatment (education, exercise, and weight loss advice). The goal was to identify factors like socioeconomic status and other health conditions that predict long-term out…

This observational study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used imaging (X-rays, CT, MRI, ultrasound), physical exams, and questionnaires to track pain, inflammation, and joint changes. The goal was to better understand how the disease pr…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…

This completed study followed 1,100 adults with shoulder pain for up to five years to see how metabolic syndrome (a cluster of conditions like high blood pressure and diabetes) affects recovery. Participants received standard treatments like physiotherapy, injections, or surgery.…

This completed study compared 12 weeks of Tai Chi to wellness education in 72 adults aged 55+ with knee osteoarthritis. Researchers looked at changes in gut bacteria and joint symptoms. The goal was to gather early data for a future larger trial, not to prove any treatment works.

This completed study looked at the safety of pharmacopuncture—herbal extracts injected into acupuncture points—in 1,000 hospitalized adults with spine or joint problems. Researchers tracked infections and other side effects to see how often problems occur. The goal was to gather …