Which probiotic stops Kids' diarrhea faster? new trial aims to find out
NCT ID NCT07660367
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea duration and stool frequency more effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- probiotics (Bacillus clausii or multistrain Lactobacillus/Bifidobacterium/Streptococcus)
- What this could lead to
- If one probiotic works better, it could offer a simple, safe way to help kids recover faster from diarrhea.
- What could go wrong
- This is a small, early-stage trial with only 138 children, so results may not apply broadly. Probiotics are generally safe but may not always shorten diarrhea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 138 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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1 year to 5 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patient with Acute watery diarrhea aged 1 year to 5 years. 2. Both genders will be included. 3. Patients whose guardians/ parents will give informed consent will participate in the study. 4. Patients having mild to moderate dehydration will be included in study. 5. Patients having mild to moderate malnutrition will be included in study. Exclusion Criteria: 1. Children having history of chronic diarrhea. 2. Children having history of blood in stools. 3. Children having cholera. 4. Children with evidence of concurrent systemic infections other than acute diarrhea (e.g. respiratory tract infections, urinary tract infections, measles, meningitis etc). 5. Children with known immunodeficiency disorders or undergoing immunosuppressive treatments (e.g., chemotherapy, corticosteroids). 6. Children who have received antibiotics or zinc within the past 72 hours prior to enrollment, as this may interfere with gut flora and probiotic efficacy. 7. Children who have received probiotics as a treatment for the current episode of diarrhea prior to study enrollment. 8. Children with known allergies or hypersensitivity to probiotic components used in the study. 9. Children who needed I/V antibiotics or I/V rehydration after enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Children Hospital and Institute of Child Health, Lahore
Lahore, Punjab Province, 54000, Pakistan
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