Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New knee injection shows promise for arthritis pain relief

NCT ID NCT05377489

Symptom relief Sponsor: Grünenthal GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested the safety of an experimental drug called RTX-GRT7039, given as a knee injection to 714 adults with moderate to severe osteoarthritis pain that wasn't helped by standard treatments. The study focused on side effects and did not measure how well the drug works. If proven safe and effective in future studies, it could offer a new way to manage knee pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RTX-GRT7039 (an experimental drug injection)
What this could lead to
If it works, this could provide a new option for easing knee pain from osteoarthritis when standard treatments aren't enough.
What could go wrong
This is a safety-focused trial, so it won't prove if the drug actually reduces pain. Side effects or lack of benefit are possible, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

714 people

The number who actually took part.

Started

Sep 2022

Finished

May 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The participant has given written informed consent to participate. * The participant is 18 years of age or older at the Screening Visit. * The participant has a diagnosis of osteoarthritis of the knee based on American College of Rheumatology criteria and functional capacity class of I to III. * There is a documented history indicating that participant has insufficient pain relief with previous Standard of Care. Exclusion Criteria: * The participant has past joint replacement surgery of the index knee. * The participant has a history of significant trauma or surgery (e.g., open or arthroscopic) to the index knee within 12 months of Screening. * The participant has periarticular pain at the index knee from any cause other than osteoarthritis, including referred pain, bursitis, tendonitis. * The participant has clinical hip osteoarthritis on the side of the index knee. * The participant has a history of osteonecrosis, subchondral insufficiency fracture, atrophic osteoarthritis, rapidly progressing osteoarthritis (RPOA) Type I or Type II,pathologic fracture, primary or metastatic tumor, or joint infection in the index knee. * The participant has significant malalignment of anatomical axis (medial angle formed by the femur and tibia) of the target knee (varus \>10°, valgus \>10°) by radiograph as assessed by independent Central Readers at Screening Visit. * The participant has other conditions that could affect trial endpoint assessments of the index knee. * The participant has current clinically significant disease(s) or condition(s) that may affect safety assessments, or any other reason which may preclude the participant's participation for the full duration of the trial. * The participant has a history of hypersensitivity to resiniferatoxin (RTX) or any similar component (capsaicin, chili peppers). * The participant is currently participating or was participating in another investigational drug trial within 3 months prior to the Screening Visit. * The participant is an employee of the investigator or trial site, with direct involvement in the proposed trial or other trials under the direction of that investigator or trial site or is a family member of the employees or the investigator. The non-index knee is not eligible for treatment in the trial, if any of the knee-related exclusion criteria applies to the non-index knee.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Osteoarthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

Contacts and locations

Locations

  • Accellacare Warwickshire

    Coventry, CV3 4FJ, United Kingdom

  • Accellacare Yorkshire

    Shipley, Yorkshire, BD18 3SA, United Kingdom

  • Accellacare-Knoxville

    Knoxville, Tennessee, 37912, United States

  • Acclaim Clinical Research, Inc.

    San Diego, California, 92120, United States

  • Aliwal Shoal Medical Centre

    eMkhomazi, KwaZulu-Natal, 4170, South Africa

  • Arizona Arthritis and Rheumatology Associates (AARA) P.C

    Glendale, Arizona, 85306, United States

  • Arthritis Clinical Research Centre

    Cape Town, 7405, South Africa

  • Centermed Krakow Sp. z o.o.

    Krakow, 31-530, Poland

  • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed SRL

    Brasov, 500283, Romania

  • Centrum Kliniczno

    Elblag, 82-300, Poland

  • Centrum Medyczne 4M Plus

    Krakow, Malopolska, 31141, Poland

  • Centrum Medyczne Semper fortis

    Krakow, 31-141, Poland

  • Chapel Allerton Hospital - Leeds Teaching Hospitals NHS Trust

    Leeds, LS7 4SA, United Kingdom

  • Chicago Clinical Research Institute Inc.

    Chicago, Illinois, 60607, United States

  • ClinicMed Badurski I Wspolnicy Spolka Jawna

    Bialystok, 15-879, Poland

  • ClinicMed Daniluk, Nowak Spolka komandytowa

    Bialystok, 15-879, Poland

  • Clinical Pharmacology Study Group

    Worcester, Massachusetts, 01605, United States

  • Clinresco Centres (Pty) Ltd.

    Kempton Park, Johannesburg, 1619, South Africa

  • Coastal Carolina Research Center

    Mt. Pleasant, South Carolina, 29464, United States

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Dr Zubar Fazal Ahmed Vawda MD

    Durban, KwaZulu-Natal, 4091, South Africa

  • Drug Trials America

    Hartsdale, New York, 10530, United States

  • ETG Warszawa

    Warsaw, Masovian Voivodeship, 02-777, Poland

  • ETG Warszawa

    Warsaw, 02-677, Poland

  • ETG Warszawa

    Warsaw, 02-793, Poland

  • ETYKA Osrodek Badan Klinicznych

    Olsztyn, 10-117, Poland

  • Elite Clinical Studies, LLC

    Phoenix, Arizona, 85018, United States

  • Europejskie Centrum leczenia Chorob Cywilizacyjnych

    Warsaw, 02-777, Poland

  • Excel Clinical Research

    Las Vegas, Nevada, 89109, United States

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 8140180, Japan

  • Global Clinical Trials

    Pretoria, Gauteng, 0001, South Africa

  • Gulfcoast Research Institute

    Sarasota, Florida, 34232, United States

  • Hakodate Central General Hospital

    Hakodate, Hokkaido, 040-8585, Japan

  • Injury Care Research

    Boise, Idaho, 83713, United States

  • Josha Research

    Bloemfontein, Free State, 9301, South Africa

  • Lakeview Hospital

    Johannesburg, Gauteng, 1500, South Africa

  • Las Vegas Clinical Trials, LLC

    North Las Vegas, Nevada, 89030, United States

  • Lubelskie Centrum Diagnostyczne

    Świdnik, 21040, Poland

  • M3-Emerging Medical Research, LLC

    Durham, North Carolina, 27704, United States

  • M3-Emerging Medical Research, LLC

    Raleigh, North Carolina, 27704, United States

  • MHAT Kaspela EOOD

    Plovdiv, 4002, Bulgaria

  • MHAT St Iv. Rilski

    Sofia, 1612, Bulgaria

  • Medical Centre Artmed

    Plovdiv, 4002, Bulgaria

  • Medical Centre N. I. Pirogov EOOD

    Sofia, 1000, Bulgaria

  • Medical Corporation Kouhoukai Takagi Hospital

    Okawa-shi, Fukuoka, 831-0016, Japan

  • Medicross Langeberg Medical & Dental Centre

    Kraaifontein, Western Cape, 7570, South Africa

  • Medicross Langeberg Medical & Dental Centre

    Kraaifontein, Western Cape, 7572, South Africa

  • Medyczne Centrum Hetmanska

    Poznan, 60-218, Poland

  • Medyczne Centrum Hetmanska Indywidualna Specjalistyczna Praktyka Lekarska Dr Hab Piotr Leszczynski

    Poznan, 60-218, Poland

  • Midrand Medical Centre

    Halfway House, Gauteng, 1685, South Africa

  • Multi-Profile District Hospital for Active Treatment Dr. Stefan Cherkezov

    Veliko Tarnovo, 5000, Bulgaria

  • NZOZ Medi Spatz

    Gliwice, 44-100, Poland

  • Neuroscience Research Center, LLC

    Overland Park, Kansas, 66210, United States

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Nzoz Centermed Krakow, Szpital I Przychodnia

    Krakow, 31-530, Poland

  • Oakland Medical Research Center

    Troy, Michigan, 48085, United States

  • Orange County Research Institute

    Anaheim, California, 92801, United States

  • OrthoIndy, Inc.

    Greenwood, Indiana, 46143, United States

  • Otakibashi Orthopedic Clinic

    Shinjuku-ku, Tokyo, 169-0073, Japan

  • PZU Zdrowie S.A. Oddzia¿ Centrum Medyczne Artimed w Kielcach

    Kielce, 25-017, Poland

  • Palm Beach Research Center

    West Palm Beach, Florida, 33409, United States

  • Precise Clinical Solutions

    Durban, KwaZulu-Natal, 4092, South Africa

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • RCMed Oddzial Sochaczew

    Sochaczew, 96-500, Poland

  • RCMed Piotr Opadczuk

    Sochaczew, 96-500, Poland

  • Roodepoort Medicross Clinical Research Centre

    Roodepoort, Gauteng, 1724, South Africa

  • SC Centrul Medical Sana SRL

    Bucharest, 011025, Romania

  • SC Medaudio-Optica SRL

    Râmnicu Vâlcea, Vâlcea County, 240762, Romania

  • SC Medicali's SRL

    Timișoara, Timiș County, 300362, Romania

  • SC Policlinica CCBR SRL

    Bucharest, 030463, Romania

  • Saiseikai Kanagawaken Hospital

    Yokohama, Kanagawa, 221-0821, Japan

  • Saitama Medical Center

    Saitama, 350-8550, Japan

  • Sandton Medical Research (Newtown CRC)

    Sandton, Gauteng, 2196, South Africa

  • Sf. Maria Hospital

    Bucharest, 11172, Romania

  • Spital Clinic Dr I Cantacuzino

    Bucharest, 020475, Romania

  • Spitalul Clinic Sf. Maria

    Bucharest, 011172, Romania

  • Spitalul Judetean Caracal

    Caracal, Olt, 235200, Romania

  • Synapta Clinical Research Center

    Durban, KwaZulu-Natal, 4001, South Africa

  • Synexus Medical Center Sofia

    Sofia, 1784, Bulgaria

  • Tekton Research, Inc.

    San Antonio, Texas, 78229, United States

  • Tread Research

    Parow, Cape Town, 7500, South Africa

  • Tygerberg hospital

    Parow, Cape Town, 7500, South Africa

  • UMBAL Sveti Ivan Rilski EAD

    Sofia, 1612, Bulgaria

  • UMHAT Eurohospital Plovdiv OOD

    Plovdiv, 4000, Bulgaria

  • UMHAT Pulmed

    Plovdiv, 4002, Bulgaria

  • University Multiprofile Hospital For Active Treatment Pulmed OOD

    Plovdiv, 4002, Bulgaria

  • University Of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University Orthopedics Center

    State College, Pennsylvania, 16801, United States

  • University of Pretoria

    Pretoria, Gauteng, 0002, South Africa

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu

    Wroclaw, Lower Silesian Voivodeship, 50-556, Poland

  • Wasatch Clinical Research

    Salt Lake City, Utah, 84107, United States

  • Welkom Clinical Trial Centre

    Welkom, Free State, 9460, South Africa

  • Westlake Medical Research

    Thousand Oaks, California, 91360, United States

  • Wojewodzki Szpital Zespolony W Kielcach

    Kielce, Świętokrzyskie Voivodeship, 25-736, Poland

  • Worthwhile Clinical Trials

    Benoni, Gauteng, South Africa

  • Zaklad Opieki Zdrowotnej w Boleslawcu

    Bolesławiec, 59-700, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.