Acute diarrhea

This study tests a new vaccine (IP-QSV) designed to protect against four types of Shigella bacteria, which cause severe diarrhea. The trial will include 370 healthy adults, children, and infants in Mali. Researchers will check if the vaccine is safe and triggers a strong immune r…

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

Researchers are testing whether adding the probiotic yeast Saccharomyces boulardii to standard care helps children aged 6 months to 5 years recover faster from acute diarrhea. All children receive fluids and zinc, and half also receive the probiotic from hospital admission to dis…

This trial is testing whether a postbiotic supplement called Lactobacillus LB (Lactéol®) is safe for hospitalized children under 18 with weakened immune systems who have diarrhea. Participants receive the supplement twice daily for 14 to 28 days alongside standard rehydration and…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…