Acute disease

Researchers are testing a new cell therapy called anti-FLT3 CAR-T (HG-CT-1) in adults and children with acute myeloid leukemia (AML) that has come back or stopped responding to standard treatment. The study is a Phase 1 dose-escalation trial, meaning its first goal is to find out…

Researchers test whether adding venetoclax to a standard conditioning regimen called FLAMSA-treosulfan is safe for people with high-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or secondary acute myeloid leukemia who are receiving a donor blood stem cell trans…

Researchers are testing a CAR-T therapy called pCAR-19B in people with CD19-positive B-cell acute lymphoblastic leukemia that has relapsed or stopped responding to standard treatment. Participants receive an intravenous infusion of their own immune cells, which have been engineer…

Older adults with acute myeloid leukemia (AML) often fare poorly with chemotherapy alone, and a stem cell transplant can offer better long-term survival but carries a high risk of transplant-related death. Researchers are comparing two drug combinations given before a haploidenti…

This trial tests different ways to prepare children and adolescents with acute lymphoblastic leukemia for a stem cell transplant. The goal is to see whether a conditioning regimen without total body irradiation works as well as one with it, and to find the best approach for diffe…

This trial is testing whether combining anti-CD19 CAR-T cell therapy with the drug lenalidomide can safely and effectively treat adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has returned or not responded to prior treatments. Participants…

This trial tests a new type of cell therapy called KCAT19 for people aged 16 to 65 with advanced B-cell blood cancers that have relapsed or not responded to at least two prior treatments. The therapy uses immune cells from a donor's cord blood, which are modified to recognize and…

This trial is testing whether a treatment plan tailored to each child's genetic risk can improve outcomes for relapsed acute lymphoblastic leukemia. Children and young adults up to age 22 whose leukemia has returned in the bone marrow receive a combination of chemotherapy drugs, …

This nationwide trial is testing whether adjusting chemotherapy intensity based on the amount of leukemia cells remaining after initial treatment (called minimal residual disease, or MRD) can improve outcomes for children and teens with high-risk acute lymphoblastic leukemia (ALL…

This phase 2 trial tests whether adding dasatinib and blinatumomab to standard chemotherapy can improve outcomes for children aged 1 to 19 with very high-risk acute lymphoblastic leukemia. The study focuses on patients with specific genetic markers or who did not respond to initi…

This trial tests whether using advanced genetic testing (NGS) to measure leftover cancer cells after initial treatment can help doctors tailor chemotherapy for children with standard-risk acute lymphoblastic leukemia. Around 116 children aged 1 to 10 will receive a standard chemo…

This large trial is testing whether adding the targeted drugs blinatumomab or venetoclax to standard chemotherapy can improve survival and reduce side effects in children with intermediate- or high-risk B-cell acute lymphoblastic leukemia (ALL). The study compares different sched…

This study tests a new approach to prevent leukemia from coming back after a stem cell transplant. It uses donor T cells that have been engineered to recognize and attack a specific target (HA-2) on leukemia cells. The trial enrolls adults with acute myeloid leukemia (AML) or mye…

Researchers are testing whether a new oral polio vaccine called nOPV2, given at birth, helps infants block type 2 poliovirus in their intestines. The trial enrolls 740 healthy newborns who have received standard injected polio vaccines. Scientists will check stool samples for sig…

This study compares three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to see which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and have their…

Researchers are testing whether adding an experimental drug called RVU120 to venetoclax can help adults with acute myeloid leukemia (AML) that has come back or stopped responding to earlier venetoclax-based treatment. The trial enrolls about 98 adults who have already failed a hy…

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in people with acute myeloid leukemia (AML). MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 par…

This early-stage trial tests two oral drugs, ziftomenib and quizartinib, together in adults with relapsed or hard-to-treat acute myeloid leukemia (AML) that has certain genetic markers. The goal is to find a safe and effective all-pill treatment for common AML subtypes. About 44 …

This study tests whether a combination of three drugs—calaspargase pegol-mknl, decitabine, and venetoclax—can help control relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LLy) in patients aged 1 month to 21 years. T…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML) that is newly diagnosed or has come back. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to see if the combo improves r…

This phase 2 trial tests a new drug combination for adults newly diagnosed with primary plasma cell leukemia, a rare and aggressive blood cancer. The treatment includes CM336 (a bispecific antibody) plus three other drugs. The study aims to see how many patients achieve deep remi…

This phase II trial tests whether adding gilteritinib to the usual two-drug therapy (azacitidine and venetoclax) can help older or frail adults with a specific type of acute myeloid leukemia (FLT3-mutated) achieve deeper remission. About 147 participants will be randomly assigned…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This study tests a new oral drug, QTX-2101, combined with standard ATRA therapy for adults newly diagnosed with a low-risk form of acute promyelocytic leukemia (APL). The goal is to see if the oral capsule works as well as the current intravenous treatment. About 150 participants…

This phase II trial is testing whether adding the drug venetoclax to standard chemotherapy can improve remission rates in younger patients with intermediate-risk acute myeloid leukemia (AML). About 153 participants will receive either standard chemo or a combination with venetocl…

This phase 2 trial is testing a combination of five drugs (fludarabine, cytarabine, filgrastim-sndz, gemtuzumab ozogamicin, and idarubicin) in 270 people with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome that have specific genetic changes. The goal…

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

Researchers are testing whether regulatory T cells taken from donated thymus tissue can control the dangerous immune overreaction that occurs in severe COVID-19 and acute respiratory distress syndrome (ARDS). The trial enrolls adults aged 18 to 65 who are hospitalized with acute …

This phase II trial tests whether adding enasidenib to standard ASTX727 and venetoclax improves remission rates in older adults (or younger unfit patients) with newly diagnosed IDH2-mutated acute myeloid leukemia (AML). About 93 participants will be randomly assigned to receive e…

This early-phase trial tests a new treatment called TSLPR-CART for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified in a lab to target a protein called TSLPR found on …

Researchers are studying the SPIKE FLOW endocardial lead, a temporary wire placed inside the heart to keep it beating during surgery or while doctors check a slow heart rhythm. The study enrolls 131 adults who need short-term cardiac pacing. Doctors implant the lead, measure how …

This early-phase trial tests a personalized treatment for people with blood cancers like leukemia. Doctors take a patient's own T cells, modify them in the lab to recognize unique cancer mutations, and infuse them back after a short course of chemotherapy. The goal is to see if t…

This early-stage trial is testing whether two drugs that lower metal levels in the body can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) respond better to chemotherapy. The study will enroll 58 adults and aims to find the safest dose and check f…

This early-phase trial is testing an experimental cell therapy called GT719 in 46 adults with relapsed or treatment-resistant B-cell lymphoma or leukemia that tests positive for CD19. The study aims to see if the treatment is safe and how well it works. Participants receive a sin…

This phase II trial tests several experimental drug combinations against the standard treatment for high-risk acute myeloid leukemia (AML) in patients aged 59 or younger. The goal is to see if newer regimens, including venetoclax and liposome formulations, can better shrink cance…

This study tests an experimental drug called NX-5948 in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to prior treatments, including BTK and BCL-2 inhibitors. The main goal is to see if the drug can shrink o…

This phase 2 trial is testing a combination of blinatumomab (an immune-boosting drug) with dasatinib or imatinib (targeted pills) and standard chemotherapy for people with a specific type of leukemia called Philadelphia chromosome-positive or Philadelphia chromosome-like B-ALL. T…

This phase 3 trial compares starting treatment with venetoclax and obinutuzumab right away versus waiting until symptoms appear in people with newly diagnosed, high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. About 247 participants will be randomly assigned t…

This study tests whether giving a chemotherapy drug (decitabine) plus a targeted therapy (ruxolitinib, fedratinib, or pacritinib) before a stem cell transplant helps people with advanced myeloproliferative neoplasms (MPN) get to transplant and have better outcomes. About 25 adult…

This study compares a new immunotherapy, MK-1045, to the standard drug blinatumomab in people whose B-cell acute lymphoblastic leukemia has returned or stopped responding to treatment. About 340 adults with CD19-positive leukemia will receive one of the two treatments. The goal i…

This phase I trial tests a new treatment for adults with acute myeloid leukemia (AML) who have minimal residual disease (MRD) — small amounts of cancer cells that remain after standard therapy. The treatment uses the patient's own T cells, genetically modified to recognize a prot…

Researchers are testing whether adding bempedoic acid to high-intensity statin and ezetimibe therapy within 72 hours after a heart procedure helps adults with acute coronary syndrome reach very low LDL cholesterol. Participants receive either the three-drug combination or the sta…

This large phase 3 trial is testing whether a new formulation of two chemotherapy drugs (CPX-351) and a targeted drug called gilteritinib can improve outcomes for children and young adults with newly diagnosed acute myeloid leukemia (AML). The study compares these new approaches …

This study tests whether giving a personalized dose of the chemotherapy drug fludarabine before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assign…

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that often requires a breathing machine. This trial compares two ways of using that machine: airway pressure release ventilation (APRV), which holds the lungs open longer with brief releases, and convent…

This study tests a drug called zilovertamab vedotin in children and young adults whose blood cancers (like certain leukemias and lymphomas) or solid tumors (neuroblastoma, Ewing sarcoma) have come back or not responded to treatment. The goal is to see if the drug is safe and can …

This phase 2 trial tests whether adding the targeted drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The study aims to see if this combination can reduce the amount of c…

This early-phase trial tests a two-step approach for people with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. First, patients receive intensive chemotherapy (CLAG-M or FLAG-Ida) followed immediately by a reduced-intensity stem …

This phase 3 trial will test whether adding the drug quizartinib to the standard two-drug combination (venetoclax and azacitidine) helps adults with newly diagnosed acute myeloid leukemia (AML) live longer. The study includes 376 people aged 18 and older who cannot receive intens…

This early-stage trial tests a new antibody called HT31-1 in 24 healthy volunteers to see if it is safe and how the body processes it. The antibody targets a protein linked to inflammation in acute respiratory distress syndrome (ARDS), a severe lung condition often caused by infe…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the d…

This study tests whether outpatient respiratory physiotherapy can prevent hospitalizations in infants up to 12 months old with mild to moderate acute viral bronchiolitis. The therapy includes gentle airway clearance techniques and, if needed, continuous positive airway pressure (…

This study tests two different doses of the drug quizartinib as a maintenance therapy for adults with a specific type of acute myeloid leukemia (FLT3-ITD positive) who are in their first complete remission after initial treatment and have not had a stem cell transplant. The goal …

This study tests an oral drug called revumenib in people with certain types of leukemia that have relapsed or not responded to standard therapy. The trial has two parts: first, finding the best dose, then testing that dose in four groups based on leukemia type. About 447 particip…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This early-phase study tests a new type of immune therapy for people with certain blood cancers (leukemias) that have returned or not responded to standard treatments. The therapy uses the patient's own T cells, which are modified in the lab to recognize and attack cancer cells c…

This early-phase trial is testing a new CAR T-cell therapy called AUTO1 (obe-cel) in up to 30 children with B-cell acute lymphoblastic leukemia or B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The therapy uses the child's own immune cells, which are…

Researchers are testing efgartigimod, an intravenous drug that reduces certain antibodies, in adults with anti-NMDAR encephalitis, a rare autoimmune condition that causes psychiatric symptoms, seizures, and movement problems. The trial enrolls 20 participants who receive four wee…

This study tests a new mix of drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML). The treatment combines a targeted drug (venetoclax) with two chemotherapy drugs, then switches to another chemo drug plus venetoclax. The goal is to see if this ap…

This study tests whether adding two targeted drugs, blinatumomab and venetoclax, to standard chemotherapy can improve outcomes for infants with a type of leukemia called acute lymphoblastic leukemia (ALL). About 153 infants will participate. The goal is to see if these combinatio…

This study tests a drug called binimetinib for people with hairy cell leukemia that does not have the common BRAF gene mutation. The drug targets a different gene, MEK, which is often altered in these patients. The goal is to see if it can shrink or control the cancer in 40 adult…

This early-phase trial tests a new treatment for hairy cell leukemia (HCL) that has come back or not responded to standard care. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. Up to 27 adults will receive chemo…

This trial tests whether fexofenadine, a common allergy medication, can help the heart heal better after a severe type of heart attack called STEMI. Participants will receive either fexofenadine or a placebo for six months, alongside standard care, after undergoing a procedure to…

This study tests whether daratumumab can eliminate tiny amounts of leukemia that remain after chemotherapy in people with T-cell acute lymphoblastic leukemia (T-ALL). About 20 adults whose cancer has come back or not fully cleared will receive the drug. The goal is to see if it c…

This study tests an experimental drug called CGT9486 (bezuclastinib) in people with advanced systemic mastocytosis, a rare and serious blood disorder. The drug aims to control the disease by blocking a key protein that drives abnormal mast cell growth. About 140 adults with aggre…

This study tests whether adding pivekimab sunirine to the standard drugs venetoclax and azacitidine helps adults with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 660 participants will be randomly assigned to receive ei…

This early-phase trial is testing a combination of two drugs—Hyper-CVAD chemotherapy and venetoclax—in 22 children and young adults whose leukemia has returned or not responded to treatment. The main goal is to find a safe dose and monitor side effects. If the combination proves …

This early-stage trial is testing an experimental drug called AMX-883, taken by mouth, for people with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. The study will first test AMX-883 alone, th…

This phase 2 trial is testing whether a single low dose of tocilizumab, a drug that blocks inflammation, can help people with sickle cell disease who develop acute chest syndrome—a serious lung complication. Researchers will enroll 200 patients aged 12 and older and track their o…

This study tests whether using stem cells from both a half-matched family donor and a cord blood donor can improve survival without cancer returning. It is for people with certain high-risk blood cancers like leukemia or myelodysplastic syndromes. The approach aims to control the…

This phase 3 trial is testing a CAR-T cell therapy called tisagenlecleucel that didn't quite meet commercial release standards. It's for people with B-cell acute lymphoblastic leukemia or diffuse large B-cell lymphoma who have no other approved options. The study will check if th…

This early-phase trial is testing whether a long-acting antibiotic called dalbavancin, given once every 28 days along with a short course of oral antibiotics, can prevent serious bloodstream infections in children and young adults with high-risk leukemia. The study will enroll 29…

This early-stage study tests an oral drug called AUTX-703 in 34 adults with relapsed or hard-to-treat acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal is to check safety and find the right dose. It's an open-label trial, meaning everyone knows they'r…

This study tests two different drug combinations for younger adults with a specific type of acute myeloid leukemia (CBF-AML). One group gets standard chemotherapy plus a targeted antibody, while the other gets the same chemotherapy plus a newer targeted pill. The goal is to see w…

This study tests a breathing machine strategy that adjusts pressure based on lung measurements to protect the right side of the heart in 180 adults with moderate to severe lung failure from pneumonia. The goal is to see if this method reduces heart strain and complications compar…

This study is testing a new drug called BGB-11417 (sonrotoclax) in people with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or related blood cancers. The drug works by blocking a protein that helps cancer cells survive. The trial will give the drug alone or toge…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

Researchers compare two intracanal medicaments, calcium hydroxide and a calcium silicate-based paste, in 56 adults with acute apical abscesses in single-rooted teeth. They place each medicament inside the cleaned root canal for 7 to 10 days. Bacterial samples are taken before and…

This early-phase trial tests whether giving patients a special infusion of donor immune cells (with certain T and B cells removed) after a stem cell transplant is safe and can help prevent their blood cancer from coming back. The study enrolls high-risk patients with hard-to-trea…

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This phase II study is testing a combination of two drugs, enasidenib and azacitidine, in people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial enrolls 50 adults with a specific IDH2 gene mutation. The goal is to see if the combinati…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This phase 3 trial is testing a new oral drug, nemtabrutinib, against two standard targeted therapies (ibrutinib or acalabrutinib) in 1,200 people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if nemtabrutinib works at least as well…

This phase 3 trial is testing whether a new drug, nemtabrutinib, combined with venetoclax works better than the current standard of venetoclax plus rituximab for people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 735 p…

This Phase 3 trial is testing an experimental oral drug called BGB-16673 against standard treatments for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has already been treated with two types of targeted therapy (BTK and BCL2 inhib…

This study tests a new type of CAR-T cell therapy, called UCD19 CAR-T, in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) or B-cell non-Hodgkin lymphoma (B-NHL) that has come back or not responded to standard treatment. The therapy is made locally to sp…

This early-stage trial is testing an experimental drug called LP-168, taken as a pill, in adults with B-cell lymphoma that has come back or not responded to standard treatments. The study aims to find the safest dose and check for side effects in about 200 participants. It is too…

This study tests a combination of three drugs—ivosidenib, venetoclax, and azacitidine—in people with blood cancers like acute myeloid leukemia (AML) that have a specific IDH1 mutation. The goal is to see if the combo is safe and works better than current treatments. About 96 adul…

This study tests a new drug called asciminib, given with chemotherapy and later with another drug (blinatumomab), in children, teens, and young adults up to age 30 who have a type of leukemia (Ph+ or Ph-like ALL) that has come back or not responded to treatment. The goal is to fi…

This early-phase trial is testing a new drug called Debio 1562M in about 134 people with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The study first checks safety and finds the right dose, then looks at whether the drug can shrink the can…

This study tests a drug called mirdametinib in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has returned or stopped responding to treatment. The drug blocks a protein that helps cancer cells grow. About 20 participants will take the drug to …

This study tests a standardized, optimized approach to cord blood transplantation for adults with high-risk blood cancers like leukemia and lymphoma. The method includes specific chemotherapy, radiation, and stem cell dosing, followed by careful monitoring. Researchers hope to im…

This study tests whether a second type of CAR T-cell therapy, targeting CD22, can extend remission in people with B-cell acute lymphoblastic leukemia who have no signs of cancer after initial CD19 CAR T-cell treatment. About 20 children, adolescents, and adults will receive the m…

This early-phase study tests a new drug called rezatapopt combined with the standard drug azacitidine in 24 adults with a specific type of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has a TP53Y220C mutation. The main goal is to check safety and find the b…

This study tests a drug called revumenib in 40 people with leukemia that has come back or not responded to treatment. The leukemia must have certain genetic changes that turn on HOX genes. The goal is to see if revumenib can safely control the disease. Participants take the drug …

This study is testing whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant, can prevent graft-versus-host disease (a common complication where donor cells attack the patient's body) while still being effective. The trial involves 260 adults with b…

This phase 2 trial tests a drug called olutasidenib combined with other targeted therapies for people with relapsed or hard-to-treat blood cancers that have a specific IDH1 mutation plus other signaling mutations. The study aims to see how safe and tolerable these drug combinatio…

This study tests an experimental pill called enpatoran for people with lupus who have active skin rashes. About 202 participants will receive either the drug or a placebo for 24 weeks, while continuing their usual treatments. The goal is to see if enpatoran can significantly redu…

This early-phase trial tests whether adding daratumumab (an immunotherapy drug) after a stem cell transplant can safely help control high-risk T-cell acute lymphoblastic leukemia or lymphoma in children, teens, and young adults up to age 39. About 30 participants will receive the…

This study compares a new drug, BGB-16673, to an existing one, pirtobrutinib, in people whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to prior treatment. About 500 adults will be randomly assigned to one of the tw…

This study tests whether adding a targeted drug (nemtabrutinib) to a personalized cell therapy (lisocabtagene maraleucel) can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma that has returned or stopped responding to treatment. About 20 adults will rec…

This study tests a daily pill called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. The goal is to see if the drug is safe and tolerable as maintenance therapy. About 31 participants will take the…

This study tests a combination of two drugs, venetoclax and azacitidine, in about 100 adults in India with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for standard intensive chemotherapy. The goal is to see if the combo can put the cancer into remissio…

This early study tests whether adding special cells from donated umbilical cord blood (called mesenchymal stromal cells) to the drug ruxolitinib can help control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious complication where donor…

This early-stage study tests whether giving patients a fecal transplant (donated stool) along with extra dietary fiber can help treat gut graft versus host disease, a serious complication after a stem cell transplant. About 72 adults who had a stem cell transplant in the past yea…

This phase II trial is testing a combination of two targeted drugs, inotuzumab ozogamicin and blinatumomab, with or without ponatinib, for adults with a type of leukemia called B-ALL. The study includes newly diagnosed older adults and those whose cancer has returned or not respo…

This phase 2 trial tests a gradual, three-drug combination (isatuximab, dexamethasone, and lenalidomide) in 40 ultra-frail patients newly diagnosed with multiple myeloma. The goal is to see if starting treatment slowly improves how well patients tolerate therapy and their quality…

Researchers are testing an experimental drug called LP-108, a BCL-2 inhibitor, combined with azacitidine in adults with acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. The trial aims to find the highest dose people can tolerate and the best …

This phase 3 trial is testing whether a new combination of two oral drugs, sonrotoclax and zanubrutinib, works better than the current standard combination (venetoclax plus acalabrutinib) for people with untreated chronic lymphocytic leukemia (CLL). About 500 adults who have not …

This study tests a combination of three drugs—olutasidenib, decitabine, and venetoclax—in people with acute myeloid leukemia (AML) that has a specific IDH1 gene mutation. The goal is to find a safe and effective dose for those whose cancer has returned or not responded to treatme…

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study tests a new oral drug, BGB-16673, designed to destroy a protein called BTK that helps certain blood cancers grow. The trial includes about 645 people with various B-cell cancers (like lymphoma and leukemia) that have come back or not responded to prior treatments. The …

This study tests an experimental drug called recombinant human plasma gelsolin (rhu-pGSN) added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive eithe…

This study tests an experimental drug called BL-M11D1 combined with either standard chemotherapy or another targeted therapy in 216 adults newly diagnosed with acute myeloid leukemia (AML). The goal is to see if the combination is safe and works better at controlling the cancer. …

This phase 2 trial is testing whether a combination of three drugs—acalabrutinib, venetoclax, and obinutuzumab—can better control chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) that has come back or is resistant to treatment. About 168 adults with high-ri…

This study tests a device called the Selective Cytopheretic Device (SCD) in 339 ICU patients with severe acute kidney injury who are already on continuous kidney replacement therapy. The device filters blood to reduce inflammation, and researchers want to see if it improves survi…

This study offers continued treatment with deucravacitinib for people with systemic lupus erythematosus (SLE) or related skin lupus who finished earlier trials. It aims to keep the disease under control by providing ongoing access to the medication. Only 35 participants are being…

This study tests a drug called IgPro20 in 63 adults who have a weakened immune system after receiving CAR T-cell therapy for blood cancers like lymphoma or multiple myeloma. The goal is to see if the drug can lower the number of serious bacterial infections, such as pneumonia or …

This Phase 3 trial tests whether adding the drug venetoclax to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) or a related high-risk condition. About 650 participants aged 18 to 75 will receive either venetoclax or a placebo alongside chemo. …

This early-stage study is testing an experimental drug called pivekimab sunirine in about 18 children whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to check the drug's safety and how it moves through the body. Partici…

This study tests a new treatment for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells…

This study tests a drug called Vyxeos in adults with acute myeloid leukemia (AML) whose cancer did not go away after standard chemotherapy. Vyxeos combines two chemo drugs inside a tiny fat bubble (liposome) to deliver them more effectively. The trial will check for side effects …

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This early-phase trial tests two drugs, ruxolitinib and duvelisib, together in people whose T- or NK-cell lymphoma has come back or stopped responding to treatment. The main goal is to find the safest dose of duvelisib when combined with a fixed dose of ruxolitinib. About 70 part…

This early-phase trial tests a new treatment for people with B-cell non-Hodgkin lymphoma that has not responded to at least two prior therapies. Participants receive donor immune cells (NK cells) along with two antibody drugs (rituximab and tafasitamab) and a support drug (IL-2) …

Researchers are testing whether manually removing blood clots from a blocked heart artery during emergency angioplasty helps people who have a severe heart attack with a large clot burden. The trial enrolls adults treated within 12 hours of symptom onset whose angiogram shows a h…

This early-stage trial tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose of momelotinib when given with gilteritini…

This study tests whether a combination of two non-chemotherapy drugs (vemurafenib and obinutuzumab) causes fewer side effects than the standard chemotherapy-based treatment (cladribine and rituximab) in people with untreated hairy cell leukemia. About 86 adults with a specific ge…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This trial studies whether removing blood clots from heart arteries during angioplasty improves outcomes for people who have had a major heart attack. 3500 participants will be randomly assigned to get either clot removal plus angioplasty or angioplasty alone. The main goal is to…

This early-stage trial is testing a new antibody drug called GEN3018 in people whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) has come back or stopped responding to treatment. The main goal is to check safety and find the right dose. Up to 78 parti…

This early-stage trial tests a new type of immune cell therapy for people with several kinds of blood cancers that have come back or stopped responding to treatment. The therapy uses natural killer (NK) cells from donated cord blood, which are genetically modified to better recog…

This pilot trial tests whether restarting renin-angiotensin system inhibitors (RASi) — common blood pressure and kidney-protecting medications — early after acute kidney injury is feasible and well-tolerated. Hospitalized adults who were on RASi before admission and stopped due t…

This early-stage trial is testing two drugs, mosunetuzumab and venetoclax, in people with chronic lymphocytic leukemia (CLL) that has come back or stopped responding to treatment. Mosunetuzumab is given as a shot under the skin, and venetoclax is a daily pill. The study will chec…

This early-phase trial is testing a new type of CAR T cell therapy called Azer-cel, which is made from healthy donor cells rather than the patient's own cells. It aims to treat adults with relapsed or refractory non-Hodgkin lymphoma, B-cell acute lymphoblastic leukemia, and relat…

This trial tests whether a monitor that measures muscle response can guide the dose of the muscle relaxant atracurium in intensive care unit patients who need a continuous drip for more than 48 hours. Researchers will compare a group whose dose is adjusted using the monitor to a …

This trial tests whether a special filter called oXiris, used during continuous blood purification, can lower endotoxin levels in adults with septic shock and acute kidney injury. Septic shock is a life-threatening condition where infection causes severe organ failure. The filter…

This early-stage trial tests a new drug called LY4152199 in about 215 adults with certain types of blood cancer (like follicular lymphoma or diffuse large B-cell lymphoma) that have already been treated. The drug is designed to help the body's immune cells attack the cancer. The …

This study tests a new drug called AZD0486, alone or with other cancer drugs, in people with B-cell blood cancers like certain lymphomas and leukemias. The goal is to see if it is safe and helps shrink or control the cancer. About 408 adults will take part in this early-phase tri…

This study looks back at medical records of heart attack patients with a large clot in a coronary artery. It compares two ways to reopen the blocked artery during emergency angioplasty: a drug-coated balloon that delivers medication and is then removed, versus a drug-eluting sten…

This Phase 3 trial is testing whether the drug surovatamig can help people with a specific type of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) stay in remission longer after their first round of treatment. About 420 participants will either receive suro…

This study compares using 30% versus 60% oxygen when resuscitating extremely preterm babies (born before 29 weeks). The goal is to see which oxygen level leads to better survival and fewer long-term developmental problems like cerebral palsy or vision/hearing loss. About 1,200 ba…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests a combination of three drugs—ASTX727, venetoclax, and gilteritinib—for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome that has a FLT3 mutation. The drugs work in different ways to stop cancer cells from growing. The trial aims to f…

This study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether giving sodium bicarbonate (baking soda) intravenously can reduce major kidney problems or death in critically ill patients with metabolic acidosis and acute kidney injury. About 660 adults in intensive care will receive either sodium bicarbonate or a stan…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests a combination of two drugs, azacitidine and enasidenib, in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to see if the drugs can stop cancer growth and improve outcomes. …

This study is checking the long-term safety of the drug pirtobrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have already been treated with other drugs. About 150 adults who completed a previous pirtobrutinib study can join. They…

This study tests a new type of immune cell therapy for people with myeloid cancers (like AML or MDS) that have come back or not responded to treatment. The cells are taken from donated cord blood, engineered to better recognize and attack cancer cells, and given after chemotherap…

This Phase 1 trial is testing a new type of immunotherapy for children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not gone away. The treatment uses the patient's own T cells, which are modified in the lab to recognize and attack leukem…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This early-phase trial is testing a combination of two oral drugs—venetoclax and decitabine/cedazuridine—in children and teens whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. The study aims to find the safest dose and check for early signs tha…

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This phase 1 study is testing a combination of three drugs—ziftomenib, venetoclax, and azacitidine—in children and young adults (ages 2 to 21) with acute leukemia that has returned or not responded to treatment. The main goal is to find the safest dose of ziftomenib when given wi…

This phase 2 trial tests a one-time infusion of WU-CART-007, a CAR-T cell therapy made from healthy donor cells, in 125 people with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma that has come back or not responded to treatment. The goal is to see if it can wipe ou…

This study looks at whether giving the drug venetoclax for a shorter time, along with the combination drug ASTX727, works as well as the usual longer course for adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for strong chemot…

This study screens people with acute myeloid leukemia (AML) for specific genetic markers to assign them to a treatment sub-study with a targeted drug or combination. It aims to improve response rates by personalizing therapy based on each person's cancer profile. The trial enroll…

This study tests a new drug called SLS009, alone or with other medicines, in people with blood cancers like leukemia and lymphoma that have come back or not responded to treatment. It also includes newly diagnosed patients with high-risk leukemia. The goal is to see if the drug i…

This phase 2 trial tests pirtobrutinib, an oral BTK inhibitor, in 40 people with chronic lymphocytic leukemia (CLL) whose disease has returned or stopped responding after treatment with zanubrutinib. Researchers will track BTK mutations before, during, and after pirtobrutinib tre…

This pilot study tests the drug olutasidenib, with or without azacitidine, in 25 adults with a specific type of acute myeloid leukemia (IDH1-mutated) that has returned or not responded after venetoclax treatment. The goal is to see if the cancer can be brought into remission. Par…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy before a stem cell transplant can help prevent cancer from returning in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 participants aged 12 to 6…

This phase III trial is testing whether adding inotuzumab ozogamicin—a drug that targets cancer cells—to standard chemotherapy can improve outcomes for young adults (ages 18-39) newly diagnosed with B-cell acute lymphoblastic leukemia. About 310 participants will be enrolled. The…

This phase 3 trial tests a drug called plozasiran in 288 adults with severe hypertriglyceridemia (very high blood fats) who have had at least two pancreatitis attacks. Participants receive either the drug or a placebo every three months. The main goal is to see if the drug can pr…

This phase 3 trial is testing whether adding revumenib, a drug that blocks a protein called menin, to the usual two-drug combination (azacitidine and venetoclax) can improve outcomes for adults newly diagnosed with acute myeloid leukemia (AML) that has a specific genetic change (…

This Phase 3 trial compares a fixed-duration combination of zanubrutinib and sonrotoclax against continuous zanubrutinib alone in older patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The study will enroll 466 participants to see if the combo i…

This study tests two chemotherapy drugs, treosulfan and melphalan, given before a stem cell transplant in 220 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see which drug works better at helping patients survive longer with fewer side …

This trial tests whether giving blinatumomab, a drug that helps the immune system destroy leukemia cells, before a stem cell transplant can improve outcomes for adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). Participants who are in remission and have no detect…

This study tests whether taking two oral medications (decitabine and ivosidenib) together can control acute myeloid leukemia (AML) in patients aged 60+ or those too frail for standard chemo. About 50 participants will take the pills in 28-day cycles until the disease worsens or s…

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This study tests whether the steroid dexamethasone, when added to standard care, can lower the chance of death within 90 days for people with a serious lung condition called ARDS caused by sepsis. About 1,474 adults on breathing machines will take part. The goal is to see if this…

This trial tests whether the combination of venetoclax and azacytidine works better than the standard chemotherapy regimen of daunorubicin plus cytarabine in adults aged 18 to 64 with newly diagnosed acute myeloid leukemia that has adverse risk features. Participants are randomly…

This early-phase trial tests a new treatment called CD64 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target and attack leukemia cells. The m…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study tests whether adding the drug ruxolitinib to standard medications (cyclophosphamide and tacrolimus) can prevent severe graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers like leukemia. About 124 adults will receive the drug com…

This study tests a combination of a PD-1 inhibitor (camrelizumab), a chemotherapy drug (azacitidine), and donor immune cells (DLI) in 43 adults with acute myeloid leukemia that has returned after a stem cell transplant. The goal is to see if this approach can help patients achiev…

This early-stage trial tests a new antibody drug called 4A10 in 24 people with relapsed or hard-to-treat acute lymphoblastic leukemia or lymphoblastic lymphoma. 4A10 targets a protein on cancer cells to block growth signals and help the immune system attack them. The main goal is…

This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This early-phase trial is testing a new drug called miRisten in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to prior treatments. The drug works by blocking a molecule that helps cancer cells grow. The main goal is to check safety and find the best …

This trial tests two standard steroid treatments for sudden sensorineural hearing loss, a condition where hearing drops quickly, often in one ear. One group takes methylprednisolone pills daily for two weeks, while the other receives dexamethasone injections into the middle ear e…

This phase 3 trial tests whether adding the drug bleximenib to standard chemotherapy helps adults with a certain genetic type of acute myeloid leukemia (AML). About 875 people will get either bleximenib or a placebo alongside chemo, then be followed for 4 years. The goal is to se…

This early-phase trial tests whether giving a second type of CAR T cell therapy (targeting CD22) after the standard CD19 CAR T therapy is safe and feasible for children and young adults with relapsed or hard-to-treat B-cell leukemia. About 20 participants will receive the standar…

This phase 2 trial is testing whether adding nivolumab to blinatumomab helps children and young adults (ages 1 to 30) with relapsed B-cell acute lymphoblastic leukemia (B-ALL), including those with Down syndrome. Blinatumomab helps the immune system find and kill cancer cells, wh…

This phase 2 trial is testing whether combining venetoclax and zanubrutinib can drive chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into deep remission. The study enrolls adults who either have not been treated before or whose cancer returned at least two…

This early-stage trial tests a new type of cell therapy for children and young adults up to age 21 with a form of leukemia (CD19-positive) that has returned or not responded to treatment. The therapy uses immune cells from a family donor that are engineered in a lab to recognize …

This study compares two drugs, NX-5948 and pirtobrutinib, in about 620 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has returned or stopped responding after prior treatment with a BTK inhibitor. The main goal is to see which drug…

This study is testing a device called the Indigo Aspiration System to remove blood clots from leg arteries in people with acute limb ischemia, a condition where a clot suddenly blocks blood flow. About 300 participants will undergo a procedure where the device sucks out the clot.…

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This early-stage trial is testing whether adding high-dose vitamin C (given through an IV) to the usual two-drug combination (azacitidine and venetoclax) is safe and effective for people newly diagnosed with acute myeloid leukemia who cannot handle intensive chemotherapy. About 3…

This study tests whether a new drug called teclistamab, given after standard treatment and a stem cell transplant, can help people with a rare and aggressive blood cancer called plasma cell leukemia live longer. About 74 participants will receive either standard follow-up therapy…

This early-phase study tests a new drug called lonitoclax combined with azacitidine in 66 adults whose acute myeloid leukemia has returned or not responded to prior treatment. The main goal is to find a safe dose and check for early signs that the combination might help control t…

After a kidney or kidney-pancreas transplant, the body may attack the new organ—a problem called acute T cell mediated rejection. Doctors use strong steroids to stop this, but there's no standard dose, and too much can cause serious side effects. This phase 3 trial will enroll 54…

This trial tests two strategies for people with moderate-to-severe acute respiratory distress syndrome (ARDS) who need a breathing machine. First, researchers compare a personalized approach to setting airway pressure based on how much lung is recruitable against standard low or …

This trial tests whether a combination of venetoclax and azacitidine can work as well as or better than standard intensive chemotherapy for adults with newly diagnosed acute myeloid leukemia that has an NPM1 mutation. Participants are aged 18 to 70 and healthy enough for intensiv…

This study tests whether quickly upgrading from a standard heart pump (Impella CP) to a more powerful one (Impella 5.5) within 24 hours after a heart attack improves outcomes for people in cardiogenic shock. The trial will enroll 115 adults aged 18-77 who have had a heart attack …

This study looks at how well a combination of two drugs—venetoclax (a pill) and azacitidine (an injection)—works for adults newly diagnosed with acute myeloid leukemia (AML), a cancer of the blood and bone marrow. The participants are people who are older or have health issues th…

This study investigates whether giving phosphate through an IV can reduce the severity of acute pancreatitis in adults. Researchers want to know if low phosphate levels make the disease worse and if replenishing it helps. Participants receive either standard care or IV phosphate …

This phase II trial is testing whether the drug ivosidenib, taken as a pill, can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic neoplasia (MDS) who have an IDH1 mutation and have recently undergone a stem cell transplant. Participants will sta…

This trial tests whether plasma exchange (a blood-cleaning procedure) given every other day works as well as daily sessions for children with autoimmune encephalitis, a condition where the immune system attacks the brain. The study involves 22 children who are randomly assigned t…

This trial tests whether a personalized diet and exercise plan during the first month of chemotherapy can make leukemia cells more sensitive to treatment in older children, adolescents, and young adults with B-cell acute lymphoblastic leukemia (B-ALL). The study also aims to redu…

This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a c…

This trial tests whether droxidopa, an oral medication that raises blood pressure, can improve kidney function in people hospitalized with cirrhosis and acute kidney injury. The study will compare droxidopa to a placebo in 75 participants, measuring changes in blood pressure and …

This trial compares two ways to access the blood vessels during cardiac catheterization: through the wrist (radial access) versus through the groin using modern techniques (femoral access). The goal is to see which approach leads to fewer bleeding events and access-site complicat…

This pilot study tests whether drinking tea made from soursop leaves can reduce the number of cancer cells in people with relapsed or refractory acute myeloid leukemia (AML) or multiple myeloma (MM) — blood cancers that have not responded to standard treatments. About 20 particip…

This trial tests whether a noninvasive procedure called RE-START, which uses a blood pressure cuff to temporarily stop blood flow in the arm, can improve blood flow in the heart's arteries before standard angioplasty in people having a severe heart attack (STEMI). The study invol…

This trial tests whether giving patients special immune cells, called TAA-T, after a stem cell transplant can help prevent high-risk blood cancers like acute myeloid leukemia from coming back. The cells are designed to recognize three common tumor markers and attack any remaining…

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This trial is testing whether a chemotherapy combination called HAD, given at intermediate doses, works better than the standard regimen for people with a specific genetic subtype of acute myeloid leukemia (AML) known as CEBPA double-mutated. The study enrolls adults aged 14 to 5…

This trial tests whether giving fluids based on real-time changes in stroke volume—a measure of how much blood the heart pumps—can improve outcomes in people with moderate to severe acute pancreatitis. Standard care uses a fixed weight-based amount, which can sometimes lead to fl…

This trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …

This trial asks whether a lower or medium intensity of continuous kidney replacement therapy (dialysis) is better for critically ill patients with acute kidney injury. It will compare a low dose (12 mL/kg/hr) against a standard medium dose (25 mL/kg/hr) to see which is more effec…

This trial tests whether a smartphone app called HeartCheck can help people who have recently survived a heart attack better manage their blood pressure, cholesterol, blood sugar, and smoking habits. The app provides education, reminders, and easy-to-understand goals to support m…

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the …

This pilot trial tests whether using an ultrasound score (VeXUS) to guide fluid removal with diuretics can help kidneys recover in patients who develop acute kidney injury after cardiac surgery. About 40 participants will be randomly assigned to either VeXUS-guided fluid manageme…

This study tests whether adding a clinical decision support tool to the electronic medical record helps doctors use the furosemide stress test in critically ill children at high risk for acute kidney injury. The furosemide stress test measures how the kidneys respond to a diureti…

This study tests different chemotherapy doses and a drug to prevent graft-versus-host disease in adults aged 18 to 60 with newly diagnosed acute myeloid leukemia. Participants receive either idarubicin or daunorubicin during initial chemo, followed by high or intermediate doses o…

This phase 2 trial tests whether a standardized extract from the ashwagandha plant, called Withaferin-A, can help people who develop graft-versus-host disease after a stem cell transplant and whose condition does not improve with steroids. The study enrolls 34 patients aged 12 an…

This phase 3 trial is for people newly diagnosed with multiple myeloma who are not healthy enough for a stem cell transplant. After six months of standard treatment with daratumumab, lenalidomide, and dexamethasone, participants are assigned to different immunotherapy combination…

This study compares delayed cord clamping (waiting at least 30 seconds after birth) with immediate clamping in preterm infants born between 32 and 37 weeks. The goal is to see if the extra time improves early health outcomes such as breathing, anemia risk, and survival. Researche…

This trial investigates a personalized cell therapy called CAR-T for children and young adults (ages 5–50) with B-cell acute lymphoblastic leukemia that has relapsed or not responded to standard treatment. The therapy involves collecting a patient's own immune cells, engineering …

This trial compares two non-surgical drainage methods for acute cholecystitis (gallbladder inflammation) in people who are too sick for surgery. One method uses a tube through the skin, the other uses an endoscope to place a stent. Researchers will track complications, repeat pro…

This trial tests whether using a suction catheter to remove large blood clots before placing a stent improves outcomes in people having a severe heart attack (STEMI). Participants must have a large clot visible on angiography. Half receive standard stent placement alone, and half…

This trial tests a two-part treatment for people with acute myeloid leukemia (AML) that has not responded to standard therapy. First, patients receive a stem cell transplant from a healthy donor, but the stem cells are gene-edited to hide from the second treatment: specially engi…

This trial compares a new aspiration-enabled access sheath to a conventional one during retrograde intrarenal surgery (RIRS) for kidney stones. The new sheath continuously removes irrigation fluid to control pressure inside the kidney, potentially reducing temporary kidney injury…

This study compares two treatments for acute cholecystitis (inflamed gallbladder) in patients aged 75 and older. One is the standard laparoscopic surgery to remove the gallbladder. The other is a newer, less invasive procedure called EUS-guided gallbladder drainage, where a small…

This trial investigates whether pioglitazone, a drug used for diabetes, can help protect the kidneys in people with ANCA-associated vasculitis—a rare autoimmune disease that causes inflammation of blood vessels, often damaging the kidneys. Participants receive either pioglitazone…

This study looks at whether a treatment called extracorporeal photopheresis can help kidney transplant recipients whose bodies are rejecting the new organ. The treatment involves filtering the patient's blood, treating it with a light-activated drug, and returning it to the body.…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This phase II trial tests whether adding targeted total marrow irradiation to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia, chronic myeloid leukemia, or myelodysplastic syndromes. The study will enroll 3…

This study tests whether a personalized care plan at hospital discharge helps people who survived acute kidney injury recover better. Depending on their risk level, patients get education, a primary care visit, or specialist monitoring. The goal is to see if this approach increas…

This study tests whether a single dose of tocilizumab, an anti-inflammatory drug, can help children and adults with sickle cell disease recover faster from acute chest syndrome—a serious lung condition. Participants receive either the drug or a placebo, and researchers measure ho…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This early-phase trial is testing whether adding the drug daratumumab to standard chemotherapy can help adults aged 60 and older with a high-risk form of acute myeloid leukemia (AML). The main goal is to find the safest dose of daratumumab when given alongside chemotherapy. The s…

This early-stage trial tests a new treatment called ICG415 CAR-T cells for adults with acute myeloid leukemia that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, engineering them to recognize and attack leukemia cel…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This study tests whether combining two drugs—ofatumumab and daratumumab—can safely and effectively treat people with severe anti-NMDAR autoimmune encephalitis, a condition where the immune system attacks the brain. The drugs aim to eliminate the harmful immune cells producing the…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This study tests whether adding the blood thinner rivaroxaban (Xarelto) to standard care helps dissolve dangerous blood clots in the heart after a major heart attack. Researchers will track 320 participants to see if the drug reduces strokes and other complications. The goal is t…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study compares a new approach using fewer stents and a drug-coated balloon to the standard method of placing stents in heart attack patients. About 1,272 participants will be randomly assigned to one of the two treatments. The goal is to see if the reduced-stent strategy low…

This study compares two drugs given directly into the heart arteries during a heart attack: rhTNK-tPA, a clot dissolver, and tirofiban, a blood thinner. Researchers will enroll 300 patients with severe blockages to see which drug restores blood flow better and causes fewer bleedi…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

Researchers are testing a noninvasive wearable sensor patch that uses near-infrared light to continuously measure tissue oxygen and blood flow in people hospitalized with cardiogenic shock after a heart attack or heart failure. Up to 20 adults in a cardiac intensive care unit wea…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study tests a new blood test (Malabsorption Blood Test, or MBT) to find mild-to-moderate pancreatic insufficiency in people with chronic or recurrent acute pancreatitis. A small group of participants who respond to pancreatic enzyme replacement therapy (PERT) will then be ra…

Researchers are studying whether biomarkers in blood, urine, and stool can predict acute kidney injury in adults scheduled for cardiovascular surgery. The trial follows about 1,500 patients, collecting samples and clinical data before and after contrast dye exposure and surgery. …

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

Paramedics and other prehospital providers often interpret ECGs under time pressure without expert backup. Missing a blocked coronary artery delays life-saving treatment, while false alarms send patients for unnecessary procedures. This trial randomizes 144 prehospital providers …

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study tests whether a smartwatch can record a 9-lead ECG that is as accurate as the standard 12-lead ECG for diagnosing ST-elevation myocardial infarction (STEMI), a severe type of heart attack. Researchers will compare the diagnostic agreement between expert cardiologists r…

This study explores whether performing a cardiac MRI (CMR) before the standard invasive coronary angiography (ICA) can accurately diagnose the cause of a suspected non-ST-elevation heart attack (NSTEMI). Currently, patients with NSTEMI often undergo an invasive angiogram, and if …

This study tests whether a lab technique called polyethylene glycol (PEG) precipitation can tell the difference between a true heart attack and a harmless condition called macrotroponin, where troponin molecules clump together and falsely signal heart damage. Researchers will com…

This study will test a new, more accurate blood test (Troponin T high-sensitivity Gen 6) to see if it helps doctors diagnose heart attacks faster. Researchers will compare emergency department visit data from 19,500 patients before and after the test is introduced. The goal is to…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

People who need emergency surgery after a traumatic event like a car crash or fall face a higher risk of developing post-traumatic stress disorder. This trial tests whether giving the sedative dexmedetomidine during surgery, with or without adding a non-invasive ear stimulation c…

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

Researchers are testing inotuzumab ozogamicin, an antibody-drug conjugate, in people with CD22-positive acute lymphocytic leukemia who have already had a stem cell transplant. The trial has two parts: a phase 1 portion to find the highest dose that is safe to give after transplan…

This phase 3 trial tests whether xylitol dental wipes can reduce bloodstream infections in children with acute myeloid leukemia (AML). Xylitol, a natural sugar that limits mouth bacteria growth, is applied via wipes during chemotherapy. The study will compare infection rates betw…

This trial tests whether a 14-week nature-based program, integrated into kindergarten routines, can enhance mental and physical well-being in children aged 4-6 from deprived areas. It will compare the program to usual activities, measuring outcomes like motor skills, physical act…

This trial tests whether giving a rapid, short course of IV fluids (Lactated Ringer's) along with a rectal anti-inflammatory drug (indomethacin) can prevent pancreatitis, a common and serious complication after ERCP, a procedure used to diagnose and treat bile duct issues. The st…

This trial tests whether giving an inhaled medication called dornase alfa to severely injured patients on breathing machines can lower their risk of developing acute respiratory distress syndrome (ARDS), a serious lung condition. The drug is thought to break down DNA fragments re…

This trial tests whether removing the gallbladder with keyhole surgery can prevent repeat episodes of acute pancreatitis in people whose cause remains unknown after thorough testing. Half the participants will have the surgery, while the other half will receive watchful waiting. …

This study tests whether a fecal microbiota transplant (FMT) can prevent graft-versus-host disease (GvHD) in 150 adults with blood cancers who receive a stem cell transplant. Patients get a single FMT enema within four weeks of transplant. The main goal is to see if FMT improves …

This study tests whether the drug R2R01 can prevent acute kidney injury in people at high risk who are having heart surgery with a heart-lung machine. Participants receive either R2R01 or a placebo before and after surgery. The goal is to see if the drug reduces kidney damage and…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

Researchers are observing how high-dose vitamin C injections affect symptoms and tolerability in adults with vitamin C deficiency caused by acute or chronic diseases. The study includes about 1,000 participants and tracks changes in general and disease-specific symptoms using a s…

Acute coronary syndrome, which includes heart attacks, often triggers intense anxiety during the rush to hospital. Researchers are testing whether playing music for 20 minutes in the ambulance, on top of usual care, lowers anxiety and pain more than usual care alone. The trial en…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications in infants born at 29 weeks o…

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study tests a program called EASE that combines psychological support with regular symptom checks and early access to palliative care. Researchers want to see if it reduces traumatic stress and physical symptoms in people newly diagnosed with acute leukemia. Half of the 266 …

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia who are about to have a stem cell transplant. The program includes aerobic and strength training to improve heart function before the procedure. Researchers will enr…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether taking vitamin D daily for 8 weeks helps healthy adults keep their thinking, simple physical tasks, and mood steady during very stressful situations. 52 participants will take either vitamin D or a placebo, then perform tasks while wearing a belt that giv…

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This trial tests two digital platforms, one for children with cancer and one for their parents, designed to improve communication with healthcare providers and address physical, emotional, social, and spiritual needs during treatment. Researchers will recruit 120 families of chil…

This study tests whether a shared decision-making tool can help pharmacists and patients better understand when antibiotics are truly needed for uncomplicated cystitis (bladder infection). About 506 women with symptoms will be enrolled. The goal is to reduce unnecessary antibioti…

This study tests whether a sublingual tablet (TNX-102 SL) can reduce acute stress symptoms and prevent long-term PTSD in adults who come to the emergency room after a car crash. 180 participants will receive either the drug or a placebo for two weeks, starting in the ER. Research…

This study explores whether an 8-week Brazilian Jiu-Jitsu (BJJ) program can help first responders—like police, firefighters, and EMS—manage trauma-related symptoms. Participants will attend beginner-friendly BJJ classes one to two times per week, while tracking their mood, stress…

This trial tests a program called ACT, which trains doctors and nurses to have compassionate, structured conversations with blood cancer patients and their families about end-of-life care. The goal is to help patients understand their prognosis and make informed decisions, potent…

This study tests whether a 9-week strength training program using resistance bands and body weight exercises is practical for children aged 6-21 newly diagnosed with acute lymphoblastic leukemia or lymphoblastic lymphoma. The program combines at-home exercises with optional Zoom …

This early-stage pilot study is testing whether psilocybin, a psychedelic compound, can be safely combined with trauma-focused psychotherapy for people with post-traumatic stress disorder (PTSD). Thirteen participants will receive two doses of psilocybin in a controlled setting, …

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether regular blood and bone marrow tests using advanced DNA sequencing can better monitor children with B-cell acute lymphoblastic leukemia (B-ALL) after they achieve remission with CAR T therapy. The goal is to see if these tests can identify who is truly cur…

This study tests a new way to screen patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) by analyzing their bone marrow and blood for specific biomarkers. The goal is to quickly match patients with a treatment trial that targets their cancer's unique mark…

This study uses non-invasive MRI and MRS scans to measure how well muscle cells produce energy in adults who survived childhood acute lymphoblastic leukemia (ALL). Researchers will compare 60 survivors with low muscle mass to healthy volunteers. The goal is to understand why many…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

Researchers at Al-Kadhimiya Teaching Hospital in Baghdad are studying how delays before and during hospital care affect outcomes for people who have a heart attack. The study follows 200 patients who receive reperfusion therapy, such as clot-busting drugs or angioplasty, within 1…

This study looks at whether adults with acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy are willing to let a computer randomly assign them to either lower- or higher-intensity treatment. The goal is to see if this approach is acceptable to patients…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

Researchers at Hospital Civil de Guadalajara are observing mechanically ventilated patients with acute respiratory distress syndrome (ARDS) to measure how often a breathing mismatch called reverse trigger occurs. They monitor patients continuously with esophageal manometry from t…

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

Researchers at Peking University First Hospital are building a prospective cohort of 2,000 people with plasma cell disorders, including multiple myeloma, amyloidosis, and related conditions. Participants give blood, bone marrow, and urine samples before and after treatment, and t…

This study collects blood, urine, bone marrow, and tumor samples from people with hairy cell leukemia and other blood cancers, as well as from healthy volunteers. Researchers will use these samples to study the diseases and develop new treatments called immunotoxins, which use an…

This study tests whether an AI tool called LuAna helps doctors find lung problems in chest X-rays more accurately than doctors working alone. About 1,470 adults with breathing issues will have their X-rays read first by doctors, then with AI support. The goal is to see if AI boos…

This study tracks how quickly the diaphragm weakens in 15 ICU patients on mechanical ventilation. Researchers use advanced muscle tests and brain stimulation to measure changes in diaphragm function and control. The goal is to better understand ventilator-induced diaphragm dysfun…

Researchers at Evangelismos Hospital are studying adults who arrive in the emergency department with sudden acute hypoxemic respiratory failure, a condition where the blood oxygen drops dangerously low. The team collects clinical, imaging, physiological, and biological data early…

This study follows up to 1,000 adults with certain slow-growing blood cancers (CLL, SLL, LPL, WM) to track how the diseases change over time. Participants have regular check-ups and blood draws every 6 to 24 months, and may also have optional biopsies or scans for research. No tr…

This study tests a telehealth program that helps older adults (60+) with blood cancers like leukemia or MDS talk to their doctors about their care wishes. The program also helps them fill out advance directive forms. Researchers want to see if it improves communication and reduce…

This study follows people of all ages who have or may have a RUNX1 gene variant, which can cause bleeding problems and increase the risk of blood cancers. Researchers will collect medical history, blood samples, and bone marrow over many years to understand how the condition deve…

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

Researchers are building a registry to collect long-term health information from adults with myelodysplastic syndromes and therapy-related acute myeloid leukemia. The study gathers details on blood counts, bone marrow tests, genetic changes, and treatments. By following these pat…

Acute intermittent porphyria (AIP) is an inherited disorder that can cause sudden, severe attacks, but not everyone who carries the gene gets sick. Researchers at Mount Sinai are collecting blood, saliva, and urine samples from about 150 people in AIP families, including affected…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

Researchers in China are reviewing medical records of 500 children diagnosed with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) between 2015 and 2024. The study compares diagnosis, treatment, and survival outcomes, including a subtype called CML-like ALL…

This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care.…

This study looks at two different approaches to help doctors and families avoid unnecessary follow-up visits after a child is hospitalized for bronchiolitis. About 2,700 children will take part to see which method works better at encouraging follow-up only when needed. The goal i…

This study looks at whether a trauma-informed approach can improve smoking cessation support for pregnant women, especially those from racial and ethnic minority groups. Researchers will interview clinicians and pregnant women to understand their needs and experiences. The goal i…

This study will check if a simple ultrasound of the neck vein, done before and right after anesthesia, can predict low blood pressure during surgery and kidney injury afterward. Researchers will observe 150 adults having major abdominal surgery. The goal is to see if changes in t…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This study looks at 60 adults with acute myeloid leukemia or related blood cancers who are receiving a gentler type of chemotherapy. Researchers will measure certain proteins in the blood to see if they can predict how well the treatment works. The goal is to better understand wh…

This study observes about 350 people with chronic lymphocytic leukemia (CLL) who received the drug acalabrutinib through a UK early access program. Researchers will review medical records to see how long patients went without their cancer worsening and how long they lived. No new…

This study follows 705 adults with Waldenström's macroglobulinemia, chronic lymphocytic leukemia, marginal zone lymphoma, or follicular lymphoma who are taking zanubrutinib (with or without obinutuzumab). Researchers will track hospital visits, quality of life, and how well the d…

This study is testing a web-based tool called TRIAL that provides information and resources about acute leukemia and clinical trials. Researchers want to see if the tool is easy to use and if people will complete the surveys. About 75 English-speaking adults with suspected acute …

This study tracks 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib alone (no other cancer drugs) to see how long they stay on treatment and why they might stop. It collects real-world data on effectiveness and side effects, filling a knowledge gap …

Researchers are studying whether the mix of bacteria in the gut relates to complications of gallstone disease, such as pancreatitis and acute cholecystitis. Adults with confirmed gallstones at East Kent hospitals provide stool samples at several points, including before and after…

This study tests whether briefly increasing the air pressure from a CPAP machine before giving surfactant therapy helps preterm babies' lungs work better. Surfactant is a natural substance that helps immature lungs stay open, and it's often given through a thin tube. The trial wi…

Researchers at IRCCS San Raffaele are creating a registry of images and videos from endoscopic ultrasound procedures performed to investigate pancreatic diseases. The study will gather data from about 12,000 patients with conditions like pancreatitis, pancreatic cancer, and neuro…

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study tests whether a bedside ultrasound tool called the VExUS score can predict acute kidney injury after open-heart surgery. The score measures fluid buildup in the veins, which may stress the kidneys. Researchers will follow 135 adults undergoing heart surgery with a hear…

This study looks at how common mild depression is in people who have had their first heart attack. Researchers will follow 100 patients for 12 months to see if these mild symptoms affect recovery, heart health, and quality of life. The goal is to better understand the link betwee…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study tracks 230 adults having planned heart surgery to see if unstable blood pressure during the operation raises the risk of serious problems like confusion, kidney injury, stroke, or death within 30 days. Researchers will monitor blood pressure dips and use of pressure-ra…

This study aims to find new blood-based markers that can predict or diagnose infected pancreatic necrosis (IPN) in people with severe pancreatitis. About 20% of acute pancreatitis cases develop tissue death (necrosis), and when that tissue gets infected, the risk of death rises t…

This study looks at how tilting the body (trunk inclination) changes lung mechanics in 40 adults with moderate to severe ARDS who are on ventilators. Researchers will measure lung pressures and use electrical imaging to see how different positions and ventilator settings affect l…

This study looks at how to adjust breathing machine settings for people with moderate-to-severe ARDS, a serious lung condition. Researchers will use a special imaging technique to see how air and blood flow match up in the lungs. The goal is to find the best settings for each pat…

This study is collecting blood, bone marrow, and leftover tissue samples from 550 people with acute myeloid leukemia or follicular lymphoma. Researchers will analyze the samples to find genetic markers that may predict how well treatments work or why some stop working. The goal i…

This study tests whether a device called FIZE kUO®, which tracks urine output every minute, can help doctors manage fluids and diuretics in patients recovering from heart surgery. Researchers will monitor 45 adults in the intensive care unit and compare urine output before and af…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study investigates whether measuring the physical effort of breathing in children with acute respiratory distress syndrome (ARDS) can predict how the disease will progress. Researchers will use advanced, non-invasive monitoring tools to track breathing drive, effort, and lun…

This study looks at medical records of 514 adults in India with acute cholangitis (a bile duct infection and blockage) who had a drainage procedure. The goal is to create a new composite index that combines factors like death, need for organ support, ICU stay, complications, hosp…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study looks at teenagers aged 12 to 17 who live in child welfare care. Researchers want to understand emotional dysregulation, which is trouble managing emotions, in those who have experienced trauma. They aim to see if this emotional difficulty can help tell apart complex p…

This study tests whether artificial intelligence can use continuous ECG data to predict and detect life-threatening heart arrhythmias in patients admitted with acute cardiac illness. Researchers will analyze stored ECG data from 3000 adult patients to see if AI models can forecas…

This observational study aims to uncover clinical and genetic risk factors for sudden cardiac arrest and death in patients with coronary artery disease (CAD). Researchers will follow about 4,000 participants who have been diagnosed with CAD, collecting data from surveys, ECG reco…

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergo…

This study compares different ways to train mental health providers in Written Exposure Therapy (WET), an effective treatment for PTSD. Some providers attend a live workshop via video, while others use a self-paced web-based program or an AI-powered training tool called TherapyTr…

This study is investigating why some patients develop pancreatitis after an ERCP, a procedure used to diagnose and treat issues in the bile and pancreatic ducts. The researchers are collecting blood samples from 700 adults undergoing ERCP to look for genetic variations that affec…

This study explores whether measuring the natural variability in a person's breathing can help predict complications after lung surgery. Researchers will use a sensor belt to continuously monitor chest movements in patients undergoing lung resection, both before anesthesia and af…

This study looks at whether cardiac MRI and blood tests can detect acute rejection in children and young adults who have had a heart transplant. Currently, doctors often use invasive heart biopsies to check for rejection, which can be uncomfortable and risky. The goal is to see i…

This study follows people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who previously received a combination of ibrutinib and venetoclax in the CAPTIVATE trial. Researchers will track their health for up to 10 years to see what treatments they need …

This study investigates whether the types and behavior of certain immune cells (neutrophils and monocytes) in the blood are linked to how the heart repairs itself after a heart attack. Researchers will follow 50 adults who have had a severe type of heart attack and are scheduled …

This study follows 1,500 people with Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases — rare conditions where the virus drives abnormal immune cell growth. Researchers will collect medical history, treatment details, and blood samples to see how the diseases beh…

This study investigates whether a blood marker called anti-Müllerian hormone (AMH) can predict future infertility in children and adolescents who have undergone cancer treatment. Many young patients recover normal menstrual cycles or puberty after chemotherapy, but their ovarian …

This study enrolls people diagnosed with cancer to build a large registry using Olivia, an AI-powered health platform. The platform will collect and combine electronic health records and patient-reported outcomes from over 1,000 healthcare systems. The goal is to create a compreh…

This study follows children and young adults with acute lymphoblastic leukemia (ALL) who receive CAR-T cell therapy. The goal is to track how long these engineered immune cells persist in the body and identify factors that cause them to disappear. By understanding why CAR-T cells…

This study looks at whether measuring the amount of venetoclax in the blood can help doctors give the right dose to people with newly diagnosed acute myeloid leukemia (AML). Currently, everyone gets the same dose, but drug levels vary a lot between patients. The goal is to find a…

This study explores whether a special PET/MR scan can detect early signs of heart muscle damage after a heart attack. Researchers will scan 25 adults about 10 days after their heart attack and then track their heart function with MRI scans at 3 and 6 months. The goal is to see if…

This study looks at whether screening adults with leukemia for social needs (like housing or food) and offering early social work help is practical and helpful. About 80 newly diagnosed patients will either get the screening and consultation or usual care. The goal is to see if t…

This study follows 400 people in Norway with multiple myeloma, plasma cell leukemia, or AL amyloidosis who are receiving newer immunotherapies like teclistamab, elranatamab, or CAR-T cell therapy outside of clinical trials. Researchers will track how well these treatments control…

This study tests a web-based decision-support tool designed to help families and doctors make shared decisions about whether a child should go on chronic home ventilation. Half of the participating families use the tool, while the other half receive usual care. Researchers then m…

This study investigates the long-term heart and lung health of adults who survived childhood acute lymphoblastic leukemia (ALL) or lymphoma. Researchers use advanced MRI and other imaging to detect subtle damage from past chemotherapy, comparing survivors to healthy volunteers. T…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study will observe 128 critically ill patients with acute kidney injury who need dialysis to remove excess fluid. Researchers want to understand why some patients become unstable during fluid removal. They will monitor heart function, blood flow, and other signs before and d…

This study tests whether advanced monitoring of breathing patterns can help prevent lung damage in intensive care unit (ICU) patients who need a ventilator for reasons other than lung failure, such as coma or sepsis. Researchers will use special sensors to track airway pressure, …

This study looks at how different ways of measuring height affect ventilator settings and lung injury risk in people with acute respiratory distress syndrome (ARDS). Researchers will measure 39 patients' heights using five methods (stadiometer, visual estimation, tape, laser, and…

This study follows adults aged 18 and older who have a specific type of acute lymphoblastic leukemia (Ph+ ALL) and are receiving a combination of targeted drugs (BCR::ABL1 inhibitors) along with chemotherapy, steroids, or antibody therapy. Researchers will track how long patients…

This study creates a registry for people with hairy cell leukemia (HCL), a rare form of adult leukemia. Researchers will track disease course, treatments, infections, and patient-reported outcomes over time. The goal is to identify trends, improve care, and design future clinical…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study gathers blood and bone marrow samples from 150 adults with myelodysplastic syndrome (MDS), a blood disorder that can turn into acute leukemia. Researchers want to find biological markers that help predict which patients are likely to progress to leukemia. The goal is t…

This study is a registry that collects information from all suspected heart attack cases in Tomsk, Russia. It aims to track how many people die within 28 days and one year after a heart attack. No new treatments or drugs are being tested—just observation and data gathering.

This study collects extra blood and bone marrow samples from people receiving CAR-T cell therapy for lymphoma or acute lymphoblastic leukemia. The goal is to build a biobank that researchers can use to investigate why about half of patients do not respond to this treatment. Parti…

This observational study examines a specific group of patients with a type of acute myeloid leukemia (AML) that has an NPM1 mutation. Researchers want to see if a particular subset, called APL-like, is linked to early blood vessel problems like bleeding or clots. The study will l…

This study follows 100 women with neuroimmune diseases (like multiple sclerosis or myasthenia gravis) through pregnancy and up to five years after. Researchers will track disease activity, pregnancy complications, and baby health to learn how these conditions affect fertility and…

This study reviews medical records from 3,000 patients who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to understand what factors increase risks and how patients fare in the long run, including complications, repeat surgeries, and survival.…

This study investigates whether blood sugar patterns, measured continuously with a wearable sensor, can predict serious heart problems in the year following a heart attack. Researchers will enroll 850 people hospitalized with acute coronary syndrome and track their glucose levels…

This study looks at blood cells from 20 adults with acute myeloid leukemia (AML) whose cancer returned after a stem cell transplant. All participants have specific genetic changes (NPM1 mutations or KMT2A rearrangements) and are being treated with a menin inhibitor. Researchers w…

This study compares a step-by-step protocol for stopping high-flow nasal oxygen therapy against usual doctor-led care in 148 adults with acute respiratory failure. The protocol uses oxygen levels and breathing rate to decide when to stop. The goal is to see if a standard approach…

This study looks at whether targeted cancer drugs called TKIs affect brain health and well-being in people with chronic leukemia. Researchers will compare 400 patients who receive TKI therapy to those who do not. The goal is to understand if these treatments cause cognitive chang…

This study looks at blood from people with ARDS, a severe lung condition with no specific medicines. Researchers will take immune cells from the blood and test a new blocking agent in the lab to see if it can reduce lung damage. The goal is to learn more about the disease and fin…

This observational study with 300 ICU patients aims to see if combining blood markers (metabolomics) with standard clinical data can better predict when high-flow nasal cannula fails, requiring a breathing tube. Researchers will collect blood samples and monitor outcomes to build…

This study collects blood and bone marrow samples from 80 adults newly diagnosed with acute myeloid leukemia (AML). Researchers will measure inflammasome activity before and after standard chemotherapy to see if it relates to how well the treatment works. The goal is to better un…

This study watches how blood flows to the kidneys in 51 adults having elective minimally invasive abdominal surgery. Researchers use two non-invasive tools—ultrasound and light sensors—to measure kidney function at key times during and after surgery. The goal is to see if these t…

After a heart attack, patients face a high risk of dangerous heart rhythms, but current monitoring methods may miss them. This trial tests whether a small implantable cardiac monitor (ICM) placed under the skin can catch these rhythms earlier and help doctors adjust treatment. Tw…

This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for sho…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study follows 1,400 children and teens (ages 3-21) in Southern Europe with acute lymphoblastic leukemia or certain brain tumors. Researchers will track their diet, lifestyle, and quality of life over time to see how these factors relate to treatment side effects and survival…

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have…

This study is watching 150 ICU patients in Estonia who doctors suspect have acute mesenteric ischemia, a rare but deadly gut condition. Researchers will track medical records, lab results, and CT scans to find clues that predict severe bowel damage. No new treatments are being te…

This study looks at whether the heart's pumping ability plays a role in why some patients fail to come off a mechanical ventilator. Researchers will use ultrasound to check heart and lung function before and during a breathing test in 250 intensive care patients. The goal is to b…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study looks at 24 ICU patients on breathing machines who are ready to try breathing on their own. Doctors will use heart ultrasound to see which of three breathing tests is easiest on the heart. The goal is to find the best way to help patients safely stop using the breathin…