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Could two doses of a common steroid improve joint replacement recovery?

NCT ID NCT06653699

Symptom relief Sponsor: Indus Hospital and Health Network Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed trial looked at whether giving two doses of dexamethasone (a steroid) along with tranexamic acid (a drug to reduce bleeding) around the time of hip or knee replacement surgery improves recovery. 92 patients were randomly assigned to receive either one or two doses of dexamethasone plus tranexamic acid. Researchers measured inflammation, pain, joint movement, fatigue, and hospital stay length. The goal is to see if the two-dose regimen leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone and tranexamic acid
What this could lead to
If it works, this could lead to a simple, low-cost way to speed up recovery and reduce pain and hospital stays after hip or knee replacement surgery.
What could go wrong
This is a small, completed trial with only 92 participants, so results may not apply to everyone. The benefits of an extra dose of dexamethasone may be modest, and there are risks like infection or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Jul 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for unilateral or bilateral total joint replacement surgery in grade 4 osteoarthritis. * Patients having pre-operative hemoglobin above 10g/dL. * Include both genders. * Patients having age more than 45 years. Exclusion Criteria * Patients having history of thromboembolic event. * Patients having tranexamic and steroidal allergy. * Patients having pre operative Hemoglobin level less than 10g/dL * Patients having history of clotting disorders including abnormal prothrombin time, prothrombin time test, or international normalized ratio.

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Conditions

The condition(s) this trial relates to.

osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip replacement Knee replacement

Contacts and locations

Locations

  • Indus Hospital & Health Network

    Lahore, Punjab Province, 54840, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.