Disease of primarily extrinsic mechanism

Researchers are comparing ceftobiprole, an intravenous antibiotic, with a standard combination of vancomycin plus aztreonam for treating acute bacterial skin and skin structure infections in hospitalized adults. The trial enrolls adults with serious skin infections such as cellul…

This study tested whether offering hepatitis C (HCV) treatment right at methadone clinics helps more people get cured compared to sending them to outside specialists. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided simplif…

Researchers in India are studying whether a 4-month daily regimen that includes moxifloxacin can cure newly diagnosed, microbiologically confirmed pulmonary tuberculosis as effectively as the standard 6-month treatment. The study enrolls 550 adults aged 18 to 65 who have not yet …

Researchers are testing a vaccine called BNT113 in people whose cancers are driven by HPV16, a common virus linked to head and neck, cervical, and anogenital tumors. The trial enrolls two groups: one with head and neck cancer that has been treated and shows no signs of disease, a…

Scabies is a skin condition caused by mites that burrow into the skin and cause intense itching. This trial compares two creams used to treat it: sulfur 7% and permethrin 5%. Ninety adults with scabies were assigned to one cream or the other. Sulfur was applied each evening for t…

This trial compares the antibiotic tigecycline with two older antibiotics, ampicillin-sulbactam and amoxicillin-clavulanate, in adults with complicated skin or skin structure infections that need intravenous treatment. About 550 participants receive one of the treatments for 4 to…

Researchers compare two 14-day oral antibiotic regimens for eradicating Helicobacter pylori, the bacterium behind most stomach ulcers. One regimen combines bismuth, doxycycline, metronidazole, and esomeprazole; the other adds bismuth to clarithromycin, amoxicillin, and esomeprazo…

Researchers are testing two experimental oral antimalarial drugs, cipargamin and INE963, given alone or in combination, against standard malaria treatment. The trial enrolls people aged 12 and older who have uncomplicated falciparum malaria and weigh between 35 and 90 kilograms. …

Researchers are running a first-in-human study of LXE408, an experimental oral tablet, to see how safe and well tolerated it is in healthy adults. About 88 healthy volunteers aged 18 to 65 will receive single or multiple ascending doses of LXE408 or a placebo. The study also meas…

This trial tests whether an 8-week course of the combination pill elbasvir/grazoprevir can cure chronic hepatitis C in people with genotype 1b who have not been treated before and have mild liver fibrosis. The main goal is to see if the virus stays undetectable 12 weeks after fin…

This phase II trial is testing whether adding the immunotherapy drug tislelizumab to a chemotherapy regimen (pegaspargase, gemcitabine, and oxaliplatin) plus radiation can improve outcomes for people with early-stage, intermediate- or high-risk extranodal NK/T-cell lymphoma. The …

This study tested two experimental nasal spray vaccines in 24 children aged 2 to 5 years. The vaccines target two viruses that can cause breathing problems: human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3). The main goal was to see if the vaccines are safe and …

This large Phase 3 trial tested an experimental mRNA-based flu vaccine (mRNA-1010) against standard flu shots in over 40,000 adults aged 50 and older. The goal was to see if the new vaccine is safer and better at preventing flu-like illness caused by influenza A or B. Researchers…

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine or a placebo to 625 healthy people aged 5 to 65. The goal was to check safety and how well the vaccine triggers an immune response. Results showed the…

This early-stage trial tested an RNA-based vaccine called BNT166a against mpox (monkeypox) in 96 healthy volunteers. The goal was to check safety and see if the vaccine triggers an immune response. Researchers looked for side effects like pain, fever, and fatigue, and monitored s…

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

This study looks at whether an inactivated enterovirus 71 (EV71) vaccine still protects children two to two-and-a-half years after the last dose. It involves 126 healthy children from Vietnam who received the vaccine in an earlier phase 3 trial. Researchers will take a blood samp…

Researchers are testing an inactivated enterovirus 71 (EV71) vaccine in healthy infants and children aged 2 months to 6 years. The trial aims to see if two shots of the vaccine can prevent hand, foot and mouth disease caused by EV71 and reduce severe complications like neurologic…

This study tests a new malaria vaccine called SUM-101 in 69 healthy children and infants aged 5 months to 5 years in Burkina Faso. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants receive three doses, and some infants also receive a ra…

This study tested a new vaccine designed to protect against Sudan ebolavirus, a close relative of the Ebola virus. Researchers gave the vaccine or a placebo to 125 healthy adults to see if it is safe and triggers an immune response. The goal is to find a way to prevent this deadl…

Researchers are testing an experimental coronavirus vaccine called OVX033 in healthy adults aged 18 to 49 who have already received 2 to 4 doses of a licensed COVID-19 vaccine. The trial randomly assigns participants to receive one of three dose levels of OVX033 or a placebo, giv…

This early-stage trial tested a new self-amplifying mRNA vaccine (ARCT-2304) designed to protect against pandemic influenza. 212 healthy adults aged 18-80 received either two doses of the experimental vaccine or one dose of a licensed flu vaccine plus placebo. Researchers monitor…

Researchers are testing a new vaccine called LBVD that combines protection against diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib into a single injection. The study will enroll healthy infants aged 6 to 8 weeks, who will receive three doses at 6, 10, and 14 week…

Researchers are testing an experimental vaccine called RBM-001 in healthy adults aged 18 to 55. The study aims to see if the vaccine is safe and triggers an immune response against COVID-19. Participants receive two doses, and researchers monitor for side effects and measure anti…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tests whether a booster dose of the Janssen COVID-19 vaccine lowers the risk of severe COVID-19, hospitalizations, and deaths in adults who received a single Janssen shot at least six months earlier. Researchers will compare boosted participants with those who were not…

This trial tests two experimental COVID-19 vaccines, AZD9838 and AZD6563, in adults to see if they are safe and trigger a strong immune response. Participants receive a single injection of one of the vaccines or a licensed mRNA vaccine for comparison. The study measures side effe…

This early-stage trial tests an experimental nasal spray vaccine called BW-1014, designed to protect against pandemic flu. Healthy adults aged 18 to 45 receive two doses of the spray, with or without a nanoemulsion adjuvant, followed by a standard flu shot six months later. Resea…

This study tests a two-dose Ebola vaccine regimen in healthcare workers in the Democratic Republic of the Congo, who are at high risk during outbreaks. Participants receive an initial shot of Ad26.ZEBOV followed by a booster of MVA-BN-Filo 56 days later. Some will also get an add…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study adapts a wellness program called Chetana to help men who have sex with men (MSM) and transgender women (TGW) in India who are living with HIV stay engaged in care. The program includes yoga, nutrition, legal advice, mental health support, and peer navigators who provid…

This phase III trial tests whether adding low-dose methotrexate to standard corticosteroid treatment works better than steroids alone for adults who develop acute graft-versus-host disease after a stem cell transplant. Participants receive either methotrexate or a placebo alongsi…

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This completed Phase 2 trial tested fecal microbiota transfer (FMT) – a freeze-dried product made from healthy donor stool – in 40 women with recurrent urinary tract infections (UTIs). The goal was to see if FMT could prevent future UTIs by restoring healthy gut bacteria. Researc…

Researchers at the University of Miami are testing two ways to help men who have sex with men take their HIV prevention medication, known as PrEP, more consistently. One group receives four weekly counseling sessions with a nurse, using techniques from cognitive behavioral therap…

Researchers are studying whether trained community workers can safely deliver HIV treatment outside clinics in Cambodia. The trial enrolls about 4,000 people living with HIV who have stable treatment and no complications. Community action workers receive training to dispense drug…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

Researchers are testing a combination of L-DEP chemotherapy (aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) and a PD-1 antibody as initial treatment for people with Epstein-Barr virus-positive lymphoma-associated hemophagocytic lymphohistiocytosis, a rare an…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

Researchers at UT Health San Antonio are testing a mobile app called PL4Y to see if it helps young people recently diagnosed with HIV stay connected to medical care. The pilot study enrolls 29 participants who either have a recent diagnosis, a high viral load, or have missed HIV …

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

This study tests a new drug called AHB-137 in 86 adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if AHB-137 can clear the hepatitis B surface antigen from the blood, which would mean the virus is under control and patients might be …

This trial compares two surgical methods—carbon dioxide laser ablation and electrocoagulation—for removing genital warts in women. The main goal is to see which technique gives a better cosmetic result six weeks after treatment. Researchers also track operation time, complication…

This study uses health records from over 1.8 million adults in the Czech Republic to see if the antiviral drug molnupiravir lowers the risk of dying from COVID-19 during the Omicron wave. Researchers compare people who received molnupiravir plus standard care with similar patient…

NUTRIREA-3 compares two feeding strategies for adults on ventilators with shock. One group receives low-calorie low-protein feeding for the first week, while the other receives standard-calorie standard-protein feeding. Researchers track survival and time to leave the ICU to see …

Researchers compare two approaches to managing antibiotics in adults hospitalized with community-acquired pneumonia. One approach uses doctors' clinical reassessment to decide whether to continue, stop, or change antibiotics. The other uses blood levels of a marker called procalc…

Researchers are testing whether transplanting a purified mix of gut bacteria from healthy donors can clear urinary tract infections caused by multidrug-resistant organisms. About 10 adults with recurrent resistant UTIs will receive the transplant three times through a tube placed…

This Phase II trial tests whether adding rituximab to standard first-line treatment with ciclosporine and corticosteroids improves remission rates in adults who develop chronic graft versus host disease after a stem cell transplant. Participants receive rituximab infusions once a…

Researchers are testing whether a once-daily form of raltegravir can keep HIV suppressed in adults who already have the virus under control with standard antiretroviral therapy. The trial enrolls about 100 adults with HIV-1 who have been on stable treatment for at least six month…

Researchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…

Researchers are testing whether four common phosphate binders change how the body processes the smallpox antiviral TPOXX. The study enrolls 44 healthy adults aged 18 to 50 with normal phosphorus levels. Each participant receives TPOXX alone and with each binder in a five-period c…

Researchers are studying the smallpox antiviral TPOXX in adults who weigh more than 120 kg. The trial measures how the drug moves through the body and checks for side effects over a week of dosing. The goal is to see whether this group processes the drug differently, which could …

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

Dermatophytosis, a common fungal skin infection, often becomes chronic and resists standard treatment. Researchers are comparing three oral antifungal combinations: terbinafine plus fluconazole, terbinafine plus itraconazole, and terbinafine plus voriconazole. The trial enrolls 1…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

Researchers are testing an experimental intravenous antifungal called HRS9432 in adults with candidemia or invasive candidiasis, serious infections caused by Candida yeast. The trial compares HRS9432 given once a week with caspofungin, a standard antifungal given daily. The main …

Researchers are testing an experimental oral drug called sabizabulin (VERU-111) in hospitalized adults with confirmed SARS-CoV-2 infection who are at high risk for acute respiratory distress syndrome (ARDS). Participants receive either sabizabulin plus standard care or a placebo …

This study compares two common IV fluids—Ringer's Lactate and Sterofundin/Plasmalyte—in adults with sepsis after abdominal surgery. Researchers will measure how well each fluid helps clear lactate from the blood and supports kidney function. The goal is to find which fluid leads …

Cerebral aspergillosis is a rare and serious brain infection caused by a mold. Doctors often use voriconazole as the first treatment, but a newer drug called isavuconazole may work as well with fewer side effects. This study looks back at the medical records of 41 children and ad…

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

Researchers are testing whether a 5% nanochitosan paste can treat oral candidosis, a fungal infection common under dentures. The trial compares this experimental paste with a standard nystatin ointment in 30 adults who wear full dentures and have type 2 denture stomatitis. Partic…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

In sub-Saharan Africa, tuberculosis often causes sepsis in people living with HIV, and many die within days. This phase 3 trial tests two changes to standard care: starting anti-TB therapy right away instead of waiting for test results, and using a higher, sepsis-specific dose in…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

Researchers are testing a drug called sonelokimab in adults with moderate to severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and abscesses. The trial compares sonelokimab, given by injection, with a placebo and with adalimumab, an existing trea…

Researchers are testing whether a daily pill combining dolutegravir and lamivudine keeps HIV suppressed in adults whose virus is already under control but who have a history of resistance to lamivudine. The study enrolls 167 participants who switch from their current HIV treatmen…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

This trial tests whether adding methotrexate to the standard steroid prednisolone better controls erythema nodosum leprosum (ENL), a painful and often recurring complication of leprosy. Adults aged 18 to 65 with active ENL will receive either prednisolone alone or prednisolone pl…

This phase 2 trial tests whether peginterferon lambda, an experimental interferon drug, can safely reduce hepatitis D virus levels in people with chronic infection. Participants receive one of two doses of the drug for 48 weeks, and researchers measure changes in viral load and l…

This study evaluates a program for HIV-positive adolescent girls and young women who are pregnant or parenting. The program offers education on sexual health, support groups, skills development, mentorship, and involvement of young fathers. Researchers will measure resilience and…

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops …

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This trial tests whether kidneys from deceased HIV-positive donors can be safely transplanted into people living with HIV. Researchers track major complications like graft failure, serious side effects, and HIV progression. The goal is to see if using these organs is a safe way t…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This trial tests whether a vaginal gel called Papilocare can repair cervical lesions caused by high-risk human papillomavirus (HPV). Researchers plan to include 164 women aged 30 to 65 who have abnormal cervical cell results and test positive for high-risk HPV. Participants will …

This trial tests whether adding a zinc-containing vaginal gel to the standard yeast infection pill can lower the chance of the infection returning. About 64 women with a current yeast infection will receive either the standard single dose of fluconazole alone or fluconazole follo…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This study tested a new approach to treat vivax malaria, a type that can hide in the liver and come back. Researchers used a quick test to check for a genetic condition (G6PD deficiency) that can cause dangerous side effects with the standard drug primaquine. Then, they gave a hi…

This trial tests whether an oral antibiotic called tebipenem-pivoxil works as well as the standard IV antibiotic ceftriaxone for children with shigellosis, a severe diarrheal disease, when first-line treatment fails. The study enrolls children aged 24 to 59 months who have not im…

This study tests whether extra telemedicine support (using a smartphone or tablet) can help kidney transplant recipients better manage their health and keep their new kidney working longer. About 384 people who received a kidney transplant in the last year will be split into two …

This early-phase trial tests a new therapy for Hodgkin and non-Hodgkin lymphoma that has returned or not responded to standard treatment. Researchers take a patient's own immune cells, train them in the lab to recognize five cancer-specific proteins (tumor-associated antigens), a…

This trial tests whether giving a higher dose of the antibiotic rifampicin (35 mg/kg) can increase drug levels in the fluid around the heart and clear tuberculosis bacteria faster than the standard dose (10 mg/kg). The study enrolls adults with suspected tuberculous pericarditis,…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This phase 2 trial tests a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard chemotherapy in people with classical Hodgkin lymphoma that has come back or stopped responding to treatment. About 200 participants will be randomly assigned to rece…

Researchers are testing a smartphone game called MyGoals to see if it can help adolescents living with HIV in Kenya stay engaged in their care. The game includes role-playing, mini-games, and personal goal-setting to boost knowledge, attitudes, and confidence around treatment and…

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study tested whether the immune-modulating drug abatacept, given early to hospitalized COVID-19 patients on low-flow oxygen, helps them recover faster compared to a placebo. A total of 285 adults participated. The goal was to see if adding abatacept to standard care improves…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This trial tests whether combining two drugs, brentuximab vedotin (Adcetris) and bendamustine (Levact), can safely and effectively treat Hodgkin lymphoma in people aged 60 to 80 who have not had prior treatment. The standard therapy, ABVD, often causes lung damage in older adults…

This trial tests an experimental antibiotic called BTZ-043 in adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. Participants take the drug by mouth once daily for 14 days, and researchers compare it to a standard combination treatment. The main goal is to check …

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study is testing two mobile health tools—a computer-delivered program and motivational text messages—to help young adults (ages 18-24) in Zambia better manage their HIV and cut down on alcohol use. The goal is to see if these tools are easy to use and acceptable to participa…

This pilot study tests whether people with HIV who receive routine care at a community center, instead of a hospital, feel more satisfied with their care. Researchers will compare satisfaction between two groups: one getting care at the community facility and one continuing usual…

This trial tests a counseling program called ImpACT+ for women in South Africa who have HIV and a history of sexual trauma. The program combines HIV treatment adherence support with coping skills to address traumatic stress. Researchers will compare viral suppression rates and ca…

This trial tests two medicines, nitazoxanide and metronidazole, to see which works better for diarrhea caused by Entamoeba histolytica in children. About 90 children aged 2 to 15 with confirmed amoeba infection will be randomly assigned to one of the two drugs. Nitazoxanide is gi…

This trial tests two potential approaches for long COVID: a dietary supplement called nicotinamide riboside (NR) and a mind-body reprocessing therapy (MBRT). The study includes 310 adults aged 18-70 with long COVID symptoms that interfere with daily life. Participants are randoml…

This study tests whether a structured transition-of-care program can improve support for adults in Malawi who are hospitalized with both HIV and a chronic condition like high blood pressure. The program includes discharge planning, nurse home visits within a week, and community f…

This trial tests whether an EHR-integrated texting platform, called Urotrust, can help women with recurrent urinary tract infections (UTIs) manage their condition better than usual care. The platform provides symptom triage, clinical guidance, and prevention education via text me…

This trial tests an experimental antiviral pill, EDP-938, in adults with a confirmed RSV infection who are at high risk for complications—such as those over 65 or with asthma, COPD, or heart failure. Participants take the drug or a placebo once daily for five days. The goal is to…

This early-stage trial is testing whether adding the targeted drug orelabrutinib to a standard chemotherapy regimen can safely treat newly diagnosed primary central nervous system lymphoma (PCNSL), a rare type of lymphoma that starts in the brain or spinal cord. The study will en…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This pilot study looks at whether a daily low-dose iron supplement (27 mg for three months) can improve iron status, gut health, and endurance in young female elite football players. Researchers will track diet, blood markers like hemoglobin and ferritin, gut leakage indicators, …

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This trial is testing an experimental drug called brincidofovir, given intravenously, in people aged 2 months and older who have an adenovirus or cytomegalovirus infection. The study aims to see how safe and tolerable different doses are, and whether the drug can reduce the amoun…

This trial compares two ways of taking the standard malaria treatment for Plasmodium vivax: one group receives chloroquine and primaquine under direct medical supervision, while the other takes the same medication at home with phone check-ins. The goal is to see if unsupervised t…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests whether adding a 12-week digital maintenance program to standard inpatient rehabilitation helps people with post-COVID syndrome maintain improvements in quality of life and symptoms. Participants are randomly assigned to either rehabilitation alone or rehabilitat…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial tests a community-based program called VINA STEAM, designed to help gay and bisexual men in Ho Chi Minh City cope with stress and HIV-related stigma. Participants join small peer-led groups to build skills that may reduce minority stress and stigma. The study measures …

This study looks at how a shorter tuberculosis (TB) treatment regimen works for children and adolescents with non-severe TB in Zambia. It involves children, caregivers, health workers, and policymakers to understand how well the regimen is accepted, followed, and feasible in real…

This study tests whether using pre-moistened wipes without water for perineal hygiene is more effective than traditional soap and water in reducing skin microbes in totally dependent hospital patients. About 468 adults in medical or geriatric wards will be randomly assigned to on…

This phase 3 trial asks whether a dolutegravir-based HIV regimen works as well as or better than an efavirenz-based regimen in pregnant women living with HIV-1. The study compares how well each treatment suppresses the virus at delivery and checks safety for both mothers and thei…

This early-stage trial is testing an experimental stem cell therapy called VUM02 in people with idiopathic pulmonary fibrosis (IPF), a condition that causes progressive lung scarring and breathing difficulty. The study aims to see if the treatment is safe and tolerable, and wheth…

This trial tests whether a combination of everolimus and low-dose tacrolimus is better than the standard tacrolimus plus mycophenolate mofetil at preventing serious long-term complications in children who have had a heart transplant. The study will follow 211 participants from 25…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial tests whether giving children with uncomplicated malaria a triple combination of artemisinin-based drugs works better than the standard two-drug treatment. The goal is to see if using three drugs together can delay the malaria parasite from becoming resistant. Children…

This trial compares two immunosuppressive regimens in CMV-positive kidney transplant recipients. One group receives everolimus with a reduced dose of cyclosporine A, while the other gets standard mycophenolic acid with full-dose cyclosporine. The goal is to see whether the everol…

This phase 2 trial is testing whether adding an experimental drug called JNJ-73763989 to standard oral antivirals can better suppress hepatitis D virus in people who are also infected with hepatitis B. About 52 adults with stable chronic co-infection will receive either the combi…

This study tests whether offering hepatitis C testing right in community pharmacies—using a simple finger-prick device—helps more people on opioid therapy get diagnosed and cured compared to the usual approach of referring them to a clinic. Participants are adults on stable metha…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study looks at whether CABENUVA, a long-acting injectable HIV medication, is safe and effective for people with HIV who also have severe kidney impairment, including those on dialysis. Participants receive the drug as monthly or every-2-month injections. The goal is to see h…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This trial investigates whether JX-594 (Pexa-Vec), a virus modified to attack cancer cells and boost the immune system, combined with best supportive care, can help people with advanced liver cancer live longer. The study enrolls adults whose liver cancer has progressed or who co…

This pilot study compares a new decolonization regimen using polyhexanide (nasal gel and body foam) to the standard mupirocin and chlorhexidine treatment for reducing Staphylococcus aureus bacteria before elective spine surgery. The trial includes 24 adults who carry Staph bacter…

This trial investigates whether a single dose of antibiotics before hip replacement surgery prevents joint infections as effectively as multiple doses. The study involves about 20,000 adults with osteoarthritis undergoing hip replacement at hospitals across Denmark. Researchers w…

This study tests a care model where each hospital patient is assigned one main nurse who plans and oversees all their care. Researchers want to see if this reduces infections, falls, and pressure injuries, and improves patient and nurse satisfaction. The study involves over 1,700…

This study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…

This study tests a program called Maisha (Swahili for 'life') that aims to reduce HIV stigma among pregnant women and their male partners entering antenatal care in Tanzania. The program includes a video and counseling session before HIV testing, plus extra support for those who …

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This trial investigates whether giving two different pneumonia vaccines—one followed by another a year later—boosts immune protection more than a single vaccine alone in adults who have had their spleen removed. People without a spleen are at higher risk for serious pneumococcal …

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This study tests whether a combination of a special omega-3 supplement (LIPINOVA®) and a home-based exercise and education program can improve quality of life for people with lingering post-COVID symptoms. About 146 adults aged 18–70 who have had symptoms for more than 12 weeks w…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested a combination of two drugs, brentuximab vedotin and bendamustine, in 65 patients with Hodgkin lymphoma or anaplastic large cell lymphoma that had come back or didn't respond to earlier treatments. The goal was to find the safest dose and see how well the drugs w…

This study investigates whether respiratory muscle training and walking exercises can improve lung function, reduce breathlessness, and enhance quality of life in women who have recovered from COVID-19 pneumonia. Eighty women aged 20 to 45 are divided into four groups: a combinat…

Researchers are studying whether small intestinal bacterial overgrowth (SIBO) is common in people with abdominal bloating or distension. Adults aged 18 to 70 with these symptoms take a breath test that measures hydrogen and methane in their exhaled air. The study aims to see how …

Malaria in pregnancy often causes no symptoms, yet it can lead to anaemia, premature birth, and low birth weight. Standard rapid tests miss many of these quiet infections. Researchers are comparing a new high-sensitivity rapid diagnostic test with conventional tests in 930 pregna…

Researchers are studying whether a point-of-care nucleic acid test can diagnose HIV faster than standard lab testing and help people get into care or prevention services sooner. The trial enrolls adults at a Seattle HIV clinic, including people living with HIV and those seeking t…

Malaria in pregnancy can hide in the placenta and harm both mother and baby, yet it often goes undetected. This study enrolls about 1,200 pregnant women in Africa to see whether malaria rapid diagnostic tests, blood smears, and PCR on maternal blood can accurately detect or predi…

Visceral leishmaniasis is a fatal parasitic disease if left untreated, and current methods to check whether treatment worked require invasive sampling of the spleen or bone marrow. Researchers at Gondar University Hospital in Ethiopia are evaluating blood-based immune and molecul…

Researchers in Senegal are testing a new way to care for children under 15 who come to primary health clinics with fever or diarrhea. The strategy combines rapid tests for malaria, dengue, and strep A with a digital tool that suggests treatment based on symptoms and test results.…

Dengue fever is common in Burkina Faso, but primary health clinics often rely only on malaria rapid tests when a child arrives with fever. Researchers are testing a digital module that walks health workers through the country's dengue management guideline and pairs it with dengue…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

Researchers in Georgia are testing whether mailing hepatitis C self-tests to people who inject drugs and men who have sex with men increases how many get tested. The trial enrolls 1,250 adults in Tbilisi and Batumi who do not know their hepatitis C status. Half receive a self-tes…

Researchers in Karachi, Pakistan, are studying whether delivering hepatitis C self-tests to people's homes increases how many get tested. The trial enrolls about 2,000 adults who live in two areas of the Malir district and have not recently been tested. Half receive a self-test k…

Researchers are testing whether giving people in Malaysia a rapid hepatitis C self-test kit to use at home increases how many get tested, compared with standard clinic-based testing. The trial enrolls 750 adults who are not known to have hepatitis C and have not been tested in th…

Researchers are testing the Liver Incyte system, an ultrasound device that measures how stiff the liver is, to see if it can tell healthy people apart from those with liver fibrosis or steatosis. The trial includes 140 adults, some healthy and some with a history of hepatitis C o…

Researchers are studying whether lung ultrasound can reliably show the patterns of COVID-19 pneumonia in hospitalized patients. The trial enrolls adults admitted with confirmed COVID-19 and respiratory symptoms who need a chest CT scan. By comparing ultrasound images with CT scan…

Researchers are testing whether ultrasound can reliably show joint damage and inflammation in people with septic arthritis, a painful joint infection. The trial follows 28 adults with septic arthritis in the shoulder, elbow, wrist, hip, knee, or ankle. Participants receive standa…

Young children who arrive at the emergency department with a fever and no obvious cause often get blood tests and antibiotics just in case. Researchers are testing whether a rapid finger-prick procalcitonin test, combined with a set of clinical rules, can help doctors identify wh…

Doctors in the ICU need to know if a patient needs more fluids, and they often use ultrasound to check a large belly vein called the inferior vena cava. But that view can be hard to get. This study tests whether measuring a vein in the neck, the right internal jugular vein, works…

Researchers in Basel are testing whether a blood marker called HNL can help emergency doctors quickly tell whether an infection is bacterial or viral. The study will enroll about 516 adults with suspected infection and signs of physiological disturbance. Doctors will measure HNL …

Researchers are studying whether adding rapid antigen testing for SARS-CoV-2 to HIV, maternal and child health, and tuberculosis clinics in Cameroon and Kenya increases the number of people tested and diagnosed with COVID-19. The study compares clinic activity before and after th…

Researchers at Izmir Katip Celebi University are testing a deep learning model called UNet to automatically outline bone sequestra, pieces of dead jawbone, on panoramic dental X-rays. The study uses 120 anonymized X-rays with 134 marked lesions from patients who had radiotherapy,…

Researchers are testing a portable device called Truenat MTB Plus/COVID-19 to see if it can accurately detect both tuberculosis and COVID-19 from the same sample. The study will enroll about 2,000 adults who have symptoms like a long-lasting cough, fever, or weight loss, which co…

This study will check how well three new rapid tests detect mpox virus compared to a standard lab test. Researchers will use about 80 stored skin swab samples from Uganda. The goal is to see if these quick, portable tests are accurate enough for use in places without full labs.

This study is testing three new diagnostic tests to see if they can correctly identify a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will use leftover samples from over 3,000 people who already tested positive for gonorrhea. If the te…

This study evaluates whether two newer line probe assays, the YD REBA MTB-MDR and Hain Genotype MTBDRplus V2, perform as well as the older Hain Genotype MTBDRplus V1 in detecting drug-resistant tuberculosis. Researchers will test stored, de-identified samples from adults with sym…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study is testing new rapid tests (lateral flow and microfluidic devices) to detect respiratory infections in children and adults in Uganda, Ethiopia, and Senegal. Researchers want to see if these tests are accurate and easy to use in low-resource clinics. Participants with r…

This trial evaluates a new rapid diagnostic test designed to detect Crimean-Congo hemorrhagic fever (CCHF) at the point of care. The test aims to provide results in minutes instead of the current 2-5 days, which could speed up treatment and reduce the risk of the disease spreadin…

This study tests whether an enhanced diagnostic workup can identify lung diseases other than tuberculosis in patients who are about to start TB treatment based on clinical signs but have negative sputum tests. Participants will undergo a thorough review and possibly additional te…

This trial tests whether a new imaging tracer, gallium-68-deferoxamine, can make Aspergillus fungus infections in the lungs visible on a PET/CT scan. The study involves 10 adults with suspected chronic pulmonary aspergillosis or allergic bronchopulmonary aspergillosis. The goal i…

This trial tests whether a vaginal self-sampling device can accurately detect high-risk human papillomavirus (HPV) compared to samples collected by a clinician. About 1,000 women aged 30-64, either regular screening attendees or those who haven't been screened in 3+ years, will p…

This pilot study explores whether a PCR-based test can deliver faster results for diagnosing invasive candidiasis in intensive care patients. The trial compares the time to results using this new strategy against standard methods, with the hope of enabling earlier, more targeted …

This trial evaluates a new blood test (ELISPOT) that looks for immune cells in a newborn's cord blood that produce antibodies against the Toxoplasma parasite. The goal is to see if this test can diagnose congenital toxoplasmosis—an infection passed from mother to baby during preg…

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This trial tests whether a rapid diagnostic test called Reveal can improve outcomes for hospitalized patients with gram-negative bloodstream infections. The test measures bacterial growth by detecting gases they release, giving results in about 5 hours instead of the usual 2-3 da…

This study investigates whether three common lab tests — blood levels of ESR and CRP, plus a leukocyte esterase dipstick test on joint fluid — can reliably diagnose chronic infection in people who have had a total joint replacement. The researchers will compare the test results a…

This study evaluates a rapid viability test for tuberculosis bacteria in sputum samples. The goal is to see if this test can accurately tell whether a patient is still contagious, compared to the standard culture method that takes weeks. If the test works, it could help doctors d…

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This study compares three automated blood tests (Abbott Architect, Siemens Immulite, and Diasorin Liaison) for diagnosing Epstein-Barr virus (EBV) infection. Researchers analyzed 91 blood samples from patients aged 3 to 82 to see how well each test detects key markers of EBV infe…

This study evaluates how well the LumiraDx SARS-CoV-2 Ag ULTRA test detects COVID-19 when used at point-of-care locations like clinics or pharmacies. Participants with COVID-19 symptoms provide nasal and nasopharyngeal swabs, and the test results are compared to a standard lab re…

This study checks whether a fingerstick blood test for COVID-19 antibodies gives the same results as standard lab tests using blood from a vein. About 42 people who recently had a positive COVID-19 PCR test will provide both fingerstick and venous blood samples. The goal is to se…

This study is adapting and testing a French version of the Athletic Disordered Eating (ADE) scale, a 17-question screening tool designed specifically for athletes. Researchers will enroll 229 athletes aged 15 to 70 who exercise more than 6 hours per week. Participants complete th…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

Researchers test whether short messages sent through a mobile wellness app can increase flu vaccination rates among insured adults. The messages, delivered as push notifications and in-app posts, either highlight incentives or use generic wording. The study compares vaccination r…

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

Researchers compare one French middle school that used the e-Bug educational programme with other schools in the region to see whether classroom lessons about vaccination relate to higher HPV and meningococcal ACWY vaccine coverage. The study uses only aggregated, anonymised vacc…

Researchers are testing a field-based sexual health program for people recently exposed to HIV who were notified by New York City's partner services program. The program adds four services to standard contact tracing: HIV and STI testing in the field, same-day start of HIV preven…

Hospital-acquired infections are a major problem in low- and middle-income countries. Researchers are developing and piloting an infection prevention and control program for healthcare workers in Cambodia and Laos. The program aims to improve hand hygiene and equipment disinfecti…

Critically ill children with central venous catheters face a risk of bloodstream infections that can lead to longer hospital stays and serious complications. Researchers are testing whether bathing these children daily with a 2% chlorhexidine gluconate solution prevents central l…

Researchers are testing whether an antiviral tablet called S-217622 can prevent symptomatic COVID-19 in people who live with someone who has symptoms. The trial enrolls household contacts of a person with symptomatic COVID-19 and gives them either the antiviral or a placebo for a…

This completed trial tested a device that uses light to kill germs in the nose before surgery, aiming to prevent surgical site infections. Over 400 adults having major surgeries received either the light treatment or standard care. Researchers tracked infections and side effects …

This study tested a new way to prevent surgical site infections by using a special light treatment inside the nose just before surgery. Over 4,700 adults having major surgeries like heart, spine, or joint replacement took part. The goal was to see if this light therapy reduces in…

Healthcare workers often get injured while moving patients in bed. Researchers at the University of New Brunswick are testing whether a bed-mounted transfer device called the Vendlet, combined with ergonomic training, lowers the muscle activity and joint strain on workers during …

Researchers are comparing two antibiotic combinations given before vascular surgery to see which better prevents MRSA infections. Adults scheduled for procedures such as carotid surgery or dialysis access creation receive either vancomycin plus cefazolin or daptomycin plus cefazo…

Researchers are testing an antiviral drug called tecovirimat to see if it is safe and well tolerated when taken by mouth for 14 days. The trial enrolls healthy adults aged 18 to 80 and compares tecovirimat with a placebo. The goal is to gather safety information that could suppor…

Researchers are studying whether an antiviral drug called tecovirimat (TPOXX) is safe and well tolerated when taken by mouth twice daily for 28 days. The trial enrolls healthy adults aged 18 to 80 and compares TPOXX with a placebo. The main goal is to measure drug levels in the b…

Researchers tested two doses of tecovirimat, an antiviral drug, in healthy volunteers to see how safe and well-tolerated it is. Participants took a daily oral dose for 14 days, and researchers monitored side effects and measured drug levels in the blood. The goal was to find the …

Researchers test whether a community-based health education program helps Hong Kong residents get tested early for COVID-19, accept vaccination, and follow self-protection measures like hand washing and mask wearing. The trial enrolls about 1,200 residents, including adults and s…

Researchers at Akdeniz University are testing Care-Up, a mobile-friendly web tool that gives family caregivers structured guidance on skin care, pressure-injury prevention, urinary-risk signs, nutrition, hydration, and when to call a professional. The trial enrolls 66 patient-car…

Researchers in St. Louis are studying whether the order of offers in a text message changes how people respond to COVID-19 testing and vaccination help. Participants are adults applying for rent or utility assistance in St. Louis City or County. Each person gets a survey with two…

Researchers follow more than 1,200 HIV-positive pregnant and postpartum women in Kigali, Rwanda, who receive standard HIV care through prevention of mother-to-child transmission programs. The study tracks whether their babies remain HIV-free through 18 to 24 months of age while m…

This trial tests whether mobile phone communication helps HIV-positive pregnant women in Kenya complete the steps that prevent passing HIV to their babies. Twenty-six health facilities are assigned to either standard care or standard care plus phone-based support for mothers, mal…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

Researchers are testing two lab-made antibodies, CAP256V2LS and VRC07-523LS, given as shots under the skin to young women who do not have HIV. The phase II trial enrolls about 990 women aged 18 to 30 in Zambia and nearby countries. It measures whether the shots cause serious reac…

Researchers at George Washington University are testing a program called Juntas Adelante to see if it helps Latina transgender women in the Washington DC area learn about and use HIV prevention medicines. The program includes five short online videos and up to two virtual coachin…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study is testing a computer-based program called MES-PrEP to help young transgender women in Thailand start and stick with HIV pre-exposure prophylaxis (PrEP). The program provides personalized feedback and information based on each person's confidence and motivation. Resear…

This trial tests whether giving infants a preventive dose of the antimalarial drug sulfadoxine-pyrimethamine during routine health visits can lower their risk of malaria and anemia. Researchers will follow about 2,100 children in Cameroon, comparing those in areas receiving this …

This trial tests whether giving infants in Côte d'Ivoire a preventive dose of an antimalarial drug at routine health visits can lower their risk of malaria and anemia. Researchers will compare outcomes for infants in areas receiving this intervention against those receiving stand…

This study explores why cranberries prevent urinary tract infections (UTIs) in some women but not others. Researchers will test the urine of 55 healthy women before and after drinking cranberry juice to see if it stops bacteria from sticking to the bladder. The goal is to identif…

This study tests whether a community-based communication program can increase flu vaccination rates among people over 65 in Can Tho City, Vietnam. The program includes direct counseling, weekly health tips via the Zalo app, and printed leaflets. Researchers will compare vaccinati…

This trial tests three flu vaccines in adults aged 65 and older: a standard dose, one with an adjuvant to boost response, and a high-dose version. Researchers measure antibody levels and immune cell activity to see which vaccine triggers the strongest protection. They also examin…

This study tests the safety of an experimental medicine called L9LS in infants aged 1 to 12 months in Mali. It also looks at how L9LS affects the immune response to a malaria vaccine called R21/Matrix-M. The goal is to find a better way to prevent malaria in young children.

This trial tests whether a single high dose of vitamin A, given before a donor stem cell transplant, can prevent gastrointestinal graft-versus-host disease (GVHD), a condition where donor cells attack the gut. Vitamin A deficiency is linked to a higher risk of this complication, …

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

This large study tested whether an enhanced flu vaccine (Fluad) works better than standard flu shots in adults aged 65 and older. Over 38,000 participants received either Fluad or a regular vaccine. The goal was to see if Fluad prevents confirmed flu cases more effectively. Resul…

This trial tests a strategy called expedited partner therapy (EPT) for men who have sex with men in Peru. When a participant is diagnosed with gonorrhea or chlamydia, they receive antibiotic packets to give to their recent sexual partners, so those partners can get treated withou…

This phase 3 trial compares a new lab-made antibody, TNM002, with the standard human tetanus immunoglobulin for preventing tetanus in adults with dirty or contaminated wounds. Participants receive one injection of either treatment, and researchers measure whether their blood reac…

This trial asks whether giving dialysis patients four doses of a double-strength hepatitis B vaccine offers better protection than the standard three doses. People with kidney failure on dialysis often respond weakly to vaccines, leaving many unprotected. The study will compare a…

This trial tests whether a community-based program can help reduce HIV infections among people who move into rural Ugandan communities. Migrants often have higher HIV rates but are less likely to use prevention and care services. The program, called WIN, trains community voluntee…

This trial tests a workshop called Floreciendo, designed for Latina teens aged 14-18 and their female caregivers. The workshop covers sexual health basics, condoms and contraception, family communication, and gender relationships. The study aims to see if the program is feasible …

This trial tests whether text messages to parents and a brief training for healthcare providers can increase HPV vaccination rates among 11- and 12-year-olds. The study involves over 8,000 adolescents and their parents across Florida clinics. Some clinics will use both interventi…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tests whether mouth care with green tea or white tea can prevent ventilator-associated pneumonia (VAP) as well as the standard antiseptic chlorhexidine. It includes adults in intensive care who are on breathing machines. The goal is to see if these natural alternatives…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

This study tests whether ketamine can reduce fatigue and improve thinking in people with Long COVID. Twenty adults aged 18–65 with ongoing tiredness or brain fog will receive four ketamine injections over two weeks. Researchers will track changes in symptoms, brain scans, and inf…

Researchers test a 12-week structured exercise program for employees at a medical garment factory. The program includes 24 sessions with aerobic exercise, team games, and stretching. The study measures changes in productivity, performance reviews, job motivation, and quality of w…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

Researchers are testing whether oral N-acetylcysteine (NAC) can reduce signs of kidney tubular injury, oxidative stress, and inflammation in adults with non-severe leptospirosis. The trial enrolls 64 adults who have had fever for three to five days and a confirmed Leptospira infe…

This study tests whether a virtual exercise program can help children and young adults (ages 8-23) recover physical function and quality of life after a stem cell transplant. Participants will have twice-weekly, 30-minute online sessions with a physical therapist for 12 weeks. Th…

Researchers are testing whether adjusting a patient's body position based on where the lung infection sits, combined with mechanical vibration on the chest, helps clear infected mucus better than routine position changes. The trial enrolls 384 adults in intensive care who need a …

Researchers are testing whether a 12-week online rehabilitation program helps people with long COVID manage their own health, fatigue, and quality of life. The program combines personalized exercise with education sessions and a mobile app for daily tracking. Participants attend …

Many people who had COVID-19 continue to struggle with fatigue, memory problems, and difficulty managing daily tasks. This study follows 120 adults with these symptoms who join a 10-week group rehabilitation program at a Swedish hospital. The program brings together occupational …

Researchers are testing whether cooling local anesthetic before injecting it into the tooth's pulp reduces pain during root canal treatment. The trial enrolls 40 people with painful, inflamed lower molars who need a root canal. Each participant receives the anesthetic at either c…

Researchers compare two root canal file systems, ProTaper Gold and ProTaper Ultimate, to see if they differ in how much pain patients feel afterward. The trial enrolls 40 adults with permanent lower molars diagnosed with symptomatic irreversible pulpitis and apical periodontitis.…

Shots and blood draws cause pain and anxiety in children, and numbing creams take time to work. Researchers are testing a device that uses cold, vibration, and distraction to block needle pain. The trial compares this device with standard numbing cream in children aged 4 to 15 at…

Researchers compare three sealers used during root canal treatment, Totalfil, NeoSealer, and AH-Plus, to see how much pain patients feel afterward. The study includes 39 people with painful, inflamed lower molars that need a root canal. Each participant receives one of the three …

Researchers compare two materials used in pulpotomy, a procedure that removes inflamed pulp from a tooth and covers the remaining tissue. Adults with deep cavities and signs of pulp inflammation in lower first or second molars receive either BIO MTA+ or Well-Root PT. The study me…

Researchers are testing whether a workplace wellbeing programme delivered through mobile apps and remote coaching can improve employees' mental health, work productivity, and reduce sick leave. The study enrolls generally healthy employees from information-intensive jobs. Partici…

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

This pilot study tested whether a four-week online ergonomic training and hand exercise program is practical and beneficial for office workers. Thirty-five desk-based workers participated, doing supervised hand exercises twice a week plus home practice. Researchers measured grip …

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tests whether adding a structured exercise program to standard ergonomics training can reduce work-related pain and improve quality of life in female dairy farmers. Sixty women who have been farming for at least 5 years will be split into two groups: one gets only ergo…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This early-phase study tests whether anakinra, a drug that blocks inflammation, can make the heart more sensitive to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. If successful, patients might need lower, safer doses of inotropes…

This study tested a resilience-building program called RISE+ in 106 people over 50 living with HIV. Participants watched videos and did activities to improve coping skills, optimism, and social connections. The goal was to see if the program helps them handle daily stress better …

This trial tests whether injecting lidocaine under the skin at the shingles rash site can reduce pain and help prevent post-herpetic neuralgia, a long-lasting nerve pain that can follow shingles. Adults with acute shingles pain or established post-herpetic neuralgia will receive …

This study tests whether adding whole-body vibration exercises to mineral bath therapy (balneotherapy) helps people with chronic low back pain feel better, move easier, and sleep more soundly. Sixty adults aged 18 to 65 with long-lasting back pain will be split into two groups: o…

This trial tests whether combining a gentle electrical brain stimulation technique called tDCS with a computer-based cognitive training program can ease the thinking and memory problems that some people experience after COVID-19. About 38 adults with long COVID-related cognitive …

This Phase 3 trial tests whether wearing a hydrogel bandage on the skin of the head and neck during radiation therapy can reduce pain and skin irritation in people with head and neck cancer. About 130 participants will either wear the bandage for at least 5 hours a day during tre…

This trial tests whether a nurse-led group programme called ViaMente can help reduce burnout and improve psychological well-being in mental health professionals. The programme consists of five weekly sessions focusing on recognizing and managing burnout, organizing time, reducing…

This study tests whether a wearable exoskeleton—a supportive device worn around the torso—can reduce physical effort and pain for nursing home staff who regularly lift, turn, and bathe residents in bed. Over 11 weeks, 35 care workers across five French nursing homes will wear the…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tested whether monthly 45-minute psychological interviews over 6 months could reduce post-traumatic stress symptoms in cancer patients affected by the COVID-19 pandemic. It included 29 adults with solid tumors who had moderate to high PTSD symptoms. The goal was to see…

This trial tests whether an internet-based self-help program called Couple HOPES can reduce PTSD symptoms and improve relationship satisfaction in couples where one partner is a military member, veteran, first responder, or healthcare worker with COVID-19-related PTSD. Participan…

This trial tests whether a corticosteroid injection given before root canal treatment can reduce pain and inflammation afterward. One hundred adults with symptomatic pulpitis (tooth nerve inflammation) are randomly assigned to receive either standard root canal treatment alone or…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are surveying people in Thailand who have chronic hepatitis B to find out how many also carry hepatitis D, a virus that can make liver disease worse. The study focuses on groups at higher risk, including people who inject drugs, men who have sex with men, prisoners, a…

Lidocaine is often injected through an existing epidural catheter to numb women for urgent cesarean delivery, and the drug can cross the placenta to the baby. Researchers at multiple hospitals are measuring lidocaine levels in paired umbilical cord blood samples collected right a…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

Dengue has become a recurring illness on Reunion Island, and repeat infections tend to be more severe. Researchers are following 258 adults and children who arrive at two island hospitals with confirmed or suspected dengue, collecting blood samples and health questionnaires over …

This study followed 775 healthy children aged 2-9 in Cambodia over three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples every wet and dry season to check for past or current infections. The goal was to understand why young children g…

This study looked at how bacteria from the gut might travel to the liver and make liver disease worse in people with hepatitis C. Thirty adults with stable liver disease took part. Researchers used blood tests, MRI scans, and liver tissue samples to measure bacterial movement and…

This study checked how many organ transplant recipients in the U.S. have antibodies to the hepatitis E virus, which can become chronic in people with weakened immune systems. Researchers enrolled 447 adults who had a liver, kidney, or small bowel transplant or were on a waiting l…

This completed study looked at how genetic differences might change the way immune cells in the lungs respond to environmental triggers like dust and germs. Researchers collected blood and lung samples from 20 healthy adults to compare cell function between people with different …

This study in Bauchi, Nigeria, is testing whether giving free Oral Rehydration Salts (ORS) and zinc directly to homes can increase how often these treatments are used for children under 5 with diarrhea. Over 100,000 children are taking part, with some areas receiving the medicine…

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study tested whether three new diagnostic tools could help doctors pick the best antibiotic faster for ICU patients with Gram-negative bloodstream infections. Researchers compared standard lab methods to the new tests in 100 patients. The goal was to see if more patients got…

This study tested a computer-assisted method for people to self-administer alcohol intravenously, aiming to achieve precise blood alcohol levels for research. 229 healthy volunteers aged 21-45 took part in sessions where they could give themselves alcohol infusions using a comput…

Anesthesiology residents in Turkey face long hours and high-stakes work, and researchers want to measure how many of them are experiencing burnout. The study surveys 154 residents using the Maslach Burnout Inventory, a standard questionnaire that scores emotional exhaustion, deta…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study follows people who have or had anthrax, those exposed, and healthy vaccinated volunteers to learn how the body fights the disease. Researchers will track symptoms, immune responses, and long-term health for up to 2 years. The goal is to better understand anthrax and im…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

Sepsis and septic shock cause organ failure and death, and doctors need simple ways to flag the patients most at risk. Researchers at Benha University Hospital followed 60 adults with sepsis or septic shock in a surgical intensive care unit for 28 days. They compared two ratios c…

This study followed over 46,000 women in the Netherlands who tested positive for HPV and had mild abnormal Pap results. Researchers tracked how many developed cervical cancer within five years. The goal was to see if these women could safely have fewer follow-up tests, making scr…

Researchers at the University of Malaya are studying how COVID-19 affects muscle loss and strength in critically ill patients. They will compare quadricep muscle thickness and cross-sectional area, along with handgrip and knee extension strength, between COVID-19 and non-COVID-19…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

Researchers at Jacobs University Bremen are running a three-phase study to understand how environmentally friendly behaviors relate to eco-anxiety, well-being, and loneliness. About 1,684 adults complete surveys about their food choices, consumption habits, and feelings of social…

Researchers in Lambaréné, Gabon, want to see if they can safely and reliably infect healthy adult volunteers with malaria using bites from local Anopheles gambiae mosquitoes carrying a local strain of Plasmodium falciparum. The team raises the mosquitoes in the lab, feeds them ma…

This study looks at long-term health problems in 400 adults who had COVID-19 and are now preparing for surgery. Researchers will ask about ongoing symptoms like breathing issues, heart problems, and fatigue. No new treatments are given; the goal is to understand how past COVID-19…

This observational study follows people with hepatitis B-related acute-on-chronic liver failure who receive one of three antiviral drugs: entecavir, tenofovir alafenamide, or tenofovir amibufenamide. Researchers measure two newer virological markers, HBV RNA and HBcrAg, over time…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study tested whether weekly community-led group discussions about health topics could change how people feel about COVID-19 testing and vaccines. 49 adults from housing authority agencies took part in Zoom meetings and completed surveys over 18 weeks. The goal was to see if …

This large observational study looks at whether getting an mRNA COVID-19 vaccine shortly before or after starting immune checkpoint inhibitor therapy is linked to longer survival in adults with cancer. Using data from nearly 100,000 patients in France, researchers are comparing t…

Researchers are reviewing safety reports from people who received the Qdenga dengue vaccine at private vaccination centers in Buenos Aires. The review covers reports collected during the 2023 and 2024 dengue seasons. The goal is to see how often side effects were reported after v…

This study is tracking how the antibiotic ceftazidime-avibactam behaves in the blood of critically ill patients with severe sepsis. Researchers are collecting blood samples at several time points to measure drug levels and build a model that could help doctors choose the right do…

This study looked at how the virus that causes COVID-19 reduces the number of infection-fighting white blood cells (lymphocytes) in the blood. Researchers collected blood samples and medical records from 240 adults with or recovering from COVID-19. The goal was to learn more abou…

This study looks at whether hospitals can safely reduce the use of fall prevention alarms. About 300 hospital staff and units will try different strategies like education and feedback to see if they can lower alarm use without increasing patient falls. The goal is to improve pati…

Researchers are collecting health records from young people with HIV in ten African countries who have taken the drugs darunavir, etravirine, or both. The study follows their demographics, clinical and laboratory profiles, and HIV drug resistance over time. The goal is to underst…

Researchers at the University of Aberdeen are studying how stress and recovery patterns relate to burnout in doctors. About 60 doctors working in NHS Grampian wear a heart rate variability monitor for seven days while answering brief surveys on their phones. The team then compare…

Prosthetic joint infections are rare but serious, often causing long hospital stays and lasting disability. Researchers at a French hospital are asking adults with these infections to fill out standard quality-of-life questionnaires during their regular follow-up visits. The stud…

This study aims to adapt the Menstrual Cycle Knowledge Questionnaire (MCKQ) into Turkish and check whether it is a valid and reliable tool for female athletes. Researchers will ask 120 women aged 16 to 35 who are licensed athletes to fill out the questionnaire, along with other s…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study looked at whether giving nutrition through a tube into the stomach (enteral) or through a vein (parenteral) early on affects survival in very sick patients who need a breathing machine and heart-support medications. Over 2,400 adults in intensive care units were random…

This study looks at whether people can reliably collect their own blood and saliva samples at home to measure how well COVID-19 vaccines work. About 4,000 adults who recently got a COVID-19 vaccine will either do everything remotely or visit a clinic. Researchers will compare the…

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

Researchers in Ethiopia are studying how HIV spreads among people with different treatment histories. They compare newly diagnosed individuals who have never taken antiretroviral therapy with those on therapy who have not achieved viral suppression, and with those who are virally…

This completed phase 1 study tested whether giving healthy adults a controlled dose of whooping cough bacteria via nasal spray can safely cause mild infection. The goal was to establish a human infection model for future vaccine and treatment research. 79 participants aged 18-40 …

This trial tests how well two polio vaccines protect the throat against poliovirus type-2. Healthy infants receive either bivalent oral polio vaccine (bOPV) or inactivated polio vaccine (IPV) in the first months of life. At 18 weeks, all infants get a dose of a newer oral polio v…

This study looked at different digital scanning methods for taking impressions of dental implants when the usual scanning parts are not available. Twelve adults with partial tooth loss and two dental implants took part. Researchers compared three digital workflows to see which ga…

This study looks back at records of over 1,000 new hospital workers in Nice, France, who were tested for latent (hidden) tuberculosis infection as part of their hiring process. The goal is to see how many test positive, what factors increase the risk, and whether the screening le…

This trial tests two common warm-up techniques in amateur athletes aged 18 to 30. After a short cycling warm-up, participants either roll their hamstrings with a foam roller or perform PNF stretching. Researchers measure hamstring flexibility, leg strength, vertical jump, and pai…

This study aims to create European certification standards for programs that support healthcare workers after stressful events, known as the 'second victim' phenomenon. Researchers will work with 66 healthcare professionals across Europe to develop and test these standards. The g…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study looks at whether taking common acid-reducing drugs (proton pump inhibitors, or PPIs) affects the accuracy of a stool DNA test for H. pylori, a stomach bacteria. Researchers will test 25 adults who need PPIs, first while on the drug and then after stopping it for 4 week…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study looks at why some medications, like the antifungal voriconazole, can cause extreme sensitivity to sunlight, leading to severe sunburn-like reactions. Researchers will measure gene activity in skin samples from 62 participants, including healthy volunteers and patients …

This study looked at children who survived Ebola and compared them to close contacts who never got sick. Researchers checked for brain, nerve, and thinking problems more than 5 years after infection. The goal was to understand what lasting issues survivors face, not to test a tre…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looks at how cumulative stress and trauma influence alcohol use and HIV self-management in young people living with HIV, ages 18 to 29. Researchers will track drinking patterns and viral load to identify modifiable targets for future interventions. The goal is to find …

This completed study looked at how COVID-19 affects the heart, lungs, brain, and kidneys in 202 people aged 18 to 80. Participants had imaging scans, blood tests, and other procedures to track inflammation and organ function over time. The goal was to understand why some people g…

Researchers are asking whether isotretinoin, a drug used for severe acne, might increase the chance of catching COVID-19 or having a worse outcome. The drug can dry out the nasal lining, which may reduce the mucus and cilia that help trap viruses. The study compares about 148 peo…

Researchers are using wearable sensors and smartphone check-ins to track fatigue as it happens in people with myeloma, long COVID, heart failure, and healthy controls. Participants wear an ECG patch and a wrist sensor that measure heart rate, activity, and posture, and they rate …

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study interviews women aged 25 to 64 who have a high-risk HPV infection to learn what they value in potential treatments, such as cost, how the treatment is given, and how long it lasts. The researchers want to understand whether women consider unapproved treatments, what be…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This completed study tested whether analyzing social media messages (like WhatsApp and Instagram) from 400 young women aged 18-24 in Kisumu, Kenya could help identify those at risk for HIV. Researchers used AI to look at language patterns and compared them to standard HIV risk sc…

This study gathers information from routine medical care on infants, children, and adolescents under 18 with confirmed mpox infection. Researchers aim to collect standardized data on symptoms, treatments, and outcomes to better understand how the disease affects young people. The…

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

This study will check 300 people living with HIV for oral HPV infection and mouth lesions using a simple swish-and-spit sample. Researchers will compare those who test positive and negative, and look at factors like age, sex, tobacco use, and HIV lab results to see what might pre…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study aims to develop a new laboratory technique to detect specific immune cells (called CD8 T cells) that target the hepatitis C virus (HCV). Researchers will use blood samples from people infected with HCV genotypes 1 or 4 to test and refine this technique. The goal is to …

This study follows 140 adults who have been treated for uncomplicated chlamydia or gonorrhea infections. Participants will have weekly swabs or urine tests to check when the bacteria's genetic material (RNA) disappears from the body, up to 4 weeks after starting treatment. The go…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at how lipoproteins, like HDL (good cholesterol) and LDL (bad cholesterol), change in patients with severe COVID-19 in the intensive care unit. Researchers will measure specific proteins on these particles to see if they can predict which patients are at higher r…

This study looks at patients receiving high-dose intravenous amoxicillin for serious bacterial infections. Researchers will measure drug levels in the blood during the first week to see how much they vary between patients and within the same patient. They will also check for side…

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study aims to find out which germs cause summer diarrhea in children who visit the emergency room. Researchers will collect stool samples from children aged 0 to 16 and test them for viruses, bacteria, and parasites. The goal is to better understand the causes of these infec…

This study looks at whether jaundice, a yellowing of the skin and eyes, makes people with cirrhosis more likely to develop infections while in the hospital. Researchers will follow 250 Egyptian patients with cirrhosis to see if those with jaundice get more hospital-acquired infec…

This study surveys senior managers at companies in Zambia with silica dust exposure to assess their knowledge, attitudes, and practices regarding tuberculosis. Since these leaders shape workplace policies, their understanding is key to protecting workers. The findings could highl…

This study looks at whether people who had leptospirosis, a bacterial infection spread by animals, may have health problems that last for years after the initial illness. Researchers in Reunion will follow about 200 patients who were previously hospitalized with the disease, chec…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study observes people in Belgium with non-invasive pneumococcal infections like pneumonia, ear infections, and sinusitis. Researchers will collect bacterial samples to see which strains are circulating and how they compare to invasive infections. The goal is to understand ho…

This study looks at how athletes who regularly lose and regain weight to meet competition categories experience changes in metabolism, body temperature, and body composition. Researchers will track 48 athletes through periods of weight maintenance, loss, and regain, using body te…

This observational study in children and adolescents with tinea capitis (a scalp fungal infection) investigates whether changes seen under a trichoscope—a special microscope for hair and scalp—can predict when the infection is cured. Participants receive the antifungal drug terbi…

Hepatitis E can cause severe liver problems in people who have had an organ transplant, and may become chronic. This study screens liver and kidney transplant patients in Guadeloupe using blood tests to measure how many carry the virus. The goal is to learn whether routine screen…

This trial looks at whether giving the antibiotic ertapenem as a shot under the skin works as well as giving it through a vein in people aged 75 and older who have infections. Many older patients have poor veins or behavioral issues that make IV access difficult. The study will m…

This observational study aims to measure tetanus antibody levels in healthy adults living in Beijing, China. Researchers will analyze how antibody protection varies across different age groups and whether vaccination history predicts current immunity. Participants provide a singl…

This study looks at how COVID-19 and acute surgical conditions (like appendicitis or internal bleeding) affect each other in hospitalized adults. Researchers will analyze real-world data from a large hospital to understand treatment outcomes and develop models to predict in-hospi…

This study looks back at medical records of transplant recipients (lung, kidney, liver, or bone marrow) who received the antifungal drug isavuconazole. Researchers want to understand why blood levels of the drug vary so much between patients and whether higher levels are linked t…

This study investigates whether telling others about an HIV diagnosis affects how consistently people take their HIV medications. Researchers believe that disclosure might lead to social support, which could improve adherence. The study follows 120 people with HIV who are already…

This study developed and tested HistoMX, an automated platform that analyzes gene activity in kidney transplant biopsy samples. Researchers used over 2,400 archived biopsies from adult kidney transplant recipients to see if the platform could accurately identify different types o…

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study looks at whether simple, non-invasive blood test scores can predict the risk of developing liver cancer in people with advanced liver disease who have been cured of hepatitis C. Researchers analyzed data from 571 adults treated at a single hospital over ten years. The …

This study follows thousands of people with multiple sclerosis (MS) in the UK to see how COVID-19 affects them. Researchers track infections, hospital stays, and deaths using questionnaires and national health data. The goal is to understand the risks and outcomes for this group,…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study follows people aged 70 and older who were hospitalized with severe COVID-19 for one year after their diagnosis. Researchers aim to describe how many survive and how well they recover, including physical and mental function. The goal is to better understand the long-ter…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looks at how drug-resistant bacteria, specifically ESBL-producing E. coli, are passed from mothers to their newborns during vaginal birth or scheduled C-sections. Researchers will test stool samples from 200 healthy mothers and their babies at a Chicago hospital to see…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study looks at how different amounts of endurance exercise—from none to high levels—affect the bacteria living in the mouth of young adults aged 18 to 30. Researchers will collect saliva and gum samples to compare the oral microbiome and signs of inflammation. The goal is to…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study looked at the emotional well-being of healthcare workers treating COVID-19 patients at two French hospitals. 78 staff members completed questionnaires about anxiety, depression, resilience, and empathy at different times during the pandemic. The goal was to understand …

This study followed 92 people who had mild COVID and were treated at home. Two years after their diagnosis, they answered a questionnaire by mail about any hospital visits or other health events. The goal was to learn how outpatients fare over time and find patterns that could he…

This study tested over 1,500 hospital workers in four French hospitals for COVID-19 antibodies to see how many had been infected. Researchers compared infection rates among staff in COVID-19 units, other care areas, and non-care roles, and across regions with different outbreak i…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This completed study monitored 1560 adults hospitalized with invasive pneumococcal infections (excluding meningitis) across France. Researchers collected information on infection severity, risk factors, and bacterial serotypes to understand how these infections occur and how vacc…

This completed study looked at 25 young adults (ages 18-65) who had severe COVID-19 and now have thinking or memory problems. Researchers used a special PET-CT scan to see if there are changes in brain activity and how that relates to lung damage. The goal was to better understan…

This study tested two peer education programs to see which better improves nursing students' knowledge, attitudes, and behaviors about sexually transmitted infections (STIs). Thirty-six first-year nursing students were split into two groups: one received a program based on a beha…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study compared two imaging methods—PET/CT and labeled leukocyte scintigraphy—for monitoring malignant otitis externa, a serious infection of the ear canal that can spread to the skull. Researchers looked at 18 patients who had both scans before and after antibiotic treatment…

This study tracks how many infants in Germany receive nirsevimab, a long-acting antibody that helps protect against severe RSV disease. Researchers will survey parents of babies born during three RSV seasons (2024–2027) to measure immunization rates. The goal is to see how well t…

This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations …

This study tested whether a specific ultrasound-based algorithm could help doctors better manage fluids in patients with septic shock. The trial involved 136 intensive care patients and compared the algorithm to standard care over the first 4 days. The goal was to see if the algo…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …