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New gel combo for aching muscles: does it beat standard pain relievers?

NCT ID NCT07475663

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee osteoarthritis used one of the three gels for about 6 days. Researchers measured pain reduction using a standard pain questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Piroxicam plus counterirritant gel (Methyl Salicylate, Menthol, Eugenol)
What this could lead to
If it works, this could offer a similar pain relief option with added cooling and warming sensations for muscle and joint pain.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all types of pain or long-term use. The study is relatively small (180 people) and short (6 days).

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

180 people

The number who actually took part.

Started

Nov 2025

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Outpatient in a health care setting. * Between the ages of 18 - 60 years of either sex. * Patients diagnosed with musculoskeletal pain as described in the target population. * Patient can read and understand how to fill out the assessment form and diary. * Patients gave written consent to participate in the study independently. Exclusion Criteria: * Patient who has osteoarthritis with Grade IV Kellgren-Lawrence (KL) grading. - - Patients who underwent any of the following treatments: * Paracentesis and drainage of joint * Intraarticular injection (joint protection agents, local anesthetic, etc.) * Nerve block (including trigger points) * Patients are being treated with an analgesic opioids for their musculosceletal pain. * Patients being treated with anti coagulant therapy such as warfarin, clopidogrel. * Patients being treated with oral corticosteroids 3 days before and until signed the informed consent. * Patients being treated using rigid orthoses those requiring such treatment * Patients with neuropsychiatric disorders including depression, dementia, schizophrenia, and anxiety neurosis * Patients with Grade 3 hypertension (systolic blood pressure ≥ 180 mmHg and diastolic blood pressure ≥ 110 mmHg regardless of the use of an antihypertensive drugs) * Patients with acute peptic ulcer * Patients with bronchial asthma with current or previous aspirin-induced asthma (asthmatic attacks induced by NSAIDs and other relevant drugs) * Patients with a history of hypersensitivity or allergy to NSAIDs * Patients with serious hepatic disease, renal disease, cardiac disease, hematologic disease, or malignancy * Patients with a history of dermatitis requiring treatment with topical agents * Patients with dermatitis or wounds at the application site of the study drug * Pregnant women ,women who may be pregnant, women who wish to become pregnant during the study, or nursing women * Patients considered by the Investigator to be inappropriate as participants of this study

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • St. Carolus Sports Clinic & Klinik Utama Eminence

    Jakarta, DKI Jakarta, 10440, Indonesia

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