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Knee surgery or PT? landmark study compares treatments for torn meniscus with arthritis

NCT ID NCT00597012

Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. Participants were randomly assigned to have knee surgery or follow a physical therapy program. The main goal was to measure changes in knee function and pain over 6 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

351 people

The number who actually took part.

Started

May 2008

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * OA symptoms lasting at least 1 month and managed with medications, activity limitations, and/or physical therapy * At least one symptom consistent with a torn meniscus. Symptoms may include clicking, catching, popping, giving way, pain with pivot or torque, episodic pain, and/or pain that is acute and localized to one joint line. * Available knee X-ray (within 6 months) and MRI (within 3 years) * Evidence of osteophyte formation or cartilage fissure, tear, or loss on a knee MRI OR plain radiographic evidence of osteophyte formation or joint space narrowing * Evidence of a meniscal tear (tear extending to surface of meniscus) on a knee MRI * Willingness to undergo random assignment and sign an informed consent Exclusion Criteria: * Chronically locked knee * Kellgren-Lawrence Grade IV status, indicating advanced OA and usually the need for total knee replacement * Contraindication to MRI * Radiographic chondrocalcinosis (a condition in which there are deposits of calcium pyrophosphate dihydrate \[CPPD\] crystals in one or more joints that eventually result in damage to the affected joints) AND acute symptomatic pseudogout * Inflammatory diseases (e.g., rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, gout, pseudogout) * Injection with viscosupplementation in the affected knee in the 4 weeks before study entry * Any medical contraindications to surgery or physical therapy * Both knees are symptomatic for meniscal tears and a candidate for bilateral APMs * Prior surgery on an affected knee * Pregnancy or possible pregnancy * Claim filed for worker's compensation * Unable or unwilling to give informed consent * Unable or unwilling to attend physical therapy sessions at designated locations or in the community

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

  • Washington University in St Louis, School of Medicine

    St Louis, Missouri, 63110, United States

More trials for these conditions

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