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New knee implant tested for better mobility and longevity

NCT ID NCT00733915

Disease control Sponsor: DePuy International Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and patient-reported outcomes like pain and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
DePuy LCS Complete mobile-bearing total knee system (a prosthetic knee implant device)
What this could lead to
If successful, this study could confirm that the LCS Complete knee system is a reliable option for knee replacement, potentially improving mobility and reducing pain for people with severe knee arthritis.
What could go wrong
This is a single-group, non-comparative study, so results may not show how it compares to other knee implants. Long-term success depends on factors like patient health and surgical technique, and some patients may still experience complications or need revision surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

241 people

The number who actually took part.

Started

Mar 2002

Finished

Oct 2014

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects. * Subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained * Subjects who, in the opinion of the Investigator, are able to understand this investigation, co-operate with the investigational procedures and are willing to return to the hospital for all the required post-operative follow-ups. * Subjects who present with idiopathic osteoarthritis, rheumatoid arthritis, post traumatic arthritis or any other pathology that in the opinion of the clinical investigator requires a primary total knee arthroplasty and who are considered suitable for treatment with a mobile bearing knee system (LCS Complete). * Subjects who in the opinion of the Clinical Investigator are considered to be suitable for treatment with the investigation device, according to the indications specified in the package insert leaflet. Exclusion Criteria: * Subjects who, in the opinion of the Investigator, have an existing condition that would compromise their participation and follow-up in this study. * Subjects with a known history of poor compliance to medical treatment. * Women who are pregnant. * Subjects who are known drug or alcohol abusers or with psychological disorders that could effect follow-up care or treatment outcomes. * Subjects involved in Medical-Legal claims. * Subjects who have participated in a clinical study with an investigational product in the last month. * Subjects who are currently involved in any injury litigation claims. * Revision of an existing knee implant.

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Conditions

The condition(s) this trial relates to.

Aagenaes syndrome osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthroplasty, replacement, knee

Contacts and locations

Locations

  • Musgrave Park Hospital

    Belfast, BT9 7JB, Ireland

More trials for these conditions

Other studies related to the condition(s) this trial covers.