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New hope for Tough-to-Treat blood cancers: experimental pill takes on CLL and SLL

NCT ID NCT06846671

Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 15, 2026 · Updated 10 times

Summary

This Phase 3 trial is testing an experimental oral drug called BGB-16673 against standard treatments for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has already been treated with two types of targeted therapy (BTK and BCL2 inhibitors). The study will enroll 250 participants and compare how long the cancer stays under control with the new drug versus other drug combinations. The goal is to see if BGB-16673 offers a better option for patients who have limited choices after prior treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BGB-16673 (an experimental oral drug)
What this could lead to
If it works, this could offer a new treatment option for people with CLL or SLL whose cancer has stopped responding to two common types of targeted therapy.
What could go wrong
This is an early-stage Phase 3 trial, so results are not yet known. The experimental drug may not work better than existing options, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Confirmed diagnosis of CLL or SLL, requiring treatment, based on 2018 international workshop on chronic lymphocytic leukemia (iwCLL) criteria. 2. Previously received treatment for CLL/SLL with both a BTKi and a BCL2i. 3. Participants with SLL must have measurable disease by computer tomography (CT)/magnetic resonance imaging (MRI) 4. Eastern Cooperative Oncology Group (ECOG) score 0, 1, or 2 5. Adequate liver function 6. Adequate blood clotting function Exclusion Criteria: 1. Known prolymphocytic leukemia or history of, or currently suspected, Richter's transformation 2. Prior autologous stem cell transplant or chimeric antigen receptor-T cell therapy in the last 3 months 3. Known central nervous system involvement 4. Prior exposure to any BTK protein degraders 5. Active fungal, bacterial and/or viral infection requiring parenteral systemic therapy 6. Clinically significant cardiovascular disease NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic lymphocytic leukemia CLL

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    130 sites in 14 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Aberdeen Royal Infirmary

    RECRUITING

    Aberdeen, AB25 2ZN, United Kingdom

  • Aichi Cancer Center Hospital Clinical Oncology

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Aiiku Hospital

    RECRUITING

    Sapporo, Hokkaido, 064-0804, Japan

  • American Oncology Partners of Maryland Pa

    RECRUITING

    Bethesda, Maryland, 20817-7847, United States

  • Amsterdam Umc Vu Mc

    RECRUITING

    Amsterdam, 1081 HV, Netherlands

  • Antalya Memorial Hospital

    RECRUITING

    Dokuma, 07025, Turkey (Türkiye)

  • Aou Careggi, Servizio Sanitario Toscana

    RECRUITING

    Florence, 50134, Italy

  • Aou Maggiore Della Carita

    RECRUITING

    Novara, 28100, Italy

  • Azienda Ospedaliera Universitaria Federico Ii

    RECRUITING

    Naples, 80131, Italy

  • Baptist Md Anderson Cancer Center

    RECRUITING

    Jacksonville, Florida, 32207-8432, United States

  • Baylor Scott and White Health

    RECRUITING

    Temple, Texas, 76508-0001, United States

  • Birmingham Heartlands Hospital

    RECRUITING

    Birmingham, B9 5SS, United Kingdom

  • CEMIC

    RECRUITING

    Caba, C1431, Argentina

  • CETUS

    RECRUITING

    Belo Horizonte, 30110-022, Brazil

  • Cancer Care Associates of York

    RECRUITING

    York, Pennsylvania, 17403-5049, United States

  • Centre Integre de Sante Et de Services Sociaux de La Monteregie Centre

    RECRUITING

    Greenfield Park, Quebec, J4V 2H1, Canada

  • Centro Gaucho Integrado de Oncologia Hospital Mae de Deus

    RECRUITING

    Porto Alegre, 90110-270, Brazil

  • Centro de Ensino E Pesquisa Em Oncologia de Santa Catarina (Cepen)

    RECRUITING

    Florianópolis, 88020-210, Brazil

  • Centrum Fur Haematologie Und Onkologie Bethanien

    RECRUITING

    Frankfurt am Main, 60389, Germany

  • Chiba Cancer Center

    RECRUITING

    Chiba, Chiba, 260-8717, Japan

  • Chonnam National University Hwasun Hospital

    RECRUITING

    HwasunGun, Jeonnam-Gwangju S.M. City, 58128, South Korea

  • Cice 9 de Julio Sanatorio 9 de Julio

    RECRUITING

    San Miguel de Tucumán, 4000, Argentina

  • Cleveland Clinic Florida

    RECRUITING

    Weston, Florida, 33331-3609, United States

  • Complexo Hospitalar de Niteroi

    RECRUITING

    Niterói, 24020-096, Brazil

  • Concord Repatriation General Hospital

    RECRUITING

    Concord, New South Wales, NSW 2139, Australia

  • Corewell Health the Michigan Cancer Consortium

    RECRUITING

    Grand Rapids, Michigan, 49503-2560, United States

  • Dayton Physician Network

    RECRUITING

    Dayton, Ohio, 45415, United States

  • Dokuz Eylul University

    RECRUITING

    Balçova, 35330, Turkey (Türkiye)

  • Dong A University Hospital

    RECRUITING

    Seogu, Busan Gwang'yeogsi, 49201, South Korea

  • Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

    RECRUITING

    Ankara, 06200, Turkey (Türkiye)

  • Emory University Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322-1013, United States

  • FUNDALEU

    RECRUITING

    Caba, CP1114, Argentina

  • Fakultni Nemocnice Brno

    RECRUITING

    Brno, 625 00, Czechia

  • Fakultni Nemocnice Hradec Kralove

    RECRUITING

    Hradec Králové, 500 03, Czechia

  • Fakultni Nemocnice Ostrava

    RECRUITING

    Ostrava, 708 00, Czechia

  • Flinders Medical Centre

    RECRUITING

    Bedford PK, South Australia, SA 5042, Australia

  • Florida Oncology and Hematology

    RECRUITING

    Fort Myers, Florida, 33912, United States

  • Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, 20122, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli

    RECRUITING

    Roma, 00168, Italy

  • Gazi University

    RECRUITING

    Ankara, 6500, Turkey (Türkiye)

  • Gosford Hospital

    RECRUITING

    Gosford, New South Wales, NSW 2250, Australia

  • Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital

    RECRUITING

    Hiroshima, Hiroshima, 730-8619, Japan

  • Hospital Aleman

    RECRUITING

    Caba, 1425, Argentina

  • Hospital Erasto Gaertner

    RECRUITING

    Curitiba, 81520-060, Brazil

  • Hospital Italiano de Buenos Aires

    RECRUITING

    Ciudad Autonoma Buenos Aires, 1413, Argentina

  • Hospital Santa Rita de Cassia Afecc

    RECRUITING

    Vitória, 29043-260, Brazil

  • Hospital Sao Lucas Dasa Oncologia

    RECRUITING

    Rio de Janeiro, 22061-080, Brazil

  • Hospital Sao Rafael (Rede Dor)

    RECRUITING

    Salvador, 41253-190, Brazil

  • Hospital Sirio Libanes Brasilia

    RECRUITING

    Brasília, 70200-730, Brazil

  • Hyogo Prefectural Amagasaki General Medical Center

    RECRUITING

    AmagasakiCity, Hyōgo, 660-8550, Japan

  • Instituto Alexander Fleming (Iaf)

    RECRUITING

    Ciudad Autonoma Buenos Aires, 1426, Argentina

  • Instituto Brasileiro de Controle Do Cancer

    RECRUITING

    São Paulo, 04014-002, Brazil

  • Instituto Dor de Pesquisa E Ensino Sao Paulo

    RECRUITING

    São Paulo, 01401-004, Brazil

  • Instituto Joinvilense de Hematologia E Oncologia

    RECRUITING

    Joinville, 89201-260, Brazil

  • Invo Institut Fur Versorgungsforschung in Der Onkologie

    RECRUITING

    Koblenz, 56068, Germany

  • Irccs Istituto Tumori Giovanni Paolo Ii

    RECRUITING

    Bari, 70124, Italy

  • Irccs Policlinico San Matteo, Universita Degli Studi Di Pavi

    RECRUITING

    Pavia, 27100, Italy

  • Jewish General Hospital

    RECRUITING

    Montreal, Quebec, QC H3t 1E2, Canada

  • Juravinski Cancer Centre

    RECRUITING

    Hamilton, Ontario, L8V 5C2, Canada

  • Kagoshima University Hospital

    RECRUITING

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Kansai Medical University Hospital

    RECRUITING

    Hirakata, Osaka, 573-1191, Japan

  • Kindai University Hospital

    RECRUITING

    Sakai, Osaka, 590-0197, Japan

  • Klinikum Chemnitz Ggmbh

    RECRUITING

    Chemnitz, 09116, Germany

  • Kumamoto University Hospital

    RECRUITING

    Kumamoto, 860-8556, Japan

  • Kurashiki Central Hospital

    RECRUITING

    Kurashikishi, Okayama-ken, 710-8602, Japan

  • Kyungpook National University Hospital

    RECRUITING

    Junggu, Daegu Gwang'yeogsi, 41944, South Korea

  • London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • Memorial Sloan Kettering Cancer Center Mskcc

    RECRUITING

    New York, New York, 10065-6800, United States

  • National Cancer Center (Korea)

    RECRUITING

    IlsandongGu GoyangSi, Gyeonggi-do, 10408, South Korea

  • National Hospital Organization Okayama Medical Center

    RECRUITING

    Okayama, 701-1192, Japan

  • New York Cancer and Blood Specialists

    RECRUITING

    Shirley, New York, 11967, United States

  • Nho Shikoku Cancer Center

    RECRUITING

    Matsuyama, Ehime, 791-0280, Japan

  • Niigata University Medical and Dental Hospital

    RECRUITING

    Niigata, Niigata, 951-8520, Japan

  • Northside Cancer Center

    RECRUITING

    Atlanta, Georgia, 30342, United States

  • Ntt Medical Center Tokyo

    RECRUITING

    Shinagawaku, Tokyo, 141-0022, Japan

  • Oncoclinicas Rio de Janeiro Sa

    RECRUITING

    Rio de Janeiro, 22250-040, Brazil

  • Oncology Associates of Oregon Willamette Valley Cancer Center

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Oncology Hematology Associates

    RECRUITING

    Springfield, Missouri, 65807-5288, United States

  • Oncology Hematology West, Pc Dba Nebraska Cancer Specialists

    RECRUITING

    Omaha, Nebraska, 68130-2042, United States

  • Optum Medical Care, Pc

    RECRUITING

    Westbury, New York, 11590-5119, United States

  • Osaka Metropolitan University Hospital

    RECRUITING

    Osaka, 545-8586, Japan

  • Ospedale San Raffaele

    RECRUITING

    Milan, 20132, Italy

  • Ospedale Santa Maria Della Misericordia

    RECRUITING

    Perugia, 6129, Italy

  • Our Lady of the Lake Hospital

    RECRUITING

    Baton Rouge, Louisiana, 70808-4365, United States

  • Perth Blood Institute

    RECRUITING

    West Perth, Western Australia, WA 6005, Australia

  • Pih Health Whittier Hospital

    RECRUITING

    Whittier, California, 90602, United States

  • Port Macquarie Base Hospital

    RECRUITING

    Port Macquarie, New South Wales, NSW 2444, Australia

  • Pratia McM Krakow

    RECRUITING

    Krakow, 30-727, Poland

  • Pratia Onkologia Katowice

    RECRUITING

    Katowice, 40-519, Poland

  • Praxis Am Volkspark

    RECRUITING

    Berlin, 10715, Germany

  • Prince of Wales Hospital

    RECRUITING

    Randwick, New South Wales, NSW 2031, Australia

  • Rocky Mountain Cancer Centers (Williams) Usor

    RECRUITING

    Aurora, Colorado, 80012-5405, United States

  • Royal Marsden Hospital

    RECRUITING

    London, SW3 6JJ, United Kingdom

  • Saitama Medical Center

    RECRUITING

    Kawagoeshi, Saitama, 350-8550, Japan

  • Sakarya Training and Research Hospital

    RECRUITING

    Sakarya, 54100, Turkey (Türkiye)

  • Samsung Medical Center

    RECRUITING

    GangnamGu, Seoul Teugbyeolsi, 06351, South Korea

  • Scripps Prebys Cancer Center

    RECRUITING

    San Diego, California, 92103-2106, United States

  • Seoul National University Hospital

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein

    RECRUITING

    São Paulo, 05652-900, Brazil

  • Southampton General Hospital

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • St Bernards Medical Center

    RECRUITING

    Jonesboro, Arkansas, 72401, United States

  • St Lukes Center For Cancer Care

    RECRUITING

    Chesterfield, Missouri, 63017, United States

  • St Vincent Frontier Cancer Center

    RECRUITING

    Billings, Montana, 59102-6746, United States

  • Szpital Specjalist W Brzozowie,Podkarpacki Osrodek Onkologiczny

    RECRUITING

    Brzozów, 36-200, Poland

  • Texas Oncology Tyler

    RECRUITING

    Tyler, Texas, 75702-7522, United States

  • The Alfred Hospital

    RECRUITING

    Melbourne, Victoria, VIC 3004, Australia

  • The Catholic University of Korea, Seoul St Marys Hospital

    RECRUITING

    SeochoGu, Seoul Teugbyeolsi, 06591, South Korea

  • The Ottawa Hospital Cancer Centre

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • The Royal Bournemouth and Christchurch Hospitals Nhs Foundation

    RECRUITING

    Bournemouth, BH7 7DW, United Kingdom

  • Tohoku University Hospital

    RECRUITING

    Sendai, Miyagi, 980-8574, Japan

  • Tokyo Metropolitan Komagome Hospital

    RECRUITING

    Bunkyoku, Tokyo, 113-8677, Japan

  • Toowoomba Hospital

    RECRUITING

    Toowoomba, Queensland, QLD 4350, Australia

  • UCLA Department of Medicine Hematologyoncology

    RECRUITING

    Los Angeles, California, 90095-3075, United States

  • Unite de Recherche Clinique Du Cisss Des Laurentides

    RECRUITING

    SaintJerome, Quebec, J7Z 5T3, Canada

  • Universitaetsklinikum Leipzig Aor

    RECRUITING

    Leipzig, 04103, Germany

  • Universitatsklinikum Augsburg

    RECRUITING

    Augsburg, 86156, Germany

  • Universitatsklinikum Des Saarlandes

    RECRUITING

    Homburg, 66421, Germany

  • Universitatsklinikum Essen (Aor)

    RECRUITING

    Essen, 45122, Germany

  • Universitatsklinikum Freiburg I Br Klinik Fur Innere Medizin I

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Universitatsklinikum Hamburg Eppendorf

    RECRUITING

    Hamburg, 20251, Germany

  • Universitatsklinikum Heidelberg

    RECRUITING

    Heidelberg, 69120, Germany

  • Universitatsklinikum Munster Medizinische Klinik A

    RECRUITING

    Münster, 48149, Germany

  • University College Hospital

    RECRUITING

    London, NW1 2PG, United Kingdom

  • University Hospital, Kyoto Prefectural Univ of Medicine

    RECRUITING

    KyotoShi, Kyoto, 602-8566, Japan

  • University Hospitals

    RECRUITING

    Cleveland, Ohio, 44106-1716, United States

  • Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu

    RECRUITING

    Wroclaw, 50-367, Poland

  • Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie

    RECRUITING

    Lublin, 20-090, Poland

  • Vseobecna Fakultni Nemocnice V Praze

    RECRUITING

    Prague, 10000, Czechia

  • West Penn Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi

    RECRUITING

    Lodz, 93-513, Poland

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