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Can a pill tame vaginal odor? scientists put an oral probiotic to the test
NCT ID NCT07829861
First seen Sep 21, 2026 ยท Last updated Sep 21, 2026
Summary
Researchers are testing whether a probiotic capsule taken by mouth can reduce vaginal odor in healthy women aged 18 to 65. About 105 participants receive either the probiotic or a placebo for 15 days and answer weekly questionnaires plus a daily diary for roughly 75 days. The trial measures how often odor occurs, how severe it feels, and how much it bothers participants.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- an oral probiotic supplement
- What this could lead to
- If it works, this could offer a simple oral option for women bothered by vaginal odor, without creams or gels.
- What could go wrong
- This is an early, single-company study of 105 women. Probiotics taken by mouth may not reach the vagina in enough numbers to change odor, and odor can have many causes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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105 people
The number who actually took part.
- Started
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Jul 2025
- Finished
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Jan 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy women who are 18-65 years of age (inclusive). * Have a body mass index (BMI) between 18.5 to 29.9 kg/m2 (inclusive). * Experiences vaginal odor. * Maintains study eligibility status during the run-in period (as outlined during the pre-screening period) from screening through the end of the study. * Have no current medical diagnosis of active bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), or urinary tract infection (UTI), or any other active infectious, inflammatory, or neoplastic vulvovaginal or genitourinary disorder. * Have not been medically diagnosed with recurrent BV as defined by 3 or more diagnosed infections in the past 12 months, recurrent VVC as defined by 3 or more symptomatic, diagnosed infections in the past 12 months, or recurrent UTIs as defined by 3 or more diagnosed infections in the past year or 2 or more diagnosed infections in the past 6 months. * In good general health (no active or uncontrolled diseases or conditions) and able to consume the study product. * Willing to report information related to your menstrual cycle and menopause status. * Agree to refrain from using probiotic/prebiotic supplements (oral or vaginal); boric acid; pH-balancing tampons, pads, wipes, and washes; antifungals (oral or vaginal); antibiotics, and other treatments listed in Section 6.5 during the defined timeframe. * Agree to refrain from making changes to current level of consumption of foods containing probiotics/prebiotics. * Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: * Active infectious, inflammatory, or neoplastic vulvovaginal or genitourinary disorder (such as vulvovaginal candidiasis, bacterial vaginosis, urinary tract infection, vulvar intraepithelial neoplasia, or lichen sclerosis). * Symptomatic sexually transmitted infection. * Use of probiotics within the past 3 months. * Any prior use of intervention product. * Use of antibiotics within the past 3 months. * Vaginal hormone therapy (unless dosage and modality has been stable for 90 days prior to enrollment). * Current use of any medications, supplements, or over-the-counter remedies (including boric acid and deodorants) for vaginal odor. * Vaginal rinses, moisturizers, cooling devices, cooling mattresses, or cooling sprays (unless habitually used for at least 90 days prior to enrollment). * Self-reported urinary incontinence. * Currently lactating, pregnant, or planning to become pregnant during the study period. * Known sensitivity, intolerability, or allergy to any of the study products or their ingredients. * Any clinically significant disease or disorder which, in the opinion of the study investigator, may place you at undue risk or harm, interfere with ability to participate, compromise the interpretability of the study data. * History of alcohol or substance abuse in the last 5 years. * History of smoking in the last 2 years. * Currently participating in another clinical research study on vulvovaginal health.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bonafide Health
Harrison, New York, 10528, United States
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