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Can a sprinkle of powder and a wash stop joint infections?

NCT ID NCT04075526

Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding vancomycin powder and a diluted povidone iodine wash during joint replacement surgery could prevent infections in high-risk patients. Over 2,100 adults with osteoarthritis who were at higher risk due to factors like obesity or smoking took part. The goal was to see if these simple steps could lower the chance of a serious infection around the new joint.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vancomycin powder and povidone iodine solution
What this could lead to
If successful, this could lead to a simple, low-cost way to reduce serious infections after joint replacement surgery.
What could go wrong
This is an early-phase study, so the results are not yet conclusive. The treatments may not reduce infection risk or could cause side effects like allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

2,129 people

The number who actually took part.

Started

Oct 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient has no open wounds on operative leg * Patient is scheduled to undergo elective primary and revision total joint arthroplasty for posttraumatic, osteoarthritis, avascular necrosis, and/or inflammatory arthritis * Patient does not have active infection on the operative leg, the operative joint * Patient are identified as high risk for the development of PJI which is determined by the presence of one or more of the following characteristics: BMI \>35, active smoker, ASA ≥ 3, immunosuppressed (i.e. being treated with chemotherapy, diagnosis of HIV, diagnosis of HCV, being treated with chronic steroids, patients with inflammatory arthropathies), diagnosis with diabetes mellitus, established colonization with S. aureus, or any patient undergoing revision TJA * Patient understand the risks and benefits associated with TJA and willing to cooperate and follow study protocol and visit schedule Exclusion Criteria: * Patient is pregnant * Patient is unable to provide written consent * Patient has psychiatric disorder that precludes safe study participation or that necessitates confinement in a custodial environment at home or in a chronic care facility * Patient does not have the mental capacity to participate and comply with the study protocol * Patient has active infections in the operative leg/joint * Patient has severe dementia * Suspicion of illicit drug abuse by patient * ASA score of 5 \& 6 * History of prior native septic joint arthritis * No planned procedure within 90 days of surgery

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Conditions

The condition(s) this trial relates to.

arthritic joint disease avascular necrosis osteoarthritis periprosthetic joint infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Centura Health

    Denver, Colorado, 80210, United States

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Cleveland Clinic Ohio

    Cleveland, Ohio, 44195, United States

  • Columbia

    New York, New York, 10036, United States

  • Eisenhower Health

    Rancho Mirage, California, 92270, United States

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • New England Baptist Hospital

    Boston, Massachusetts, 02120, United States

  • New York University Dept of Orthopedic Surgery

    New York, New York, 10003, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • St. Francis Hospital

    Roslyn, New York, 11576, United States

  • The Orthopedic Institute of New Jersey

    Sparta, New Jersey, 07871, United States

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