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Jaw pain showdown: which injection works best?

NCT ID NCT07571265

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three different injections for people with painful jaw arthritis: platelet-rich plasma (PRP), hyaluronic acid, and a steroid called triamcinolone acetonide. 64 adults received one of these or a placebo saline injection. Researchers measured pain and mouth opening after one week, one month, and three months to see which treatment worked best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich plasma, hyaluronic acid, triamcinolone acetonide
What this could lead to
If one injection works best, it could offer a simple, non-surgical option for easing jaw arthritis pain.
What could go wrong
This is a small, single-center study with only 64 participants. Results may not apply to everyone, and any injection carries risks like infection or temporary discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

May 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Patients with temporomandibular joint osteoarthritis with or without disc displacement. * 2\. Age ≥ 18 years \< 50 Exclusion Criteria: * 1\. Previous TMJ surgery * 2\. Medical history of blood-derived illness or any medication known to affect platelet function or concentration for a minimum of two weeks prior to treatment. * 3\. specific osteoarthritis like rheumatoid arthritis or psoriatic arthritis. * 4\. pregnant women or breastfeeding ones

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular arthritis

Contacts and locations

Locations

  • Faculty of Dentistry

    Al Manyal, Cairo Governorate, 11553, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.