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Zimbabwe study tracks how Mother's nutrition shapes Baby's gut and future health

NCT ID NCT07195006

Knowledge-focused Sponsor: University of Zimbabwe Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 368 mothers and their babies in Zimbabwe from pregnancy until the child turns 3. Researchers want to understand how malnutrition, poor water and sanitation, and gut problems affect child growth, infections, and development. They will measure gut bacteria, immune cells, and breast milk quality to find links between these factors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal key factors linking maternal malnutrition, gut health, and infections to child development, pointing toward better prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 368 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women at least 20 weeks gestational age seeking antenatal care services at any of the two primary health care centres, Kuwadzana and Hopely.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Cases: * MUAC ≤23 cm in pregnancy * ≥18 years' old * At least 20 weeks' gestational age * Height ≥150 cm * Planning to be staying in the study area for the next 3 years * Willing to participate and comply with all study requirements and procedures. Any pregnant woman meeting the above eligible criteria regardless of HIV status who meet the above inclusion criteria will be invited to participate in the study Inclusion criteria for Controls * Age, HIV status, gestational age at enrolment, and area residence matched normo-nourished peers with MUAC ≥25 - ≤35 cm * Haemoglobin level of ≥11g/dL * ≥18 years' old * At least 20 weeks' gestational age * Height ≥150 cm * Planning to stay in the study area for the next 3 years Exclusion Criteria * Acute or chronic conditions in mothers interfering with the study according to the judgment of the investigator (HIV infection is not an exclusion criterion) * Presence of severe mental health disorders interfering with study procedures according to the judgment of the investigator.

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Conditions

The condition(s) this trial relates to.

Child Nutrition Disorders dysentery Infant Death Malnutrition nutritional deficiency disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cell-mediated immune deficiency Child mental health Diarrhea infectious Environmental enteric dysfunction Environmental exposures Gut dysbiosis Gut permeability, gut inflammation Malnutrition (calorie) Malnutrition in children Malnutrition pregnancy Maternal stress Mycotoxin biomonitoring Natural killer cell mediated immunity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Zimbabwe

    RECRUITING

    Harare, Zimbabwe

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