Human disease

Researchers are comparing ceftobiprole, an intravenous antibiotic, with a standard combination of vancomycin plus aztreonam for treating acute bacterial skin and skin structure infections in hospitalized adults. The trial enrolls adults with serious skin infections such as cellul…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

Researchers are testing whether a 13-valent pneumococcal conjugate vaccine is safe and prompts a strong immune response in healthy infants in India. The trial enrolls 708 infants who receive the vaccine or an older seven-strain version alongside their routine childhood shots. The…

Researchers are testing six different formulations of a cell culture-derived H2N3 influenza vaccine in about 600 healthy adults aged 18 and older. Participants receive two injections three weeks apart and are followed for about a year. The study measures antibody levels and check…

This study tested two experimental nasal spray vaccines in 24 children aged 2 to 5 years. The vaccines target two viruses that can cause breathing problems: human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3). The main goal was to see if the vaccines are safe and …

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

This early-phase trial is testing a new way to deliver radiation therapy for people with advanced head and neck cancer. Using MRI guidance, doctors can adjust the radiation dose in real time—giving higher doses to remaining tumor while reducing doses to areas that have shrunk. Th…

Researchers at Yale University are testing whether abrocitinib, an oral JAK1 inhibitor already approved for atopic dermatitis, can reduce inflammation in people with moderate to severe cutaneous sarcoidosis. The trial enrolls adults with a confirmed skin biopsy and a CSAMI activi…

This study tests an experimental drug called efinopegdutide in 80 adults with liver scarring (cirrhosis) caused by metabolic dysfunction-associated steatohepatitis (MASH), a type of fatty liver disease. The goal is to see if the drug can reduce liver fat, inflammation, and scarri…

This completed Phase 2 study tested an oral antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. Participants took either the drug or a placebo tablet for a short time. The main goal was to see if the drug could lower the amount of virus in the nose and th…

Researchers at Xiangya Hospital of Central South University are comparing different sedation regimens used for patients with severe pneumonia in the intensive care unit. The study looks at 260 patients and measures how long they need mechanical ventilation, how well sedation targ…

Researchers test whether adults with chronic coronary artery disease can safely go home within 6 hours after a successful elective transradial heart stent procedure, compared with the usual overnight hospital stay. The trial enrolls 58 adults at a Brazilian public hospital and fo…

This phase 2b trial tested whether saroglitazar magnesium can help people with nonalcoholic steatohepatitis (NASH) and liver fibrosis. 189 adults took either a 2 mg or 4 mg dose of the drug or a placebo daily for several months. The main goal was to see if the drug could resolve …

Researchers compare two surgical approaches for primary congenital glaucoma, a rare eye condition in children that raises pressure inside the eye. One group receives a combined operation: nasal goniotomy plus temporal trabeculotomy. The other group receives temporal trabeculotomy…

This completed study looked at 60 adults with acute decompensated heart failure and kidney impairment. Researchers compared three intravenous heart medications—levosimendan, dobutamine, and milrinone—to see which one improved heart and kidney function best. The goal was to find t…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tests a web-based program called CAMP Air to help urban teens, mostly Black and Hispanic, better control their asthma. The program teaches steps to prevent symptoms and manage the condition. Researchers will check if it reduces asthma attacks and urgent care visits.

This early-stage study tests a new drug called LY3971297 in healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. The main goal is to check for side effects and measure how the drug moves through the body. The study involves up t…

Researchers at a Belgian hospital are tracking how well bevacizumab eye injections work and how safe they stay over the long term in adults with abnormal blood vessel growth in the retina or macular edema. The study follows 583 participants who receive the drug directly into the …

This completed Phase 3 study tested whether a battery toothbrush paired with a stannous fluoride toothpaste is more effective at reducing plaque and gingivitis than a regular fluoride toothpaste with a manual toothbrush. 130 adults with mild gum disease brushed twice daily for 12…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This early-stage trial is testing a drug called vixarelimab in 24 people with moderate to severe ulcerative colitis who have not improved with standard treatments. The study looks at how the drug affects the gut, how it moves through the body, and whether it is safe. It is too ea…

Researchers compare the Trilogy ventilator, a portable breathing machine, with conventional mechanical ventilators in people who need breathing support. Participants use each device for one hour while set to their usual breathing mode and prescription settings. The study measures…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

Researchers are testing whether delivering chemotherapy directly into the liver through a catheter in the hepatic artery can help people with biliary tract cancer or colorectal cancer that has spread to the liver and stopped responding to standard intravenous chemotherapy. The st…

This study compares two methods for monitoring the blood thinner heparin in hospitalized patients with blood clots. One method uses a standard clotting test (PTT), while the other uses a newer test (anti-Xa). The goal is to see which method helps patients reach the right blood th…

This Phase 3 trial tests whether a tenecteplase biosimilar called GNR-060 works as well as the reference drug Metalyse in people having a severe heart attack known as ST elevation myocardial infarction. Participants receive a single weight-based intravenous dose of one drug or th…

Researchers are testing whether adding an experimental drug called AJU-C52 helps lower blood pressure in adults with essential hypertension that is not well controlled on a standard treatment called C52R1L. The trial enrolls about 193 adults with high blood pressure despite medic…

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

Researchers are testing whether switching from a standard three-drug HIV regimen to a two-drug regimen keeps the virus under control just as well. The trial enrolls 134 adults whose HIV is already suppressed on a three-drug regimen and randomly assigns them to continue that regim…

This study tests whether dapagliflozin, a drug currently used for diabetes, can help control inflammation in people with mild-to-moderate ulcerative colitis. Researchers will give 50 adults either dapagliflozin plus standard mesalamine or mesalamine alone, and track changes in sy…

This study looked at whether pioglitazone, a drug used for diabetes, can help people who recently stopped using cocaine stay off the drug when combined with talk therapy. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and redu…

This phase 2 study tested whether adding the targeted drug erlotinib to standard chemotherapy (docetaxel) works better than chemotherapy alone for people with advanced non-small cell lung cancer whose first treatment stopped working. 156 participants were randomly assigned to one…

This study tested a new once-weekly injection called UBT251 in 211 adults with type 2 diabetes. Participants received either UBT251, a placebo, or the existing drug semaglutide for 24 weeks. The main goal was to see how well UBT251 lowers blood sugar (HbA1c) and to find the right…

Researchers are testing whether a telehealth counseling program can reduce heavy drinking and improve HIV viral control in people with HIV. Participants receive either a single brief alcohol counseling session or that session plus a referral to a program with multiple video couns…

This phase 2 trial tests a daily oral drug called sevasemten (EDG-5506) in 244 adults and adolescents with Becker muscular dystrophy, a condition that causes progressive muscle weakness. The study compares the drug to a placebo to see if it can reduce muscle damage, improve walki…

This study tests whether transplanting healthy bacteria from the eye's surface can help people with moderate to severe dry eye. Forty participants will either receive the bacteria transplant or a fake procedure. Researchers will measure changes in eye discomfort and surface damag…

This early-phase trial tests whether adding an experimental drug called NKTR-255 to standard CAR-T cell therapy can improve outcomes for people with large B-cell lymphoma that has returned or not responded to treatment. The study involves 27 adults and focuses on safety and how w…

This phase 2 trial tests an experimental drug called XmAb20717 in 27 adults with advanced biliary tract cancers (bile duct or gallbladder cancer) that worsened after standard chemotherapy. The drug is a bispecific antibody designed to activate the immune system against cancer by …

This study tests whether the anti-inflammatory drug celecoxib can help people with a specific type of depression linked to inflammation, called immuno-metabolic depression (IMD). Researchers will give 140 people with IMD either celecoxib or a placebo, in addition to their usual d…

This study tests a small ear device that gently stimulates nerves to see if it helps people with both PTSD and opioid use disorder stay on buprenorphine therapy. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if they keep t…

This early-stage study tests a new drug, BGB-11417, in 64 adults with B-cell blood cancers that have come back or not responded to prior treatments. The main goals are to find the safest dose and understand side effects. Researchers will also look for signs that the drug shrinks …

Researchers are running a Phase I trial of HG146, an experimental oral drug, in adults with advanced solid tumors or lymphoma that have worsened despite standard treatments. The study first tests HG146 alone to find a safe dose, then tests it combined with a PD-(L)1 antibody, a t…

Langerhans cell histiocytosis is a rare disease in which immune cells called Langerhans cells build up in organs and cause damage. This phase 2 trial gives adults newly diagnosed with the disease a combination of two chemotherapy drugs, methotrexate and cytosine arabinoside (cyta…

This study tested a new weekly injection called UBT251 in 205 overweight or obese adults to see if it helps with weight loss. Participants received different doses of the drug or a placebo for 24 weeks. The main goal was to measure the percentage change in body weight, with addit…

Researchers are testing a new oral drug called rintodestrant (G1T48) in women with advanced breast cancer that is estrogen receptor-positive and HER2-negative. The trial gives the drug alone or with palbociclib, a standard breast cancer medicine. The main goals are to find a safe…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 people with COPD. The goal was to see if the triple combination improves lung function and reduces serious breathing attacks over 52 weeks. Participant…

Researchers are testing whether serine supplements and fenofibrate can reduce levels of deoxysphingolipids, which are harmful fats linked to macular telangiectasia type 2 (MacTel). Adults with confirmed MacTel type 2 join one of six groups: different doses of serine, fenofibrate …

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This small Phase 2 study tested INV-102 eye drops in 19 people with diabetic macular edema, a swelling in the back of the eye caused by diabetes. Participants used the drops daily for 8 to 12 weeks. The goal was to see if the drops could improve retinal health and reduce swelling…

This study compares an electronic brief intervention delivered via an app to a traditional face-to-face brief intervention for people with unhealthy alcohol use. Researchers will enroll 1,200 adults in Mexico and South Africa who score 8 or higher on an alcohol screening test. Pa…

Researchers are testing a drug called APR-246 combined with azacitidine in people with myeloid blood cancers that carry a TP53 mutation, including myelodysplastic syndrome, acute myeloid leukemia, myeloproliferative neoplasms, and chronic myelomonocytic leukemia. The trial aims t…

This early-stage trial tests a drug called PH-762, injected directly into skin tumors, for people with squamous cell carcinoma, melanoma, or Merkel cell carcinoma. Participants receive four weekly injections into one tumor, then have it surgically removed about two weeks later. T…

Researchers are comparing two first-line treatment strategies for women with advanced HER2-positive breast cancer: pertuzumab plus trastuzumab and docetaxel, versus trastuzumab and docetaxel alone. The study uses real-world electronic health records from about 2,250 patients trea…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to bone tumors before surgery is safe and can prevent the cancer from returning. About 39 adults with cancer that has spread to their bones and who need surgery to stabilize a fracture risk will recei…

This study tests an experimental tablet called ASC30 in 100 adults with type 2 diabetes. The goal is to see if it safely lowers blood sugar and helps with weight over 13 weeks compared to a placebo. Participants must have stable weight and a BMI of 23 or higher.

Researchers are testing whether GNR-068, a ustekinumab biosimilar, works as well as the reference drug Stelara in adults with moderate to severe plaque psoriasis. About 422 participants receive either GNR-068 or Stelara as injections over several months, and everyone eventually r…

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

Researchers in China are testing three exercise programs for children and teens with obesity or metabolic syndrome. Participants are randomly assigned to low, moderate, or intermittent high intensity training using broadcast gymnastics and sports dance. The study measures changes…

Researchers are testing an experimental drug called arhalofenate (MBX-102) in adults with gout and high uric acid levels. Participants take either arhalofenate or a placebo once daily for four weeks. The trial measures changes in blood uric acid and checks for side effects.

Researchers are testing a new adhesive system that seals the great saphenous vein in people with varicose veins. The trial compares this adhesive, delivered through a tube, with radiofrequency ablation, a standard treatment that uses heat to close the vein. About 179 adults with …

Researchers are testing whether a breath test called FeNO, which measures inflammation in the airways, can help primary care doctors better adjust asthma treatment for adults. The study assigns entire clinics to either use FeNO measurements alongside usual care or continue with u…

Researchers are testing whether adding tofacitinib to prednisone works better than prednisone alone for people with active IgG4-related disease. The trial enrolls 58 adults with active disease and assigns them to either tofacitinib plus prednisone or prednisone alone. The main go…

Researchers test whether they can place sutures inside the uterus using a hysteroscope and the X-Tack device. The pilot enrolls women who are already scheduled for laparoscopic hysterectomy for benign conditions. After the sutures are placed, surgeons open the removed uterus to c…

This study tests a drug called leniolisib in 20 people with common variable immunodeficiency (CVID), a condition that weakens the immune system. All participants will receive the drug for 6 months, starting at a low dose and increasing. The main goal is to check safety and tolera…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

Researchers are testing whether arhalofenate, an experimental drug, can safely be combined with febuxostat to lower uric acid in adults with gout. The trial enrolls 32 people with gout and high uric acid levels. Participants receive both drugs at different doses over several week…

This study adapts a wellness program called Chetana to help men who have sex with men (MSM) and transgender women (TGW) in India who are living with HIV stay engaged in care. The program includes yoga, nutrition, legal advice, mental health support, and peer navigators who provid…

This study tests whether a steroid injection given during retinal detachment surgery can replace the usual course of antibiotic and steroid eye drops afterward. About 168 adults with a first-time retinal detachment will receive either the injection or standard drops. The goal is …

Researchers are testing whether adding the immunotherapy drug tislelizumab to standard TAC chemotherapy helps shrink triple-negative breast cancer before surgery. The trial enrolls 36 women with newly diagnosed triple-negative breast cancer. Participants receive six cycles of tis…

This study tested a plant-based tablet called PH3 in 100 adults with diabetic nephropathy (kidney damage from diabetes). The goal was to see if PH3 can safely reduce protein in the urine, a sign of kidney stress, over 24 weeks. Researchers also looked at the best dose to use in f…

Researchers are testing whether two dose combinations of metyrapone and oxazepam can help adults with cocaine addiction. The study enrolls 45 people aged 18 to 50 who want treatment and have cocaine in their system. Participants take the drugs or a placebo twice daily for six wee…

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

Researchers test whether fecal microbiota transplantation delivered by oral capsules can help cirrhosis patients whose hepatic encephalopathy no longer responds to standard lactulose and rifaximin. The trial enrolls 33 adults with cirrhosis and persistent or recurrent hepatic enc…

This phase III trial tests whether adding low-dose methotrexate to standard corticosteroid treatment works better than steroids alone for adults who develop acute graft-versus-host disease after a stem cell transplant. Participants receive either methotrexate or a placebo alongsi…

This completed Phase 4 trial tested two different doses of chemotherapy (standard and low-dose) combined with the immunotherapy drug Sintilimab in 20 people with advanced squamous non-small cell lung cancer. The goal was to see if the lower-dose combination could shrink tumors an…

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

Researchers are testing an experimental oral drug called MDR-001 in healthy adults and in people who are overweight or obese. The trial gives single and increasing repeated doses to see how the body processes the drug and whether it causes side effects. They also measure changes …

This Phase 3 study tests whether adding tiragolumab (an experimental immunotherapy) to the standard combination of atezolizumab plus chemotherapy can help people with untreated, widespread small cell lung cancer live longer without their disease worsening. About 123 participants …

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

Researchers are testing whether a combination of mycophenolate mofetil and steroids works better than cyclosporine at reducing protein in the urine of people with focal segmental glomerulosclerosis (FSGS), a rare kidney disease. The trial enrolls people aged 2 to 40 with biopsy-c…

This trial is testing whether regular, short periods of sunlight exposure can increase vitamin D levels in children aged 1-5 with cerebral palsy. Half the children will get 10 minutes of sun three times a week for 8 weeks, while the other half continues their usual routine. The s…

Researchers are testing an experimental oral drug called MBX-2982 in adults with type 2 diabetes. The trial compares three daily doses of MBX-2982 against a placebo and sitagliptin, a standard diabetes drug, over four weeks. Participants are treatment-naive or taking a single ora…

Researchers are testing whether a synbiotic supplement called SLP07 can reduce liver fat in people with metabolic dysfunction-associated fatty liver disease. The supplement combines probiotic bacteria, omega 3, and vitamin E. The trial enrolls 54 adults aged 50 and older who have…

This study tests an experimental drug called rezpegaldesleukin in 94 adults with severe to very severe alopecia areata, a condition causing significant hair loss. Participants receive either the drug or a placebo for 36 weeks, with an optional extension. The main goal is to measu…

This study looks at the long-term safety of a drug called itepekimab for people with chronic obstructive pulmonary disease (COPD). About 700 adults who already completed earlier itepekimab studies will receive the drug every 2 or 4 weeks for up to 52 weeks, plus a 20-week follow-…

Researchers are testing whether a higher dose of dexamethasone works better than a lower dose for adults on ventilators with acute hypoxemic respiratory failure caused by infections, including COVID-19. The trial enrolls 980 patients in Spanish intensive care units and randomly a…

Ulcerative colitis causes ongoing inflammation in the colon and rectum, and current treatments do not work for everyone. Researchers are testing whether adding pentoxifylline, a drug with anti-inflammatory and antioxidant effects, to standard care can reduce disease activity. The…

This study tests whether people with chronic kidney disease can safely eat potassium-rich fruits and vegetables instead of following the usual low-potassium diet. Thirty participants will receive home-delivered groceries with either high- or low-potassium produce in a random orde…

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

This study tested a smart cap that attaches to insulin pens to help people with type 1 diabetes track their injections and glucose data. 42 adults used the device or a blinded version for comparison. The goal was to see if it reduces time spent with high blood sugar and improves …

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

Researchers compare two weight-loss strategies in 66 obese women: a 16:8 time-restricted eating plan (fasting 16 hours, eating within 8 hours) plus home exercise, versus a standard calorie-restricted diet plus home exercise. Over 12 weeks, they measure changes in body composition…

This study is testing whether adding an experimental anti-inflammatory drug called NT-0796 to the weight-loss medication semaglutide can help people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 to 45 will take either the combination or a…

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

Researchers compare two drugs, metformin and febuxostat, for lowering uric acid in obese adults who have gout but not diabetes. Both drugs may reduce uric acid, the substance that forms painful crystals in joints. The trial measures changes in blood uric acid levels over time. Ab…

Researchers are testing whether lucitanib, an oral drug, can slow the growth of advanced thymic carcinoma that has worsened after at least one round of chemotherapy. The trial enrolls adults with recurrent or metastatic thymic carcinoma. In one part, participants receive lucitani…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

Researchers are testing whether adding fruquintinib to standard chemotherapy (mFOLFOX6 or FOLFIRI) helps people with metastatic colorectal cancer who have not yet received treatment for advanced disease. The trial enrolls adults up to age 75 with confirmed metastatic colorectal c…

Researchers test whether adding doxycycline to sitagliptin helps control blood sugar and heart health in adults over 40 with newly diagnosed type 2 diabetes. Participants receive both drugs, and the team tracks changes in fasting blood sugar and HbA1c. The trial also measures hea…

This study tests a structured, 8-week smoking cessation program delivered via weekly video group sessions. It enrolls adults addicted to nicotine who want to quit. Researchers track whether participants stay smoke-free six months after the program ends, and how their anxiety and …

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers compare two versions of corneal crosslinking to treat progressive keratoconus or corneal ectasia, conditions where the cornea thins and bulges. Both use riboflavin eye drops and ultraviolet light, but one delivers the light faster and more intensely. The trial measure…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This trial investigates how a new experimental drug called KL0011034 interacts with alfentanil, a strong opioid painkiller, in adults with moderate-to-severe chronic pain. The study measures how the drugs affect each other's levels in the body and monitors safety. Participants re…

Researchers at Tanta University are comparing melatonin with folic acid in adults who have type 2 diabetes and early kidney damage. All 75 participants receive standard diabetes care, with one group adding melatonin (3 mg daily) and another adding folic acid (400 µg daily). The s…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

Researchers are testing sorafenib, a drug that blocks enzymes tumors need to grow and cuts off their blood supply, in people with angiosarcoma that is locally advanced, has spread, or cannot be removed by surgery. The trial enrolls about 88 participants and measures how many rema…

This study looks at how well minimally invasive procedures (like balloons and stents) work for people with severe blockages in the leg arteries. It will track 1000 patients to see if these treatments restore blood flow and keep arteries open over time. The goal is to find the bes…

This trial tests whether an experimental antibody called 611, given as a shot alongside a topical corticosteroid, can improve moderate-to-severe atopic dermatitis (eczema) better than the steroid alone. Adults aged 18 to 75 with a history of inadequate response to topical treatme…

This study tested two treatments for people with advanced cancer who cannot have standard therapy. One group took a low-dose chemotherapy pill (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could slow cancer growth for…

This phase 3 trial is testing the safety and tolerability of fenfluramine (Fintepla) in 25 infants aged 1 to 2 years with Dravet syndrome, a severe form of epilepsy. The drug is given as an oral solution twice daily alongside other seizure medications. Researchers will monitor he…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

Researchers are testing whether combining cetuximab, a drug that blocks tumor growth, with stereotactic body radiation therapy can help patients whose head and neck cancer has returned after earlier radiation and cannot be removed by surgery. The trial enrolls about 45 people wit…

Researchers are studying aflibercept (Eylea), an anti-VEGF drug given as an injection into the eye, in adults aged 50 and older with wet age-related macular degeneration. Everyone in the trial receives three monthly loading doses over 12 weeks. The team uses detailed retinal scan…

This study will test if the Oura Ring can identify signs of high blood pressure using a new algorithm. Researchers will compare the ring's readings to what participants report about their own blood pressure. Up to 2 million adults in the US who already use an Oura Ring will take …

Hospitals use different definitions to diagnose undernutrition, and those definitions may label different numbers of patients as undernourished. This study compares the French HAS definition with the international GLIM definition in 260 adults hospitalized in diabetes-obesity, lu…

Women with pathological nipple discharge often need surgery to find the cause, but standard mammograms and ultrasounds can miss cancer. Researchers are testing a non-invasive breast scan called high-resolution magnetic resonance ductography (HR-MRD) that uses a powerful magnet an…

Researchers test whether checking infants with Down syndrome for obstructive sleep apnea every six months, starting at six months old, helps their brain development by age three. The trial compares a group that gets regular sleep studies to a group that receives standard care. Ab…

Researchers want to know whether a bedside device that measures how blood clots can predict which patients with an infection will develop sepsis. The study enrolls 147 adults arriving at an emergency department with a suspected infection. Everyone gives blood for the clotting mon…

Researchers are studying whether features from pretreatment 18F-FDG PET/CT scans can predict how well people with metastatic kidney cancer respond to first-line targeted therapy plus immunotherapy. The study reviews medical records and imaging data from 228 patients treated at a …

Researchers compare two devices, Amy Check and Osstell, for measuring the stability of dental implants placed during a graftless closed sinus lift. The trial enrolls 30 adults who need tooth replacement in the upper back jaw and have limited bone height. Each participant receives…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

Some people have a severe allergic reaction, called anaphylaxis, after a COVID-19 vaccine. This study checks whether those people can safely receive another dose. Researchers also run allergy tests to find out which vaccine ingredients, such as PEG2000 or PS80, might cause the re…

Malaria in pregnancy often causes no symptoms, yet it can lead to anaemia, premature birth, and low birth weight. Standard rapid tests miss many of these quiet infections. Researchers are comparing a new high-sensitivity rapid diagnostic test with conventional tests in 930 pregna…

Researchers are testing a new face mask, the Smart Mask V1 System, that uses built-in light sensors to measure blood oxygen (SpO2) and pulse rate. The study enrolls healthy adults aged 18 to 65 who wear the mask while breathing air with gradually lower oxygen levels in a special …

Researchers are studying whether small intestinal bacterial overgrowth (SIBO) is common in people with abdominal bloating or distension. Adults aged 18 to 70 with these symptoms take a breath test that measures hydrogen and methane in their exhaled air. The study aims to see how …

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

Researchers are studying whether PET scans help doctors plan radiation more precisely for people with locally advanced head and neck cancer. Participants receive 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy, which shape beams to the tumor. T…

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

This Phase 3 trial tests a radioactive imaging agent called 18F-mFBG to see if it can accurately detect neuroblastoma, a type of childhood cancer. The study involves 43 participants who either have or are suspected of having neuroblastoma. Researchers will compare the new PET sca…

Researchers are studying whether a point-of-care nucleic acid test can diagnose HIV faster than standard lab testing and help people get into care or prevention services sooner. The trial enrolls adults at a Seattle HIV clinic, including people living with HIV and those seeking t…

Researchers are testing whether a very-low-carbohydrate diet can help adults with prediabetes and obesity lose weight, reduce body fat, and improve insulin sensitivity. The trial enrolls adults aged 30 to 65 with obesity and newly diagnosed prediabetes. Participants are randomly …

Researchers are testing whether a six-month supervised exercise program can improve forearm muscle strength and support radial bone health in older adults living in nursing homes. Thirty-four participants are assigned to either an exercise group or a control group. The exercise g…

Researchers are testing whether a high-protein diet before and after abdominal surgery helps older veterans recover better. Participants receive either 30 grams of protein three times a day for two weeks before and four weeks after surgery, or standard nutrition education with on…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

Researchers are testing whether DHA-NAT, a substance made in the body from omega-3 fatty acids, can lower blood triglycerides after a high-fat meal. The trial enrolls 20 healthy men aged 18 to 30 with a normal body mass index. In a randomized, double-blind, crossover design, each…

Researchers at two intensive care units in Budapest studied whether professional oral care and staff education improve oral hygiene in critically ill adults. Dentate patients were assigned to receive either professional cleaning by dentists three times a week or standard care fro…

This study tested whether treating private well water with ultraviolet (UV) light can prevent stomach and respiratory infections in children under 5. Researchers gave 28 Pennsylvania households either a real UV device or a fake one and tracked illness symptoms via weekly texts. T…

Researchers are testing whether adding an in-service professional development component to the WayToServe online responsible beverage service training helps alcohol servers refuse service to intoxicated patrons more often. The trial enrolls licensed premises owners, managers, and…

Researchers compare two ways to place a pacemaker's ventricular lead in people who need permanent pacing for atrioventricular block. One method, conduction system pacing, targets the heart's natural electrical pathways; the other uses the traditional right ventricular apical posi…

This study tests whether a dental assistant can help patients with head and neck cancer keep their mouths clean during and after radiotherapy. Patients receive oral hygiene education and a written guide before treatment starts. Researchers measure plaque levels at the beginning a…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

Women with class III obesity who gain too much weight during pregnancy face higher risks of diabetes, high blood pressure, cesarean delivery, and larger babies. Standard prenatal care often does not include nutrition counseling based on weight. This trial tests whether adding gro…

Researchers test whether short messages sent through a mobile wellness app can increase flu vaccination rates among insured adults. The messages, delivered as push notifications and in-app posts, either highlight incentives or use generic wording. The study compares vaccination r…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

Researchers compare one French middle school that used the e-Bug educational programme with other schools in the region to see whether classroom lessons about vaccination relate to higher HPV and meningococcal ACWY vaccine coverage. The study uses only aggregated, anonymised vacc…

Older adults who have major reconstructive spine surgery often develop postoperative delirium, a sudden state of confusion that can lead to longer hospital stays and lasting cognitive problems. Poor pain control raises that risk, and opioids used for pain bring their own side eff…

Researchers in Shangrao, China, are testing whether short exercise videos played during school breaks can increase physical activity and improve attitudes toward exercise in overweight and obese children aged 9 to 15. About 100 participants are randomly assigned to either follow …

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers are testing whether a toothpaste containing proteins, enzymes, and fluoride improves gum health and reduces plaque more than a standard fluoride toothpaste. The study enrolls healthy adults aged 18 to 70 with mild gum inflammation. Participants use one of the two toot…

This study tests whether a mobile app called Safety in Seconds can effectively teach parents of infants about safe sleep practices to reduce the risk of Sudden Unexpected Infant Death (SUID). The app delivers educational modules on safe sleep, such as placing babies on their back…

Researchers are testing a field-based sexual health program for people recently exposed to HIV who were notified by New York City's partner services program. The program adds four services to standard contact tracing: HIV and STI testing in the field, same-day start of HIV preven…

Researchers are testing whether a 7-week attachment-focused therapy program can reduce the severity of substance use disorder in adults with insecure or disorganized attachment styles. The study enrolls 48 people receiving care at an addictology day hospital. Participants are ran…

This study tests whether using a special monitor (ANI) during ovarian cancer surgery to guide pain medicine can lower the chance of chronic pain three months after the operation. About 126 women having open surgery for ovarian cancer will be randomly assigned to standard care or …

Researchers test a robotic assistance module that attaches to an electric wheelchair and helps the driver steer. The study includes 25 adults with neurological conditions such as brain injury or neurodegeneration who have used an electric wheelchair as their main transport for at…

This study tested a device called Cereset Research that plays tones in response to a person's brainwaves, aiming to reduce stress and improve sleep. 94 stressed healthcare workers used the device for several sessions and were followed for a year. The goal was to see if the device…

This study tested whether ketoconazole, an antifungal drug, can reduce the skin rash caused by EGFR inhibitor cancer therapy. 58 participants with ongoing rash were given either ketoconazole or a placebo. The main goal was to see if the drug improved rash symptoms and quality of …

Researchers are testing whether injections of botulinum toxin into the soles of the feet can reduce blistering in people with localized epidermolysis bullosa simplex, a rare skin condition that causes painful foot blisters. The trial enrolls 18 people with similar blisters on bot…

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

Researchers are testing whether a probiotic capsule taken by mouth can reduce vaginal odor in healthy women aged 18 to 65. About 105 participants receive either the probiotic or a placebo for 15 days and answer weekly questionnaires plus a daily diary for roughly 75 days. The tri…

Hailey-Hailey and Darier disease are rare inherited skin conditions that cause painful, itchy lesions in skin folds. Sweating makes them worse, and standard treatments often do not work well. Researchers are testing whether botulinum toxin injections into large skin folds can red…

Researchers are testing whether a topical melatonin gel helps dental implants stay stable when placed immediately into tooth sockets that had chronic infection. Sixty adults with non-restorable teeth and long-standing apical lesions will receive either standard implant placement …

Researchers at Hanoi Medical University are studying zirconia laminate veneers, thin tooth-colored shells that bond to the front of teeth. The trial enrolls 50 people with chipped, discolored, spaced, or mildly crowded teeth. The team measures how well the veneers fit, how health…

This study is testing whether taking pumpkin seed oil extract can improve bladder function in people with overactive bladder. Researchers will ask 40 participants to take the supplement for 12 weeks and track their symptoms using surveys. The goal is to see if this natural option…

This trial compares a new treatment combining a woman's own platelet-rich plasma with hyaluronic acid against standard local estrogen therapy for genitourinary syndrome of menopause. It enrolls 192 sexually active women up to age 70 who have vaginal dryness, burning, or discomfor…

Researchers are testing whether mazdutide, a weekly injection, can lower androgen levels in obese women with polycystic ovary syndrome (PCOS). The trial enrolls 43 women who receive increasing doses of mazdutide for 24 weeks. The main goal is to see if the drug reduces the free a…

Many adults with ADHD still struggle with inattention, planning and impulsivity even after medication. Researchers are testing whether group cognitive behavioural therapy helps more than a structured activity group. About 226 adults with ADHD join weekly two-hour sessions for 12 …

Researchers are testing whether a guided exercise program done with a baby can improve body composition, stress, fatigue, and parent-child bonding in postpartum women. The trial enrolls healthy mothers who had uncomplicated vaginal deliveries and their healthy newborns. Over thre…

Researchers are testing whether stroke patients can safely use a hand rehabilitation robot called ReHandyBot on their own, first in a clinic and then at home. The study enrolls 15 adults who recently had a stroke and have hand weakness. Participants learn to use the robot with a …

This study tested a new drug called ENX-102 in 252 adults with generalized anxiety disorder. Participants received either the drug or a placebo for several weeks. Researchers measured changes in anxiety symptoms using a standard rating scale. The goal was to see if ENX-102 reduce…

This study tests a new treatment called GNR-127 for people with seasonal allergies to birch pollen. The treatment is a protein that aims to reduce allergy symptoms like sneezing, runny nose, and itchy eyes. The trial involves 150 adults and will check for safety and how well it w…

This early-stage trial tests a new drug called HRS-2129 in 200 people with moderate to severe knee osteoarthritis pain. Participants will receive either HRS-2129, a placebo, or an active comparator (celecoxib) to see if it reduces pain and improves joint function. The study is do…

This study tests whether a special infrared light can help nurses see veins better when placing IVs in lung cancer patients receiving chemotherapy. The goal is to reduce pain, improve comfort, and strengthen trust between patients and nurses. About 160 patients will take part, wi…

Researchers are testing whether an inhaled dual bronchodilator (umeclidinium/vilanterol) can improve heart function during exercise in people who have COPD, lung hyperinflation, and mild heart failure. About 60 adults aged 40 to 85 with these conditions will take either the drug …

This study tested a free smartphone app called the Healthy Minds Program (HMP) in over 1,100 US adults with mild to moderate depression. Participants used the app for 4 weeks and were compared to those who received only educational content or were placed on a waitlist. The goal w…

This study tests whether applying kinesio tape to the neck muscles can improve swallowing safety in people who have trouble swallowing after a stroke. Researchers will measure changes in swallowing using a special X-ray video before and right after the tape is applied. The study …

Researchers are testing whether adding interferential current or kinesio taping to pelvic floor muscle exercises helps women with primary dysmenorrhea. Sixty women aged 18 to 30 will be randomly assigned to one of three groups: exercises alone, exercises plus interferential curre…

Researchers at National Taiwan University Hospital are testing how different exercise programs affect people with atrial fibrillation. Participants take part in aerobic training, resistance training, or a control physical exercise program. The study measures heart rhythm over 14 …

Diabetic polyneuropathy damages nerves in the feet, dulling the sense of touch and raising the risk of unnoticed injuries. This trial tests whether transcutaneous electrical nerve stimulation (TENS) can restore that sensation. Researchers compare high-frequency TENS, low-frequenc…

Cervical radiculopathy happens when a nerve in the neck is compressed, causing pain, numbness, and weakness in the arm. Researchers are testing whether adding manual therapy to the lower back and sacroiliac joints makes neck-focused manual therapy work better. Adults aged 18 to 5…

Researchers are testing EMB-001, a combination of metyrapone and oxazepam, in adults with moderate-to-severe cocaine use disorder. The trial aims to see if the drug helps people stay away from cocaine during the last three weeks of treatment. About 80 participants will take eithe…

Researchers are testing whether inhaling a low dose of xenon gas can ease anxiety before laser vision correction. The trial enrolls 140 people who score high on stress and anxiety tests and are scheduled for ReLEx SMILE eye surgery. Participants receive either xenon or a standard…

Researchers are testing whether a structured program of interactions with horses improves quality of life for young people and women who have finished chemotherapy or radiotherapy for cancer or blood disorders. Participants are randomly assigned to receive standard follow-up care…

This study tests whether a daily supplement called APPORTAL® can reduce fatigue in breast cancer patients undergoing chemotherapy. The supplement contains a mix of vitamins, minerals, and other nutrients. 92 women will take either the supplement or a placebo for 8 weeks, alongsid…

This study tested whether wet cupping therapy, an ancient practice where small cuts are made on the skin and cups are used to draw out a small amount of blood, can help people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Half of the 100 particip…

This study is testing the drug eluxadoline (Viberzi) in children aged 6 to 17 who have irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if it improves stool consistency and is safe for kids. About 95 children will take either the drug or a placebo for 4 weeks, a…

Researchers compare catheter ablation with medication for people who have heart failure and persistent atrial fibrillation. Half the participants receive ablation to restore normal heart rhythm, and half receive standard drugs to control rate or rhythm. The trial measures changes…

Researchers are testing a cognitive behavioral therapy program designed for autistic teens who have anxiety, depression, or both. The therapy focuses on exposure and behavioral activation, with adjustments for autism. Teens and their caregivers take part together. The trial compa…

Researchers are testing whether 20 minutes of mindful breathing each day for 8 weeks can reduce symptoms and improve clinical measures in people with heart failure. The trial enrolls 64 adults with NYHA stage II or III heart failure. Half practice mindful breathing with audio gui…

People with type 2 diabetes often need daily insulin injections and blood sugar checks, which can cause pain and fear. Researchers are testing whether viewing a nature image on a screen for a few minutes before these procedures reduces pain and fear. The trial enrolls 64 adults w…

Researchers are testing an experimental drug called IRL201104 in adults with seasonal allergic rhinitis triggered by grass pollen. Participants receive six intravenous doses over 10 weeks. The trial measures how the skin reacts to a controlled allergen challenge, comparing IRL201…

This study is testing whether personalized text messages can help older adults (age 50+) with heart failure improve their self-care, like taking medications correctly and following a heart-healthy diet. Thirty participants will be split into two groups: one gets usual care plus t…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

Researchers test whether repetitive transcranial magnetic stimulation (rTMS) can reduce depression and anhedonia, the inability to feel pleasure, in teenagers. The trial enrolls 88 adolescents with major depressive disorder who score high on measures of depression and anhedonia. …

Researchers compare three dietary approaches for adults with irritable bowel syndrome (IBS): a low-FODMAP diet, adapted NICE dietary advice, and adapted NICE advice combined with 16:8 intermittent fasting. About 90 adults aged 18 to 65 with IBS follow one diet for two weeks. The …

This study tested whether taking a cistanche supplement for 8 weeks, along with a supervised training program, improves anaerobic exercise performance and recovery in young men. 56 men aged 18-25, either elite or amateur athletes, were randomly assigned to receive cistanche extra…

Researchers at the University of Alcala are testing whether a three-month strength and balance training program changes walking patterns and pelvic floor muscle activity in sedentary menopausal women. Thirty-four women aged 45 to 77 will either join guided training sessions twice…

This study compared two common surgeries for kidney stones 20 mm or smaller: super-mini percutaneous nephrolithotomy (SMP) and flexible ureteroscopy (fURS). Researchers in Vietnam randomly assigned 72 adults to one of the two procedures and measured how well the stones were remov…

Researchers at Hebrew University of Jerusalem are testing a group program called Cog-Fun Ageing for older adults who feel their memory is worsening even though standard tests do not show it. The program involves 14 weekly group sessions led by occupational therapists, where parti…

Researchers are testing whether a new eye gel called Myrialen works as well as an existing gel called Recugel in people with moderate to severe dry eye syndrome. Both gels contain 5% dexpanthenol and are applied as drops four times a day for 30 days. The trial enrolls about 125 a…

This study tests whether suvorexant, a drug used for insomnia, can reduce nicotine cravings and withdrawal symptoms in daily smokers. Participants, who smoke at least 5 cigarettes a day and are nicotine-dependent, will receive either a low or high dose of suvorexant or a placebo.…

This study is testing whether a low dose of ketamine can reduce the amount of strong painkillers (opioids) needed and improve pain control in people recovering from thoracic endovascular aortic repair (TEVAR). About 30 adults scheduled for this surgery will receive either ketamin…

Researchers are testing an experimental oral drug called XEN1101 in adults with major depressive disorder. The trial enrolls 168 people aged 18 to 65 who are in a moderate to severe depressive episode. Participants receive either 10 mg or 20 mg of XEN1101 or a placebo for six wee…

This study tested a group teletherapy platform called TheraGroup for Black college students dealing with anxiety and depression. Forty students took part in 12 weeks of cognitive behavioral therapy (CBT) coping skills training delivered online in a group setting. The goal was to …

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

Researchers at Meiho University are studying whether applying an oral moisturizing gel changes the mix of bacteria in the mouths of older adults living in long-term care. The trial enrolls people aged 65 and older who have lived in a care facility for at least six months, includi…

Researchers are testing whether lavender aromatherapy or calming music can improve sleep and brain oxygen levels in children with epilepsy. The trial enrolls 90 children who have generalized tonic-clonic seizures and take at least one anti-seizure drug. Children are assigned to r…

Researchers compare spinal anesthesia and general anesthesia for people having hip or knee replacement surgery for osteoarthritis. The trial checks whether patients can safely walk 5 meters within 6 hours after surgery and how they feel in terms of pain, nausea, dizziness, confus…

Researchers are studying whether injecting platelet-rich plasma (PRP), a concentrated mix made from a patient's own blood, into the knee can reduce pain and improve movement in people with moderate knee osteoarthritis. The study enrolls adults over 50 with persistent knee pain an…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

This study tests a dual-task training program for children aged 6-8 with unilateral cerebral palsy. About 70 participants will be split into two groups: one doing balance exercises while also performing fine motor tasks, and the other doing single-task exercises. The goal is to s…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

Researchers are testing whether a combined exercise program can improve muscle thickness, balance, and fall risk in people with multiple sclerosis who also have sarcopenia, a condition involving loss of muscle mass and strength. Participants in the exercise group attend 60-minute…

This study tests whether a set of breathing exercises, called breath booster training, can strengthen respiratory muscles and improve quality of life in people on hemodialysis. Fifty patients aged 50 to 60 will do the exercises three times a week during their dialysis sessions. R…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

Researchers compare two chest drain sizes, 20-Fr and 24-Fr, in people having part of a lung removed for early-stage lung cancer. After surgery, each participant receives one of the two drains to clear fluid and air from the chest. The trial tracks complications such as collapsed …

Researchers are testing whether an online exercise and self-massage program can lower jaw pain and improve jaw movement in adults with bruxism, the habit of grinding or clenching teeth. Participants complete eight sessions over four weeks, either exercising live with a physical t…

Researchers compare two six-week stress-management programs for female hospital nurses and midwives: heart rate variability biofeedback and eurythmy therapy. Participants are assigned at random to one program. Before and after, questionnaires and heart rate measurements track cha…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

Researchers are testing whether a 12-week Taekwondo training program can help adults with ankylosing spondylitis and axial spondyloarthritis. The trial enrolls 21 adults aged 19 to 59 who have stable treatment or no medication for at least three months. Participants join either a…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

Researchers at Hanoi Medical University are testing whether personalized meals and diet coaching help stomach and colon cancer patients who are starting chemotherapy. About 120 adults receive tailored menus in the hospital, then learn to prepare high-energy, high-protein diets at…

This early-stage trial tested an experimental eyedrop called INV-102 in 84 adults with moderate dry eye disease. The study had two parts: first, checking safety at different doses, and second, seeing if the drops improve eye dryness symptoms after two weeks. Participants used the…

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

Researchers compare two spinal anesthesia mixtures for pain relief after lower limb surgery. One group receives bupivacaine alone, and the other receives bupivacaine plus tramadol. The trial measures pain scores and how long it takes before patients need additional pain medicine.…

Researchers are testing whether adding neuromuscular electrical stimulation (NMES) to chest physiotherapy helps older adults with severe COPD walk farther and gain muscle strength. Sixty participants receive either chest physiotherapy alone or chest physiotherapy plus NMES applie…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

Researchers are testing whether giving children a popit toy or a stress ball during inhaled medication can reduce anxiety, fear, and distress. The trial includes children aged 4 to 6 who come to a pediatric emergency unit with a respiratory condition needing nebulizer or inhaler …

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers are studying ozone therapy in adults who have a herniated lumbar disc and are on a waiting list for discectomy or microdiscectomy. Participants receive ozone injections and are followed for up to two years. The study measures changes in sciatic and lumbar pain, how ma…

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

Researchers are testing an experimental eyedrop called INV-102 in adults with acute infectious keratoconjunctivitis, a common eye infection that causes redness and discharge. The Phase 2 trial randomly assigns participants to receive either INV-102 or a vehicle drop for one week,…

Researchers are testing an 8-session mindfulness-based self-compassion program for women diagnosed with breast cancer. The program combines meditation, yoga, and homework to help participants focus on the present moment. The trial measures changes in self-esteem and spiritual wel…

Keloids are raised, itchy scars that grow beyond the original wound and often return after treatment. Researchers are testing dupilumab, an antibody that blocks two inflammation signals, in 20 adults with keloids. Participants receive the drug and doctors track scar appearance, i…

Researchers at Pamukkale University are testing whether adding virtual reality cycling to standard pulmonary rehabilitation helps people hospitalized for a COPD flare. Fifty participants with moderate COPD receive either the virtual reality add-on or standard rehab alone. The tri…

Researchers are testing whether a New Zealand blackcurrant extract can reduce muscle damage, soreness, and inflammation in elite male taekwondo athletes after high-intensity training. Twenty-nine athletes take either the extract or a placebo for seven days. The study measures blo…

Researchers are testing an experimental eyedrop called INV-102 in adults with moderate to severe dry eye disease. The trial compares INV-102 with a vehicle drop over four weeks of repeated dosing. The main goal is to see whether INV-102 reduces corneal damage, measured by a stand…

This study tests whether a special nano calcium fluoride varnish, a diode laser, or both together can reduce tooth sensitivity. Thirty adults with sensitive teeth will receive one of the treatments and rate their pain on a scale. The goal is to see which approach provides the bes…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers are comparing two diets to see whether either one reduces fatigue in people with relapsing-remitting multiple sclerosis. Participants follow their usual diet for 12 weeks, then are randomly assigned to the Swank low-saturated-fat diet or the Wahls Elimination modified…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

Researchers are testing two eye drops that contain hyaluronic acid and amino acids in people with dry eye syndrome. Adults with moderate to severe dry eye receive the 0.30% drop, while those with mild dry eye receive the 0.15% drop. The study measures changes in eye surface stain…

Researchers compare kalifilcon A daily disposable toric contact lenses with Ultra for Astigmatism lenses in adults who already wear soft contacts and need astigmatism correction. Each participant wears both lens types for about one week each, in random order. The study measures h…

Researchers at Sohag University are studying a minimally invasive spine surgery called MI-TLIF for people with degenerative lumbar and lumbosacral spine diseases. The trial enrolls about 30 adults with conditions such as degenerative spondylolisthesis, disc herniation, or recurre…

This study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, brain scans, and inf…

Researchers test a 10-week lifestyle program for people who have finished cancer treatment. The program combines structured exercise, nutrition counseling, and behavioral therapy. They compare it with a waitlist group to see how it affects cardiorespiratory fitness and body weigh…

Researchers test a guided exercise program for people aged 60 and older recovering from lung cancer surgery. The program combines breathing exercises, shoulder training, and strength work, taught through videos and a manual. The trial measures how far participants can walk in six…

Nausea and vomiting are common after bariatric surgery, and researchers want to know whether a simple cold compress can help. In this trial, 60 adults having weight-loss surgery receive a gauze-wrapped cold pack on the upper neck for five minutes, and care teams rate their nausea…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

Researchers at the University of Minnesota are testing whether exercise reduces the amount of time people spend in atrial fibrillation. The trial enrolls 60 sedentary adults aged 18 to 65 who have symptomatic, non-permanent AF. Participants are assigned to high-intensity interval…

Researchers compare two dental implant connection designs to see how each affects the bone around implants that hold lower dentures. Fourteen fully edentulous men, aged 45 to 60, receive two implants in the lower jaw, with one group getting internal tri-lobe implants and the othe…

Researchers are testing whether a horticultural therapy program can reduce anxiety and improve quality of life in older adults. The trial enrolls 56 volunteers who take part in gardening activities. Participants complete standard questionnaires about anxiety and well-being before…

Researchers at National Taiwan University Hospital are testing whether a single-port robotic surgery system can safely remove the gallbladder and clear stones from the bile duct in one operation. The study enrolls 24 adults with symptomatic gallstones, with or without bile duct s…

People with Parkinson's disease often struggle with walking, and their brains have trouble learning new movement skills. Researchers want to know if adding aerobic exercise or resistance exercise after gait training helps them learn and remember walking tasks better than gait tra…

This study tests whether a personalized 4-week exercise program can improve quality of life and physical function in men with metastatic prostate cancer who are receiving radiation therapy. Eighty participants will either exercise or not, and researchers will track changes in wel…

This study tests a new artificial tear called ABBV-444 against an existing brand, Refresh Optive, in 250 adults with dry eye disease. Participants use the assigned eye drops for 90 days. The goal is to see if the new formula improves eye comfort and surface health better than the…

Researchers at Ain Shams University are testing whether aloe vera gel, placed inside a tooth after root canal cleaning, reduces inflammation and pain better than the standard calcium hydroxide dressing. The trial enrolls 33 adults with dead or dying teeth and infection around the…

This study follows 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life over time. Researchers want to understand how well patients tolerate this treatment and how it affects t…

Researchers are studying whether a 6-month home walking program can help people with peripheral arterial disease of the legs. Participants wear a smartwatch that counts daily steps and receive weekly phone calls from a researcher who reviews their activity and offers guidance. Th…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

Doctors often place a ureteral stent after flexible surgery to remove kidney stones, but stents cause discomfort and may need a second procedure for removal. This study at Ain Shams University follows 140 adults with upper urinary tract stones up to 2.5 cm who have the surgery wi…

Researchers test whether adjusting cardiac rehabilitation to each person's muscle power profile and heart rate variability helps heart attack survivors recover better. Adults who had acute coronary syndrome in the past six months and received a stent or bypass surgery join the st…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers test a 12-week structured exercise program for employees at a medical garment factory. The program includes 24 sessions with aerobic exercise, team games, and stretching. The study measures changes in productivity, performance reviews, job motivation, and quality of w…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

Researchers are testing whether showing adults with gingivitis personalized 3D images of possible future gum changes helps them brush and clean between their teeth more consistently. The study enrolls 88 adults aged 18 to 60 with gingivitis, divided into three groups. One group r…

Researchers compare three ways to preserve the jawbone after a tooth is removed. Participants are randomly assigned to receive no bone graft, a graft made from their own extracted tooth, or a synthetic bone substitute called beta-tricalcium phosphate. The trial measures changes i…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study looked at whether giving a specific type of numbing medicine (called PECS) during mastectomy surgery can lower the chance of having chronic pain 6 months later. It included 194 women having a breast removed, with or without lymph node removal or reconstruction. The goa…

Researchers are testing whether AI-generated videos shown through a virtual reality headset can reduce fear and pain for boys aged 4 to 12 during circumcision. The trial assigns 80 children to either the VR distraction or routine care. Children, parents, and nurses rate pain and …

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study looked at whether adding nutrition and hygiene support to an existing farming program can reduce malnutrition in pregnant women and their children. About 1,200 pregnant women in Kenya took part, with half getting the extra nutrition help. The goal was to see if childre…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

Researchers are examining skin cancer among people whose jobs involve long hours in the sun. The study uses national administrative and medical records to describe who develops these cancers, including age, sex, region, cancer type, and disability outcomes. The goal is to underst…

Researchers are following people with Leber congenital amaurosis caused by RPE65 gene mutations to see how their vision and retinas change over time. The study enrolls children and adults, ages 3 and older, who have this inherited retinal dystrophy. Participants undergo regular e…

Researchers reviewed hospital records from 1,441 patients to compare fungal infection rates during the SARS-CoV-2 pandemic and afterward. They calculated positivity rates for Candida and Aspergillus species and other fungi. The study examines whether infection control measures ch…

This study looks at how the drug Hydronidone is absorbed, broken down, and removed from the body. Eight healthy Chinese men will take a single dose with a radioactive tracer so researchers can measure the drug in blood, urine, and stool. The goal is to understand the drug's journ…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

This study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…

Researchers are building risk models to predict death or rehospitalization within a year for people aged 80 and older who have heart failure with preserved ejection fraction and were hospitalized for acute heart failure. The study collects clinical and biological data during hosp…

This study looked at 488 adults with alcohol use disorder who had suicidal thoughts or attempts. Researchers wanted to understand why some people call the National Suicide Prevention Lifeline during a crisis and others don't. They also tested if a therapy session about the hotlin…

This completed study tested an oral form of the painkiller nalbuphine, called PHN131, in 16 healthy adults. The goal was to see how the body absorbs and processes the pill compared to the injected version. Researchers also monitored safety by checking vital signs like blood press…

Researchers want to know whether a specific brain wave, called mismatch negativity, can serve as a marker for problems locating sound. They will compare three groups: people with normal hearing, people with single-sided deafness, and people with a cochlear implant in one ear. Par…

This early-stage trial is testing a new drug called HRS-9813 in 20 healthy volunteers to see how it interacts with two standard treatments for pulmonary fibrosis (lung scarring): pirfenidone and nintedanib. The goal is to measure drug levels in the blood and check for side effect…

This study tests a new way to find the first lymph node (sentinel node) during breast cancer surgery. Instead of using the usual armpit hairline as a guide, doctors will use ultrasound to mark the exact spot. The goal is to see if this leads to a smaller cut, less tissue damage, …

This study looks at whether a short sleep education program can improve sleep habits and quality in health sciences students. About 100 students will attend four weekly 40-minute classes covering bedtime routines, caffeine limits, and stress management. Researchers will measure s…

This study looked at how two prostate cancer drugs, darolutamide and enzalutamide, affect thinking and memory in men with advanced prostate cancer. About 111 men took one of the two drugs and completed computer-based cognitive tests over time. The goal was to see if one drug caus…

Children with growth hormone deficiency often need daily injections, which can be hard to keep up with. Researchers in Belgium and Luxembourg are asking families in the BELGROW registry to fill out a questionnaire about whether they would consider switching to long-acting growth …

This observational study follows 75 people with shoulder impingement syndrome who are already receiving standard physical therapy. Researchers want to see if nerve-related pain and negative thinking about pain (called pain catastrophizing) affect how well patients stick to their …

Researchers collect small samples of abdominal fat during planned surgery to study how fat tissue releases chemical messengers called endocannabinoids. They compare samples from people with obesity, with or without type 2 diabetes, to samples from people without these conditions.…

This study tests whether a new, high-field 3T MRI technique can more accurately pinpoint the subthalamic nucleus — a key brain area targeted during deep brain stimulation (DBS) for Parkinson's disease. Researchers will compare images from the new method with standard 1.5T MRI in …

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

This study looked at whether obesity increases the body's production of oxalate, a substance that can lead to kidney stones. 58 adults without a history of kidney stones ate a special low-oxalate diet for 4 days and provided urine samples. Researchers measured oxalate levels to s…

This early-stage study tests a new formulation of the cancer drug HRS-2189 in 28 healthy adults aged 18-45. The goal is to compare how the body absorbs the new versus the old tablet version and to check for safety. Participants will take a single dose of each formulation in rando…

Researchers at Peking Union Medical College Hospital are observing 121 older adults scheduled for non-cardiac surgery under general anesthesia. They want to see whether a drop in blood pressure after eating is related to a sudden drop in blood pressure during anesthesia induction…

Children with congenital heart disease often need a breathing machine after surgery, and the pressure it creates can affect blood flow to the brain. This study compares conventional ventilation with NAVA, a mode that works with the child's own breathing signals, in 30 children re…

Researchers at LMU Munich are studying how children, teenagers, and parents use a German website called 'ich bin alles,' which provides evidence-based information about depression in young people. The study aims to understand who visits the site, how they perceive its content, an…

Researchers in the Ile-de-France region are following adults hospitalized with COVID-19 or suspected of having it. They collect blood samples at admission and, for severe cases, at several later points, and they track health outcomes over time. The goal is to identify which facto…

This completed Phase 4 trial studied how sugammadex, a drug that reverses muscle relaxants, works in 48 patients undergoing laparoscopic surgery. Researchers measured drug levels in the blood and how quickly patients recovered muscle function. The study focused on patients with a…

This is the first time BAR502, an experimental drug for NASH (a serious liver condition), is being tested in humans. The study involves 52 healthy adults to check the drug's safety, tolerability, and how the body processes it. Participants receive either a single dose or multiple…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

Researchers compare two operations for pancreatic tumors: partial removal of the pancreas and duodenum versus total removal of the pancreas. They analyze anonymized hospital records from 2013 to 2022 for about 3,600 adults in Switzerland. The study asks whether total removal is l…

Researchers are comparing serious health events, such as death and unplanned hospital stays, between elderly residents of retirement homes and long-term care units who received a COVID-19 vaccination and those who did not. The study includes about 3,300 residents in the Ile-de-Fr…

Hospitals face rising numbers of patients with chronic and complex conditions, and care teams are stretched thin. Researchers at a Belgian university hospital are studying what happens when nurse practitioners join four departments, including digestive surgery, liver cirrhosis ca…

This study is looking at whether tracking tiny bits of tumor DNA in the blood can help predict if breast cancer will come back after chemotherapy and surgery. Researchers will take blood samples from 180 people every 6 months for 5 years. The goal is to see if these DNA clues can…

This study looked at 516 patients who had surgery for a torn aorta (aortic dissection). Researchers checked if a high ankle-brachial index (a simple test of blood flow in the legs) before surgery was linked to kidney problems afterward. The goal was to see if this test could help…

Researchers are analyzing national administrative records to see how often workers file recognized hernia claims and how those claims are distributed by job type, hernia type, and region. The study uses existing data from about 4,500 recognized occupational hernia claims, so no o…

This early-stage study will check if two different tablet forms of the drug HRS-1893 are processed the same way in the body. Thirty-six healthy adults will take both versions and have blood tests to measure drug levels. The goal is to see if the two formulations are equivalent, n…

Researchers are studying whether certain immune substances in the blood are linked to physical and mental abilities in people with relapsing-remitting multiple sclerosis. The study includes 20 adults aged 19 to 45 with mild disability. Participants give blood samples, and researc…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

Children can break the upper arm bone just above the elbow, and sometimes the break presses on blood vessels so the wrist pulse disappears. Doctors disagree about when to operate on those vessels and when to wait. This study follows 190 children up to age 15 at pediatric surgery …

This study compares a new formulation (AJU-G721) of a drug used for benign prostatic hyperplasia (BPH) to the original version (G721R) in healthy adult men. The goal is to see if the two versions are absorbed and processed by the body in the same way. Participants receive a singl…

Researchers want to know whether certain calcium channels, called Cav1, appear on the immune cells of children with allergic asthma. These channels normally sit on nerve and muscle cells, but earlier animal work hinted they might also show up on the T cells that fuel asthma infla…

This early-stage study is testing how the drug BMS-986435 behaves in the body and whether it is safe for people with mild to moderate liver problems compared to those with healthy livers. 24 adults will receive a single dose, and researchers will measure drug levels and monitor f…

Researchers at Ghent University Hospital are studying whether MRI scans combined with computer models can measure the pressure inside tumors. High pressure in tumor tissue can block cancer drugs from reaching their target. The study enrolls 22 patients with pancreatic cancer or w…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

Researchers measure levels of the protein periostin in the blood and adenoid tissue of children with enlarged adenoids. They compare children scheduled for adenoid removal with children who have only mild enlargement and no symptoms. The study asks whether periostin is linked to …

Researchers are testing whether high-definition transcranial direct current stimulation (HD-tDCS) changes brain blood flow and breathing muscle strength in adults with chronic obstructive pulmonary disease (COPD). Twenty participants receive three 20-minute sessions of brain stim…

This early-stage study tests a single dose of the experimental drug efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check safety, how the body processes the drug, and immune reactions. Participants will not receive any trea…

This study explores whether a special PET/MRI scan can predict how well esophageal cancer responds to chemotherapy and radiation given before surgery. Researchers will scan 121 patients during treatment and compare the images with the actual tumor response seen after surgery. The…

This early-stage study tests a higher dose of Hydronidone capsules in 138 healthy Chinese adults to see how the drug moves through the body and if it is safe. Participants will receive single or multiple doses, and some will take the drug with food to see if meals affect absorpti…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…

This study gives questionnaires to patients, interpreters, and healthcare professionals to understand how language and cultural differences impact care for women with gynecologic cancer. The goal is to identify barriers and improve the patient experience. About 45 people will tak…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

This study tested a new MRI technique using inhaled hyperpolarized xenon gas to detect early signs of bronchiolitis obliterans syndrome (BOS), a common form of chronic rejection after lung transplant. Only 3 participants were involved, and the goal was to see if the imaging could…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

Bronchoscopy lets doctors look inside the airways to diagnose and treat lung diseases, and deep sedation can make the procedure more comfortable and efficient. Deep sedation also carries risks, including low oxygen levels and airway blockage. This study observes whether giving a …

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This study is looking for new markers in blood and urine that could predict kidney injury after heart surgery in high-risk patients. Researchers will follow about 1,500 adults undergoing open-heart surgery and check for kidney problems within a week. The goal is to find better wa…

This study uses advanced brain imaging and non-invasive stimulation to understand how the brain changes in the early stages of Parkinson's disease. Researchers will compare people with early Parkinson's (not yet on medication) to healthy volunteers of similar age and sex. The goa…

This study tested whether training local community members as wellness coaches could help African American adults in economically disadvantaged areas manage their weight. Researchers recruited and trained coaches to lead a 12-week group lifestyle program. The goal was to see if t…

Researchers are studying a technique to remove fewer lymph nodes in women with breast cancer that has spread to the lymph nodes and who receive chemotherapy before surgery. The approach uses a clip placed in the affected node to guide surgeons during a selective axillary dissecti…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

Researchers at the American University of Beirut are studying whether the rate at which an e-cigarette emits nicotine, called nicotine flux, predicts how much nicotine reaches the body and how users feel. About 142 adult dual users of e-cigarettes and tobacco will use devices wit…

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …

Knee osteoarthritis treatments vary widely, and doctors lack clear guidance on which option suits which patient. This study follows 5,000 people with knee osteoarthritis who receive usual care, recording the treatments they get and how they fare. Researchers aim to map common tre…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

Researchers are looking at whether the FIB-4 index, a blood-based score that estimates liver fibrosis risk, tracks with the severity of obstructive sleep apnea (OSA) and low oxygen levels during sleep. They will review records from 373 adults who had full-night sleep studies, gro…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This study tested whether a home rehabilitation program, with daily activity tasks and heart rate monitoring sent by text or email, helps people recover better after a serious blood clot in the lung (pulmonary embolism). 32 adults who had been hospitalized for this condition took…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are studying how two types of ulcerative colitis treatment, tofacitinib and anti-TNF drugs, affect platelet function and the body's clotting system. The trial enrolls adults with ulcerative colitis and compares blood and tissue samples before and after they start trea…

Researchers are studying whether delays in follow-up colonoscopies after certain polyp findings raise the risk of advanced growths or colorectal cancer. The study looks at medical records of adults aged 45 to 80 who had serrated lesions or high-grade dysplasia found during a colo…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

Researchers are studying how traditional and non-traditional heart risk factors relate to cholesterol levels in hospitalized Mexican adults. The study focuses on HDL cholesterol, often called good cholesterol, and how it behaves in people who smoke or have certain dietary habits.…

Researchers want to understand what patients with early oesophageal cancer value most when deciding whether to have major surgery. The study uses interviews and a choice experiment with about 118 people under care for Barrett's, dysplasia, or oesophageal cancer. Participants answ…

This study looks at how the labels and marketing claims on cannabis products affect what people think about the product's risks and effects. About 2,000 adults in states where recreational cannabis is legal will answer online survey questions after viewing a cannabis advertisemen…

Metered-dose inhalers release propellant gases that add to the NHS carbon footprint, while dry powder inhalers do not. Researchers want to know whether giving NHS clinicians the carbon footprint of each inhaler changes which device they prefer for asthma patients. The trial asks …

Researchers are studying how chronic obstructive pulmonary disease (COPD) relates to sensorimotor function, thinking skills, pain sensitivity, and muscle quality. The study compares adults aged 40 to 65 with COPD at different disease stages against healthy adults of the same age.…

Researchers are analyzing records from about 180,000 people who received cochlear implants in China between 1995 and 2026. The study aims to map how severe hearing loss and implant use have changed over time, how age and gender patterns look, and how patients move between provinc…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

This study looked at how the drug remibrutinib behaves in people with severe kidney problems compared to healthy people. Researchers measured drug levels in blood and urine to understand how the kidneys process it. The goal is to help doctors decide the right dose for patients wi…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

This study collects videos and images from 1,650 adults having a camera test of their stomach or bowel (endoscopy). Researchers will use these recordings to see how well artificial intelligence (AI) can spot early signs of cancer. The goal is to improve detection and help doctors…

Researchers want to know if exercising in the morning or evening changes physical performance and blood markers in healthy young male soccer players. Eight participants complete the same jump and shuttle-run tests twice, once in the morning and once in the evening, with a four-da…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Using CT scans, researchers want to see how common this condition is and if it affects treatment timing. The goal is to better understand how muscle health rela…

Researchers are studying people who have surgery for cervical radiculopathy, a condition where a pinched nerve in the neck causes arm or hand weakness. The study follows about 2,000 patients to see how many recover full strength and whether factors like how severe the weakness wa…

Critically ill patients on hemofiltration face high odds of pressure injuries from immobility, medical devices, and long treatment hours. Researchers at one Turkish hospital observe 109 adults receiving hemofiltration in intensive care, tracking skin condition, consciousness, nut…

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

Researchers are studying whether protein patterns in the blood can predict which people with esophageal cancer will respond completely to combined chemotherapy and radiation. The trial enrolls about 50 adults with invasive esophageal cancer who receive standard radiochemotherapy.…

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study looked at the emotional and practical challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured how each person perceived the burden, using surveys and statistical analysis to find fa…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study explores whether things a mother is exposed to during early pregnancy might cause uveal coloboma, a rare eye condition present at birth. Researchers will survey mothers of affected children and compare their answers to historical data. The goal is to identify possible …

This study looks at whether a continuous glucose monitor (CGM) can provide better insight into blood sugar patterns in pregnant women at risk for gestational diabetes than the usual oral glucose tolerance test (OGTT). Researchers will give 400 high-risk pregnant women a CGM senso…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

Researchers at Renmin Hospital of Wuhan University are studying whether brown fat activity is linked to nonalcoholic fatty liver disease. They analyze stored PET/CT scans and blood samples from 96 people who had clinically indicated scans. The goal is to find blood proteins that …

Researchers are surveying people in Thailand who have chronic hepatitis B to find out how many also carry hepatitis D, a virus that can make liver disease worse. The study focuses on groups at higher risk, including people who inject drugs, men who have sex with men, prisoners, a…