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Obesity linked to higher knee implant infection risk in massive registry study

NCT ID NCT07398742

Knowledge-focused Sponsor: Bispebjerg Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study used Danish national health records to compare infection rates after total knee replacement in obese (BMI ≥30) versus non-obese patients. Researchers analyzed data from over 100,000 adults who had knee replacement for osteoarthritis between 2011 and 2021. They looked at how many needed revision surgery due to infection within two years, and what types of bacteria caused those infections. The goal is to help tailor preventive antibiotics and infection management for obese patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors choose better antibiotics and preventive measures for obese patients undergoing knee replacement.
What could go wrong
This is an observational study using existing records, not a controlled trial. It can show links but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

101,299 people

The number who actually took part.

Started

Jan 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

In order to be eligible, we will include adult patients with primary or secondary osteoarthritis (due to meniscus or cruciate ligament lesion) who underwent primary TKA between January 1, 2011, and February 28, 2021, and for whom weight and height data are available. Patients will be identified from the DKR. Patients are followed for 2 years, until first revision, death or migration, whichever comes first.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults with available BMI data recieved knee arthroplasty due to osteoarthritis Exclusion Criteria: \-

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Conditions

The condition(s) this trial relates to.

arthropathy juvenile polyposis syndrome Obesity osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthropathy PJI

Contacts and locations

Locations

  • Department of Orthopedic surgery and traumatology, Bispebjerg Hospital, Copenhagen, Denmark

    Copenhagen NV, 2400, Denmark

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