Acute diarrhea

This early-stage study tests a new vaccine called IVT Shigella-04 to see if it is safe and helps the immune system fight Shigella bacteria, a major cause of severe diarrhea. About 60 healthy adults aged 18 to 49 will receive two shots of either the vaccine or a placebo. Researche…

This large Phase 3 trial tests whether VE303, a capsule containing 8 harmless bacteria, can prevent repeat Clostridioides difficile (C. diff) infections. About 852 people who have had at least one prior C. diff infection will take VE303 or a placebo for 14 days. The main goal is …

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study tests how the drug rifaximin (Xifaxan) works in children aged 6 to 11 with acute diarrhea likely caused by bacteria. Half the children get the drug plus oral rehydration therapy, the other half get rehydration alone. Researchers want to see if adding the drug helps dia…

This study looks at whether giving antibiotics to children with a certain type of Shigella infection (non-dysentery watery diarrhea) helps them recover faster and grow better. About 700 children in Bangladesh and Zambia will receive either azithromycin or a placebo. Researchers w…

This study tests whether whole genome sequencing (looking at all DNA) finds more answers than whole exome sequencing (looking at just the protein-making parts) for children with long-lasting diarrhea and gut problems. About 180 children will be randomly assigned to one test or th…

This study tests a program called CHoBI7, which teaches handwashing, water treatment, and safe water storage to diarrhea patients and their families in Bangladesh hospitals. Researchers want to see if this program reduces diarrhea and improves hygiene behaviors compared to standa…

This study tests whether providing targeted water, sanitation, and hygiene (WASH) supplies and education to households of cholera patients can reduce the spread of diarrhea. About 2,900 people in South Kivu, DRC, will take part. The goal is to see if these simple measures can pre…

This study tests whether a daily probiotic supplement called BioAmicus Complete can help infants with colic, constipation, diarrhea, and eczema. 140 babies will receive either the probiotic drops or a placebo (sunflower oil) for 25 days. Researchers will track changes in stool, c…

This study tests whether adding amino acids to the standard rehydration drink can help children aged 6 months to 5 years recover faster from acute gastroenteritis (stomach flu). About 72 kids with mild to moderate diarrhea will receive either the fortified drink or standard oral …

This study follows 368 mothers and their babies in Zimbabwe from pregnancy until the child turns 3. Researchers want to understand how malnutrition, poor water and sanitation, and gut problems affect child growth, infections, and development. They will measure gut bacteria, immun…

This study looks at 60 children with congenital diarrhea and enteropathy (CODE) in China. Researchers will collect medical history, blood, and stool samples to find biological markers and build a risk prediction model. No new treatment is being tested; the goal is to better under…