Simple knee moves may cut arthritis pain without drugs
NCT ID NCT05577403
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether adding a gentle joint-gliding technique called Mulligan's mobilization to simple isometric exercises could help people with knee osteoarthritis. Fifty adults with moderate knee arthritis received either the mobilization plus exercises or a sham version for three weeks. Researchers measured pain, range of motion, and disability before and after treatment to see if the combination worked better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mulligan's mobilization with movement plus isometric exercises
- What this could lead to
- If it works, this could offer a simple, drug-free way to reduce pain and improve movement for people with knee osteoarthritis.
- What could go wrong
- This is a small, completed trial with only 50 participants, so results may not apply to everyone. The treatment is a physical therapy technique, not a cure, and benefits may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Nov 2022
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale. * Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee. Exclusion Criteria: * Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement. * They had received steroids or intra-articular injection within the previous three months, uncooperative patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rehabilitation center, Majmaah University
Al Majma'ah, Riyadh Region, 15341, Saudi Arabia
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Other studies related to the condition(s) this trial covers.
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