New gel combo for aching muscles: does it beat standard pain relievers?
NCT ID NCT07475663
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee osteoarthritis used one of the three gels for about 6 days. Researchers measured pain reduction using a standard pain questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Piroxicam plus counterirritant gel (Methyl Salicylate, Menthol, Eugenol)
- What this could lead to
- If it works, this could offer a similar pain relief option with added cooling and warming sensations for muscle and joint pain.
- What could go wrong
- This is a completed Phase 3 trial, but results may not apply to all types of pain or long-term use. The study is relatively small (180 people) and short (6 days).
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
180 people
The number who actually took part.
- Started
-
Nov 2025
- Finished
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Feb 2026
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 60 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Outpatient in a health care setting. * Between the ages of 18 - 60 years of either sex. * Patients diagnosed with musculoskeletal pain as described in the target population. * Patient can read and understand how to fill out the assessment form and diary. * Patients gave written consent to participate in the study independently. Exclusion Criteria: * Patient who has osteoarthritis with Grade IV Kellgren-Lawrence (KL) grading. - - Patients who underwent any of the following treatments: * Paracentesis and drainage of joint * Intraarticular injection (joint protection agents, local anesthetic, etc.) * Nerve block (including trigger points) * Patients are being treated with an analgesic opioids for their musculosceletal pain. * Patients being treated with anti coagulant therapy such as warfarin, clopidogrel. * Patients being treated with oral corticosteroids 3 days before and until signed the informed consent. * Patients being treated using rigid orthoses those requiring such treatment * Patients with neuropsychiatric disorders including depression, dementia, schizophrenia, and anxiety neurosis * Patients with Grade 3 hypertension (systolic blood pressure ≥ 180 mmHg and diastolic blood pressure ≥ 110 mmHg regardless of the use of an antihypertensive drugs) * Patients with acute peptic ulcer * Patients with bronchial asthma with current or previous aspirin-induced asthma (asthmatic attacks induced by NSAIDs and other relevant drugs) * Patients with a history of hypersensitivity or allergy to NSAIDs * Patients with serious hepatic disease, renal disease, cardiac disease, hematologic disease, or malignancy * Patients with a history of dermatitis requiring treatment with topical agents * Patients with dermatitis or wounds at the application site of the study drug * Pregnant women ,women who may be pregnant, women who wish to become pregnant during the study, or nursing women * Patients considered by the Investigator to be inappropriate as participants of this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
St. Carolus Sports Clinic & Klinik Utama Eminence
Jakarta, DKI Jakarta, 10440, Indonesia
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