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Can a pill tame vaginal odor? scientists put an oral probiotic to the test

NCT ID NCT07829861

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing whether a probiotic capsule taken by mouth can reduce vaginal odor in healthy women aged 18 to 65. About 105 participants receive either the probiotic or a placebo for 15 days and answer weekly questionnaires plus a daily diary for roughly 75 days. The trial measures how often odor occurs, how severe it feels, and how much it bothers participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an oral probiotic supplement
What this could lead to
If it works, this could offer a simple oral option for women bothered by vaginal odor, without creams or gels.
What could go wrong
This is an early, single-company study of 105 women. Probiotics taken by mouth may not reach the vagina in enough numbers to change odor, and odor can have many causes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

105 people

The number who actually took part.

Started

Jul 2025

Finished

Jan 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy women who are 18-65 years of age (inclusive). * Have a body mass index (BMI) between 18.5 to 29.9 kg/m2 (inclusive). * Experiences vaginal odor. * Maintains study eligibility status during the run-in period (as outlined during the pre-screening period) from screening through the end of the study. * Have no current medical diagnosis of active bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), or urinary tract infection (UTI), or any other active infectious, inflammatory, or neoplastic vulvovaginal or genitourinary disorder. * Have not been medically diagnosed with recurrent BV as defined by 3 or more diagnosed infections in the past 12 months, recurrent VVC as defined by 3 or more symptomatic, diagnosed infections in the past 12 months, or recurrent UTIs as defined by 3 or more diagnosed infections in the past year or 2 or more diagnosed infections in the past 6 months. * In good general health (no active or uncontrolled diseases or conditions) and able to consume the study product. * Willing to report information related to your menstrual cycle and menopause status. * Agree to refrain from using probiotic/prebiotic supplements (oral or vaginal); boric acid; pH-balancing tampons, pads, wipes, and washes; antifungals (oral or vaginal); antibiotics, and other treatments listed in Section 6.5 during the defined timeframe. * Agree to refrain from making changes to current level of consumption of foods containing probiotics/prebiotics. * Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: * Active infectious, inflammatory, or neoplastic vulvovaginal or genitourinary disorder (such as vulvovaginal candidiasis, bacterial vaginosis, urinary tract infection, vulvar intraepithelial neoplasia, or lichen sclerosis). * Symptomatic sexually transmitted infection. * Use of probiotics within the past 3 months. * Any prior use of intervention product. * Use of antibiotics within the past 3 months. * Vaginal hormone therapy (unless dosage and modality has been stable for 90 days prior to enrollment). * Current use of any medications, supplements, or over-the-counter remedies (including boric acid and deodorants) for vaginal odor. * Vaginal rinses, moisturizers, cooling devices, cooling mattresses, or cooling sprays (unless habitually used for at least 90 days prior to enrollment). * Self-reported urinary incontinence. * Currently lactating, pregnant, or planning to become pregnant during the study period. * Known sensitivity, intolerability, or allergy to any of the study products or their ingredients. * Any clinically significant disease or disorder which, in the opinion of the study investigator, may place you at undue risk or harm, interfere with ability to participate, compromise the interpretability of the study data. * History of alcohol or substance abuse in the last 5 years. * History of smoking in the last 2 years. * Currently participating in another clinical research study on vulvovaginal health.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Bonafide Health

    Harrison, New York, 10528, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.