Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

One-Shot knee injection could ease arthritis pain

NCT ID NCT05449132

Symptom relief Sponsor: Grünenthal GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested whether a single injection of RTX-GRT7039 into the knee can reduce pain in adults with knee osteoarthritis who haven't gotten enough relief from standard treatments. 466 participants received either the drug or a placebo injection. The study measured pain changes over 12 and 26 weeks using a standard pain scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
RTX-GRT7039 (a single injection into the knee joint)
What this could lead to
If it works, this could offer a new option for easing knee osteoarthritis pain with just one injection, reducing the need for daily pain pills.
What could go wrong
This is a completed Phase 3 trial, but results are not yet public. The injection may not work better than placebo, and side effects like joint pain or swelling are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

466 people

The number who actually took part.

Started

Sep 2022

Finished

Aug 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The participant has given written informed consent to participate. * The participant is 18 years of age or older at the Screening Visit. * The participant has a diagnosis of osteoarthritis of the knee based on American College of Rheumatology criteria and functional capacity class of I to III. * There is a documented history indicating that participant has insufficient pain relief with previous Standard of Care. Exclusion Criteria: * The participant has past joint replacement surgery of the index knee. * The participant has a history of significant trauma or surgery (e.g., open or arthroscopic) to the index knee within 12 months of Screening. * The participant has periarticular pain from any cause other than osteoarthritis, including referred pain, bursitis, or tendonitis. * The participant has clinical hip osteoarthritis on the side of the index knee. * The participant has pre-existing osteonecrosis, subchondral insufficiency fracture, atrophic osteoarthritis, severe bone on bone osteoarthritis, knee pain attributable to disease other than osteoarthritis, or the participant has rapidly progressing osteoarthritis (RPOA) Type I or Type II. * The participant has significant malalignment of anatomical axis (medial angle formed by the femur and tibia) of the target knee (varus \>10, valgus \>10) by X-ray as assessed by independent Central Readers at Screening Visit. * The participant has other conditions that could affect trial endpoint assessments of the index knee. * The participant has current clinically significant disease(s) or condition(s) that may affect efficacy or safety assessments, or any other reason which, in the investigator's opinion, may preclude the participant's participation in the full duration of the trial. * The participant has a history of hypersensitivity to resiniferatoxin (RTX) or any similar component (capsaicin, chili peppers). * The participant is currently participating or was participating in another investigational drug trial within 3 months prior to the Screening Visit. * The participant is an employee of the investigator or trial site, with direct involvement in the proposed trial or other trials under the direction of that investigator or trial site or is a family member of the employees or the investigator.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Osteoarthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

Contacts and locations

Locations

  • Accellacare - Knoxville

    Knoxville, Tennessee, 37912, United States

  • Accellacare Alcobendas

    Madrid, 28100, Spain

  • Accellacare North London

    Northwood, HA6 2RN, United Kingdom

  • Accellacare Research of Charlotte

    Charlotte, North Carolina, 28209, United States

  • Accellacare Research of Winston Salem

    Winston-Salem, North Carolina, 27103, United States

  • Accellacare South London

    Orpington, BR5 3QG, United Kingdom

  • Accellacare of Raleigh

    Raleigh, North Carolina, 27609, United States

  • Accellacare-Northamptonshire

    Corby, Northamptonshire, NN18 9EZ, United Kingdom

  • Acclaim Clinical Research, Inc.

    San Diego, California, 92120, United States

  • Achieve Clinical Research, LLC

    Birmingham, Alabama, 35216, United States

  • Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, 87102, United States

  • Allied Biomedical Research Institute

    Miami, Florida, 33155, United States

  • Altoona Center for Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Antria Inc.

    Indiana, Pennsylvania, 15701, United States

  • Arizona Arthritis and Rheumatology Associates (AARA) P.C

    Glendale, Arizona, 85351, United States

  • Arthritis Group

    Philadelphia, Pennsylvania, 19152-3303, United States

  • Arthroscopic Center, Copenhagen University Hospital

    Amager, 2650, Denmark

  • Better Health Clinical Research, Inc.

    Newnan, Georgia, 30265, United States

  • Chan Soon-Shiong Medical Center at Windber

    Windber, Pennsylvania, 15963, United States

  • Charlottesville Medical Research Center LLC

    Charlottesville, Virginia, 22911, United States

  • Chicago Clinical Research Institute Inc.

    Chicago, Illinois, 60607, United States

  • Chicago Medical Research, LLC

    Hazel Crest, Illinois, 60429, United States

  • Clinica Gaias

    Santiago de Compostela, 15702, Spain

  • Clinical Neuroscience Solutions, Inc.

    Orlando, Florida, 32806, United States

  • Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

    Orlando, Florida, 32801, United States

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Complejo Hospitalario Universitario A Coruna

    A Coruña, 15006, Spain

  • Complexo Hospitalario Universitario De Santiago De Compostela

    Santiago de Compostela, 15706, Spain

  • Consorci Corporacio Sanitaria Parc Tauli

    Sabadell, 08208, Spain

  • Core Health Care Group

    Cerritos, California, 90703, United States

  • DelRicht Research

    New Orleans, Louisiana, 70124, United States

  • Dr. Hans Richard Barthel, MD Office Of

    Santa Barbara, California, 93108, United States

  • Drug Trials America

    Hartsdale, New York, 10530, United States

  • Elite Clinical Studies, LLC

    Phoenix, Arizona, 85018, United States

  • Excel Clinical Research

    Las Vegas, Nevada, 89109, United States

  • Gastroenterology Associates of the Piedmont

    Winston-Salem, North Carolina, 27103, United States

  • Glasgow Royal Infirmary - Greater Glasgow Health Board

    Glasgow, G4 0SF, United Kingdom

  • Gulfcoast Research Institute

    Sarasota, Florida, 34232, United States

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Hospital CUF Porto

    Porto, 4100-180, Portugal

  • Hospital Clinico Universitario De Santiago De Compostela

    Santiago de Compostela, 15706, Spain

  • Hospital Dos Lusiadas Lisboa

    Lisbon, 1500-458, Portugal

  • Hospital General Universitario de Elche

    Elche, 03203, Spain

  • Hospital Quironsalud Infanta Luisa

    Seville, 41010, Spain

  • Hospital Sanitas Cima

    Barcelona, 08034, Spain

  • Hospital Universitario Virgen De La Arrixaca (Huva)

    Murcia, 30120, Spain

  • Hospital Universitario Virgen de las Nieves

    Granada, 18014, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • Hospital Universitaro De Elche

    Elche, 7105, Spain

  • Hospital de Cascais

    Alcabideche, 2755-009, Portugal

  • Injury Care Research

    Boise, Idaho, 83713, United States

  • Institut d Investigacio i Innovacio Parc Tauli, Hospital Universitari Parc Tauli

    Sabadell, 08208, Spain

  • June DO,PC

    Lansing, Michigan, 48911, United States

  • LCMC Health Urgent Care - Lakeview

    New Orleans, Louisiana, 70124, United States

  • Las Vegas Clinical Trials, LLC

    North Las Vegas, Nevada, 89030, United States

  • MediSphere Medical Research Center, LLC

    Evansville, Indiana, 47714, United States

  • Medvin Clinical Research

    Thousand Oaks, California, 91360, United States

  • Neuroscience Research Center, LLC

    Overland Park, Kansas, 66210, United States

  • Noble Clinical Research

    Tucson, Arizona, 85704, United States

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Oakland Medical Research Center

    Troy, Michigan, 48085, United States

  • Orange County Research Institute

    Anaheim, California, 92801, United States

  • PCPMG Clinical Research Unit, LLC

    Greenville, South Carolina, 29601, United States

  • Park Road Medical Clinic

    Charlotte, North Carolina, 28211, United States

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • Raleigh Medical Group

    Raleigh, North Carolina, 27609, United States

  • Robert Jones & Agnes Hunt Orthopaedic Hospital - Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

    Oswestry, Powys, SY10 7AG, United Kingdom

  • Royal Orthopaedic Hospital - Nhs Foundation Trust

    Birmingham, B31 2AP, United Kingdom

  • Sensible Healthcare LLC

    Ocoee, Florida, 34761, United States

  • Sundance Clinical Research, LLC

    St Louis, Missouri, 63141, United States

  • The Center For Clinical Research

    Winston-Salem, North Carolina, 27103, United States

  • The Parker Institute-Frederiksberg Hospital

    Frederiksberg, 2000, Denmark

  • Tucson Orthopaedic Research Center

    Tucson, Arizona, 85712, United States

  • University Orthopedics Center

    Altoona, Pennsylvania, 16602, United States

  • University Orthopedics Center

    Altoona, Pennsylvania, 9421166, United States

  • University Orthopedics Center

    State College, Pennsylvania, 16801, United States

  • Upstate Clinical Research Associates

    Williamsville, New York, 14221, United States

  • Vista Clinical Research

    Newnan, Georgia, 30265, United States

  • Wasatch Clinical Research

    Salt Lake City, Utah, 84107, United States

  • Well Pharma Medical Research, Corp.

    Miami, Florida, 33173, United States

  • Westlake Medical Research

    Thousand Oaks, California, 91360, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.