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Knee pain showdown: PRP, gel, or exercise – which works best?

NCT ID NCT05877027

Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study compared three common treatments for knee osteoarthritis (gonarthrosis) in 82 adults aged 40–65. Participants received either platelet-rich plasma (PRP) injections, topical diclofenac gel, or a structured exercise program for 6 weeks. The goal was to see which approach best reduces pain, improves function, and boosts quality of life. Results may help guide treatment choices for this common condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich plasma (PRP), topical diclofenac, and exercise
What this could lead to
If this study shows one approach works better, it could help doctors choose the most effective treatment for knee osteoarthritis symptoms.
What could go wrong
This is a small, completed study with no phase designation, so results may not apply to everyone. PRP and exercise effects vary, and topical diclofenac may cause skin irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

82 people

The number who actually took part.

Started

Mar 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with gonarthrosis according to the criteria of the American Society of Rheumatology (ACR) * Stage 2 or 3 according to Kellgren Lawrence radiological staging criteria, * Those between the ages of 40 and 65, * Body mass index below 30 kg/m2, * Pain intensity defined by the patient in the last 3 months is at least 3 out of 10 according to NPRS, * Patients who do not have any barriers to being included in the exercise program Exclusion Criteria: * Being in stage 4 according to Kellgren Lawrence radiological staging criteria, * Hemoglobin level \<11.5 g/dL * Platelet level \<100,000/μL * Thrombocytopenia, coagulopathy, crystal arthropathy, hemophilia or hematological malignancy, * Presence of active infection or tumor, * Chronic antiaggregant use or taking immunosuppressive therapy, * Pregnancy or lactation, * Viscosupplementation or steroid injection in the related knee in the last 3 months, or using systemic steroids, * To have received a physiotherapy program for the relevant knee in the last 3 months, * Having a valgus or varus deformity greater than 15°, * Presence of neurological diseases and/or deformity leading to lower extremity muscle weakness * Having serious systemic and cardiovascular diseases that interfere with exercise

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gonarthrosis

Contacts and locations

Locations

  • Istanbul University-Cerrahpasa

    Istanbul, Istanbul, 34500, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.